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Understanding Holism in the light of principle underlying practice of Unani Medicine.

Rev Environ Health 2021 May 13. Epub 2021 May 13.

Central Council for Research in Unani Medicine, New Delhi, India.

The holistic Unani medicine is fundamentally different from the reductionist conventional medicine. It asserts the self-integration amongst its basic disciplines, without considering them underlying principles of Unani system of medicine cannot be understood. The diagnosis, selection of drugs, and plan of treatment is also overlooked. Read More

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ADHD and autism symptoms in youth: a network analysis.

J Child Psychol Psychiatry 2021 May 13. Epub 2021 May 13.

Departamento de Psiquiatria da Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.

Background: Previous research investigating the overlap between attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (henceforth, autism) symptoms in population samples have relied on latent variable modeling in which averaged scores representing dimensions were derived from observed symptoms. There are no studies evaluating how ADHD and autism symptoms interact at the level of individual symptom items.

Methods: We aimed to address this gap by performing a network analysis on data from a school survey of children aged 6-17 years old (N = 7,405). Read More

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Plasma levels of bigEndothelin-1 are associated with renal insufficiency and in-hospital mortality of immune thrombotic thrombocytopenic purpura.

Thromb Haemost 2021 May 13. Epub 2021 May 13.

Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, United States.

Immune thrombotic thrombocytopenic purpura (iTTP) is caused by severe deficiency of plasma ADAMTS13 activity. Despite advances in early diagnosis and management, the mortality rate of acute iTTP remains high in a large part of world where access to some of the most novel therapies is limited. To determine the role of plasma bigEndothelin-1 (bigET-1) or its bioactive product ET-1 as a biomarker and/or a pathogenic factor in acute iTTP, plasma levels of bigET-1 were determined using an immunoassay in patients with iTTP on admission and during remission, as well as in healthy controls; moreover, the biological effect of ET-1 in thrombus formation was determined by a microfluidic assay. Read More

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A prospective cohort study of ambient air pollution exposure and risk of uterine leiomyomata.

Hum Reprod 2021 May 13. Epub 2021 May 13.

Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

Study Question: To what extent are ambient concentrations of particulate matter <2.5 microns (PM2.5), nitrogen dioxide (NO2) and ozone (O3) associated with risk of self-reported physician-diagnosed uterine leiomyomata (UL)?

Summary Answer: In this large prospective cohort study of Black women, ambient concentrations of O3, but not PM2. Read More

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Dual-target compounds for Alzheimer's disease: Natural and synthetic AChE and BACE-1 dual-inhibitors and their structure-activity relationship (SAR).

Eur J Med Chem 2021 Apr 24;221:113492. Epub 2021 Apr 24.

LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal. Electronic address:

Alzheimer's disease (AD) is a chronic neurodegenerative disease and represents the major cause of dementia worldwide. Currently, there are no available treatments capable to deliver disease-modifying effects, and the available drugs can only alleviate the symptoms. The exact pathology of AD is not yet fully understood and several hallmarks such as the presence of amyloid-β (Aβ) senile plaques, neurofibrillary tangles (NFTs) as well as the loss of cholinergic function have been associated to AD. Read More

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Inflammatory Biomarkers Correlate with Time Evolution in Cerebral Venous Thrombosis.

J Stroke Cerebrovasc Dis 2021 May 10;30(7):105844. Epub 2021 May 10.

Department of Neurology, Centro Hospitalar Universitário de São João, EPE, Department of Clinical Neurosciences and Mental Health, Faculty of Medicine of University of Porto.

Objectives: We aimed to analyse the relationship between specific inflammatory biomarkers' levels and the temporal pattern of cerebral venous thrombosis (CVT) symptoms.

Materials And Methods: We performed a retrospective study of adult CVT patients admitted between Jan 01 2006 and Dec 31 2019. We excluded patients with infection at admission, autoimmune, inflammatory or haematological disorders. Read More

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Complementary and alternative medicine (CAM) in women with endometriosis.

Eur J Obstet Gynecol Reprod Biol 2021 May 4;262:7-12. Epub 2021 May 4.

Department of Obstetrics and Gynaecology, Erlangen University Hospital, Erlangen, Germany; Friedrich Alexander University of Erlangen-Nürnberg, Erlangen, Germany.

Objective: This study aimed to provide an overview of the extent to which women with endometriosis are informed about, interested in, and make use of CAM, and to evaluate which of the methods are most often applied.

Study Design: A retrospective, two-center cohort study was conducted using a validated questionnaire among women with laparoscopically confirmed endometriosis at two urban teaching hospitals, certified as endometriosis centres.

Results: A total of 592 patients were included in the study and received the questionnaire; 114 (19. Read More

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A pilot study for treatment of COVID-19 patients in moderate stage using intravenous administration of ozonized saline as an adjuvant treatment-registered clinical trial.

Int Immunopharmacol 2021 Apr 30;96:107743. Epub 2021 Apr 30.

Department of Medical Services and Clinical Research, NeuroGen Brain & Spine Institute, Navi Mumbai, India.

Objective: Ozone therapy has tremendous therapeutic potential owing to its antiviral, anti-inflammatory and antioxidant properties, and potential to improve oxygenation. A pilot clinical trial was conducted to evaluate the safety and efficacy ofintravenous ozonised saline treatment in patients with moderate COVID-19 pneumonia.

Patients And Methods: 10 patients were administered 200 ml freshly prepared ozonised saline intravenously over 1 h once a day for 8 days along with standard medical treatment. Read More

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Delayed care for patients with newly diagnosed cancer due to COVID-19 and estimated impact on cancer mortality in France.

ESMO Open 2021 Apr 17;6(3):100134. Epub 2021 Apr 17.

Centre Henri Becquerel, Rouen, France.

Background: The impact of the first coronavirus disease 2019 (COVID-19) wave on cancer patient management was measured within the nationwide network of the Unicancer comprehensive cancer centers in France.

Patients And Methods: The number of patients diagnosed and treated within 17 of the 18 Unicancer centers was collected in 2020 and compared with that during the same periods between 2016 and 2019. Unicancer centers treat close to 20% of cancer patients in France yearly. Read More

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Predicting outcome of patients with psychogenic nonepileptic seizures after diagnosis in an epilepsy monitoring unit.

Epilepsy Behav 2021 May 10;120:108004. Epub 2021 May 10.

Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada; Psychology, Western University, London, Ontario, Canada.

Objective: To identify predictors of Psychogenic NonEpileptic Seizure (PNES) improvement and anti-seizure medication (ASM) discontinuation in patients with PNES only.

Methods: This is a retrospective study of a consecutively enrolled cohort of 271 patients diagnosed with PNES by video-EEG (vEEG) telemetry in our Epilepsy Monitoring Unit (EMU) between May 2000 and February 2010. Patients with any possibility of past or present comorbid epilepsy based on clinical, EEG, and neuroimaging, or less than one year of follow-up after discharge were excluded. Read More

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Lateralization bias for autoimmune optic neuritis.

Mult Scler Relat Disord 2021 Apr 28;52:102980. Epub 2021 Apr 28.

Department of Neurology, University Hospital Frankfurt, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany.

The asymmetrical structure of the human brain is reflected not only by innate interhemispheric differences but also by lateralization in neurological disease. We tested if unilateral autoimmune optic neuritis (aON) manifests more frequently on the left than the right eye in clinical and neuroimaging terms and whether Google searches for aON symptoms reflect this bias, too. We employed a retrospective analysis of a patient cohort from 2009 to 2019 with 552 unilateral aONs and 374 corresponding MRI imaging data sets. Read More

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Electrospun polycaprolactone/hydroxyapatite/ZnO films as potential biomaterials for application in bone-tendon interface repair.

Colloids Surf B Biointerfaces 2021 May 10;204:111825. Epub 2021 May 10.

Department of Orthopaedical Surgery, Xiangya Hospital, Central South University, Changsha, 410078, China; Hunan Engineering Research Center of Biomedical Metal and Ceramic Implants, Xiangya Hospital, Central South University, Changsha, 410078, China. Electronic address:

The bone-tendon interface (BTI) is a graded structure consisting of bone, mineralized and nonmineralized fibrocartilage, and tendons. Due to the complexity of the BTI structure, BTI healing is particularly challenging. To achieve a better material for BTI healing, polycaprolactone (PCL)/hydroxyapatite (HA)/ZnO films were constructed by the electrospinning method; in addition, the relevant material characteristics were tested. Read More

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Clinical implications of panic attack in Chinese patients with somatoform disorders.

J Psychosom Res 2021 May 10;146:110509. Epub 2021 May 10.

Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

Objective: Somatoform disorders are frequently accompanied by panic attack and causes many clinical symptoms. This study aimed to compare clinical features between patients with and without panic attack in somatoform disorder.

Methods: In this cross-sectional study, 341 patients with somatoform disorder according to the MINI-International Neuropsychiatric Interview (M. Read More

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Prescription pattern of antimicrobial use in small animal veterinary practice in Cameroon.

Top Companion Anim Med 2021 May 10:100540. Epub 2021 May 10.

College of Technology, University of Bamenda, Bambili, Cameroon. Electronic address:

Retrospective data on antimicrobial use (AMU) within the period ranging from January 2012 to December 2015 was collected to assess the antimicrobial prescription patterns in pets (cats and dogs) treated by 16 veterinary private practitioners in the two main urban cities of Cameroon (Douala and Yaounde). The vet practitioners were interviewed in order to analyze prescribing behavior and factors influencing antimicrobial prescription. Out of a total of 3928 antimicrobial prescriptions, 3673(93. Read More

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An uncommon disease included commonly in the differential diagnosis of neurological diseases: Neuro-Behçet's syndrome.

J Neurol Sci 2021 Apr 20;426:117436. Epub 2021 Apr 20.

Istanbul University Cerrahpaşa School of Medicine, Department of Neurology, Istanbul, Turkey. Electronic address:

Behçet's Syndrome (BS) may present with different neurological problems, related either directly (primary) or indirectly (secondary) to BS. Primary neurological involvement is named as neuro-Behcet's syndrome (NBS), and its two major subtypes that are classified mainly on the clinical and MRI findings are (1) Parenchymal-NBS (p-NBS) and (2) Extra parenchymal neuro-vascular involvement mostly seen as cerebral dural venous sinus thrombosis (CVST). The less commonly seen forms of NBS are cognitive and behavioral syndromes and peripheral nervous system involvement. Read More

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Sentinel lymph node sampling as an alternative to lymphadenectomy in patients with endometrial cancer and obesity.

J Obstet Gynaecol Can 2021 May 10. Epub 2021 May 10.

Division of Gynecologic Oncology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.; Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, affiliated with the Hebrew.

Objective: Although its use in endometrial cancer staging is relatively new, sentinel lymph node (SLN) sampling has been shown to be highly accurate and is associated with few complications. However, some studies report lower rates of detection with SLN sampling among patients with obesity. The aim of the current study is to evaluate the feasibility of SLN sampling in endometrial cancer for patients with obesity, and to determine whether omitting lymph node dissection (LND) in surgical staging using SLN sampling impacts oncologic outcomes. Read More

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Low-dose candesartan prevents schizophrenia-like behavioral alterations in a neurodevelopmental two-hit model of schizophrenia.

Prog Neuropsychopharmacol Biol Psychiatry 2021 May 10:110348. Epub 2021 May 10.

Drug Research and Development Center, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil; National Institute for Translational Medicine (INCT-TM, CNPq), Ribeirão Preto, SP, Brazil. Electronic address:

Schizophrenia is a severe mental disorder with complex etiopathogenesis. Based on its neurodevelopmental features, an animal model induced by "two-hit" based on perinatal immune activation followed by peripubertal unpredictable stress was proposed. Sex influences the immune response, and concerning schizophrenia, it impacts the age of onset and symptoms severity. Read More

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Development of an immunochromatographic kit to detect severe acute respiratory syndrome coronavirus 2.

J Virol Methods 2021 May 10:114183. Epub 2021 May 10.

Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan. Electronic address:

Background: The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the worldwide coronavirus disease-19 (COVID-19) pandemic, starting in late 2019. The standard diagnostic methods to detect SARS-CoV-2 are PCR-based genetic assays. Antigen-antibody-based immunochromatographic assays are alternative methods of detecting this virus. Read More

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Basic Principles and New Advances in Kidney Imaging.

Kidney Int 2021 May 10. Epub 2021 May 10.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.

Over the past few years, clinical renal imaging has seen great advances, allowing assessments of kidney structure and morphology, perfusion, function and metabolism, oxygenation, as well as microstructure and interstitium. Medical imaging is becoming increasingly important in the evaluation of kidney physiology and pathophysiology, showing promise in management of patients with renal disease, in particular with regard to diagnosis, classification, and prediction of disease development and progression, monitoring response to therapy, detection of drug toxicity, and patient selection for clinical trials. A variety of imaging modalities, ranging from routine to advanced tools, are currently available to probe the kidney both spatially and temporally, particularly ultrasonography, computed tomography, positron emission tomography, renal scintigraphy, and multiparametric magnetic resonance imaging. Read More

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Interferon-Gamma Release Assays Differentiate Between Mycobacterium avium Complex and Tuberculous Lymphadenitis in Children.

J Pediatr 2021 May 10. Epub 2021 May 10.

Infectious Diseases and Systemic Inflammatory Response in Pediatrics, Infectious Diseases Unit, Department of Pediatrics, Sant Joan de Déu Hospital Research Foundation, Barcelona, Spain; Center for Biomedical Network Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Pediatrics, University of Barcelona, Barcelona, Spain; Translational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain. Electronic address:

Objectives: To assess the performance of interferon-gamma release assays (IGRAs) in the differential diagnosis between Mycobacterium avium complex (MAC) and tuberculosis (TB) in children affected with subacute/chronic submandibular/cervical lymphadenitis.

Study Design: Multicenter observational study comparing children with microbiologically-confirmed MAC lymphadenitis from the European NontuberculouS MycoBacterial Lymphadenitis in childrEn (ENSeMBLE) study with children with TB lymphadenitis from the Spanish Network for the Study of Pediatric TB (pTBred) database.

Results: Overall, 78 patients with MAC and 34 with TB lymphadenitis were included. Read More

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Nephrogenic syndrome of inappropriate antidiuresis - an ethnically, genetically and phenotypically diverse disorder: First report in a Chinese adult and review of published cases.

Clin Chim Acta 2021 May 10. Epub 2021 May 10.

Department of Pathology, Queen Elizabeth Hospital, Hong Kong.

Background: Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a rare inherited disorder characterised by hyponatraemia. To date, most reported cases are Caucasians with gain-of-function variants in AVPR2, an X-linked gene which encodes the vasopressin V2 receptor (V2R). Recently, germline gain-of-function variants in the stimulatory G protein α-subunit (Gsα) were reported to cause dominantly inherited NSIAD. Read More

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Depressive-hypertension: A proposed human endotype of brain/gut microbiome dysbiosis.

Am Heart J 2021 May 10:100540. Epub 2021 May 10.

Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville.

Background: Hypertension is frequently linked with depression in adults with cardiovascular disease (CVD), yet the underlying mechanism and successful management remain elusive. We approached this knowledge gap through the lens that humans are eukaryote-prokaryote "meta-organisms", such that CVD dysregulation is a mosaic disorder involving dysbiosis of the gut. We hypothesized that patients diagnosed with hypertension plus depression harbor a unique gut microbial ecology with attending functional genomics engaged with their hosts' gut/brain axis physiology. Read More

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Post-acute effects of SARS-CoV-2 infection in individuals not requiring hospital admission: a Danish population-based cohort study.

Lancet Infect Dis 2021 May 10. Epub 2021 May 10.

Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark. Electronic address:

Background: Individuals admitted to hospital for COVID-19 might have persisting symptoms (so-called long COVID) and delayed complications after discharge. However, little is known regarding the risk for those not admitted to hospital. We therefore examined prescription drug and health-care use after SARS-CoV-2 infection not requiring hospital admission. Read More

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Articulatory Correlates of Stress Pattern Disturbances in Talkers With Dysarthria.

J Speech Lang Hear Res 2021 May 13:1-14. Epub 2021 May 13.

Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN.

Purpose Reduced stress commonly occurs in talkers with Parkinson's disease (PD), whereas excessive and equal stress is frequently associated with dysarthria of talkers with amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS). This study sought to identify articulatory impairment patterns that underlie these two impaired stress patterns. We further aimed to determine if talkers with the same stress pattern disturbance but different diseases (ALS and MS) exhibit disease-specific articulatory deficits. Read More

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Effects of Short-Term Air Pollution Exposure on Venous Thromboembolism: A Case-Crossover Study.

Ann Am Thorac Soc 2021 May 13. Epub 2021 May 13.

University of Utah, Pulmonary and Critical Care Medicine, Salt Lake City, Utah, United States.

Rationale: Exposure to outdoor air pollution is associated with increased cardiovascular disease, respiratory illness, and mortality. The effect of air pollution on venous thromboembolism (VTE) is less certain.

Objectives: To test for associations between short-term exposure to air pollution and VTE. Read More

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Towards clinical application of tau PET tracers for diagnosing dementia due to Alzheimer's disease.

Alzheimers Dement 2021 May 13. Epub 2021 May 13.

Lund University, Clinical Memory Research Unit, Lund, Sweden.

The recent development of several tau positron emission tomography (PET) tracers represents a major milestone for the Alzheimer's disease (AD) field. These tau PET tracers bind tau neurofibrillary tangles, a key neuropathological characteristic of AD that is tightly linked to synaptic loss, brain atrophy, and cognitive decline. It is notable that these tau PET tracers show low uptake in most non-AD tauopathies and other neurodegenerative disorders, resulting in a diagnostic specificity that is superior to that of amyloid beta (Aβ) PET and biofluid markers, especially at an older age when incidental Aβ pathology is common. Read More

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Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe.

Alzheimers Dement 2021 May 13. Epub 2021 May 13.

Department of Medicine and Surgery, Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy.

Introduction: Harmonized neuropsychological assessment for neurocognitive disorders, an international priority for valid and reliable diagnostic procedures, has been achieved only in specific countries or research contexts.

Methods: To harmonize the assessment of mild cognitive impairment in Europe, a workshop (Geneva, May 2018) convened stakeholders, methodologists, academic, and non-academic clinicians and experts from European, US, and Australian harmonization initiatives.

Results: With formal presentations and thematic working-groups we defined a standard battery consistent with the U. Read More

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Reactor-based boron neutron capture therapy for 44 cases of recurrent and refractory high-grade meningiomas with long-term follow-up.

Neuro Oncol 2021 May 13. Epub 2021 May 13.

Department of Neurosurgery, Osaka Medical College, Takatsuki, Osaka, Japan.

Background: High-grade meningioma (HGM) is difficult to treat, and recurrent HGM after radiotherapy has an especially poor prognosis. We retrospectively analyzed the cases of 44 consecutive patients with recurrent and refractory HGM who were treated by reactor-based boron neutron capture therapy (BNCT).

Methods: In 2005-2019, we treated 44 recurrent and refractory HGMs by reactor-based BNCT. Read More

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