10,848 results match your criteria dlpfc stimulation


An active role of inferior frontal cortex in conscious experience.

Curr Biol 2021 May 7. Epub 2021 May 7.

Department of Psychiatry, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany; Berlin Institute of Health, Charité-Universitätsmedizin Berlin and Max Delbrück Center, 10178 Berlin, Germany; Bernstein Center for Computational Neuroscience, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany; Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, 10099 Berlin, Germany; Einstein Center for Neurosciences Berlin, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.

In the search for the neural correlates of consciousness, it has remained controversial whether prefrontal cortex determines what is consciously experienced or, alternatively, serves only complementary functions, such as introspection or action. Here, we provide converging evidence from computational modeling and two functional magnetic resonance imaging experiments that indicated a key role of inferior frontal cortex in detecting perceptual conflicts caused by ambiguous sensory information. Crucially, the detection of perceptual conflicts by prefrontal cortex turned out to be critical in the process of transforming ambiguous sensory information into unambiguous conscious experiences: in a third experiment, disruption of neural activity in inferior frontal cortex through transcranial magnetic stimulation slowed down the updating of conscious experience that occurs in response to perceptual conflicts. Read More

View Article and Full-Text PDF

A ventromedial prefrontal dysrhythmia in obsessive-compulsive disorder is attenuated by nucleus accumbens deep brain stimulation.

Brain Stimul 2021 May 10. Epub 2021 May 10.

Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, Universidad Politécnica de Madrid, Spain.

Background: Obsessive-compulsive disorder (OCD) has consistently been linked to abnormal frontostriatal activity. The electrophysiological disruption in this circuit, however, remains to be characterized.

Objective/hypothesispabst: The primary goal of this study was to investigate the neuronal synchronization in OCD patients. Read More

View Article and Full-Text PDF

Repetitive Transcranial Magnetic Stimulation for Treating Chronic Neuropathic Pain: a Systematic Review.

Curr Pain Headache Rep 2021 May 12;25(7):48. Epub 2021 May 12.

Department of Anaesthesia and Pain Medicine, Manchester University Foundation Trust, Manchester, UK.

Given pharmacological interventions' limited efficacy and abundance of its adverse effects, the repetitive transcranial magnetic stimulation (rTMS) is considered a viable non-invasive option for managing chronic neuropathic pain of different origins with promising outcomes. PURPOSE OF REVIEW: The provision of a systematic review of current literature on rTMS for managing chronic neuropathic pain of different origins, and assess its efficacy and outcomes, highlighting the need for standard protocols for utilizing rTMS. RECENT FINDINGS: Variable stimulation modalities were trialed targeting the M1, DLPFC, and somatosensory cortices S1 and S2. Read More

View Article and Full-Text PDF

Mechanism of Action of Peripheral Nerve Stimulation.

Curr Pain Headache Rep 2021 May 11;25(7):47. Epub 2021 May 11.

Department of Anesthesiology, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.

Purpose Of Review: The number of applications for peripheral nerve stimulation (PNS) in the pain management field is ever-growing. With the increasing number of clinical applications for peripheral nerve stimulation, the purpose of this article is to review the mechanism of action surrounding PNS, the recent literature from January 2018 to January 2021, and pertinent clinical outcomes.

Recent Findings: The authors searched articles identified from PubMed (January 2018-January 2021), Cochrane Central Register of Controlled Trials databases (January 2018-January 2021), and Scopus (January 2018-January 2021) databases, and manually searched references of identified publications. Read More

View Article and Full-Text PDF

Efficacy and acceptability of noninvasive brain stimulation interventions for weight reduction in obesity: a pilot network meta-analysis.

Int J Obes (Lond) 2021 May 10. Epub 2021 May 10.

Division of Community & Rehabilitation Psychiatry, Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.

Background/objectives: Obesity has recently been recognized as a neurocognitive disorder involving circuits associated with the reward system and the dorsolateral prefrontal cortex (DLPFC). Noninvasive brain stimulation (NIBS) has been proposed as a strategy for the management of obesity. However, the results have been inconclusive. Read More

View Article and Full-Text PDF

Short-Term High-Intensity Interval Exercise Promotes Motor Cortex Plasticity and Executive Function in Sedentary Females.

Front Hum Neurosci 2021 23;15:620958. Epub 2021 Apr 23.

Guangdong Provincial Key Laboratory of Sports and Health Promotion, Scientific Research Center, Guangzhou Sport University, Guangzhou, China.

Previous research has demonstrated that regular exercise modulates motor cortical plasticity and cognitive function, but the influence of short-term high-intensity interval training (HIIT) remains unclear. In the present study, the effect of short-term HIIT on neuroplasticity and executive function was assessed in 32 sedentary females. Half of the participants undertook 2 weeks of HIIT. Read More

View Article and Full-Text PDF

The Changes in Brain Oxygenation During Transcranial Alternating Current Stimulation as Consequences of Traumatic Brain Injury: A Near-Infrared Spectroscopy Study.

Adv Exp Med Biol 2021 ;1269:235-239

Lovelace Biomedical Research Institute, Albuquerque, NM, USA.

The aim was to evaluate the changes in brain tissue oxygenation, assessed by near-infrared spectroscopy (NIRS), during transcranial alternating current stimulation (tACS) in patients with mild and moderate traumatic brain injury (TBI). Nineteen patients with diffuse, blunt, non-severe TBI (mean age 32.7 ± 11. Read More

View Article and Full-Text PDF

Effects of Anodal Transcranial Direct Current Stimulation on Training Volume and Pleasure Responses in the Back Squat Exercise Following a Bench Press.

J Strength Cond Res 2021 May 5. Epub 2021 May 5.

Laboratory of Physical Activity Neuroscience (LABNAF), Physical Activity Sciences Postgraduate Program, Salgado de Oliveira University (UNIVERSO), Niterói, Brazil; Laboratory of Physical Activity Neuroscience (LABNAF), Neurodiversity Institute, Queimados, RJ, Brazil; Physical Activity Sciences Laboratory (LACAF), Physical Activity Sciences Postgraduate Program, Salgado de Oliveira University (UNIVERSO), Niterói, Brazil; Federal Rural University of Rio de Janeiro, Physical Education and Sports Department, Seropédica, (Rio de Janeiro), Brazil; and University of A Coruña, Department of Physical Education and Sport, Faculty of Sport Sciences and Physical Education, A Coruña, Spain.

Abstract: Rodrigues, GM, Machado, S, Faria Vieira, LA, Ramalho de Oliveira, BR, Jesus Abreu, MA, Marquez, G, Maranhão Neto, GA, and Lattari, E. Effects of anodal transcranial direct current stimulation on training volume and pleasure responses in the back squat exercise following a bench press. J Strength Cond Res XX(X): 000-000, 2021-This study aimed to investigate the effects of anodal transcranial direct current stimulation (a-tDCS) on volume-load and pleasure responses in a back squat following a bench press. Read More

View Article and Full-Text PDF

Memories are not written in stone: Re-writing fear memories by means of non-invasive brain stimulation and optogenetic manipulations.

Neurosci Biobehav Rev 2021 May 5;127:334-352. Epub 2021 May 5.

IRCCS Fondazione Santa Lucia, 00179 Rome, Italy.

The acquisition of fear associative memory requires brain processes of coordinated neural activity within the amygdala, prefrontal cortex (PFC), hippocampus, thalamus and brainstem. After fear consolidation, a suppression of fear memory in the absence of danger is crucial to permit adaptive coping behavior. Acquisition and maintenance of fear extinction critically depend on amygdala-PFC projections. Read More

View Article and Full-Text PDF

The Role of the Lateral Habenula in Inhibitory Learning from Reward Omission Experiences.

eNeuro 2021 May 7. Epub 2021 May 7.

Universidad Iberoamericana

The lateral habenula (LHb) is a phylogenetically primitive brain structure that plays a key role in learning to inhibit distinct responses to specific stimuli. This structure is activated by primary aversive stimuli, cues predicting an imminent aversive event, unexpected reward omissions, and cues associated with the omission of an expected reward. The most widely described effect of LHb activation is acutely suppressing midbrain dopaminergic signaling. Read More

View Article and Full-Text PDF

The limited effect of neural stimulation on visual attention and social cognition in individuals with schizophrenia.

Neuropsychologia 2021 May 4;157:107880. Epub 2021 May 4.

School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, USA; Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX,, USA.

Background: Research demonstrates a relationship between faulty visual attention and poorer social cognition in schizophrenia. One potential explanatory model suggests abnormal neuromodulation in specific neural networks may result in reduced attention to socially important cues, leading to poorer understanding of another's emotional state or intentions.

Objective: The current study experimentally manipulated neural networks using tDCS to examine this potential causal mechanism. Read More

View Article and Full-Text PDF

Inducing Cortical Plasticity to Manipulate and Consolidate Subjective Time Interval Production.

Neuromodulation 2021 May 7. Epub 2021 May 7.

Department of Medical Physiology, Kyorin University School of Medicine, Tokyo, Japan.

Objectives: Time awareness may change depending on the mental state or disease conditions, although each individual perceives his/her own sense of time as stable and accurate. Nevertheless, the processes that consolidate altered duration production remain unclear. The present study aimed to manipulate the subjective duration production via memory consolidation through the modulation of neural plasticity. Read More

View Article and Full-Text PDF

Effect of transcranial direct current stimulation on the psychomotor, cognitive, and motor performances of power athletes.

Sci Rep 2021 May 6;11(1):9731. Epub 2021 May 6.

Service de Psychiatrie de L'Adulte, Centre Hospitalier Universitaire de Besançon, 25030, Besançon Cedex, France.

In sports science, transcranial direct current stimulation (tDCS) has many unknown effects on neuromuscular, psychomotor and cognitive aspects. Particularly, its impact on power performances remains poorly investigated. Eighteen healthy young males, all trained in a jumping sport (parkour) performed three experimental sessions: anodal tDCS applied either on the left dorsolateral prefrontal cortex (dlPFC, cathode in supraorbital area) or on the primary motor cortex (M1, cathode on contralateral shoulder), and a placebo condition (SHAM), each applied for 20 min at 2 mA. Read More

View Article and Full-Text PDF

Transcranial direct current stimulation as an adjunct to cognitive training for older adults with mild cognitive impairment: A randomized controlled trial.

Ann Phys Rehabil Med 2021 May 3:101536. Epub 2021 May 3.

Department of Occupational Therapy, Monash University - Peninsula Campus, Frankston, 3199 Victoria, Australia.

Background: Cognitive training (CT) for individuals with mild cognitive impairment (MCI) may not be optimal for enhancing cognitive functioning. Coupling CT with transcranial direct current stimulation (tDCS) may maximize the strength of transmission across synaptic circuits in pathways that are stimulated by CT. The synergistic effects arising from this combination could be superior to those with administration of CT alone. Read More

View Article and Full-Text PDF

Right prefrontal activation predicts ADHD and its severity: A TMS-EEG study in young adults.

Prog Neuropsychopharmacol Biol Psychiatry 2021 May 3;111:110340. Epub 2021 May 3.

Life Science Department and the Zlotowski Center for Neuroscience, Ben Gurion University in the Negev, Beer Sheva, Israel.

Objective: Here we bring a neurophysiological diagnostic tool, based on pathophysiologically-relevant brain region, that is critical for reducing the variability between clinicians, and necessary for quantitative measures of ADHD severity.

Methods: 54 healthy and 57 ADHD adults participated in the study. Electroencephalography (EEG) was recorded when combined with transcranial magnetic stimulation (TMS) over the right prefrontal cortex and also recorded during the Stop Signal task. Read More

View Article and Full-Text PDF

Cognitive Aftereffects of Acute tDCS Coupled with Cognitive Training: An fMRI Study in Healthy Seniors.

Neural Plast 2021 13;2021:6664479. Epub 2021 Apr 13.

Central European Institute of Technology-CEITEC, Masaryk University, Applied Neuroscience Research Group, Brno, Czech Republic.

Enhancing cognitive functions through noninvasive brain stimulation is of enormous public interest, particularly for the aging population in whom processes such as working memory are known to decline. In a randomized double-blind crossover study, we investigated the acute behavioral and neural aftereffects of bifrontal and frontoparietal transcranial direct current stimulation (tDCS) combined with visual working memory (VWM) training on 25 highly educated older adults. Resting-state functional connectivity (rs-FC) analysis was performed prior to and after each stimulation session with a focus on the frontoparietal control network (FPCN). Read More

View Article and Full-Text PDF

fMRI findings in MTBI patients with headaches following rTMS.

Sci Rep 2021 May 5;11(1):9573. Epub 2021 May 5.

Anesthesiology, UC San Diego School of Medicine, La Jolla, CA, 92093, USA.

Mild Traumatic Brain Injury (MTBI) patients with persistent headaches are known to have diminished supraspinal modulatory connectivity from their prefrontal cortices. Repetitive transcranial magnetic stimulation (rTMS) is able to alleviate MTBI-related headache (MTBI-HA). This functional magnetic resonance imaging (fMRI) study assessed supraspinal correlates associated with the headache analgesic effect of rTMS at left prefrontal cortex (LPFC), hypothesizing real rTMS would significantly increase modulatory functions at LPFC in comparison to sham treatment. Read More

View Article and Full-Text PDF

Nicotine Enhances Firing Activity of Layer 5 Pyramidal Neurons in the Medial Prefrontal Cortex through Inhibition of Kv7 Channels.

Biol Pharm Bull 2021 ;44(5):724-731

Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University.

Nicotine enhances attention, working memory and recognition. One of the brain regions associated with these effects of nicotine is the medial prefrontal cortex (mPFC). However, cellular mechanisms that induce the enhancing effects of nicotine remain unclear. Read More

View Article and Full-Text PDF
January 2021

Accelerated transcranial magnetic stimulation (aTMS) to treat depression with treatment switching: study protocol of a pilot, randomized, delayed-start trial.

Pilot Feasibility Stud 2021 May 5;7(1):104. Epub 2021 May 5.

Department of Mood and Anxiety, Institute of Mental Health, 10 Buangkok View, Singapore, 539747, Singapore.

Background: Repetitive transcranial magnetic stimulation (rTMS) is a technique for stimulating brain activity using a transient magnetic field to induce an electrical current in the brain producing depolarization of focal groups of brain cells. TMS is a protocol approved by the U.S. Read More

View Article and Full-Text PDF

Manipulating placebo analgesia and nocebo hyperalgesia by changing brain excitability.

Proc Natl Acad Sci U S A 2021 May;118(19)

Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129;

Harnessing placebo and nocebo effects has significant implications for research and medical practice. Placebo analgesia and nocebo hyperalgesia, the most well-studied placebo and nocebo effects, are thought to initiate from the dorsal lateral prefrontal cortex (DLPFC) and then trigger the brain's descending pain modulatory system and other pain regulation pathways. Combining repeated transcranial direct current stimulation (tDCS), an expectancy manipulation model, and functional MRI, we investigated the modulatory effects of anodal and cathodal tDCS at the right DLPFC on placebo analgesia and nocebo hyperalgesia using a randomized, double-blind and sham-controlled design. Read More

View Article and Full-Text PDF

Transcranial direct current stimulation of the prefrontal cortex reduces cigarette craving in not motivated to quit smokers: A randomized, sham-controlled study.

Addict Behav 2021 Apr 23;120:106956. Epub 2021 Apr 23.

University Niccolò Cusano, Rome, Italy.

Transcranial direct current stimulation (tDCS) over the dorsolaterateral prefrontal cortex (DLPFC) has been indicated as a promising treatment for several addictions, while its contribution for smoking cessation was less investigated. In particular, the role of motivation to quit and the nicotine dependence level as possible mediators of tDCS effect needs to be deepened. In the present study, we recruited twenty smokers who did not look for a treatment to quit: most of them presented a mild level of nicotine addiction, and they were randomly assigned to active or sham group for receiving bilateral tDCS over the DLPFC. Read More

View Article and Full-Text PDF

Transcranial magnetic stimulation as a treatment for posttraumatic stress disorder: A meta-analysis.

J Affect Disord 2021 Apr 14;289:55-65. Epub 2021 Apr 14.

School of Psychological Sciences, Australian College of Applied Psychology, Melbourne, Australia.

Background: Posttraumatic stress disorder (PTSD) is a pervasive mental health condition with limited treatment success. Transcranial magnetic stimulation (TMS) has shown positive outcomes for people with PTSD, using different treatment protocols. This meta-analysis sought to examine which variables in TMS treatment are associated with treatment benefits. Read More

View Article and Full-Text PDF

Targeting repetitive transcranial magnetic stimulation in depression: do we really know what we are stimulating and how best to do it?

Brain Stimul 2021 Apr 30;14(3):730-736. Epub 2021 Apr 30.

Background: Repetitive transcranial magnetic stimulation (rTMS) is an established treatment for patients with depression who have not achieved optimal outcomes with one or more trials of antidepressant medication. It is an effective antidepressant treatment but there remains considerable scope for improving clinical outcomes. One method to potentially enhance the efficacy of rTMS is through the improvement of methods of stimulation localization. Read More

View Article and Full-Text PDF

Verbal Fluency in Mild Alzheimer's Disease: Transcranial Direct Current Stimulation over the Dorsolateral Prefrontal Cortex.

J Alzheimers Dis 2021 Apr 28. Epub 2021 Apr 28.

Department of Psychology, Educational Science and Human Movement, University of Palermo, Palermo, Italy.

Background: Recent studies showed that in healthy controls and in aphasic patients, inhibitory trains of repetitive transcranial magnetic stimulation (rTMS) over the right prefrontal cortex can improve phonemic fluency performance, while anodal transcranial direct current stimulation (tDCS) over the left prefrontal cortex can improve performance in naming and semantic fluency tasks.

Objective: This study aimed at investigating the effects of cathodal tDCS over the left or the right dorsolateral prefrontal cortex (DLPFC) on verbal fluency tasks (VFT) in patients with mild Alzheimer's disease (AD).

Methods: Forty mild AD patients participated in the study (mean age 73. Read More

View Article and Full-Text PDF

Perturbing fMRI brain dynamics using transcranial direct current stimulation.

Neuroimage 2021 Apr 29:118100. Epub 2021 Apr 29.

Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA; Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA. Electronic address:

The dynamic nature of resting-state functional magnetic resonance imaging (fMRI) brain activity and connectivity has drawn great interest in the past decade. Specific temporal properties of fMRI brain dynamics, including metrics such as occurrence rate and transitions, have been associated with cognition and behaviors, indicating the existence of mechanism distruption in neuropsychiatric disorders. The development of new methods to manipulate fMRI brain dynamics will advance our understanding of these pathophysiological mechanisms from native observation to experimental mechanistic manipulation. Read More

View Article and Full-Text PDF

Sexually divergent cortical control of affective-autonomic integration.

Psychoneuroendocrinology 2021 Apr 21;129:105238. Epub 2021 Apr 21.

Biomedical Sciences, Colorado State University, Fort Collins, CO, United States. Electronic address:

Depression and cardiovascular disease reduce quality of life and increase mortality risk. These conditions commonly co-occur with sex-based differences in incidence and severity. However, the biological mechanisms linking the disorders are poorly understood. Read More

View Article and Full-Text PDF

The Effects of Functionally Guided, Connectivity-Based rTMS on Amygdala Activation.

Brain Sci 2021 Apr 13;11(4). Epub 2021 Apr 13.

Department of Psychiatry and Behavioral Science, Duke University School of Medicine, 200 Trent Drive, Box 3620 DUMC, Durham, NC 27710, USA.

While repetitive transcranial magnetic stimulation (rTMS) is widely used to treat psychiatric disorders, innovations are needed to improve its efficacy. An important limitation is that while psychiatric disorders are associated with fronto-limbic dysregulation, rTMS does not have sufficient depth penetration to modulate affected subcortical structures. Recent advances in task-related functional connectivity provide a means to better link superficial and deeper cortical sources with the possibility of increasing fronto-limbic modulation to induce stronger therapeutic effects. Read More

View Article and Full-Text PDF

Null Effect of Transcranial Static Magnetic Field Stimulation over the Dorsolateral Prefrontal Cortex on Behavioral Performance in a Go/NoGo Task.

Brain Sci 2021 Apr 11;11(4). Epub 2021 Apr 11.

Department of Sensorimotor Neuroscience, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.

The purpose of this pilot study was to investigate whether transcranial static magnetic field stimulation (tSMS), which can modulate cortical excitability, would influence inhibitory control function when applied over the dorsolateral prefrontal cortex (DLPFC). Young healthy adults ( = 8, mean age ± SD = 24.4 ± 4. Read More

View Article and Full-Text PDF

Could tDCS Be a Potential Performance-Enhancing Tool for Acute Neurocognitive Modulation in eSports? A Perspective Review.

Int J Environ Res Public Health 2021 Apr 1;18(7). Epub 2021 Apr 1.

Research Center in Sport, Health and Human Development (CIDESD), 5000-558 Vila Real, Portugal.

Competitive sports involve physical and cognitive skills. In traditional sports, there is a greater dependence on the development and performance of both motor and cognitive skills, unlike electronic sports (eSports), which depend much more on neurocognitive skills for success. However, little is known about neurocognitive functions and effective strategies designed to develop and optimize neurocognitive performance in eSports athletes. Read More

View Article and Full-Text PDF

Preliminary evidence for the efficacy of single-session transcranial direct current stimulation to the ventrolateral prefrontal cortex for reducing subclinical paranoia in healthy individuals.

Br J Clin Psychol 2021 Apr 29. Epub 2021 Apr 29.

School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, Texas, USA.

Objectives: Paranoia manifests similarly in subclinical and clinical populations and is related to distress and impairment. Previous work links paranoia to amygdala hyperactivity and reduced activation of the ventrolateral prefrontal cortex (VLPFC), a region thought to regulate amygdala activity.

Methods: This study aimed to reduce subclinical paranoia in 40 undergraduates by increasing activity of the VLPFC via single-session transcranial Direct Current Stimulation (tDCS). Read More

View Article and Full-Text PDF