4,092 results match your criteria disruption sleep

Breaching the Delivery Barrier: Chemical and Physical Airway Epithelium Disruption Strategies for Enhancing Lentiviral-Mediated Gene Therapy.

Front Pharmacol 2021 26;12:669635. Epub 2021 Apr 26.

Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.

The lungs have evolved complex physical, biological and immunological defences to prevent foreign material from entering the airway epithelial cells. These mechanisms can also affect both viral and non-viral gene transfer agents, and significantly diminish the effectiveness of airway gene-addition therapies. One strategy to overcome the physical barrier properties of the airway is to transiently disturb the integrity of the epithelium prior to delivery of the gene transfer vector. Read More

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Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling.

Nat Commun 2021 May 12;12(1):2736. Epub 2021 May 12.

Division of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.

Endothelial barrier integrity is ensured by the stability of the adherens junction (AJ) complexes comprised of vascular endothelial (VE)-cadherin as well as accessory proteins such as β-catenin and p120-catenin. Disruption of the endothelial barrier due to disassembly of AJs results in tissue edema and the influx of inflammatory cells. Using three-dimensional structured illumination microscopy, we observe that the mitochondrial protein Mitofusin-2 (Mfn2) co-localizes at the plasma membrane with VE-cadherin and β-catenin in endothelial cells during homeostasis. Read More

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How is the COVID-19 lockdown impacting the mental health of parents of school-age children in the UK? A cross-sectional online survey.

BMJ Open 2021 05 11;11(5):e043397. Epub 2021 May 11.

Department of Primary Care and Public Health, Imperial College London Faculty of Medicine, London, UK.

Objective: Investigate the impact of the COVID-19 lockdown on feelings of loneliness and social isolation in parents of school-age children.

Design: Cross-sectional online survey of parents of primary and secondary school-age children.

Setting: Community setting. Read More

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Overview of sleep management during COVID-19.

Philip M Becker

Sleep Med 2021 Apr 24. Epub 2021 Apr 24.

Sleep Medicine Associates of Texas, Department of Psychiatry, University of Texas Medical Center at Dallas, 12327 Brittany Circle, Dallas, TX 75230 USA. Electronic address:

The sleep of millions has suffered during the global COVID-19 pandemic. Prevalence rates of 20-45% are reported globally for insomnia symptoms during the pandemic. Affected populations include the public and health care workers. Read More

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Trait positive affect buffers the association between experimental sleep disruption and inflammation.

Psychoneuroendocrinology 2021 Apr 28;129:105240. Epub 2021 Apr 28.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background: Sleep disturbances and insufficient sleep are highly prevalent. Both clinical sleep disorders and multiple forms of experimental sleep loss predict heightened inflammation. As such, it is necessary to investigate potential protective factors. Read More

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Impact of the COVID-19 pandemic on mental health among local residents in South of Brazil: during pandemic times, youth sleep matters.

Trends Psychiatry Psychother 2021 May 7. Epub 2021 May 7.

Programa de Pós-Graduação em Psicologia, Departamento de Psicologia do Desenvolvimento e da Personalidade, Instituto de Psicologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.

Introduction: Social isolation has been associated with poor sleep quality and mental health problems during the COVID-19 pandemic. However, most studies included a heterogeneous sample with variances in social disruption policies and did not focus on a local profile with homogeneous prevention policies.

Objectives: Thus, the present study's purpose was to evaluate the impact of the COVID-19 pandemic on mental health and sleep quality in a specific region in South of Brazil with similar culture and social distance policies adopted by the local governments. Read More

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β-adrenergic Receptor Activity in the Hippocampal Dentate Gyrus Participates in Spatial Learning and Memory Impairment in Sleep-deprived Rats.

Huan-Jun Lu Jing Lv

Exp Neurobiol 2021 Apr;30(2):144-154

Department of Physiology, Hebei University of Engineering, Hebei 056000, China.

Sleep deprivation (SD) leads to cognitive impairment, especially hippocampus-dependent learning and memory (L&M). The hippocampal dentate gyrus (DG) is the key structure involved in spatial L&M while long-term potentiation (LTP) is an important cellular mechanism responsible for L&M. Physiological and behavioral evidences support the hypothesis that norepinephrine (NE) and β-adrenoceptors (β-AR) may play an important role in regulating L&M, including LTP. Read More

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Music intervention for sleep quality in critically ill and surgical patients: a meta-analysis.

BMJ Open 2021 May 10;11(5):e042510. Epub 2021 May 10.

Department of Intensive Care Unit, Erasmus MC, Rotterdam, The Netherlands.

Objective: Sleep disruption occurs frequently in hospitalised patients. Given the potential of music intervention as a non-pharmacological measure to improve sleep quality, we aimed to assess and quantify current literature on the effect of recorded music interventions on sleep quality and quantity in the adult critical care and surgical populations.

Design: Systematic review and meta-analysis. Read More

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Chronic disruption of circadian rhythm with mistimed sleep and appetite - an exploratory research.

Chronobiol Int 2021 May 10:1-10. Epub 2021 May 10.

Department of Diabetes and Nutrition Diseases, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

This research aimed to explore the relation of social jetlag (SJL) with perceived appetite, and hormones involved in hunger regulation in healthy subjects in free-living conditions (study registration number: ACTRN12618001182280). Eighty normally diurnally active men and women were enrolled in 4 study groups according to the presence of SJL and sleep deprivation (2 groups with SJL with or without sleep deprivations and 2 groups without SJL with or without sleep deprivation) matched 1:1:1:1 for age, gender, and body mass index. Appetite was assessed in fasting state, by measuring acylated ghrelin level and using 100 mm visual analog scales. Read More

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Fetal neuromatuation in late gestation is affected by maternal sleep disordered breathing and sleep disruption in pregnant women with obesity.

Int J Gynaecol Obstet 2021 May 9. Epub 2021 May 9.

Grace W. Pien, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Objective: Maternal sleep disordered breathing and sleep disruption have adverse effects on pregnancy outcomes through multiple potential pathophysiological pathways. We hypothesize that disordered maternal sleep also adversely impacts the neuromaturation of the fetus.

Methods: Participants in this prospective observational study included 102 obese pregnant women (pre-pregnancy body mass index (BMI) > 30 kg/m ) at 36 weeks gestation. Read More

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Sleep disruptions and bone health: what do we know so far?

Curr Opin Endocrinol Diabetes Obes 2021 May 6. Epub 2021 May 6.

Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Purpose Of Review: This review briefly summarizes the growing body of literature addressing the skeletal consequences of sleep and circadian disruption.

Recent Findings: The most recent data in the field suggest that the diurnal variation in bone turnover markers are because of endogenous circadian rhythmicity linked to clock genes in all bone cells; in a small human intervention study, cumulative sleep restriction with concurrent circadian disruption negatively alter bone turnover markers in a way that could explain the lower BMD and increased fracture risk identified in some prior night shift work studies; abnormal sleep duration and obstructive sleep apnea are associated with low BMD and increased fracture risk in some but not all studies.

Summary: Normal physiology and some animal and human intervention studies suggest that sleep and circadian disruptions, such as night shift work, abnormal sleep durations and obstructive sleep apnea are detrimental to skeletal health. Read More

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Transcriptomic Analysis Reveals an Altered Hcy Metabolism in the Stria Vascularis of the Pendred Syndrome Mouse Model.

Neural Plast 2021 17;2021:5585394. Epub 2021 Apr 17.

Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Purpose: mice exhibit severer defects in the development of the cochlea and develop deafness, while the underlying mechanisms responsible for these effects remain unclear. Our study was to investigate the potential mechanism linking deficiency to hearing loss.

Materials And Methods: RNA sequencing was applied to analyze the differential gene expression of the stria vascularis (SV) from wildtype and mice. Read More

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Disruption of entire locus leads to embryonic lethality by diminished gene expression and enhanced p53 pathway.

Elife 2021 May 5;10. Epub 2021 May 5.

Laboratory Animal Resource Center, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

In vivo function of CDK5 and Abl enzyme substrate 2 (Cables2), belonging to the Cables protein family, is unknown. Here, we found that targeted disruption of the entire locus () caused growth retardation and enhanced apoptosis at the gastrulation stage and then induced embryonic lethality in mice. Comparative transcriptome analysis revealed disruption of , 50% down-regulation of abutting on the locus, and up-regulation of p53-target genes in gastrulas. Read More

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Household chaos, family routines, and young child movement behaviors in the U.S. during the COVID-19 outbreak: a cross-sectional study.

BMC Public Health 2021 05 4;21(1):860. Epub 2021 May 4.

Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.

Background: The home environment is an important facilitator of young child movement behaviors, including physical activity (PA), sleep, and screen-time. Household chaos, characterized by crowding, noise, and disorder in the home, may hinder efforts to obtain adequate amounts of movement behaviors. The COVID-19 outbreak impacted many families, and social distancing during this time may create conditions for more household chaos. Read More

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Social jetlag, a novel predictor for high cardiovascular risk in blue-collar workers following permanent atypical work schedules.

J Sleep Res 2021 May 4:e13380. Epub 2021 May 4.

Institute and Polyclinic for Occupational- Social- and Environmental Medicine, LMU Munich, Munich, Germany.

Cardiovascular diseases cause >4 million deaths each year in Europe alone. Preventive approaches that do not only consider individual risk factors but their interaction, such as the Systematic COronary Risk Evaluation (SCORE), are recommended by European guidelines. Increased cardiovascular risk is associated with shift-work, surely interacting with the concurrent conditions: disruption of sleep, unhealthy behaviours, and circadian misalignment. Read More

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The connections of Locus Coeruleus with hypothalamus: potential involvement in Alzheimer's disease.

J Neural Transm (Vienna) 2021 May 3;128(5):589-613. Epub 2021 May 3.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, 56126, Pisa, Italy.

The hypothalamus and Locus Coeruleus (LC) share a variety of functions, as both of them take part in the regulation of the sleep/wake cycle and in the modulation of autonomic and homeostatic activities. Such a functional interplay takes place due to the dense and complex anatomical connections linking the two brain structures. In Alzheimer's disease (AD), the occurrence of endocrine, autonomic and sleep disturbances have been associated with the disruption of the hypothalamic network; at the same time, in this disease, the occurrence of LC degeneration is receiving growing attention for the potential roles it may have both from a pathophysiological and pathogenetic point of view. Read More

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Non-convulsive status epilepticus induced by acute thalamic lesions: A report of three cases.

Seizure 2021 Apr 22;89:1-4. Epub 2021 Apr 22.

EEG/Sleep Laboratory, Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal; Univ Lisboa, Fac Med, Clin Univ Neurol, Lisboa, Portugal; Centro de Referência para Epilepsias Refratárias do CHULN, Member of ERN EpiCare, Portugal.

The thalamocortical network appears to play a pivotal role in ictogenesis. We herein present three cases of non-convulsive status epilepticus (SE), in adult patients without previous history of epilepsy or seizures, precipitated by acute thalamic vascular and metabolic-induced lesions. In all cases the EEG showed patterns consistent with generalized SE confirmed either by a fast and complete clinical and EEG response to anti-seizure medication or definitive subtle motor signs consistent with SE. Read More

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Weekend light shifts evoke persistent Drosophila circadian neural network desynchrony.

J Neurosci 2021 Apr 30. Epub 2021 Apr 30.

Department of Physiology & Biophysics, University of California, Irvine. Irvine, CA 92697

We developed a method for single-cell resolution longitudinal bioluminescence imaging of PERIOD (PER) protein and TIMELESS (TIM) oscillations in cultured male adult brains that captures circadian circuit-wide cycling under simulated day/night cycles. Light input analysis confirms that CRYPTOCHROME (CRY) is the primary circadian photoreceptor and mediates clock disruption by constant light, and that eye light input is redundant to CRY. 3hr light phase delays (Friday) followed by 3hr light phase advances (Monday morning) simulate the common practice of staying up later at night on weekends, sleeping in later on weekend days then returning to standard schedule Monday morning (weekend light shift, WLS). Read More

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Beneficial Effects of Early Time-Restricted Feeding on Metabolic Diseases: Importance of Aligning Food Habits with the Circadian Clock.

Nutrients 2021 Apr 22;13(5). Epub 2021 Apr 22.

CRBS, UR3072: Mitochondria, Oxidative Stress and Muscular Protection, University of Strasbourg, 1 rue Eugène Boeckel, 67000 Strasbourg, France.

The importance of metabolic health is a major societal concern due to the increasing prevalence of metabolic diseases such as obesity, diabetes, and various cardiovascular diseases. The circadian clock is clearly implicated in the development of these metabolic diseases. Indeed, it regulates physiological processes by hormone modulation, thus helping the body to perform them at the ideal time of day. Read More

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Sleep Quality and Physical Activity as Predictors of Mental Wellbeing Variance in Older Adults during COVID-19 Lockdown: ECLB COVID-19 International Online Survey.

Int J Environ Res Public Health 2021 04 19;18(8). Epub 2021 Apr 19.

School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough E11 3TU, UK.

Background: The COVID-19 lockdown could engender disruption to lifestyle behaviors, thus impairing mental wellbeing in the general population. This study investigated whether sociodemographic variables, changes in physical activity, and sleep quality from pre- to during lockdown were predictors of change in mental wellbeing in quarantined older adults.

Methods: A 12-week international online survey was launched in 14 languages on 6 April 2020. Read More

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The impact of COVID-19 on the lives and mental health of Australian adolescents.

Eur Child Adolesc Psychiatry 2021 Apr 28. Epub 2021 Apr 28.

Black Dog Institute, UNSW, Hospital Road, Randwick, Sydney, 2022, Australia.

There has been significant disruption to the lives and mental health of adolescents during the COVID-19 pandemic. The purpose of this study was to assess the psychological and lifestyle impact of the pandemic on Australian adolescents, using an online survey, administered during the outbreak. Self-report surveys were administered online to a sample of 760 Australian adolescents aged 12-18 years assessing impact on a range of domains including behaviour, education, relationships, lifestyle factors (exercise, technology use, and sleep), and mental health outcomes (psychological distress, loneliness, health anxiety and well-being). Read More

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Phenotypic Spectrum of Seizure Disorders in MBD5-Associated Neurodevelopmental Disorder.

Neurol Genet 2021 Apr 18;7(2):e579. Epub 2021 Mar 18.

Research Institute of the McGill University Health Centre (K.M.), Montreal, PQ; Division of Child Neurology (K.M.), Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, PQ; Department of Neurology & Neurosurgery (K.M.), Montreal Children's Hospital, McGill University, Montreal, PQ; Child Neurology and Psychiatry (C.M.), Salesi Pediatric Hospital, United Hospitals of Ancona, Ancona, Italy; Division of Genetic Medicine (G.L.C., J.N., H.C.M.), Department of Pediatrics, University of Washington, Seattle, WA; Department of Neurology (A.M.), Great Ormond Street Hospital for Children, London, UK; Developmental Neurosciences Programme (A.M.), UCL Great Ormond Street Institute of Child Health, London, UK; Neurology Network Melbourne (J.P.), Melbourne, Victoria, Australia; Murdoch Children's Research Institute (C.S., I.E.S.), Parkville, Victoria, Australia; Department of Paediatrics and Child Health (T.S.), School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand; Division of Neurology (S.M.), Department of Pediatrics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada; Neurology Unit and Neurogenetic Laboratories (C.B., A.R., R.G.), Meyer Children's Hospital, Florence, Italy; Department of Clinical Genetics (R.H.S.), Great Ormond Street Hospital, London, UK; Epilepsy Research Centre (I.E.S.), Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Victoria, Australia; Department of Paediatrics (I.E.S.), Royal Children's Hospital, The University of Melbourne, Parkville, Victoria, Australia; and The Florey Institute of Neuroscience and Mental Health (I.E.S.), Heidelberg, Victoria, Australia.

Objective: To describe the phenotypic spectrum in patients with MBD5-associated neurodevelopmental disorder (MAND) and seizures; features of MAND include intellectual disability, epilepsy, psychiatric features of aggression and hyperactivity, and dysmorphic features including short stature and microcephaly, sleep disturbance, and ataxia.

Methods: We performed phenotyping on patients with deletions, duplications, or point mutations and a history of seizures.

Results: Twenty-three patients with MAND and seizures were included. Read More

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Sleep disruption and duration are associated with variants in genes involved in energy homeostasis in adults with HIV/AIDS.

Sleep Med 2020 Aug 28;82:84-95. Epub 2020 Aug 28.

Department of Family Health Care Nursing, University of California at San Francisco, San Francisco, CA, USA.

Objective: To determine whether selected genes and plasma markers involved in energy homeostasis are associated with sleep disruption or duration in adults with HIV/AIDS.

Methods: A sample of 289 adults with HIV/AIDS wore a wrist actigraph for 72 h to estimate total sleep time (TST) and wake after sleep onset (WASO). Twenty-three single nucleotide polymorphisms (SNP) spanning 5 energy homeostasis genes (adiponectin [ADIPOQ], ghrelin [GHRL], leptin [LEP], peroxisome proliferator-activated receptor-alpha [PPARA], and -gamma [PPARG]) were genotyped using a custom array. Read More

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Sleep in the Hospitalized Child: A contemporary review.

Chest 2021 Apr 22. Epub 2021 Apr 22.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD; Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD; Department of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD. Electronic address:

Acute illness and hospitalization introduce several risk factors for sleep disruption in children that can negatively affect recovery and healing and potentially compromise long-term cognition and executive function. The hospital setting is not optimized for pediatric sleep promotion, and many of the pharmacologic interventions intended to promote sleep in the hospital may actually have deleterious effects on sleep quality and quantity. To date, evidence to support pharmacologic sleep promotion in the pediatric inpatient setting is sparse. Read More

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The Molecular Clock and Neurodegenerative Disease: A Stressful Time.

Front Mol Biosci 2021 26;8:644747. Epub 2021 Mar 26.

Gamsby Laboratory, USF Health Byrd Alzheimer's Center and Research Institute, University of South Florida Health, Tampa, FL, United States.

Circadian rhythm dysfunction occurs in both common and rare neurodegenerative diseases. This dysfunction manifests as sleep cycle mistiming, alterations in body temperature rhythms, and an increase in symptomatology during the early evening hours known as Sundown Syndrome. Disruption of circadian rhythm homeostasis has also been implicated in the etiology of neurodegenerative disease. Read More

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The role of the COVID-19 pandemic in altered psychological well-being, mental health and sleep: an online cross-sectional study.

Psychol Health Med 2021 Apr 20:1-9. Epub 2021 Apr 20.

Centre for Behavioural Science and Applied Psychology, Sheffield Hallam University, Sheffield, UK.

Coronavirus disease 2019 (COVID-19) is a global pandemic. Measures to reduce transmission of the virus have altered usual activities, routines, and livelihoods, and have had a significant impact on mental health. The current study aims to examine the potential alterations in psychological wellbeing, mental health, sleep and diurnal preference due to the COVID-19 pandemic. Read More

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Associations of sleep and female sexual function: good sleep quality matters.

Menopause 2021 Apr 19. Epub 2021 Apr 19.

Division of Women's Health Internal Medicine, Mayo Clinic, Scottsdale, AZ Mayo Clinic Center for Women's Health, Mayo Clinic, Rochester, MN Division of General Internal Medicine, Mayo Clinic, Rochester, MN Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN Division of General Internal Medicine, Mayo Clinic, Jacksonville, FL.

Objective: To evaluate associations between sleep and female sexual function.

Methods: A cross-sectional analysis from the Data Registry on Experiences of Aging, Menopause and Sexuality (DREAMS) was performed using questionnaires in women presenting for menopause or sexual health consult at Mayo Clinic from December, 2016 to September, 2019. Female Sexual Function Index (FSFI), Female Sexual Distress Scale-Revised (FSDS-R), and the Pittsburgh Sleep Quality Index (PSQI) assessed sexual function and sleep parameters, respectively. Read More

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Short-term physical health effects of sleep disruptions attributed to the acute hospital environment: a systematic review.

Sleep Health 2021 Apr 16. Epub 2021 Apr 16.

Department of Respiratory Medicine, Liverpool Hospital, South Western Sydney Local Health District, Australia; Faculty of Medicine, University of New South Wales, Sydney, Australia.

The sleep disruption experienced by patients admitted to hospital may have a negative effect on health but the nature and magnitude of the effect has not been conclusively outlined. The review was designed to examine the impact of sleep disruption associated with being a hospital inpatient, on short-term physical health outcomes in adult patients. Searches comprised journal databases, gray literature sources, and backward and forward citation searching. Read More

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K3.1 channels regulate the rate of critical period plasticity.

Neurosci Res 2021 Apr 16. Epub 2021 Apr 16.

Laboratory for Neuronal Circuit Development, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan; International Research Center for Neurointelligence, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan; Center for Brain Science, Department of Molecular Cellular Biology, Harvard University, 52 Oxford Street, Cambridge, MA, 02138, USA. Electronic address:

Experience-dependent plasticity within visual cortex is controlled by postnatal maturation of inhibitory circuits, which are both morphologically diverse and precisely connected. Gene-targeted disruption of the voltage-dependent potassium channel K3.1 broadens action potentials and reduces net inhibitory function of parvalbumin (PV)-positive GABA subtypes within the neocortex. Read More

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Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer's Disease.

Neurochem Res 2021 Apr 19. Epub 2021 Apr 19.

Pre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.

Alzheimer's disease (AD) is one of the crucial causative factors for progressive dementia. Neuropathologically, AD is characterized by the extracellular accumulation of amyloid beta plaques and intracellular neurofibrillary tangles in cortical and limbic regions of the human brain. The circadian system is one of the many affected physiological processes in AD, the dysfunction of which may reflect in the irregularity of the sleep/wake cycle. Read More

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