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Traditional East Asian herbal medicines for the treatment of poststroke constipation: A protocol for systematic review and meta analysis.

Medicine (Baltimore) 2021 Apr;100(15):e25503

Department of Cardiology and Neurology.

Background: Post-stroke constipation is a major complication of stroke and increases the incidence of poor neurological outcomes and infectious complications and, therefore, warrants active and prompt treatment. In East Asian countries, several types of herbal medicines have been used for the treatment of post-stroke constipation because they are considered safer than existing pharmacotherapies. However, no systematic review has investigated the efficacy and safety of traditional East Asian herbal medicine in the treatment of post-stroke constipation. Read More

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Redeveloping a Digital Sexual Health Intervention for Adolescents to Allow for Broader Dissemination: Implications for HIV and STD Prevention.

AIDS Educ Prev 2021 04;33(2):89-102

North Carolina State University, Department of Computer Science, Raleigh, North Carolina.

HIV/STDs and unintended pregnancy persist among adolescents in the United States; thus, effective sexual health interventions that can be broadly disseminated are necessary. Digital health interventions are highly promising because they allow for customization and widespread reach. The current project involved redeveloping and expanding HEART (Health Education and Relationship Training)-a brief, digital sexual health intervention efficacious at improving safer sex knowledge, self-efficacy, and behavior-onto an open-source platform to allow for greater interactivity and accessibility while reducing long-term program costs. Read More

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Abdominal Recurrence after Robotic Nephron-Sparing Surgery for Wilms Tumor in an Adult Patient.

Urol Int 2021 Mar 29:1-4. Epub 2021 Mar 29.

Pediatric Surgery Unit, "Sapienza" University Rome, Rome, Italy.

A 31-year-old man was referred to an adult urologist for a renal polar mass that measured 7.2 cm in maximum diameter. Robotic assisted complete tumor excision for suspicious renal cell carcinoma was carried out, preserving the rest of the left kidney. Read More

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Awareness of infant safe sleep messages and associated care practices: findings from an Australian cohort of families with young infants.

BMJ Paediatr Open 2021 24;5(1):e000972. Epub 2021 Feb 24.

School of Nursing, Midwifery and Paramedicine, University of the Sunshine Coast, Maroochydore DC, Queensland, Australia.

Objective: To investigate primary infant caregiver awareness of the current national public health safe sleep messages and the associations of awareness with care practices.

Design And Setting: A cross-sectional survey in Queensland, Australia. All families with live babies birthed during April-May 2017 were eligible. Read More

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February 2021

Community Participation Approaches for Effective National COVID-19 Pandemic Preparedness and Response: An Experience From Oman.

Front Public Health 2020;8:616763. Epub 2021 Jan 26.

Office of Health Affairs, Ministry of Health, Muscat, Oman.

Oman, like other countries in the world, was affected by the COVID-19 pandemic. Since the WHO's declaration of the pandemic, the Ministry of Health of Oman has initiated its preparedness and response to the pandemic, with community participation as one of the key components of the national preparedness and response plan. This paper is a descriptive study aims at describing the three community approaches that exist in Oman and reviewing their role in preparedness and response strategies to COVID-19 pandemic and discuss the lessons learned. Read More

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February 2021

Efficacy and safety of Shi-style cervical manipulation therapy for treating acute and subacute neck pain: study protocol for a randomized controlled trial.

Trials 2021 Feb 8;22(1):123. Epub 2021 Feb 8.

Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of TCM, Institute of Traumatology & Orthopedics, Shanghai Academy of TCM, Shanghai, 201203, People's Republic of China.

Background: Neck pain is a common clinical disease, which seriously affects people's mental health and quality of life and results in loss of social productivity. Improving neck pain's curative effect and reducing its recurrence rate are major medical problems. Shi's manipulation therapy has unique advantages and technical features that aid in the diagnosis and treatment of neck pain. Read More

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February 2021

Chemoinformatics for the Safety of Energetic and Reactive Materials at Ineris.

Mol Inform 2020 Dec 7. Epub 2020 Dec 7.

Ineris, Accidental Risk Divisionn Parc Technologique Alata, 60550, Verneuil-en-Halatte, France.

The characterization of physical hazards of substances is a key information to manage the risks associated to their use, storage and transport. With decades of work in this area, Ineris develops and implements cutting-edge experimental facilities allowing such characterizations at different scales and under various conditions to study all of the dreaded accident scenarios. This review presents the efforts engaged by Ineris more recently in the field of chemoinformatics to develop and use new predictive methods for the anticipation and management of industrials risks associated to energetic and reactive materials as a complement to experiments. Read More

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December 2020

Predictors of skin and soft tissue infections among sample of rural residents who inject drugs.

Harm Reduct J 2020 12 2;17(1):96. Epub 2020 Dec 2.

Department of Family Medicine and Community Health, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.

Introduction: Skin and soft tissue infections (SSTIs) are among the leading causes of morbidity and mortality for people who inject drugs (PWID). Studies demonstrate that certain injection practices correlate with SSTI incidence among PWID. The opioid epidemic in the USA has particularly affected rural communities, where access to prevention and treatment presents unique challenges. Read More

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December 2020

Potential Drug Interactions of Repurposed COVID-19 Drugs with Lung Cancer Pharmacotherapies.

Arch Med Res 2021 04 17;52(3):261-269. Epub 2020 Nov 17.

Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India. Electronic address:

Lung cancer patients are at heightened risk for developing COVID-19 infection as well as complications due to multiple risk factors such as underlying malignancy, anti-cancer treatment induced immunosuppression, additional comorbidities and history of smoking. Recent literatures have reported a significant proportion of lung cancer patients coinfected with COVID-19. Chloroquine, hydroxychloroquine, lopinavir/ritonavir, ribavirin, oseltamivir, remdesivir, favipiravir, and umifenovir represent the major repurposed drugs used as potential experimental agents for COVID-19 whereas azithromycin, dexamethasone, tocilizumab, sarilumab, famotidine and ceftriaxone are some of the supporting agents that are under investigation for COVID-19 management. Read More

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Active and Protected: Developing a "Safer Sex" Handout for Adolescents and Young Adults with Cancer.

J Adolesc Young Adult Oncol 2020 Oct 20. Epub 2020 Oct 20.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

There is a critical need to engage adolescents and young adults (AYAs) with cancer in conversations regarding "safer" sexual activity during treatment. Many providers, however, report lacking the knowledge and/or tools to engage in these discussions. This article describes the experience of one pediatric institution in assessing and addressing provider barriers to safer sexual activity discussions among AYAs with cancer. Read More

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October 2020

SAFety, Effectiveness of care and Resource use among Australian Hospitals (SAFER Hospitals): a protocol for a population-wide cohort study of outcomes of hospital care.

BMJ Open 2020 08 20;10(8):e035446. Epub 2020 Aug 20.

Flinders Centre for Epidemiology and Biostatistics, Flinders University, Adelaide, South Australia, Australia.

Introduction: Despite global concerns about the safety and quality of health care, population-wide studies of hospital outcomes are uncommon. The SAFety, Effectiveness of care and Resource use among Australian Hospitals (SAFER Hospitals) study seeks to estimate the incidence of serious adverse events, mortality, unplanned rehospitalisations and direct costs following hospital encounters using nationwide data, and to assess the variation and trends in these outcomes.

Methods And Analysis: SAFER Hospitals is a cohort study with retrospective and prospective components. Read More

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Complex Large-Bore Radial percutaneous coronary intervention: rationale of the COLOR trial study protocol.

BMJ Open 2020 07 20;10(7):e038042. Epub 2020 Jul 20.

Cardiology, Isala Hospitals, Zwolle, The Netherlands

Introduction: The radial artery has become the standard access site for percutaneous coronary intervention (PCI) in stable coronary artery disease and acute coronary syndrome, because of less access site related bleeding complications. Patients with complex coronary lesions are under-represented in randomised trials comparing radial with femoral access with regard to safety and efficacy. The femoral artery is currently the most applied access site in patients with complex coronary lesions, especially when large bore guiding catheters are required. Read More

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Modeling neoplastic disease with spheroids and organoids.

J Hematol Oncol 2020 07 16;13(1):97. Epub 2020 Jul 16.

Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.

Cancer is a complex disease in which both genetic defects and microenvironmental components contribute to the development, progression, and metastasization of disease, representing major hurdles in the identification of more effective and safer treatment regimens for patients. Three-dimensional (3D) models are changing the paradigm of preclinical cancer research as they more closely resemble the complex tissue environment and architecture found in clinical tumors than in bidimensional (2D) cell cultures. Among 3D models, spheroids and organoids represent the most versatile and promising models in that they are capable of recapitulating the heterogeneity and pathophysiology of human cancers and of filling the gap between conventional 2D in vitro testing and animal models. Read More

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Exploring the acceptability of controlled human infection with SARSCoV2-a public consultation.

BMC Med 2020 07 7;18(1):209. Epub 2020 Jul 7.

Faculty of Medicine and Institute for Life Sciences, University of Southampton, School of Clinical and Experimental Sciences, NIHR Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton General Hospital, South Academic Block, Mailpoint 814, Tremona Road, Southampton, SO16 6YD, UK.

Rapid development of an effective vaccine for SARSCoV2 is a global priority. A controlled human infection model (CHIM) would accelerate the efficacy assessment of candidate vaccines. This strategy would require deliberate exposure of volunteers to SARSCoV2 with no currently available treatment and a small but definite risk of serious illness or death. Read More

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An Overview of Current Alternative Models for Use in the Context of Prostate Cancer Research.

Altern Lab Anim 2020 Mar 2;48(2):58-69. Epub 2020 Jul 2.

Center for the Research and Technology of Agro-Environmental and Biological Sciences, 56066University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.

Prostate cancer is one of the most commonly diagnosed cancers worldwide, particularly in elderly populations. To mitigate the expected increase in prostate cancer-related morbidity and mortality as a result of an expanding aged population, safer and more effective therapeutics are required. To this end, plenty of research is focusing on the mechanisms underlying cancer initiation and development, the metastatic process and on the discovery of new therapies. Read More

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The Roles of Endoscopic Ultrasound and Endoscopic Retrograde Cholangiopancreatography in the Evaluation and Treatment of Chronic Pancreatitis in Children: A Position Paper From the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Pancreas Committee.

J Pediatr Gastroenterol Nutr 2020 05;70(5):681-693

Montreal Children's Hospital, Division of Pediatric Gastroenterology and Nutrition. McGill University Health Center, Montreal, Quebec, Canada.

Introduction: Pediatric chronic pancreatitis is increasingly diagnosed. Endoscopic methods [endoscopic ultrasound (EUS), endoscopic retrograde cholangiopancreatography (ERCP)] are useful tools to diagnose and manage chronic pancreatitis. Pediatric knowledge and use of these modalities is limited and warrants dissemination. Read More

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Overview, Challenges and Future Prospects of Drug Information Services in Nepal: A Reflective Commentary.

J Multidiscip Healthc 2020 19;13:287-295. Epub 2020 Mar 19.

Department of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab Emirates.

Drug information center (DIC) or Medicine information services provides impartial, well-referenced, critically evaluated, updated information on various aspects of medications to healthcare professionals and consumers. Medicine information services also contribute to the minimization of medication errors by promoting medication education and supporting pharmaceutical services. The main objective of this reflective commentary is to highlight the recent scenario of medicine information services in Nepal, challenges for DIC, how DICs can be strengthened and future perspectives of DIC. Read More

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Safetxt: a safer sex intervention delivered by mobile phone messaging on sexually transmitted infections (STI) among young people in the UK - protocol for a randomised controlled trial.

BMJ Open 2020 03 8;10(3):e031635. Epub 2020 Mar 8.

Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, London, UK.

Introduction: Young people aged 16 to 24 have the highest prevalence of genital chlamydia and gonorrhoea compared with other age groups and re-infection rates following treatment are high. Long-term adverse health effects include subfertility and ectopic pregnancy, particularly among those with repeated infections. We developed the safetxt intervention delivered by text message to reduce sexually transmitted infection (STI) by increasing partner notification, condom use and (STI) testing among young people in the UK. Read More

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SEPSIS. Educational and Best Practice Frontiers. Beyond the Boundaries of Fatality, Enhancing Clinical Skills and Precision Medicine.

Ther Clin Risk Manag 2020 12;16:87-93. Epub 2020 Feb 12.

The European Medical Association (EMA) and the School of Medicine, State University of Catania, Catania, Italy.

Dissemination and exploitation of knowledge regarding affordable clinical skills and innovative precision medicine, two current topics in active development in medicine, may contribute to improve also sepsis management. Sepsis is a life-threatening organ dysfunction due to a dysregulated host response to infection. Sepsis is strongly related to all body organs or to systemic diseases and to the quality of the best-practice in use, which is particularly critical in surgical or intervention techniques. Read More

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February 2020

Case Study: More Patient Safety by Design - System-based Approaches for Hospitals.

Adv Health Care Manag 2019 Oct;18

Since the publication of the report "To Err Is Human: Building a Safer Health System" by the US Institute of Medicine in 2000, much has changed with regard to patient safety. Many of the more recent initiatives to improve patient safety target the behavior of health care staff (e.g. Read More

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October 2019

Anticoagulation regimens during pregnancy in patients with mechanical heart valves: a protocol for a systematic review and network meta-analysis.

BMJ Open 2020 02 10;10(2):e033917. Epub 2020 Feb 10.

School of Public Health, Xiamen University, Xiamen, China

Introduction: Pregnancy in patients with mechanical heart valves (MHVs) is associated with high maternal complications and fetal complications.Anticoagulation treatments serve to decrease their venous clotting risk. Although some anticoagulation regimens have been used for patients during pregnancy with MHVs, no one is definitively superior among different regimens in recent studies. Read More

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February 2020

Retrospective qualitative study evaluating the application of IG4 curriculum: an adaptable concept for holistic surgical education.

BMJ Open 2020 02 9;10(2):e033181. Epub 2020 Feb 9.

European University Cyprus, Nicosia, Nicosia, Cyprus.

Objectives: Faced with a costly and demanding learning curve of surgical skills acquisition, the growing necessity for improved surgical curricula has now become irrefutable. We took this opportunity to formulate a teaching framework with the capacity to provide holistic surgical education at the undergraduate level.

Setting: Data collection was conducted in all the relevant healthcare centres the participants worked in. Read More

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February 2020

Vaccine hesitancy and the resurgence of vaccine preventable diseases: the way forward for Malaysia, a Southeast Asian country.

Hum Vaccin Immunother 2020 07 24;16(7):1511-1520. Epub 2020 Jan 24.

Department of Medical Microbiology, Faculty of Medicine, University of Malaya , Kuala Lumpur, Malaysia.

This study engaged health professionals in in-depth, semi-structured interviews to explore their opinions concerning the issues surrounding vaccine hesitancy in Malaysia and strategies to improve vaccination to stamp the rise of vaccine preventable diseases (VPDs). Opinions on how to address the resurgence of VPDs in the era of increasing vaccine hesitancy were obtained. Eight health professionals, including geriatricians, pediatricians, microbiologists, public health specialists, and family medicine specialists were interviewed. Read More

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Development and evaluation of an intervention based on the provision of patient feedback to improve patient safety in Spanish primary healthcare centres: study protocol.

BMJ Open 2019 12 23;9(12):e031367. Epub 2019 Dec 23.

Primary Care Research Unit of Mallorca, Balearic Islands Health Service, Palma, Balearic Islands, Spain

Introduction: Despite the enormous potential for adverse events in primary healthcare (PHC), the knowledge about how to improve patient safety in this context is still sparse. We describe the methods for the development and evaluation of an intervention targeted at PHC professionals to improve patient safety in Spanish PHC centres.

Methods And Analysis: The intervention will consist in using the patient reported experiences and outcomes of safety in primary care (PREOS-PC) survey to gather patient-reported experiences and outcomes concerning the safety of the healthcare patients receive in their PHC centres, and feed that information back to the PHC professionals to help them identify opportunities for safer healthcare provision. Read More

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December 2019

Exploring the barriers to patient engagement in the delivery of safe care in Iranian hospitals: A qualitative study.

Nurs Open 2020 01 25;7(1):457-465. Epub 2019 Nov 25.

Emergency Medicine Research Team Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran.

Aim: To investigate barriers to patient engagement in the delivery of safe hospital care.

Design: Qualitative exploratory study.

Methods: A qualitative study with 35 Iranian health professionals was conducted from February to April 2019 using semi-structured interviews to elicit their opinions. Read More

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January 2020

New warfarin anticoagulation management model after heart valve surgery: rationale and design of a prospective, multicentre, randomised trial to compare an internet-based warfarin anticoagulation management model with the traditional warfarin management model.

BMJ Open 2019 12 5;9(12):e032949. Epub 2019 Dec 5.

Beijing Anzhen Hospital, Capital Medical University, Beijing, China

Introduction: Warfarin is an effective anticoagulant and the only oral anticoagulant available for patients with mechanical heart valves. The prothrombin time and the associated international normalised ratio (INR) are routinely tested to monitor the response to anticoagulation therapy in patients. Patients who undergo mechanical heart valve replacement need lifelong anticoagulation therapy, and their INR is regularly measured to adjust the anticoagulation strength and the dose of anticoagulation drugs. Read More

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December 2019

MEchanical DIlatation of the Cervix-- in a Scarred uterus (MEDICS): the study protocol of a randomised controlled trial comparing a single cervical catheter balloon and prostaglandin PGE2 for cervical ripening and labour induction following caesarean delivery.

BMJ Open 2019 11 6;9(11):e028896. Epub 2019 Nov 6.

Obstetrics and Gynaecology, National University Hospital, Singapore, Singapore

Introduction: Labour induction in women with a previous caesarean delivery currently uses vaginal prostaglandin E2 (PGE2), which carries the risks of uterine hyperstimulation and scar rupture. We aim to compare the efficacy of mechanical labour induction using a transcervically applied Foley catheter balloon (FCB) with PGE2 in affected women attempting trial of labour after caesarean (TOLAC).

Methods And Analysis: This single-centre non-inferiority prospective, randomised, open, blinded-endpoint study conducted at an academic maternity unit in Singapore will recruit a total of 100 women with one previous uncomplicated caesarean section and no contraindications to vaginal delivery. Read More

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November 2019

Early Steps of Mammary Stem Cell Transformation by Exogenous Signals; Effects of Bisphenol Endocrine Disrupting Chemicals and Bone Morphogenetic Proteins.

Cancers (Basel) 2019 Sep 12;11(9). Epub 2019 Sep 12.

CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, F-69000 Lyon, France.

Estrogens are major regulators of the mammary gland development, notably during puberty, via estrogen receptor (ER) activation, leading to the proliferation and differentiation of mammary cells. In addition to estrogens, the bone morphogenetic proteins (BMPs) family is involved in breast stem cell/progenitor commitment. However, these two pathways that synergistically contribute to the biology of the normal mammary gland have also been described to initiate and/or promote breast cancer development. Read More

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September 2019

Prioritizing Evidence-based Interventions for Dissemination and Implementation Investments: AHRQ's Model and Experience.

Med Care 2019 10;57 Suppl 10 Suppl 3:S272-S277

Agency for Healthcare Research and Quality (AHRQ), Center for Evidence and Practice Improvement, Rockville, MD.

Background: The Agency for Healthcare Research and Quality (AHRQ) is mandated to implement patient-centered outcomes research (PCOR) to promote safer, higher quality care. With this goal, we developed a process to identify which evidence-based PCOR interventions merit investment in implementation. We present our process and experience to date. Read More

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October 2019