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Heme Detoxification in the Malaria Parasite: A Target for Antimalarial Drug Development.

Acc Chem Res 2021 May 13. Epub 2021 May 13.

Department of Chemistry, University of Cape Town, Private Bag, Rondebosch 7701, South Africa.

ConspectusOver the last century, malaria deaths have decreased by more than 85%. Nonetheless, there were 405 000 deaths in 2018, mostly resulting from infection. In the 21st century, much of the advance has arisen from the deployment of insecticide-treated bed nets and artemisinin combination therapy. Read More

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Needle-in-needle Pinning Technique Using Disposable Hypodermic Needles for Fractures of Distal Phalanx With Dorsal Disruption.

Tech Hand Up Extrem Surg 2021 May 12. Epub 2021 May 12.

Ichihara Orthopedic Clinic, Ichihara, Chiba Prefecture, Japan.

Fingertip injuries are frequently encountered by the hand surgeon, and often present with a combination of the following: avulsed or broken nail plate, nail bed disruption, and/or distal phalangeal fracture. Recommended management of these injuries consists of reduction of the fracture followed by repair of soft tissues. To achieve an anatomic reduction and sufficient stability of the fracture, current management consists of temporary Kirschner-wire stabilization. Read More

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Household chaos, family routines, and young child movement behaviors in the U.S. during the COVID-19 outbreak: a cross-sectional study.

BMC Public Health 2021 05 4;21(1):860. Epub 2021 May 4.

Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.

Background: The home environment is an important facilitator of young child movement behaviors, including physical activity (PA), sleep, and screen-time. Household chaos, characterized by crowding, noise, and disorder in the home, may hinder efforts to obtain adequate amounts of movement behaviors. The COVID-19 outbreak impacted many families, and social distancing during this time may create conditions for more household chaos. Read More

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Smoke on the Water: Comparative Assessment of Combined Thermal Shock Treatments for Control of Invasive Asian Clam, Corbicula fluminea.

Environ Manage 2021 Apr 29. Epub 2021 Apr 29.

Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, 19 Chlorine Gardens, Belfast, BT9 5DL, Northern Ireland, UK.

Suppression of established populations of invasive alien species can be a complex and expensive process, which is frequently unsuccessful. The Asian clam, Corbicula fluminea (Müller, 1774), is considered a high impact invader that can adversely alter freshwater ecosystems and decrease their socioeconomic value. To date, C. Read More

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P2X1: a unique platelet receptor with a key role in thromboinflammation.

Platelets 2021 Mar 24:1-7. Epub 2021 Mar 24.

GIGA Cardiovascular Sciences, Laboratory of Cardiology, University of Liège, Liège, Belgium.

Thromboinflammation involves complex interactions between actors of inflammation and immunity and components of the hemostatic system, which are elicited upon infection or tissue injury. In this context, the interplay between platelets and innate immune cells has been intensively investigated. The ATP-gated P2X1 ion channel, expressed on both platelets and neutrophils is of particular interest. Read More

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Georgian Med News 2021 Jan(310):36-39

Ivane Javakhishvili Tbilisi State University, Georgia.

Bruxism has become more and more debatable and pressing issue all over the world last years. the etiology of bruxism has been changing diverse definitions, over the years, however recently it is defined as a repetitive jaw-muscle activity characterized by clenching or grinding of the teeth and by bracing or thrusting of the mandible. This literature review discusses the possible risk factors of bruxism in children and adolescence, among which behavioral abnormalities and sleep disturbances predominates. Read More

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January 2021

A mixed methods study of perinatal sleep and breastfeeding outcomes in women at risk for postpartum depression.

Sleep Health 2021 Feb 25. Epub 2021 Feb 25.

The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA; Sleep for Science Research Laboratory, Providence, Rhode Island, USA; Rhode Island Hospital, Divison of Pulmonary, Critical Care, and Sleep Medicine, Providence, Rhode Island, USA. Electronic address:

Introduction: Pregnant and postpartum women experience significant sleep disruption, but the role of perinatal sleep disturbances in breastfeeding is understudied.

Methods: In this observational cohort study, we used mixed methods to examine associations between perinatal sleep and breastfeeding. Forty-eight women (mean age 28. Read More

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February 2021

Narrative review of lung cancer treatment at the time of COVID-19 pandemia: pitfall and issues.

Transl Lung Cancer Res 2021 Jan;10(1):475-482

A.O.R.N. San Giuseppe Moscati, Contrada Amoretta, Avellino, AV, Italy.

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), responsible for coronavirus disease 2019 (COVID-19) pandemic, has caused disruption in cancer care and research, changing daily management approach of cancer patients, above all for those affected by lung cancer disease. Unfortunately, its length and severity beyond today is still uncertain. This emerged viral pandemic has produced severe illness to overwhelm healthcare infrastructure, with worse impact on public health system and on providers of essential community services, and needing to ration medical equipment and interventions. Read More

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January 2021

Emerging carbapenem-resistant sequence type 16 causing multiple outbreaks in a tertiary hospital in southern Vietnam.

Microb Genom 2021 03 10;7(3). Epub 2021 Feb 10.

Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.

The emergence of carbapenem resistance in represents a major global public health concern. Nosocomial outbreaks caused by multidrug-resistant are commonly reported to result in high morbidity and mortality due to limited treatment options. Between October 2019 and January 2020, two concurrent high-mortality nosocomial outbreaks occurred in a referral hospital in Ho Chi Minh City, Vietnam. Read More

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Sleep timing, chronotype and social jetlag: Impact on cognitive abilities and psychiatric disorders.

Biochem Pharmacol 2021 Feb 2:114438. Epub 2021 Feb 2.

Univ. Bordeaux, SANPSY (Sommeil Addiction et Neuropsychiatrie), USR 3413, F-33000 Bordeaux, France; CNRS, SANPSY, USR 3413, F-33000 Bordeaux, France; CHU de Bordeaux, Pôle Neurosciences Cliniques, F-33000 Bordeaux, France.

Sleep timing is controlled by the subtle interplay between circadian and homeostatic oscillators which, according to their endogenous properties, allow beings to feel spontaneously that it is time to go to bed or wake up in synchrony with the earth's light/dark cycle. In humans, however, social time and nocturnal artificial light modify sleep timing. Our modern lifestyle and artificial nocturnal light delay our bedtime, make us wake up, and lead to a greater intraindividual variability in sleep timing. Read More

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February 2021

Acute Seymour fractures in children/adolescents overlooked as a simple nail injury: Reduction without pinning.

Hand Surg Rehabil 2021 Apr 27;40(2):171-176. Epub 2021 Jan 27.

Department of Orthopedic Surgery, Regional Rheumatoid and Degenerative Arthritis Center, Chungnam National University Hospital, Chungnam National University School of Medicine, 282 Munhwa-ro, Daesa-dong, Jung-gu, Daejeon, South Korea.

We retrospectively report the outcomes of several cases in which acute Seymour fractures were treated by open reduction of displaced distal bony fragments with concurrent nail repair, following complete incision and drainage without K-wire fixation. Among 21 patients surgically treated between March 2004 and December 2018, the final 12 were evaluated after at least 2 years of follow-up. All children/adolescents presented more than 24 h after the injury. Read More

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Social Jetlag and Prostate Cancer Incidence in Alberta's Tomorrow Project: A Prospective Cohort Study.

Cancers (Basel) 2020 Dec 21;12(12). Epub 2020 Dec 21.

Cancer Epidemiology and Prevention Research, Cancer Care Alberta, Alberta Health Services, Calgary, AB T2S 3C3, Canada.

We investigated the association of social jetlag (misalignment between the internal clock and socially required timing of activities) and prostate cancer incidence in a prospective cohort in Alberta, Canada. Data were collected from 7455 cancer-free men aged 35-69 years enrolled in Alberta's Tomorrow Project (ATP) from 2001-2007. In the 2008 survey, participants reported usual bed- and wake-times on weekdays and weekend days. Read More

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December 2020

Neurology training and research in the COVID-19 pandemic: a survey of the Resident and Research Fellow Section of the European Academy of Neurology.

Eur J Neurol 2020 Dec 23. Epub 2020 Dec 23.

Department of Neurology, Inselspital, University of Bern, Bern, Switzerland.

Background And Purpose: The COVID-19 (SARS-CoV-2) outbreak has disrupted residency programmes due to university and hospitals' priorities to face this emergency at all cost. Most research projects and clinical trials were temporarily stopped or postponed. The Resident and Research Fellow Section (RRFS) of the European Academy of Neurology (EAN) has decided to assess the impact of the COVID-19 pandemic on neurology training. Read More

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December 2020

System-wide molecular dynamics of endothelial dysfunction in Gram-negative sepsis.

BMC Biol 2020 11 24;18(1):175. Epub 2020 Nov 24.

School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore.

Background: Inflammation affecting whole organism vascular networks plays a central role in the progression and establishment of several human diseases, including Gram-negative sepsis. Although the molecular mechanisms that control inflammation of specific vascular beds have been partially defined, knowledge lacks on the impact of these on the molecular dynamics of whole organism vascular beds. In this study, we have generated an in vivo model by coupling administration of lipopolysaccharide with stable isotope labeling in mammals to mimic vascular beds inflammation in Gram-negative sepsis and to evaluate its effects on the proteome molecular dynamics. Read More

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November 2020

Longer Cortical Silent Period Length Is Associated to Binge Eating Disorder: An Exploratory Study.

Front Psychiatry 2020 14;11:559966. Epub 2020 Oct 14.

Post-Graduate Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Although binge eating disorder (BED) is an eating disorder and obesity is a clinical disease, it is known that both conditions present overlapped symptoms related to, at least partially, the disruption of homeostatic and hedonistic eating behavior pathways. Therefore, the understanding of neural substrates, such as the motor cortex excitability assessed by transcranial magnetic stimulation (TMS), might provide new insights into the pathophysiology of BED and obesity. (i) To compare, among BED, obesity, ex-obese, and HC (healthy control) subjects, the cortical excitability indexed by TMS measures, such as CSP (cortical silent period; primary outcome), SICI (intracortical inhibition), and ICF (intracortical facilitation; secondary outcome). Read More

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October 2020

Coordination of social behaviors by the bed nucleus of the stria terminalis.

Eur J Neurosci 2020 Oct 2. Epub 2020 Oct 2.

Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

The bed nucleus of the stria terminalis (BNST) is a sexually dimorphic, neuropeptide-rich node of the extended amygdala that has been implicated in responses to stress, drugs of abuse, and natural rewards. Its function is dysregulated in neuropsychiatric disorders that are characterized by stress- or drug-induced alterations in mood, arousal, motivation, and social behavior. However, compared to the BNST's role in mood, arousal, and motivation, its role in social behavior has remained relatively understudied. Read More

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October 2020

New indicator of cellular ischemia in coronary slow-flow phenomenon: Cell-free DNA.

Turk Kardiyol Dern Ars 2020 09;48(6):558-565

Department of Medical Biology, Erzincan University Faculty of Medicine, Erzincan, Turkey.

Objective: Coronary slow-flow phenomenon (CSFP) is defined as the delayed arrival of coronary blood flow to the distal vascular bed in at least 1 major epicardial coronary artery. Cell-free DNA (cfDNA) is a type of DNA that circulates freely in the blood once released from nucleated cells. The aim of this study was to determine if the level of cfDNA, which is an indicator of ischemia at the cellular level, was increased in CSFP. Read More

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September 2020

Non-REM sleep instability in children with restless sleep disorder.

Sleep Med 2020 11 3;75:276-281. Epub 2020 Aug 3.

Sleep Research Centre, Oasi Research Institute - IRCCS, Troina, Italy.

Study Objectives: Restless sleep disorder (RSD) is a newly recognized condition characterized by motor movements involving large muscle groups with frequent repositioning or bed sheets disruption. We analyzed cyclic alternating pattern (CAP) in these children, a marker of sleep instability that might be associated with the motor episodes of RSD and may play a role in their daytime symptoms.

Methods: Polysomnographic recordings from thirty-eight children who fulfilled RSD diagnostic criteria (23 boys and 15 girls), 23 children with restless legs syndrome (RLS, 18 boys and 5 girls) and 19 controls (10 boys and 9 girls) were included. Read More

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November 2020

Sleep as a Novel Biomarker and a Promising Therapeutic Target for Cerebral Small Vessel Disease: A Review Focusing on Alzheimer's Disease and the Blood-Brain Barrier.

Int J Mol Sci 2020 Aug 31;21(17). Epub 2020 Aug 31.

Department of Human and Animal Physiology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.

Cerebral small vessel disease (CSVD) is a leading cause of cognitive decline in elderly people and development of Alzheimer's disease (AD). Blood-brain barrier (BBB) leakage is a key pathophysiological mechanism of amyloidal CSVD. Sleep plays a crucial role in keeping health of the central nervous system and in resistance to CSVD. Read More

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Viewing atherosclerosis through a crystal lens: How the evolving structure of cholesterol crystals in atherosclerotic plaque alters its stability.

J Clin Lipidol 2020 Sep - Oct;14(5):619-630. Epub 2020 Jul 11.

Division of Cardiovascular Medicine, Department of Medicine, Michigan State University, College of Human Medicine, East Lansing, MI, USA. Electronic address:

Reducing the residual risk of cardiovascular (CV) events in patients with atherosclerosis continues to be a challenge. Thus, understanding how cholesterol spontaneously self assembles into metastable structures that evolve into flat plate cholesterol crystals (CCs) in atherosclerotic plaque, and why they fundamentally change the nature of the disease provides a paradigm for the development of additional therapies. Specifically, flat plate CCs that form within lysosomes of macrophages may become large enough to disrupt lysosomal membranes leading to the release of cathepsin B and CCs fragments directly into the cytosol. Read More

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Pathologic Disparities Between Peripheral Artery Disease and Coronary Artery Disease.

Arterioscler Thromb Vasc Biol 2020 09 16;40(9):1982-1989. Epub 2020 Jul 16.

Department of Pathology, New York University Grossman School of Medicine, New York, NY (Navneet Narula).

Atherosclerosis is a systemic disease that involves multiple vascular beds. The pathological characteristics and clinical presentation, however, vary among the different vascular territories. Acute coronary syndrome is a relatively common manifestation of coronary atherosclerotic disease, wherein the thrombosis occurs secondary to disruption (65%-75%) and erosion (25%-35%) of the fibrous caps of atheromatous plaques. Read More

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September 2020

An investigation of the status and maturity of hospitals' health information governance in Victoria, Australia.

Health Inf Manag 2020 Jul 14:1833358320938309. Epub 2020 Jul 14.

La Trobe University, Australia.

Background: Health information governance (IG) in Australian hospitals was hitherto unexplored.

Objectives: To determine hospitals' health IG status and maturity in Victoria, Australia, identify drivers and barriers affecting IG adoption, examine electronic health data breach response plan usage and assess employees' electronic data breach awareness.

Method: Mixed-methods descriptive study utilising an online survey of directors - clinical/health information services and chief health information managers (HIMs) in Victorian hospitals, ≥50 beds. Read More

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Associations between pain, objective sleep efficiency and cognition in patients with implantable cardioverter defibrillators.

Sleep Med 2020 08 6;72:122-125. Epub 2020 Apr 6.

Department of Psychiatry, University of Missouri, Columbia, MO, USA. Electronic address:

Introduction: Patients with implantable cardioverter defibrillators (ICDs) frequently experience sleep disruption. Prior work shows associations between objective (actigraphic) sleep and cognition in these patients, but whether pain affects associations between measures of sleep fragmentation (eg, sleep efficiency, SE) and cognition is unknown. The present study examined independent and interactive associations between objective SE and pain on cognitive performance in patients with ICDs. Read More

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Feasibility Case Series of Environment and Sleep in Infants With Congenital Heart Disease.

Nurs Res 2020 Sep/Oct;69(5S Suppl 1):S79-S84

Laura Beth Kalvas, MS, RN, PCCN, is Graduate Fellow, The Ohio State University College of Nursing, Columbus. Tondi M. Harrison, PhD, RN, FAAN, is Associate Professor, The Ohio State University College of Nursing, Columbus.

Background: Developmental delay is a significant concern for infants born with complex congenital heart disease (CCHD). Environmental exposures (e.g. Read More

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February 2021

Consolidating malignant pleural and peritoneal services during the COVID-19 response.

Avinash Aujayeb

Future Healthc J 2020 Jun;7(2):161-162

Northumbria Specialist Emergency Care Hospital, Cramlington, UK.

Delivery of routine and established medical care has been significantly disrupted by the COVID-19 pandemic. Acutely unwell patients are being prioritised, and large numbers of doctors and inpatient beds are required to deliver this care. We have recognised the impact that this disruption will have on patients with presumed and/or confirmed pleural and/or peritoneal malignancies. Read More

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Predictors of voluntary and compulsory admissions after psychiatric emergency consultation in youth.

Eur Child Adolesc Psychiatry 2021 May 21;30(5):747-756. Epub 2020 May 21.

Parnassia Psychiatric Institute, Rotterdam, The Netherlands.

As hospital beds are scarce, and emergency admissions to a psychiatric ward are major life-events for children and adolescents, it is essential to have insight into the decision-making process that leads to them. To identify potentially modifiable factors, we, therefore, studied the contextual and clinical characteristics associated with the voluntary and compulsory emergency admission of minors. We used registry data (2008-2017) on 1194 outpatient emergencies involving children aged 6-18 who had been referred to the mobile psychiatric emergency service in two city areas in The Netherlands. Read More

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COVID-19 Mitigation Steps Provide a Blueprint for Malaria Control and Elimination.

Am J Trop Med Hyg 2020 07 7;103(1):28-30. Epub 2020 May 7.

ICMR-National Institute of Malaria Research, New Delhi, India.

Most countries around the world have responded promptly to the novel coronavirus disease (COVID-19) challenge by adopting considered and scientifically guided strategies for its containment. However, the situation is more complex for nations where malaria is endemic, as they now have the additional burden of COVID-19. In such nations, the healthcare systems are either in the preparatory or containment phase of the current pandemic. Read More

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The Inadequacy of Regulatory Frameworks in Time of Crisis and in Low-Resource Settings: Personal Protective Equipment and COVID-19.

Health Technol (Berl) 2020 May 2:1-9. Epub 2020 May 2.

Health Technology Assessment Division, International Federation for Medical and Biological Engineering, Florence, Italy.

COVID-19 pandemic is plaguing the world and representing the most significant stress test for many national healthcare systems and services, since their foundation. The supply-chain disruption and the unprecedented request for intensive care unit (ICU) beds have created in Europe conditions typical of low-resources settings. This generated a remarkable race to find solutions for the prevention, treatment and management of this disease which is involving a large amount of people. Read More

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Vulnerability and resistance to sleep disruption by a partner: A study of bed-sharing couples.

Sleep Health 2020 08 21;6(4):506-512. Epub 2020 Apr 21.

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia. Electronic address:

Objectives: Methods for analyzing sleep as a dyadic behavior remain relatively unexplored. We aimed to (1) characterize how bedpartners influence each other's sleep, and (2) identify factors that predict sensitivity to wake transmission between bedpartners.

Design: Cross-sectional study. Read More

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Tablet vs. station-based laptop ultrasound devices increases internal medicine resident point-of-care ultrasound performance: a prospective cohort study.

Ultrasound J 2020 Apr 16;12(1):18. Epub 2020 Apr 16.

Department of Graduate Medical Education #11135, Abbott Northwestern Hospital, 800 E. 28th Street, Minneapolis, MN, 55407, USA.

Background: Point-of-care ultrasound (POCUS) is becoming an important part of internal medicine (IM) residency training. Achieving competency requires performing a large volume of clinical exams which can be difficult within the constraints of residency. Often-cited barriers include insufficient resident time and the interruption of daily workflow. Read More

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