1,004 results match your criteria disseminated cryptococcosis


Abatacept for rheumatoid arthritis complicated by disseminated cryptococcosis: a case report.

Mod Rheumatol Case Rep 2021 Apr 12:1-13. Epub 2021 Apr 12.

Department of Internal Medicine, Osaka Anti-Tuberculosis Association Osaka Hospital, Neyagawa, Osaka, Japan.

A 78-year-old man developed disseminated cryptococcosis with central nervous system involvement as encapsulated yeast cells were detected in transbronchial biopsy and skin biopsy specimens, and cerebrospinal fluid. was confirmed by culture. He had been treated with low-dose prednisolone and methotrexate for rheumatoid arthritis. Read More

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Disseminated Cryptococcosis Presenting as Cellulitis Diagnosed by Laser Capture Microdissection: A Case Report and Literature Review.

Mycopathologia 2021 Apr 3. Epub 2021 Apr 3.

Department of Dermatology and Venerology, Peking University First Hospital, 8 Xishiku Street, Xicheng District, Beijing, 100034, China.

Disseminated cryptococcosis primarily affects immunosuppressed patients and has a poor outcome if diagnosis and treatment are delayed. Skin lesions are rarely manifest causing misdiagnosis. We present a case of cryptococcal cellulitis with severe pain in a kidney transplant recipient on long-term immunosuppressive therapy. Read More

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Disseminated cryptococcosis in a deceased with HIV-1 diagnosed by minimally invasive tissue sampling technique.

Clin Case Rep 2021 Mar 2;9(3):1667-1671. Epub 2021 Feb 2.

Department of Internal Medicine Gandaki Medical College Pokhara Nepal.

Minimal invasive tissue sampling (MITS) technique detected HIV infection and disseminated cryptococcosis in an adult female with sudden death. A proper autopsy is essential to diagnose the exact cause of death and MITS can suffice in natural deaths. Read More

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Osteoarticular Cryptococcosis Successfully Treated with High-Dose Liposomal Amphotericin B Followed by Oral Fluconazole.

Infect Drug Resist 2021 24;14:719-722. Epub 2021 Feb 24.

Infectious Diseases Service, Hospital del Mar, Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona (UAB), CEXS-Universitat Pompeu Fabra, Barcelona, Spain.

Background: Skeletal involvement of is infrequent and usually associated with disseminated cryptococcosis or underlying predisposing conditions. We present an atypical case of osteoarticular cryptococcosis in an immunocompetent patient.

Case Presentation: We herein report a case of bone and soft tissue cryptococcal infection in a 42-year-old male from Pakistan with well-controlled diabetes without other associated immunodeficiencies treated with antifungal therapy without surgical debridement. Read More

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February 2021

Atypical Presentation of Pediatric Systemic Lupus Erythematosus Complicated by Cryptococcal Meningitis.

Case Rep Med 2021 11;2021:6692767. Epub 2021 Feb 11.

General Surgery Department, Al-Azhar University, Cairo, Egypt.

Background: is an opportunistic fungal pathogen that leads to life-threatening infections. Cryptococcal infections are mainly reported in HIV patients and less commonly encountered in non-HIV immunocompromised host. () is the most common species causing diseases in humans which can be presented as pulmonary, meningitis, cutaneous, and/or disseminated cryptococcosis. Read More

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February 2021

A single-centre, retrospective study of the incidence of invasive fungal infections during 85 years of autopsy service in Brazil.

Sci Rep 2021 Feb 17;11(1):3943. Epub 2021 Feb 17.

Department of Pathology, University of São Paulo-School of Medicine (FMUSP), São Paulo, Brazil.

Autopsy continues to play an essential role in monitoring opportunistic fungal infections. However, few studies have analysed the historical trends of fungal infections in autopsies. Here, we analyse available data on fungal infections obtained from autopsy reports during 85 years of autopsies performed by the largest autopsy service in Brazil. Read More

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February 2021

Disseminated Cryptococcal Disease in a Patient With Monoclonal Gammopathy of Undetermined Significance and Polycythemia Vera: A Case Report and Review of the Literature.

Cureus 2021 Jan 3;13(1):e12458. Epub 2021 Jan 3.

Pulmonary and Critical Care Medicine, Bronxcare Health System, Bronx, USA.

Cryptococcosis is a life-threatening opportunistic infection caused by Cryptococcus gattii and Cryptococcus neoformans. It affects both immunocompetent and immunosuppressed hosts. Disseminated cryptococcal infection is rare in immunocompetent patients, but the cryptococcal disease's neurological sequelae may be more prominent in this group. Read More

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January 2021

Disseminated cryptococcosis in a patient with newly diagnosed HTLV-1 infection.

BMJ Case Rep 2021 Jan 28;14(1). Epub 2021 Jan 28.

Divsion Of Infectious Diseases, Mayo Clinic, Jacksonville, Florida, USA

Infection by human T-lymphotropic virus 1 (HTLV-1) is often seen as the cause of chronic infection or lymphoproliferative disorders, but many clinicians do not recognise its association with severe immunosuppression. We report the case of a woman in her 70s from the Caribbean who sought care at the emergency department for weakness, fatigue and weight loss. Further work-up showed atypical lymphocytosis with floral lymphocytes and smudge cells in the peripheral blood smear and hypercalcaemia. Read More

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January 2021

Disseminated cryptococcosis and anti-granulocyte-macrophage colony-stimulating factor autoantibodies: An underappreciated association.

Mycoses 2021 Jan 21. Epub 2021 Jan 21.

Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

The development of disseminated cryptococcosis has historically occurred in patients living with advanced human immunodeficiency virus or other immunosuppressive conditions affecting T-cell function. Recently, patients with anti-cytokine neutralising autoantibodies have been recognised to be at risk for disseminated infections by opportunistic intracellular pathogens, including Cryptococcus species. Herein, we present a previously healthy 26-year-old man who was evaluated with disseminated cryptococcosis involving the bone, lung, mediastinum and brain. Read More

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January 2021

Disseminated cryptococcal infection in an immunocompetent patient treated with short course induction therapy.

Med Mycol Case Rep 2021 Jun 24;32:1-3. Epub 2020 Dec 24.

Department of Infectious Diseases, University College London Hospital, London, UK.

A 49- year old immunocompetent male presented with a right flank abscess and was found to have disseminated cryptococcal disease. Treatment was initiated with a one-week intravenous regime of amphotericin B and flucytosine based on recent trial data that this is as effective, and less toxic, than the standard two weeks. After completion of intravenous treatment he was discharged with oral anti-fungals and is making a good recovery with ongoing follow up. Read More

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Disseminated cryptococcosis presenting with cutaneous involvement in an immunocompromised patient.

Dermatol Online J 2020 Dec 15;26(12). Epub 2020 Dec 15.

Department of Dermatology, Wayne State University, Detroit, MI.

Cryptococcosis is a fungal infection that typically affects immunocompromised patients. It most commonly affects the lungs and may then disseminate to the central nervous system, bone, skin, and adrenal glands. Herein, we describe a 69-year-old man who presented with skin lesions as the initial manifestation of disseminated cryptococcosis. Read More

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December 2020

[A prospective multi-center clinical investigation of HIV-negative pulmonary cryptococcosis in China].

Zhonghua Jie He He Hu Xi Za Zhi 2021 Jan;44(1):14-27

Department of Pulmonary and Critical Care Medicine, the First Medical Center of General Hospital of Chinese People's Liberation Army, Beijing 100853, China.

To investigate the current status of the diagnosis and treatment of pulmonary cryptococcosis in respiratory medicine and improve the understanding of the clinical characteristics of HIV-negative pulmonary cryptococcosis in China. A prospective multi-center open cohort study was designed to screen for pulmonary cryptococcosis in the general wards and intensive care units of the Department of Respiratory Diseases in 22 hospitals. The HIV-negative patients with positive cryptococcal etiological diagnosis based on smear culture, antigen detection and histopathology were enrolled in the study. Read More

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January 2021

Tongue lesion due to Cryptococcus neoformans as the first finding in an HIV-positive patient.

Rev Iberoam Micol 2021 Jan-Mar;38(1):19-22. Epub 2020 Dec 30.

Unidad Micología del Hospital de Infecciosas F. J. Muñiz, Buenos Aires, Argentina.

Background: Cryptococcosis is a severe universally distributed mycosis which mainly affects immunocompromised hosts. This mycosis is caused by yeasts of two species complex of the genus Cryptococcus: Cryptococcus neoformans and Cryptococcus gattii. Meningeal cryptococcosis is the most frequent clinical presentation of this disseminated mycosis. Read More

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December 2020

Disseminated cryptococcosis and hemochromatosis: clues to diagnosis.

Autops Case Rep 2020 Jun 5;10(3):e2020180. Epub 2020 Jun 5.

Mercer University School of Medicine. Macon, GA, USA.

Hepatic cirrhosis, diabetes mellitus and iron overload can each independently predispose to cryptococcosis. Hereditary hemochromatosis leads to all three of these predispositions. This report is the case of a patient with chronic hepatitis B virus infection and cirrhosis, who had markedly elevated serum ferritin and 99% transferrin saturation, and developed a leukemoid reaction. Read More

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Cross-reactivity of a Histoplasma capsulatum antigen enzyme immunoassay in urine specimens from persons with emergomycosis in South Africa.

Med Mycol 2020 Dec 16. Epub 2020 Dec 16.

National Institute for Communicable Diseases (Centre for Healthcare-Associated Infections, Antimicrobial Resistance and Mycoses), a Division of the National Health Laboratory Service, Johannesburg, South Africa.

Histoplasma antigen detection in urine is a rapid diagnostic method for disseminated histoplasmosis, although cross-reactivity has been reported in specimens from patients with other thermally dimorphic fungal infections. We tested urine specimens, from persons with suspected invasive fungal infections, using a commercial monoclonal antibody Histoplasma enzyme immunoassay (EIA) at a South African national mycology reference laboratory from August 2014 through December 2018. Corresponding fungal culture and histopathology results were obtained from an electronic laboratory information system. Read More

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December 2020

Skin Lesions Caused by Disseminated Cryptococcosis.

Intern Med 2020 Dec 15. Epub 2020 Dec 15.

Department of Infectious Diseases, Osaka City General Hospital, Japan.

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December 2020

Two cases of cryptococcus gattii infection in the rhesus macaque (Macaca Mulatta).

J Med Primatol 2021 02 11;50(1):67-70. Epub 2020 Dec 11.

Pathology Services Unit, Division of Comparative Medicine, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.

Cryptococcus gattii was diagnosed in two female indoor-housed rhesus macaques. Gross and histopathologic findings included an isolated pulmonary cryptococcoma in a non-SIV-infected macaque and disseminated disease centered on the lungs of an SIV-infected macaque. Fungal yeast were positive with special stains, and the diagnoses were confirmed with a lateral flow assay and PCR. Read More

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February 2021

Genome-Wide Association Study Identifies Novel Colony Stimulating Factor 1 Locus Conferring Susceptibility to Cryptococcosis in Human Immunodeficiency Virus-Infected South Africans.

Open Forum Infect Dis 2020 Nov 16;7(11):ofaa489. Epub 2020 Oct 16.

Institute of Infection and Immunity, St George's University of London, London, United Kingdom.

Background: is the most common cause of meningitis in human immunodeficiency virus (HIV)-infected Africans. Despite universal exposure, only 5%-10% of patients with HIV/acquired immune deficiency syndrome and profound CD4 T-cell depletion develop disseminated cryptococcosis: host genetic factors may play a role. Prior targeted immunogenetic studies in cryptococcosis have comprised few Africans. Read More

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November 2020

Estimates of serious fungal infection burden in Côte d'Ivoire and country health profile.

J Mycol Med 2021 Mar 21;31(1):101086. Epub 2020 Nov 21.

Manchester Fungal Infection Group, faculty of medicine, biology and health, university of Manchester and Manchester academic health science centre, Manchester, UK.

Due to limited access to more powerful diagnostic tools, there are few data on the burden of fungal infections in Côte d'Ivoire, despite a high HIV and TB burden and many cutaneous diseases. Here we estimate the burden of serious fungal infections in this sub-Saharan country with a health profiling description. National demographics were used and PubMed searches to retrieve all published articles on fungal infections in Côte d'Ivoire and other bordering countries in West Africa. Read More

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Effective Voriconazole in an Immunocompetent Patient With Amphotericin B Resistant Systemic Cryptococcal Granulomatosis.

Cureus 2020 Oct 23;12(10):e11101. Epub 2020 Oct 23.

Immunohematology Cellular Therapy, Faculty of Medicine and Pharmacy, Mohammed Premier University, Oujda, MAR.

The diagnostic management of systemic granulomatosis is a difficult clinical exercise. The most frequent etiologies are tuberculosis and sarcoidosis. However, it is important to search as well for the other causes of granulomas, especially infections and malignancies, the prognosis of which can be poor without adequate treatment. Read More

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October 2020

Phagosomal F-Actin Retention by Cryptococcus gattii Induces Dendritic Cell Immunoparalysis.

mBio 2020 11 24;11(6). Epub 2020 Nov 24.

The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

is a major cause of life-threatening mycosis in immunocompetent individuals and responsible for the ongoing epidemic outbreak of cryptococcosis in the Pacific Northwest of North America. This deadly fungus is known to evade important host immune responses, including dendritic cell (DC) maturation and concomitant T cell immunity, via immune evasion mechanisms that remain unclear. Here, we demonstrate that primary human DCs phagocytose but the maturation of phagosomes to phagolysosomes was blocked as a result of sustained filamentous actin (F-actin) that entrapped and concealed the phagosomes from recognition. Read More

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November 2020

Cryptococcosis in Hematopoietic Stem Cell Transplant Recipients: A Rare Presentation Warranting Recognition.

Can J Infect Dis Med Microbiol 2020 19;2020:3713241. Epub 2020 Aug 19.

Internal Medicine Department, Hospital Universitario Erasmo Meoz, Universidad de Pamplona, Cucuta 540003, Colombia.

Cryptococcosis, a life-threatening mycosis caused mainly by , appears to be distinctly rare in hematopoietic stem cell transplant (HSCT) recipients. When it occurs, this fungal infection is a major limitation for a successful transplant. This review comprehensively analyses 24 cases, reported in the literature, of patients with haematological malignancies including leukemias, multiple myeloma, and lymphomas, as indication for HSCT, who presented with cryptococcosis after transplantation. Read More

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Impaired B-Cell Differentiation in a Patient With Gain-of-Function Mutation.

Front Immunol 2020 29;11:557521. Epub 2020 Sep 29.

Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.

Hypogammaglobulinemia is a rare complication of gain-of-function (GOF) mutations. We report an adult patient diagnosed with hypogammaglobulinemia caused by B-cell depletion during the treatment of disseminated cryptococcosis. The patient carried the GOF mutation (c. Read More

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September 2020

Widely Disseminated Cryptococcosis Manifesting in a Previously Undiagnosed Human Immunodeficiency Virus (HIV)-Positive 18-Year-Old.

Am J Case Rep 2020 Oct 12;21:e924410. Epub 2020 Oct 12.

Department of Pathology, Medical College of Georgia at Augusta University, Augusta, GA, USA.

BACKGROUND After initial infection with HIV, loss of CD4+ T cells progresses along a predictable timeline. The clinical latency stage lasts an average of 10 years, until the CD4+ T cell count falls below 200 cells/uL or the patient develops an AIDS-defining opportunistic infection/cancer. This report describes an unusual opportunistic infection in a young patient with no prior clinical evidence of HIV infection. Read More

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October 2020

Unilateral leg pain caused by cryptococcal myositis: An unusual presentation of disseminated cryptococcosis in a kidney transplant recipient.

Transpl Infect Dis 2020 Oct 11:e13491. Epub 2020 Oct 11.

Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

Cryptococcal disease is a rare but often serious infection in solid organ transplant recipients, commonly presenting as meningitis and pneumonia but can rarely cause myositis. We report the case of a 43-year-old female kidney transplant recipient with two previous graft failures requiring re-transplantations who presented with a 1-month duration of worsening unilateral leg pain, swelling, and shortness of breath. Blood cultures isolated Cryptococcus neoformans. Read More

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October 2020

Performance of the Lateral Flow Assay and the Latex Agglutination Serum Cryptococcal Antigen Test in Cryptococcal Disease in Patients with and without HIV.

J Clin Microbiol 2020 10 21;58(11). Epub 2020 Oct 21.

Division of Infectious Diseases, Department of Medicine, Washington University in St. Louis, St Louis, Missouri, USA

Cryptococcal epidemiology is shifting toward HIV-negative populations who have diverse presentations. Cryptococcal antigen (CrAg) testing is also changing, with development of the lateral flow assay (LFA) having reported increased sensitivity and specificity, but with minimal knowledge in the HIV-negative population. In this study, we evaluate the real-life performance of CrAg testing in patients with cryptococcal disease. Read More

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October 2020

Umbilicated papules on the bilateral upper and lower extremities.

Dermatol Online J 2020 Jun 15;26(6). Epub 2020 Jun 15.

Division of Dermatology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.

Cryptococcosis is a rare opportunistic infection with morphologically diverse cutaneous presentations. Primary infection typically occurs in the lungs with subsequent hematogenous dissemination to other organ systems, especially in immunocompromised patients. Herein, we report a woman in her 70's who presented with pruritic, umbilicated papulonodules of the bilateral upper and lower extremities present for many weeks. Read More

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Pulmonary Cryptococcosis in a Human Immunodeficiency Virus Negative Patient: A Case Report.

Cureus 2020 Jul 5;12(7):e9006. Epub 2020 Jul 5.

Internal Medicine, Sir Ganga Ram Hospital, New Delhi, IND.

Cryptococcosis is a major life-threatening fungal infection in patients with severe HIV infection and other immunocompromised states. Lung and central nervous system (CNS) are the most commonly involved organs in disseminated cryptococcosis. Others include skin, prostate, medullary cavity of bones, eyes, heart, liver, etc. Read More

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An Overview of the Management of the Most Important Invasive Fungal Infections in Patients with Blood Malignancies.

Infect Drug Resist 2020 14;13:2329-2354. Epub 2020 Jul 14.

Department of Medical Parasitology and Mycology, Arak University of Medical Sciences, Arak, Iran.

In patients with hematologic malignancies due to immune system disorders, especially persistent febrile neutropenia, invasive fungal infections (IFI) occur with high mortality. Aspergillosis, candidiasis, fusariosis, mucormycosis, cryptococcosis and trichosporonosis are the most important infections reported in patients with hematologic malignancies that undergo hematopoietic stem cell transplantation. These infections are caused by opportunistic fungal pathogens that do not cause severe issues in healthy individuals, but in patients with hematologic malignancies lead to disseminated infection with different clinical manifestations. Read More

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Disseminated cryptococcosis in a patient with adrenocortical carcinoma and Cushing's syndrome.

J Infect Chemother 2020 Dec 31;26(12):1301-1304. Epub 2020 Jul 31.

Department of Internal Medicine, Suwa Central Hospital, 4300 Tamagawa, Chino, Nagano, 391-8503, Japan. Electronic address:

Corticosteroids have been used for the treatment of a great variety of diseases. Therefore, the relationship between high doses of cortisol and infections has been widely known and prophylactic therapy has been established. Adrenocortical carcinoma is a rare malignancy with poor prognosis, so little is known about how to deal with the complications resulting from hormone excess such as Cushing's syndrome. Read More

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December 2020