297,435 results match your criteria divided groups


Does the power of the laser devices matter for a successful HoLEP procedure? A prospective comparative study.

Int J Clin Pract 2021 Jun 15:e14531. Epub 2021 Jun 15.

Department of Urology, Biruni University School of Medicine, Istanbul, Turkey.

Background: The objectives of this prospective study were to evaluate the efficiency, safety and applicability of medium power (MP) holmium laser devices in the endoscopic enucleation of the enlarged prostate (HoLEP) compared to high power (HP) laser devices.

Methods: From October 2019 to July 2020, a total of 120 consecutive patients planned for HoLEP were divided randomly into two groups formed in terms of the power of the device used. While patients in Group 1 were treated with a MP device (50W) at 39. Read More

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Effects of Ultrashort Wave Therapy on Inflammation and Macrophage Polarization after Acute Lung Injury in Rats.

Bioelectromagnetics 2021 Jun 15. Epub 2021 Jun 15.

Rehabilitation Medicine Center, The First Affiliated Hospital of University of South China, Hengyang, People's Republic of China.

Acute lung injury (ALI) features dysregulated pulmonary inflammation. Ultrashort waves (USWs) exert anti-inflammatory effects but no studies have evaluated their activity in ALI. Herein, we used an in vivo lipopolysaccharide (LPS)-induced ALI model to investigate whether the anti-inflammatory activity of USWs is mediated by altering the polarization of M1 to M2 macrophages. Read More

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Effect of Sleep-Disordered Breathing During Rapid Eye Movement Sleep and Non-Rapid Eye Movement sleep on Acute Ischemic Stroke.

J Stroke Cerebrovasc Dis 2021 Jun 12;30(8):105913. Epub 2021 Jun 12.

Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; Department of Neurology, Taicang Affiliated Hospital of Soochow University, The first People's Hospital of Taicang, Taicang 215400, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou 215123, China. Electronic address:

Objectives: Sleep-disordered breathing adversely impacts stroke outcomes. We investigated whether sleep-disordered breathing during rapid eye movement sleep and non-rapid eye movement sleep differentially influenced stroke outcomes.

Materials And Methods: Acute ischemic stroke patients who finished polysomnography within 14 days of stroke onset from April 2010 to August 2018 were reviewed. Read More

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Saponins from Panax japonicus alleviate HFD-induced impaired behaviors through inhibiting NLRP3 inflammasome to upregulate AMPA receptors.

Neurochem Int 2021 Jun 12:105098. Epub 2021 Jun 12.

Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan, 430065, China; New Medicine Innovation and Development Institute, Department of Pharmacy, College of Medicine, Wuhan University of Science and Technology, Wuhan, 430065, China. Electronic address:

Obesity is characterized by a condition of low-grade chronic inflammation that facilitates development of numerous comorbidities and dysregulation of brain homeostasis. It is reported that obesity can lead to behavioral alterations such as cognitive decline and depression-like behaviors both in humans and rodents. Saponins from panax japonicus (SPJ) have been reported to exhibit anti-inflammatory action in mouse model of diet-induced obesity. Read More

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IN VITRO and IN VIVO TRYPANOCIDAL ACTIVITY OF A BENZOFUROXAN DERIVATIVE AGAINST Trypanosoma cruzi.

Exp Parasitol 2021 Jun 12:108125. Epub 2021 Jun 12.

Department of Microbiology and Parasitology, Federal University of Santa Maria, Santa Maria, RS, Brazil.

Chagas disease, caused by Trypanosoma cruzi, is a major public health problem and is described as one of the most neglected diseases worldwide. It affects about 6-7 million people. Currently, only two drugs are available for the treatment of this disease: nifurtimox and benznidazole. Read More

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Evaluation of aging changes in the superficial fat compartments of the midface: a computed tomography study.

J Cosmet Dermatol 2021 Jun 15. Epub 2021 Jun 15.

Dr. Sadiye Kus Dermatology Clinic, Istanbul.

Background: Previous studies on alterations in superficial fat compartments with age yielded contradictory results; the superficial fat tissue volume or thickness was reported to increase, decrease, or remain unchanged.

Aims: To investigate volumetric and dimensional changes in superficial midfacial fat tissue retrospectively in patients who underwent a repeated computed tomography (CT).

Methods: A total of 262 patients (mean age, 46 years; median elapsed time between two CT imagings, 56 months) were included. Read More

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The optimal timing of interval laparoscopic cholecystectomy following percutaneous cholecystostomy based on pathological findings and the incidence of biliary events.

J Hepatobiliary Pancreat Sci 2021 Jun 15. Epub 2021 Jun 15.

Division of General Surgery, Chang Gung Memorial Hospital, Taoyuan City, Taiwan.

Background: The incidence of biliary events (BE) following percutaneous cholecystostomy (PC) in acute cholecystitis (AC) patients is high. Therefore, definitive laparoscopic cholecystectomy (LC) is recommended. We aimed to investigate the optimal timing of LC following PC with regard to the clinical course and pathological findings. Read More

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Early Cerebral Hypoperfusion in Patients with Orthostatic Intolerance Without Tachycardia During Head-Up Tilt Test is Independent of Vasovagal Response.

Rev Invest Clin 2021 Jun 15. Epub 2021 Jun 15.

Department of Electromechanical Instrumentation, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.

Background: Cerebral hypoperfusion before syncope has been shown in patients with chronic orthostatic intolerance (OI) without tachycardia, but it is unknown if an initial decrease of cerebral blood flow velocity (CBFv) could be related to the vasovagal response (VVR) to head-up tilt test (HUTT).

Objective: The objective of the study was to compare cardiovascular, cerebrovascular, and autonomic variables during HUTT in OI patients with or without a VVR.

Methods: We included 74 subjects (58% female, mean age 33 ± 12 years) who underwent a 30-min HUTT and were divided into three groups: OI with VVR positive (VVR+), OI without VVR negative (VVR-), and asymptomatic healthy subjects with negative HUTT (control group). Read More

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Investigation of particle transfer to sampler covers during the transportation of samples.

J Occup Environ Hyg 2021 Jun 15:1-10. Epub 2021 Jun 15.

Exposure Assessment Branch, HELD, NIOSH, Morgantown, West Virginia.

This study investigated the effects of particle transfer to the covers of aerosol samplers during transportation of wood dust and welding fume samples. Wood dust samples were collected in a sanding chamber using four sampler types: closed-face cassettes (CFC), CFC with Accu-CAP inserts, disposable inhalable samplers (DIS), and Institute of Occupational Medicine (IOM). Welding fumes were collected in a walk-in chamber using the same samplers, with Solu-Sert replacing Accu-CAP. Read More

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Randomness in Cancer Breakpoint Prediction.

J Comput Biol 2021 Jun 15. Epub 2021 Jun 15.

Laboratory of Bioinformatics, Faculty of Computer Science, National Research University Higher School of Economics, Moscow, Russia.

Cancer genomes are susceptible to multiple rearrangements by deleting, inserting, and translocating genomic regions. Recently, the problem of finding determinants of breakpoint formations was approached with machine learning methods; however, unlike cancer point mutations, breakpoint prediction appeared to be a more difficult task, and various machine learning models did not achieve high prediction power often slightly exceeding the threshold of random guessing. This raised the question of whether the breakpoints are random noise in cancer mutagenesis or there exist determinants in structural mutagenesis. Read More

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The Validity of Neutrophil/lymphocyte Ratio as A Predictive Factor for Systemic Inflammatory Response Syndrome after Flexible Ureteroscopy Lithotripsy.

Urol J 2021 06 15. Epub 2021 Jun 15.

Department of Urology, the Second Affiliated Hospital of Chongqing Medical University, China 74#Linjiang Road, Chongqing, CN 400010.

Purpose: To explore the risk factors and predictive factors of systemic inflammatory response syndrome (SIRS) after flexible ureteroscopy (fURS) for upper urinary tract stones.

Materials And Methods: Patients experienced fURS from January 2014 to September 2019 were retrospectively analyzed, which were divided into the SIRS group and non-SIRS group. Clinical data of all patients, including gender, age, American society of anesthesia score, diabetes, etc. Read More

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Assessment of the hydrochemistry, water quality, and human health risk of groundwater in the northwest of Nansi Lake Catchment, north China.

Environ Geochem Health 2021 Jun 15. Epub 2021 Jun 15.

801 Institute of Hydrogeology and Engineering Geology, Shandong Provincial Bureau of Geology & Mineral Resources, Jinan, 250014, China.

In this study, the formation mechanism and water quality of groundwater in the northwest of Nansi Lake Catchment (NNLC) were analyzed through mathematical statistics, hydrochemical analysis and entropy weighted water quality index (EWQI), and the human health risk of nitrate was also evaluated. To this end, 89 wells in the NNLC were sampled, and the groundwater samples were divided into three groups (I, II, and III) according to cluster analysis results and spatial distribution. The main results are as follows: Topographically, Groups I, II, and III correspond to the alluvial plains, apron plain, and low hills and its front margin, respectively. Read More

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Impact of polypharmacy on all-cause mortality and hospitalization in incident hemodialysis patients: a cohort study.

Clin Exp Nephrol 2021 Jun 15. Epub 2021 Jun 15.

Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, 5200 Kihara Kiyotake, Miyazaki city, Miyazaki, 889-1692, Japan.

Background: Polypharmacy (PP) is common in end-stage chronic renal disease patients largely due to the presence of multiple comorbid conditions. Although PP is potentially harmful, its relationship with mortality and morbidity in hemodialysis patients currently remains unclear.

Methods: Study design: cohort study. Read More

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Effects of ankylosing spondylitis and non-radiographic axial spondyloarthropathy on female sexual functions.

Clin Exp Rheumatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Obstetrics and Gynaecology, Yıldırım Beyazıt University, Bilkent, Ankara, Turkey.

Objectives: Rheumatologic diseases may impair the quality of life (QoL) by affecting sexual functions in different ways. We aimed to evaluate sexual functions and the disease-related variables, physical and psychogenic states in female patients with ankylosing spondylitis and non-radiographic axial spondyloarthropathy.

Methods: A total of 98 women with axial spondyloarthropathy (axSpA) and 99 healthy females were included in the study. Read More

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LA14 Alleviates Liver Injury.

mSystems 2021 Jun 15:e0038421. Epub 2021 Jun 15.

Key Laboratory of Nutrition of Zhejiang Province, Institute of Health Food, Hangzhou Medical College, Hangzhou, China.

Although the probiotic Lactobacillus acidophilus LA14 is used worldwide, its effect on liver diseases remains unelucidated. Here, 32 rats were divided into four groups, gavaged with L. acidophilus LA14 (3 × 10 CFU) or phosphate-buffered saline for 7 days, and then intraperitoneally injected with d-galactosamine or saline. Read More

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How can stretched ductus diameter be predicted from angiographic diameter?

Minerva Pediatr (Torino) 2021 Jun 15. Epub 2021 Jun 15.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Corea.

Background: An appropriate size of device for patent ductus arteriosus (PDA) could be chosen by a stretched PDA size. We propose prediction of stretched size from intact PDA size.

Methods: A total of 361 patients was enrolled. Read More

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Reproductive toxicity of cadmium in pubertal male rats induced by cell apoptosis.

Toxicol Ind Health 2021 Jun 15:7482337211022615. Epub 2021 Jun 15.

School of Public Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, 481115Wuhan University of Science and Technology, Wuhan, China.

Cadmium (Cd) is a heavy metal that is widely present in modern industrial production. It is a known, highly toxic environmental endocrine disruptor. Long-term exposure to Cd can cause varying degrees of damage to the liver, kidney, and reproductive system of organisms, especially the male reproductive system. Read More

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Prehospital Variables Alone Can Predict Mortality After Blunt Trauma: A Novel Scoring Tool.

Am Surg 2021 Jun 15:31348211024192. Epub 2021 Jun 15.

Department of Surgery, University of California, Irvine, Orange, CA, USA.

Background: We sought to develop a novel Prehospital Injury Mortality Score (PIMS) to predict blunt trauma mortality using only prehospital variables.

Study Design: The 2017 Trauma Quality Improvement Program database was queried and divided into two equal sized sets at random (derivation and validation sets). Multiple logistic regression models were created to determine the risk of mortality using age, sex, mechanism, and trauma activation criterion. Read More

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Which Endoscopic Methods in Prepubertal Patients with 10-20 mm Bladder Stones: Transurethral Cystolithotripsy or Percutaneous Cystolithotripsy?

J Endourol 2021 Jun 15. Epub 2021 Jun 15.

Necmettin Erbakan University Meram Medical Faculty Hospital, 64222, Department of Urology, Konya, Turkey;

Background: The aim of this study was to evaluate the efficacy and safety of transurethral cystolithotripsy(TUC) and percutaneous cystolithotripsy(PCC) in prepubertal patients with 10-20 mm bladder stones.

Materials And Methods: The files of patients the age of 12 and under who were admitted our clinic for bladder stones from January 2007 to January 2021 were reviewed retrospectively. Inclusion criteria were patients who were 12 years of age and under with 10-20 mm bladder stones, and who underwent endoscopic surgery(TUC or PCC). Read More

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A novel nomogram with preferable capability in predicting the overall survival of patients after radical esophageal cancer resection based on accessible clinical indicators: A comparison with AJCC staging.

Cancer Med 2021 Jun 15. Epub 2021 Jun 15.

Department of Thoracic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Background: Esophageal cancer (EC) is a malignant tumor with high mortality. Nomogram is an important tool used in clinical prognostic assessment. We aimed to establish a novel nomogram to predict the overall survival (OS) of EC patients after radical esophagectomy. Read More

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BP230 IgE autoantibodies in topical-steroid-resistant bullous pemphigoid.

J Dermatol 2021 Jun 14. Epub 2021 Jun 14.

Department of Dermatology, School of Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.

Background: IgE autoantibodies targeting BP230 can be identified in 38%-68% of bullous pemphigoid (BP) patients, yet the diagnostic and pathogenic value of anti-BP230 IgE still remains inconclusive.

Objective: We intend to investigate the clinical and immunological characteristics of anti-BP230 IgE in BP patients.

Methods And Results: Fifty-four BP patients were divided into two groups based on the responsiveness of a topical steroid. Read More

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Distribution of Fluoride in Plasma, Brain, and Bones and Associated Oxidative Damage After Induced Chronic Fluorosis in Wistar Rats.

Biol Trace Elem Res 2021 Jun 14. Epub 2021 Jun 14.

Division of Veterinary Animal Nutrition, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST-J, Ranbir Singh Pura, 181102, Jammu and Kashmir, India.

The study was aimed to determine fluoride levels in plasma, brain, and bones of Wistar rats following chronic administration of fluoride at different dose levels and the consequent oxidative damage inflicted in these tissues. Brain histomorphology and bone radiographs were also evaluated to assess the extent of damage in these organs. Eighteen rats were randomly divided into three groups with six animals in each group. Read More

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Long-term copper exposure promotes apoptosis and autophagy by inducing oxidative stress in pig testis.

Environ Sci Pollut Res Int 2021 Jun 15. Epub 2021 Jun 15.

College of Veterinary, South China Agricultural University, Guangzhou, 510642, China.

Copper (Cu) is a heavy metal which is being used widely in the industry and agriculture. However, the overuse of Cu makes it a common environmental pollutant. In order to investigate the testicular toxicity of Cu, the pigs were divided into three groups and were given Cu at 10 (control), 125, and 250 mg/kg body weight, respectively. Read More

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Does wearing personal protective equipment affect the performance and decision of physicians? A cross-sectional study during the COVID-19 pandemic.

Ann Med Surg (Lond) 2021 Jul 10;67:102488. Epub 2021 Jun 10.

Department of Obstetrics and Gynaecology, Faculty of Medicine, Alexandria University, Egypt.

Background: The use of personal protective equipment (PPE) decreased the probability of viral transmission during the COVID-19 pandemic. However, some drawbacks have been observed with its extensive use, such as headaches, anxiety, and stress among physicians, which could affect decision-making processes, the performance of physicians, and consequently patients' safety. Few articles have studied the impact of PPE on physicians from different specialties. Read More

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Optimal timing of delivery for pregnancies with prenatally diagnosed congenital diaphragmatic hernia: a propensity-score analysis using the inverse probability of treatment weighting.

J Perinatol 2021 Jun 14. Epub 2021 Jun 14.

Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

Objective: To evaluate the optimal timing of neonates with prenatally diagnosed congenital diaphragmatic hernia (CDH).

Methods: Data from a retrospective cohort study conducted by the Japanese CDH Study Group between 2011 and 2018 were divided into two groups according to delivery timing: 36-37 and 38-41 weeks of gestation (wg). Death before 90 days as the primary outcome and the duration of hospitalization, oxygen therapy and tube feeding at discharge as the secondary outcomes were analyzed with generalized linear model applying inverse probability of treatment weighting method. Read More

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The impact of fluid resuscitation via colon on patients with severe acute pancreatitis.

Sci Rep 2021 Jun 14;11(1):12488. Epub 2021 Jun 14.

Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin er Road, Huangpu District, Shanghai, 200025, China.

Severe acute pancreatitis (SAP) is a life-threatening disease. Fluid Resuscitation Via Colon (FRVC) may be a complementary therapy for early controlled fluid resuscitation. But its clinical application has not been reported. Read More

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Characteristics of left atrial remodeling in patients with atrial fibrillation and hypertrophic cardiomyopathy in comparison to patients without hypertrophy.

Sci Rep 2021 Jun 14;11(1):12411. Epub 2021 Jun 14.

Department of Electrophysiology, Heart Center, University of Leipzig, Strümpellstr. 39, 04289, Leipzig, Germany.

Atrial fibrillation (AF) leads to remodeling characterized by changes in both size and shape of the left atrium (LA). Here we aimed to study the effect of hypertrophic cardiomyopathy (HCM) on the pattern of LA remodeling in AF-patients. HCM-patients (n = 23) undergoing AF ablation (2009-2012) were matched and compared with 125 Non-HCM patients from our prospective registry. Read More

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Lysyl oxidase inhibitors attenuate cyclosporin A-induced nephropathy in mouse.

Sci Rep 2021 Jun 14;11(1):12437. Epub 2021 Jun 14.

Renal Medicine, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, NSW, Australia.

Calcineurin inhibitors, such as Cyclosporin (CsA), are the mainstay of anti-rejection therapy in solid organ transplants but can paradoxically induce progressive nephropathy characterised by renal dysfunction and interstitial fibrosis. Lysyl oxidases (LOXs), a group of enzymes that catalyse extracellular matrix (ECM) crosslinking, were shown to implicate in tissue scarring. It is hypothesized that inhibition of these enzymes may render therapeutic effects against CsA-induced nephropathy. Read More

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Integrative Neuromuscular Training Enhances Physical Fitness in 6- to 14-Year-Old Rugby Players.

J Strength Cond Res 2021 Jun 11. Epub 2021 Jun 11.

Department of General and Specific Didactics, University of Alicante, Alicante, Spain; Tamara Rial Exercise and Women's Health, Newtown, Pennsylvania; Department of Health and Exercise Science, The College of New Jersey Ewing, Ewing, New Jersey; and Department of Physical and Sports Education, Faculty of Sciences Physical Activity and Sport, University of Valencia, Valencia, Spain.

Abstract: Alonso-Aubin, DA, Picón-Martínez, M, Rebullido, TR, Faigenbaum, AD, Cortell-Tormo, JM, and Chulvi-Medrano, I. Integrative neuromuscular training enhances physical fitness in 6- to 14-year-old rugby players. J Strength Cond Res XX(X): 000-000, 2021-The purpose of this study was to assess the effects of an 8-week integrative neuromuscular training (INT) program on physical fitness measures in young rugby players. Read More

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Effects of pill splitting training on drug physiochemical properties, compliance, and clinical outcomes in the elderly population: a randomised trial.

Hong Kong Med J 2021 Jun 11. Epub 2021 Jun 11.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.

Introduction: This study aimed to provide information about the clinical and physiochemical effects of pill splitting training in elderly cardiac patients in Hong Kong.

Methods: A parallel study design was adopted. Patients taking lisinopril, amlodipine, simvastatin, metformin, or perindopril who needed to split pills were recruited from the Prince of Wales Hospital. Read More

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