EBioMedicine 2021 Aug 25;71:103542. Epub 2021 Aug 25.
Department of Breast Cancer, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China; School of Medicine, South China University of Technology, 106 Zhongshan Er Road, Guangzhou 510080, Guangdong, China;; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China;; Shantou University Medical College, Shantou, Guangdong, China. Electronic address:
Background: Patients with breast cancer presenting with single lymph node metastasis (from a sentinel node) experience prolonged survival compared to patients with multiple lymph node metastases (≥3). However, little information is available on the genetic and immunological characteristics of breast cancer metastases within the regional lymph nodes as they progress from the sentinel lymph node (SLN) downstream to multiple regional lymph nodes (MLNs).
Methods: Genomic profiling was performed using a next-generation sequencing panel covering 520 cancer-related genes in the primary tumour and metastatic lymph nodes of 157 female patients with breast cancer. Read More