1,158,780 results match your criteria distribution metabolitefevipiprant


Zein based-nanoparticles loaded botanical pesticides in pest control: An enzyme stimuli-responsive approach aiming sustainable agriculture.

J Hazard Mater 2021 May 7;417:126004. Epub 2021 May 7.

Laboratory of Bioactivity Assessment and Toxicology of Nanomaterials (LABiToN), University of Sorocaba (UNISO), Sorocaba, São Paulo 18023-000, Brazil. Electronic address:

Nanoencapsulation of biopesticides is an important strategy to increase the efficiency of these compounds, reducing losses and adverse effects on non-target organisms. This study describes the preparation and characterisation of zein nanoparticles containing the botanical compounds limonene and carvacrol, responsive to proteolytic enzymes present in the insects guts. The spherical nanoparticles, prepared by the anti-solvent precipitation method, presented in the nanoparticle tracking analysis (NTA) a concentration of 4. Read More

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Spatial characteristics of microplastics in the high-altitude area on the Tibetan Plateau.

J Hazard Mater 2021 May 7;417:126034. Epub 2021 May 7.

School of Renewable Energy, North China Electric Power University, Beijing 102206, China.

Microplastics (MPs) have been widely detected in the environments, yet the sources of MPs in freshwater of remote areas at high altitude were not well understood. This study investigated the abundance and distribution of MPs in water bodies and sediments at the Qinghai-Tibet Plateau (QTP). MPs were detected in all samples (47 water and 33 sediment samples) with the mean abundance of 624. Read More

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Seasonal microplastic variations in estuarine sediments from urban canal on the west coast of Thailand: A case study in Phuket province.

Mar Pollut Bull 2021 May 12;168:112452. Epub 2021 May 12.

Faculty of Technology and Environment, Prince of Songkla University, Phuket Campus, Phuket 83120, Thailand.

To improve knowledge of the relationships of human activities with microplastic pollution in the urban estuary in Phuket province, which has a densely populated city on the western coast of Thailand, a total of 463 plastic-like items from 24 sediment samples in the dry and the rainy seasons were identified by micro-Fourier transform infrared spectroscopy. The microplastic abundance ranged in 300-900 and 33-400 items/kg dry weight in the dry and the rainy seasons, respectively, indicating that the estuary is moderately contaminated with microplastics. The most abundant polymer types were rayon and polyester with colored fibers, suggesting that the microplastics deposited in this area originate mainly from washing effluents. Read More

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Microplastic fibers in the gut of highly consumed fish species from the southern Caspian Sea.

Mar Pollut Bull 2021 May 12;168:112461. Epub 2021 May 12.

Department of Chemical and Environmental Engineering, University of Arizona, Tucson, AZ 85721, USA; Department of Hydrology and Atmospheric Sciences, University of Arizona, Tucson, AZ 85721, USA. Electronic address:

This study assesses the frequency, distribution, characteristics, and chemical composition of microplastics (MPs) in the gut of highly consumed fish species, namely leaping mullet (Chelon saliens), common carp (Cyprinus carpioi), and Caspian kutum (Rutilus caspicus), in the southern Caspian Sea biome. Fibers are found to be the only shape of MPs. Black MPs and polystyrene, polypropylene, and polyethylene terephthalate polymers are dominant. Read More

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Study on the dinoflagellate cysts in ballast tank sediments of international vessels in Chinese shipyards.

Mar Environ Res 2021 Apr 28;169:105348. Epub 2021 Apr 28.

College of Marine Ecology and Environment, Shanghai Ocean University, Shanghai, 201306, China; Ballast Water Detecting Lab, Shanghai Ocean University, Shanghai, 201306, China. Electronic address:

The problem of aquatic invasive species caused by discharge of ballast water and sediments from ships' ballast tanks has become extremely prominent. Seventeen sediment samples taken from ballast tanks of different ships docked in two Chinese shipyards were examined to identify the variety of resting dinoflagellate cysts. Twenty-two dinoflagellate cyst taxa were identified in these samples, including 11 photosynthetic and eleven heterotrophic species. Read More

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Bacteriophage-host depth distribution patterns in soil are maintained after nutrient stimulation in vitro.

Sci Total Environ 2021 May 12;787:147589. Epub 2021 May 12.

Department of Biosystems Engineering and Soil Science, The University of Tennessee, Knoxville, TN 37996, USA. Electronic address:

Previous research has revealed the ecological importance of viruses in different ecosystems. However, bacteriophage-host distribution patterns in soil depth profiles have not been investigated. Environmental factors such as nutrient availability and physiological stress can impact the mode (either lytic or lysogenic) of viral reproduction and subsequent influence of virus infection on ecological processes. Read More

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Occurrence, spatiotemporal distribution, and ecological risks of organophosphate esters in the water of the Yellow River to the Laizhou Bay, Bohai Sea.

Sci Total Environ 2021 May 6;787:147528. Epub 2021 May 6.

State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing 100875, China.

Limited information is available on the spatiotemporal occurrence and ecological risks of organophosphate esters (OPEs) in coastal environments. 175 water samples were collected in Laizhou Bay (LZB) and its rivers and estuaries during spring and summer for the determination of 12 targeted OPEs. Total concentration of OPEs ranged from 234. Read More

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Root responses to localised soil arsenic enrichment in the fern Pityrogramma calomelanos var. austroamericana grown in rhizoboxes.

Plant Physiol Biochem 2021 Apr 28;164:147-159. Epub 2021 Apr 28.

Centre for Mined Land Rehabilitation, Sustainable Minerals Institute, The University of Queensland, Brisbane, QLD, 4072, Australia.

The terrestrial fern Pityrogramma calomelanos, a cosmopolitan tropical species, is one of the strongest known arsenic (As) hyperaccumulator plants. This study aimed to determine whether P. calomelanos preferentially forages for arsenite (As) or arsenate (As) in As-contaminated soils, and whether a positive root response to As enhances accumulation in P. Read More

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Phytic acid accumulation in plants: Biosynthesis pathway regulation and role in human diet.

Plant Physiol Biochem 2021 May 7;164:132-146. Epub 2021 May 7.

São Paulo State University (UNESP), 17602-496, Tupã, SP, Brazil. Electronic address:

Phytate or phytic acid (PA), is a phosphorus (P) containing compound generated by the stepwise phosphorylation of myo-inositol. It forms complexes with some nutrient cations, such as Ca, Fe and Zn, compromising their absorption and thus acting as an anti-nutrient in the digestive tract of humans and monogastric animals. Conversely, PAs are an important form of P storage in seeds, making up to 90% of total seed P. Read More

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Structural dynamics and vibrational feature of N-Acetyl-d-glucosamine in aqueous solution.

Spectrochim Acta A Mol Biomol Spectrosc 2021 May 5;259:119918. Epub 2021 May 5.

College of Chemistry and Materials Science, Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, Fujian Normal University, Fuzhou 350007, PR China; Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, Xiamen 361005, PR China. Electronic address:

Molecular dynamics simulations and DFT calculations were performed for the demonstration of the structural dynamics and vibrational feature of N-Acetyl-d-glucosamine (NAG) in solution phase. The interactions between NAG and solvent molecules were evaluated through spatial distribution function and radial distribution function, and the preferred conformations of NAG in aqueous solution were revealed by cluster analysis. Results from normal mode analysis show that the solvent induced structural fluctuation of NAG could be reflected in the vibrational feature of specific chromophores, thus we can evaluate the molecular structure with the help of its vibrational signature based on the built correlation between molecular structure and vibrational frequencies of specific groups. Read More

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Interfacial flow of a surfactant-laden interface under asymmetric shear flow.

J Colloid Interface Sci 2021 Apr 28;599:837-848. Epub 2021 Apr 28.

Institute of Fluid Dynamics, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstrasse 400, 01328 Dresden, Germany; Institute of Process Engineering and Environmental Technology, Technische Universität Dresden, 01062 Dresden, Germany.

Hypothesis: The shear stress of the axisymmetric flow field triggers a nonuniform distribution of the surfactants at the surface of a rising bubble, known as stagnant cap. The formation of the stagnant cap gives rise to Marangoni stresses that reduce the mobility of the interface, which in return reduces the rising velocity. However, the conditions in technological processes usually deviate from the linear rise of a single bubble in a quiescent unbounded liquid. Read More

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Improvement of quality and flavor of salted egg yolks by ultrasonic assisted cooking.

Ultrason Sonochem 2021 May 6;75:105579. Epub 2021 May 6.

School of Food and Biological Engineering, Hubei University of Technology, Wuhan 430068, Hubei, China; Engineering Research Center of Bio-process, Ministry of Education, Hefei University of Technology/School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, Anhui, China. Electronic address:

Physicochemical, texture indexes, microstructure and volatiles were used to characterize the changes in quality, structure and flavor of cooked salted egg yolks (SEYs) with or without ultrasonic treatment. Experimental results indicated that ultrasonic significantly increased cooking (water) loss, oil exudation, lipids oxidation (TBARS), accelerated the doneness of cooked SEYs and then promoted the generation of volatiles. These results were further confirmed by the improvement of thermal stability, the changes in color, secondary structure of proteins, water distribution and mobility. Read More

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MiR-128-3p suppresses tumor proliferation and metastasis via targeting CDC6 in hepatocellular carcinoma cells.

Tissue Cell 2021 Mar 23;72:101534. Epub 2021 Mar 23.

School of Medicine, Shaoxing University, China; Department of General Surgery, Xinchang People's Hospital, China. Electronic address:

Background: MicroRNAs (miRNAs) are known to be involved in the pathogenesis of various cancers. The present study devotes efforts to discover the role of miR-128-3p in hepatocellular carcinoma (HCC).

Methods: MiR-128-3p and cell division cycle 6 (CDC6) expressions in HCC tissue (n = 50) and adjacent normal tissue (n = 50) were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Read More

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Radium desorption behavior of riverine suspended sediment: Theoretical and experimental.

J Environ Radioact 2021 May 12;234:106644. Epub 2021 May 12.

State Key Laboratory of Estuarine and Coastal Research, East China Normal University, Shanghai, 200241, China. Electronic address:

Radium desorption from riverine or suspended sediment is an important source term of Ra isotopes in estuarine water, which is one of the significant factors affecting the source/sink material balance for Ra applications, such as estimating submarine groundwater discharge flux in coastal zones. In this paper, a theoretical model is proposed to study Ra desorption considering several influencing factors, including salinity, particle size and size distribution, alpha recoil range of atoms in the sediment grains, and grain surface roughness. The results of the model parameter sensitivity analysis show that the alpha-decay recoil can improve the number of total exchangeable Ra on grain surfaces, but it is more significant for sediment of small grain size. Read More

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Protocol for sampling and analysis of food and agricultural produces consequent to a nuclear accident in India.

J Environ Radioact 2021 May 12;234:106621. Epub 2021 May 12.

Health Physics Division, Bhabha Atomic Research Centre, Mumbai, 400085, India.

Nuclear accidents, despite having an extremely low probability of occurrence, could cause uncontrolled release of radioactive elements (fission and activation products) into the environment, and may ultimately lead to contamination of food products. Such a scenario requires extraordinary measures for control of food, which might be contaminated to a level not suitable for human consumption. Agricultural products (which include grain crops, vegetable, fruits, dairy, meat, eggs and poultry) pass through a series of local, district and state level markets to finally reach consumers. Read More

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Nitrate leaching and NH volatilization during soil reclamation in the Yellow River Delta, China.

Environ Pollut 2021 May 10;286:117330. Epub 2021 May 10.

Yellow River Delta Ecological Research Station of Coastal Wetlands, Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, 264003, China.

The agricultural ecological system is an important part of the Yellow River Delta (YRD); however, soil reclamation may trigger environmental concerns about nitrate leaching and NH volatilization in this area. To assess nitrogen losses during soil reclamation, a two-year field experiment was conducted with plastic film mulch, which is an effective way to alleviate water-salt stress. The Hydrus-2D software package was used to calculate nitrogen transport, transformation and losses. Read More

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Sediment grain size determines microplastic exposure landscapes for sandy beach macroinfauna.

Environ Pollut 2021 May 5;286:117308. Epub 2021 May 5.

UNDECIMAR, Departamento de Ecología y Evolución, Facultad de Ciencias, Universidad de la República, Iguá 4225, Montevideo, 11400, Uruguay.

Despite the global occurrence of microplastic contamination on sandy beaches, evidence of microplastic distribution within beaches remains contradictory. When conflicting evidence is used to inform sampling surveys, it increases uncertainty in resulting data. Moreover, it hampers spatially explicit risk characterization of microplastic pollution to intertidal fauna. Read More

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Prevalence and distribution of lice on sheep and cattle farms in Great Britain.

Vet Parasitol 2021 May 7;294:109444. Epub 2021 May 7.

School of Biological Sciences, University of Bristol, Bristol, BS8 1TQ, UK. Electronic address:

Lice are common production-limiting ectoparasites affecting livestock. Up-to-date data on their prevalence and spatial distribution on farms in Great Britain is important given that prevalence is believed to be increasing as a result of insecticide resistance. Here the prevalence of farms reporting lice, and factors associated with louse presence, were assessed using a retrospective questionnaire. Read More

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Role of genetic variants of Vitamin D receptor, Toll-like receptor 2 and Toll-like receptor 4 in extrapulmonary tuberculosis.

Microb Pathog 2021 May 12:104911. Epub 2021 May 12.

Advanced Centre for Human Genetics, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, J&K, India. Electronic address:

Background: Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (MTB). Vitamin D deficiency and vitamin D receptor (VDR) gene abnormalities confer susceptibility to tuberculosis. Toll-like receptors (TLRs), such as TLR-2, are also important mediators of inflammatory response against Mycobacterium tuberculosis. Read More

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From forest to pharmacy: should we be depressed about a sustainable Griffonia simplicifolia (Fabaceae) seed supply chain?

J Ethnopharmacol 2021 May 12:114202. Epub 2021 May 12.

Bundesamt für Naturschutz (BfN), Konstantinstr. 110, Bonn 53179, Germany.

Ethnopharmacological Relevance: Griffonia simplicifolia D.C (Baill.) (Fabaceae) seeds are unusually high (6-20% wet weight) in 5-HTP (5-Hydroxytryptophan), a serotonin precursor widely used to treat depression. Read More

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Case analysis of kinetics investigations in toxicity studies of pesticides to identify the nonlinearity of internal exposure and the influences of nonlinearity on the toxicological interpretation of pesticide residue.

Regul Toxicol Pharmacol 2021 May 12:104958. Epub 2021 May 12.

School of Pharmacy, Iwate Medical University 2-1-1 Nishitokuta, Yahaba-cho, Shiwa-gun, Iwate, 028-3684, Japan. Electronic address:

The nonlinearity of internal exposure to 8 pesticides was investigated in toxicity studies using kinetics to identify nonlinearity visually and to investigate the influence of nonlinearity on toxicological evaluation. Data were obtained from risk assessment reports published by the Food Safety Commission (FSCJ). Nonlinearity was defined using 2 indicators: the lowest visual inflection point (LVIP) and the second lowest visual inflection point (SVIP) of kinetics by drawing a linear distribution chart. Read More

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CTRP3 promotes TNF-α-induced apoptosis and barrier dysfunction in salivary epithelial cells.

Cell Signal 2021 May 12:110042. Epub 2021 May 12.

Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China. Electronic address:

Background: C1q/tumour necrosis factor-related protein 3 (CTRP3) plays important roles in metabolism and inflammatory responses in various cells and tissues. However, the expression and function of CTRP3 in salivary glands have not been explored.

Methods: The expression and distribution of CTRP3 were detected by western blot, polymerase chain reaction, immunohistochemical and immunofluorescence staining. Read More

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Age-related ocular conditions: Current treatments and role of cyclodextrin-based nanotherapies.

Int J Pharm 2021 May 12:120707. Epub 2021 May 12.

Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, IS-107 Reykjavik, Iceland. Electronic address:

Age-related eye disorders are chronic diseases that affect millions of people worldwide. They cause visual impairment and, in some cases, irreversible blindness. Drug targeting to the retina is still a challenge due to the difficulties with drug distribution, crossing eye barriers, and reaching intraocular tissues in an effective therapeutic concentration. Read More

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Follicular Cells in Pituitary Neuroendocrine Tumors.

Hum Pathol 2021 May 12. Epub 2021 May 12.

Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH USA, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA. Electronic address:

Follicular cells (FCs) are thought to be agranular, non-hormone producing stellate cells distributed throughout the adenohypophysis, occasionally arranged around colloid-filled follicles, and thought to be more prominent in the vicinity of necrosis and apoptotic cells. A distinct but similar cell type, the folliculostellate cell (FSC), is a sustentacular cell that is negative for keratins and stains for S100, GFAP and SOX10. While several studies have examined FSCs in pituitary neuroendocrine tumors (PitNETs), the distribution and derivation of FCs in these lesions is unclear. Read More

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Can di-4-ANEPPDHQ reveal the structural differences between nanodiscs and liposomes?

Biochim Biophys Acta Biomembr 2021 May 12:183649. Epub 2021 May 12.

Faculty of Biochemistry Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland. Electronic address:

The potential-sensitive di-4-ANEPPDHQ dye is presently gaining popularity in structural studies of the lipid bilayer. Within the bilayer, dye environmental sensitivity originates from the excitation induced charge redistribution and is usually attributed to solvent relaxation. Here, di-4-ANEPPDHQ is utilized to compare the structure of neutral and negatively charged lipid bilayers between two model systems: the nanodiscs and the liposomes. Read More

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Enzymes of acetylcholine metabolism in the rat inferior colliculus.

Brain Res 2021 May 12:147518. Epub 2021 May 12.

Department of Neurology and Division of Otolaryngology and Dentistry, Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio.

Although there is strong evidence for cholinergic projections to the rat inferior colliculus, especially from the pedunculopontine tegmental nucleus (Noftz et al., 2020), there is a lack of information about the quantitative prevalence of the enzymes of acetylcholine metabolism in its various portions. We have used microdissection of freeze-dried sections combined with radiometric assays to map the distributions in the rat inferior colliculus of the activities of choline acetyltransferase (ChAT), which catalyzes synthesis of acetylcholine, and acetylcholinesterase (AChE), which catalyzes its breakdown by hydrolysis. Read More

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Building supply chain capacity for neglected tropical diseases: experience from the Ascend West and Central Africa programme.

Trans R Soc Trop Med Hyg 2021 May 15. Epub 2021 May 15.

Hypha Group Limited, 320 Firecrest Court Centre Park, Warrington, UK, WA1 1RG, UK.

The Ascend West and Central Africa programme, funded by the UK Foreign, Commonwealth and Development Office (FCDO) is supporting integrated preventative chemotherapy for up to five neglected tropical diseases (NTDs), including intestinal worms, lymphatic filariasis, river blindness, trachoma and schistosomiasis. The programme is implemented across 13 countries by a consortium of four leading international development partners: Sightsavers, Liverpool School of Tropical Medicine, Schistosomiasis Control Initiative Foundation and Mott Macdonald. This paper presents messages learnt from country assessments that took place prior to the global outbreak of coronavirus disease 2019 (COVID-19). Read More

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Epidemiology of biopsy-proven glomerulonephritis in the past 25 years in the North-Eastern area of Romania.

Int Urol Nephrol 2021 May 15. Epub 2021 May 15.

Nephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. Parhon' University Hospital, and "Grigore T. Popa" University of Medicine, Iasi, Romania.

Purpose: The aim of this retrospective study was: to analyze the epidemiological patterns of the kidney disease based on clinical and histological features in a single-center in the N-E region of Romania, between 2011 and 2019 and to compare the biopsy results with the others periods, as well as the results from other countries.

Methods: We studied 442 renal biopsies. The indications for renal biopsy were represented by the clinical features: nephrotic syndrome, nephritic syndrome, asymptomatic urinary abnormalities, acute kidney injury, and chronic kidney disease of unknown etiology. Read More

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A physiologically-based pharmacokinetic model to describe antisense oligonucleotide distribution after intrathecal administration.

J Pharmacokinet Pharmacodyn 2021 May 15. Epub 2021 May 15.

Clinical Pharmacology and Pharmacometrics, Biogen Inc., 225 Binney Street, Cambridge, MA, 02142, USA.

Antisense oligonucleotides (ASOs) are promising therapeutic agents for a variety of neurodegenerative and neuromuscular disorders, e.g., Alzheimer's, Parkinson's and Huntington's diseases, spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS), caused by genetic abnormalities or increased protein accumulation. Read More

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Lithium cobalt phosphate electrode for the simultaneous determination of ascorbic acid, dopamine, and serum uric acid by differential pulse voltammetry.

Mikrochim Acta 2021 May 15;188(6):190. Epub 2021 May 15.

Institute of Advanced Study, Chengdu University, No. 2025, Chengluo Avenue, Chengdu, People's Republic of China.

Lithium cobalt phosphate (LCP) was prepared and modified on the surface of glassy carbon electrode (GCE) to fabricate the electrochemical sensor (LCP/GCE) for the simultaneous determination of ascorbic acid (AA), dopamine (DA), and serum uric acid (UA). The homogenous incorporation of carbon improved the conductivity of LCP. Benefiting from the small particle size distribution, LCP/GCE has a large active surface and responds to AA, DA, and UA sensitively and rapidly. Read More

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