20,329 results match your criteria disorder asd


Measuring Transactional Engagement Among Young Children with Elevated Likelihood for Later Autism Spectrum Disorder Diagnosis.

J Autism Dev Disord 2021 Jun 12. Epub 2021 Jun 12.

TEACCH Autism Program, The University of North Carolina At Chapel Hill, Chapel Hill, NC, USA.

This analytical study documented the presence of transactions in parent-child engagement within a sample of young children at an elevated likelihood for an eventual diagnosis of autism spectrum disorder (ASD). Specifically, the study examined the establishment of transactional engagement through reciprocal behaviors between parents and their young children at-risk for ASD. In the study sample, established transactional engagement occurred at a higher rate than other levels of engagement. Read More

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Maternal Psychiatric Conditions, Treatment With Selective Serotonin Reuptake Inhibitors, and Neurodevelopmental Disorders.

Biol Psychiatry 2021 Apr 14. Epub 2021 Apr 14.

Division of Research, Kaiser Permanente Northern California, Oakland, California.

Background: This study aims to clarify relationships of maternal psychiatric conditions and selective serotonin reuptake inhibitor (SSRI) use during preconception and pregnancy with risk of neurodevelopmental disorders in offspring.

Methods: We used data from the Study to Explore Early Development, a multisite case-control study conducted in the United States among children born between 2003 and 2011. Final study group classifications of autism spectrum disorder (ASD) (n = 1367), developmental delays or disorders (DDs) (n = 1750), and general population controls (n = 1671) were determined by an in-person standardized developmental assessment. Read More

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Timing and Intertemporal Choice Behavior in the Valproic Acid Rat Model of Autism Spectrum Disorder.

J Autism Dev Disord 2021 Jun 11. Epub 2021 Jun 11.

St. Lawrence University, Canton, USA.

Recently it has been proposed that impairments related to autism spectrum disorder (ASD) may reflect a more fundamental disruption in time perception. Here, we examined whether in utero exposure to valproic acid (VPA) can generate specific behavioral deficits related to ASD and time perception. Pups from control and VPA groups were tested using fixed-interval (FI) temporal bisection, peak interval, and intertemporal choice tasks. Read More

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MEG3 lncRNA is over-expressed in autism spectrum disorder.

Metab Brain Dis 2021 Jun 11. Epub 2021 Jun 11.

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Long non-coding RNAs (lncRNAs) comprise a group of regulatory transcripts which partake in the biological processes leading to development of neuropsychiatric disorders such as autism spectrum disorder (ASD). We measured circulatory levels of MEG3, GAS5, CYTOR, UCA1 lncRNAs and CRYBG3 gene in children with ASD and controls. Expression of MEG3 was remarkably higher in children with ASD when compared with controls (Posterior Beta = 2. Read More

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Genetic risk factors for autism-spectrum disorders: a systematic review based on systematic reviews and meta-analysis.

J Neural Transm (Vienna) 2021 Jun 11. Epub 2021 Jun 11.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, 230032, China.

Background: Based on recent evidence, more than 200 susceptibility genes have been identified to be associated with autism until now. Correspondingly, cytogenetic abnormalities have been reported for almost every chromosome. While the results of multiple genes associated with risk factors for autism are still incomplete, this paper systematically reviews published meta-analyses and systematic reviews of evidence related to autism occurrence. Read More

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Telehealth and Autism Prior to and in the Age of COVID-19: A Systematic and Critical Review of the Last Decade.

Clin Child Fam Psychol Rev 2021 Jun 10. Epub 2021 Jun 10.

Department of Psychology, Louisiana State University, 236 Audubon Hall, Baton Rouge, LA, 70803, USA.

There has been growing interest in the use of telehealth; however, the COVID-19 pandemic and the subsequent isolation and restrictions placed on in-person services have fast-tracked implementation needs for these services. Individuals with autism spectrum disorder (ASD) have been particularly affected due to the often-intensive service needs required by this population. As a result, the aim of this review was to examine the evidence base, methodology, and outcomes of studies that have used telehealth for assessment and/or intervention with children and adolescents with ASD as well as their families over the last decade. Read More

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Comparison of the early cardiac electromechanical remodeling following transcatheter and surgical secundum atrial septal defect closure in adults.

Egypt Heart J 2021 Jun 10;73(1):53. Epub 2021 Jun 10.

Cardiology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Background: Secundum atrial septal defect (ASD) closure leads to electrical and mechanical remodeling that occurs early after shunt disappearance. The relationship between electromechanical remodeling using electrocardiogram (ECG) and cardiac magnetic resonance (CMR) after percutaneous and surgical closure has not yet been recorded in prospective studies.

Objective: We thought to study right atrium (RA) and right ventricle (RV) changes by CMR 3 months after transcatheter and surgical closure and their comparison with electrical remodeling by ECG. Read More

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Microbiota and Microglia Interactions in ASD.

Front Immunol 2021 25;12:676255. Epub 2021 May 25.

Department of Physiology and Pharmacology, Snyder Institute of Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Autism spectrum disorders (ASD) are serious, highly variable neurodevelopmental disorders, commonly characterized by the manifestation of specific behavioral abnormalities, such as stereotypic behaviors and deficits in social skills, including communication. Although the neurobiological basis for ASD has attracted attention in recent decades, the role of microglial cells, which are the main resident myeloid cell population in the brain, is still controversial and underexplored. Microglia play several fundamental roles in orchestrating brain development and homeostasis. Read More

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Children ASD Evaluation Through Joint Analysis of EEG and Eye-Tracking Recordings With Graph Convolution Network.

Front Hum Neurosci 2021 25;15:651349. Epub 2021 May 25.

School of Computer Science, Wuhan University, Wuhan, China.

Recent advances in neuroscience indicate that analysis of bio-signals such as rest state electroencephalogram (EEG) and eye-tracking data can provide more reliable evaluation of children autism spectrum disorder (ASD) than traditional methods of behavior measurement relying on scales do. However, the effectiveness of the new approaches still lags behind the increasing requirement in clinical or educational practices as the "bio-marker" information carried by the bio-signal of a single-modality is likely insufficient or distorted. This study proposes an approach to joint analysis of EEG and eye-tracking for children ASD evaluation. Read More

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Waitlist and post-transplant outcomes for eisenmenger syndrome: A comparison of transplant strategies.

J Heart Lung Transplant 2021 Apr 21. Epub 2021 Apr 21.

Heart Transplant and Pulmonary Hypertension Unit, St Vincent's Hospital, Sydney, Australia; St Vincent's Clinical School, University of New South Wales, Sydney, Australia.

Background: End-stage Eisenmenger syndrome (ES) due to unrepaired atrial septal defect (ASD) or ventricular septal defect (VSD) is an indication for lung transplantation (LTx) or heart-lung transplantation (HLTx). Limited evidence exists as to the optimal transplant strategy for this unique population.

Aim: To describe waitlist characteristics and post-transplant outcomes in patients with ES-ASD or ES-VSD. Read More

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Zinc.

Adv Food Nutr Res 2021 24;96:251-310. Epub 2021 May 24.

IM Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; Yaroslavl State University, Yaroslavl, Russia. Electronic address:

Since the discovery of manifest Zn deficiency in 1961, the increasing number of studies demonstrated the association between altered Zn status and multiple diseases. In this chapter, we provide a review of the most recent advances on the role of Zn in health and disease (2010-20), with a special focus on the role of Zn in neurodegenerative and neurodevelopmental disorders, diabetes and obesity, male and female reproduction, as well as COVID-19. In parallel with the revealed tight association between ASD risk and severity and Zn status, the particular mechanisms linking Zn and ASD pathogenesis like modulation of synaptic plasticity through ProSAP/Shank scaffold, neurotransmitter metabolism, and gut microbiota, have been elucidated. Read More

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"There's nothing here": Perspectives from rural parents promoting safe active recreation for children living with autism spectrum disorders.

Res Dev Disabil 2021 Jun 7;115:103998. Epub 2021 Jun 7.

University of British Columbia, Okanagan, 3333 University Way, Kelowna, BC, V1V 1V7, Canada; School of Nursing, University of British Columbia, Okanagan, Canada.

Background: Children with autism spectrum disorder (ASD) and their families experience challenges and barriers at multiple levels that influence their activity participation. The purpose of this study was to develop understanding about factors influencing how families can promote safe, active recreation for their children 3-12 years living with ASD across rural settings and how supports for these families can be enhanced.

Methods: This qualitative study used an interpretive descriptive approach. Read More

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Clinical presentations of social communication disorder: A case series.

Asian J Psychiatr 2021 May 31;62:102718. Epub 2021 May 31.

Department of Developmental Psychiatry, Institute of Mental Health, Child Guidance Clinic, 03-01, 3 Second Hospital Avenue, Health Promotion Board Building, 168937, Singapore.

Social Communication Disorder (SCD) is a new DSM-5 diagnostic category poorly understood by clinicians. We describe a case series of four individuals diagnosed with SCD to identify common characteristics and differences in presentations of the disorder. All cases had deficits in the area of social communication, and sub-threshold level of restricted and repetitive behaviours, not sufficient to meet criteria for Autism Spectrum Disorder (ASD). Read More

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The role of PTEN signaling in synaptic function: implications in autism spectrum disorder.

Neurosci Lett 2021 Jun 7:136015. Epub 2021 Jun 7.

Laboratory of Molecular and Functional Neurobiology, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address:

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) regulates several cellular processes including survival, proliferation, and metabolism. In the brain, PTEN is a key modulator of synaptic function, and is involved in regulating synaptogenesis, connectivity, and synaptic plasticity. Herein we discuss how alterations in PTEN can disturb these mechanisms, thus compromising normal synaptic function and consequently contributing to behavioral and cognitive phenotypes observed in autism spectrum disorder (ASD). Read More

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Influencing Factors of Acute Stress Disorder Among Frontline Nurses in Wuhan, China.

J Psychosoc Nurs Ment Health Serv 2021 Jun 1:1-10. Epub 2021 Jun 1.

The current study aimed to investigate the influencing factors of acute stress disorder (ASD) in frontline nurses delivering care in a hospital for COVID-19 in Wuhan, China. In this cross-sectional study, 298 frontline nurses were surveyed during the first month of direct care delivery for patients with COVID-19 via the Stanford Acute Stress Reaction Questionnaire, Simplified Coping Style Questionnaire, and Multidimensional Scale of Perceived Social Support. Through logistic regression analysis, we identified the influencing factors of ASD. Read More

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The Association of Prenatal Vitamins and Folic Acid Supplement Intake with Odds of Autism Spectrum Disorder in a High-Risk Sibling Cohort, the Early Autism Risk Longitudinal Investigation (EARLI).

J Autism Dev Disord 2021 Jun 10. Epub 2021 Jun 10.

Department of Public Health Sciences and The MIND Institute, School of Medicine, University of California-Davis, UC Davis School of Medicine - Medical Sciences 1C, Suite 123, Davis, CA, 95616, USA.

We examined maternal prenatal vitamin use or supplemental folic acid intake during month one of pregnancy for association with autism spectrum disorder (ASD) in the Early Autism Risk Longitudinal Investigation, an enriched-risk pregnancy cohort. Total folic acid intake was calculated from monthly prenatal vitamins, multivitamins, and other supplement reports. Clinical assessments through age 3 years classified children as ASD (n = 38) or non-ASD (n = 153). Read More

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Collateral Child and Parent Effects of Function‑Based Behavioral Interventions for Sleep Problems in Children and Adolescents with Autism.

J Autism Dev Disord 2021 Jun 10. Epub 2021 Jun 10.

Department of Special Education, Center for Autism Research, Evaluation, and Support, Texas State University, San Marcos, TX, USA.

This study follows McLay et al., Journal of Autism and Developmental Disorders, (2020) to investigate whether the function-based behavioral sleep interventions received by 41 children and adolescents with autism spectrum disorder (ASD) produced collateral improvements in ASD severity, internalizing and externalizing symptoms and parent relationship quality, ratings of depression, anxiety and stress, and personal sleep quality. Concomitant with reduced sleep problem severity, improvements were found in children's internalizing and externalizing behavior and ASD symptom severity. Read More

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Adaptive Behavior Profiles of Intellectually Gifted Children with Autism Spectrum Disorder.

J Dev Behav Pediatr 2021 Jun-Jul 01;42(5):374-379

Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO.

Objective: The purpose of this study is to identify whether the well-described pattern of declining adaptive functioning across age among children with autism spectrum disorder (ASD) also exists among intellectually gifted children with ASD because their cognitive abilities might serve as a protective factor.

Methods: Data from the Simons Simplex Collection were used to identify 51 participants with full-scale intelligence (IQ) scores of 130 or above with this group labeled as the intellectually gifted range (IGR). Two comparison samples of children with IQs in the intellectual disability range (IDR; < 70 Standard Score [SS]) and average range (AR; 85-115 SS) were created based on matching of age (±2 years), maternal education level, and sex. Read More

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Early concerns in parents of infants at risk for autism.

Dev Med Child Neurol 2021 Jun 9. Epub 2021 Jun 9.

Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, CA, USA.

Aim: To examine parental concerns about children at increased familial risk (i.e. high risk) of developing autism spectrum disorder (ASD) in early infancy. Read More

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Incidence and Risk Factors for Early Postoperative Complications and Mortality Following Adult Spinal Deformity Surgery: Data From the National Surgical Quality Improvement Program From 2011 to 2013.

Clin Spine Surg 2021 Jun 9. Epub 2021 Jun 9.

Spine Center and Department of Orthopedic Surgery, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seoul, Republic of Korea Department of Orthopedic Surgery, Division of Spinal Surgery, The Och Spine Hospital at New York-Presbyterian/Allen Hospital, Columbia University, New York, NY.

Study Design: Retrospective cohort analysis using the American College of Surgeons National Surgical Quality Improvement Program database.

Objective: The objective of this study was to investigate the incidence and risk factors of perioperative complications and mortality in patients undergoing adult spinal deformity (ASD) surgery.

Summary Of Background Data: Although ASD surgery has been associated with a relatively high complication rate, a focus on perioperative complications in a large cohort has rarely been reported. Read More

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Genetic and morphological estimates of androgen exposure predict social deficits in multiple neurodevelopmental disorder cohorts.

Mol Autism 2021 Jun 9;12(1):43. Epub 2021 Jun 9.

Department of Psychiatry, University of Iowa, Iowa City, USA.

Background: Neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD) display a strong male bias. Androgen exposure is profoundly increased in typical male development, but it also varies within the sexes, and previous work has sought to connect morphological proxies of androgen exposure, including digit ratio and facial morphology, to neurodevelopmental outcomes. The results of these studies have been mixed, and the relationships between androgen exposure and behavior remain unclear. Read More

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Comparing Mid-Term Outcomes Between ACDF and Minimally Invasive Posterior Cervical Foraminotomy in the Treatment of Cervical Radiculopathy.

Spine (Phila Pa 1976) 2021 Jun 8. Epub 2021 Jun 8.

St. Joseph's University Medical Center, Department of Orthopaedic Surgery, Paterson, NJ.

Study Design: Retrospective Cohort Study.

Objective: To compare MI-PCF and ACDF in the treatment of unilateral cervical radiculopathy.

Summary Of Background Data: Minimally invasive posterior cervical foraminotomy (MI-PCF) has been shown to be equally effective as ACDF in treating cervical radiculopathy due to foraminal stenosis and similar pathologies. Read More

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Pivotal Response Treatment with and without robot-assistance for children with autism: a randomized controlled trial.

Eur Child Adolesc Psychiatry 2021 Jun 3. Epub 2021 Jun 3.

Karakter Child and Adolescent Psychiatry University Centre, Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands.

Pivotal response treatment (PRT) is a promising intervention focused on improving social communication skills in children with autism spectrum disorder (ASD). Since robots potentially appeal to children with ASD and may contribute to their motivation for social interaction, this exploratory randomized controlled trial (RCT) was conducted comparing PRT (PRT and robot-assisted PRT) with treatment-as-usual (TAU). Seventy-three children (PRT: n = 25; PRT + robot: n = 25; TAU: n = 23) with ASD, aged 3-8 years were assessed at baseline, after 10 and 20 weeks of intervention, and at 3-month follow-up. Read More

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Social synchronization during joint attention in children with autism spectrum disorder.

Autism Res 2021 Jun 9. Epub 2021 Jun 9.

School of Psychological and Cognitive Sciences & Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, China.

We explored the social synchronization of gaze-shift behaviors when responding to joint attention in children with autism spectrum disorder (ASD). Forty-one children aged 5 to 8 with ASD and 43 typically developing (TD) children watched a video to complete the response to joint attention (RJA) tasks, during which their gaze data were collected. The synchronization of gaze-shift behaviors between children and the female model in the video was measured with the cross-recurrence quantification analysis (CRQA). Read More

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Theory of Mind and Moral Decision-Making in the Context of Autism Spectrum Disorder.

J Autism Dev Disord 2021 Jun 8. Epub 2021 Jun 8.

ACSENT Laboratory, Department of Psychology, Faculty of Humanities, University of Cape Town, Cape Town, South Africa.

Social impairment in Autism Spectrum Disorder (ASD) has been linked to Theory of Mind (ToM) deficits. However, little research has investigated the relationship between ToM and moral decision-making in children with ASD. This study compared moral decision-making and ToM between aggregate-matched ASD and neurotypical boys (n = 38 per group; aged 6-12). Read More

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Characteristics of Visual Fixation in Chinese Children with Autism During Face-to-Face Conversations.

J Autism Dev Disord 2021 Jun 8. Epub 2021 Jun 8.

Department of Child Psychiatry of Shenzhen Kangning Hospital, Shenzhen Mental Health Center, Shenzhen, China.

Few eye tracking studies have examined how people with autism spectrum disorder (ASD) visually attend during live interpersonal interaction, and none with the Chinese population. This study used an eye tracker to record the gaze behavior in 20 Chinese children with ASD and 23 children with typical development (TD) when they were engaged in a structured conversation. Results demonstrated that children with ASD looked significantly less at the interlocutor's mouth and whole-face, and more at background. Read More

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Maternal multiple sclerosis is not a risk factor for neurodevelopmental disorders in offspring.

Mult Scler J Exp Transl Clin 2021 Apr-Jun;7(2):20552173211017301. Epub 2021 May 28.

Unit of Child Neuropsychiatry, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

Background: Childhood neurodevelopmental disorders (NDDs), including specific learning disorders (SLD), attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), are pathogenically linked to familial autoimmunity and maternal immune-mediated diseases during pregnancy.

Objective: We studied maternal MS as a potential risk factor for NDDs occurrence in offspring.

Methods: MS and control mothers were subjected to questionnaires to ascertain NDD diagnosis in their progeny and the occurrence of both autoimmune and neurodevelopment disorders in their families. Read More

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Left ventricular restrictive physiology in kids with atrial septal defects: Something unexpected!

Ann Pediatr Cardiol 2021 Apr-Jun;14(2):228-230. Epub 2021 Apr 10.

Department of Pediatric Cardiology and Adults with Congenital Heart Disease, Evelina Children's, Hospital, St Thomas Hospital, 249 Westminster Bridge Road, SE1 7EH, London, England.

Atrial septal defect (ASD) associated with left ventricular (LV) diastolic dysfunction (DD) is rare in children. DD is common in elderly patients undergoing ASD closure. Restrictive physiology among children undergoing percutaneous ASD closure is something unexpected that has not been described before in the literature. Read More

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BOLD Lag Patterns Differ Between Rest And Task Conditions, But Are Largely Typical in Autism.

Brain Connect 2021 Jun 9. Epub 2021 Jun 9.

San Diego State University, 7117, Brain Development Imaging Laboratories, San Diego, California, United States;

Autism spectrum disorder (ASD) is characterized by atypical functional connectivity (FC) within and between distributed brain networks. However, FC findings have often been inconsistent, possibly due to focus on static FC rather than brain dynamics. Lagged connectivity analyses aim to evaluate temporal latency, and presumably neural propagation, between regions. Read More

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Subtyping Autism Spectrum Disorder via Joint Modeling of Clinical and Connectomic Profiles.

Brain Connect 2021 Jun 9. Epub 2021 Jun 9.

University of California Riverside, 8790, Center for Advanced NeuroImaging, Riverside, California, United States;

Background: Autism Spectrum Disorder (ASD) is a highly heterogeneous developmental disorder with diverse clinical manifestations. Neuroimaging studies have explored functional connectivity (FC) of ASD through resting-state functional MRI studies, however the findings have remained inconsistent, thus reflecting the possibility of multiple subtypes. Identification of the relationship between clinical symptoms and FC measures may help clarify the inconsistencies in earlier findings and advance our understanding of ASD subtypes. Read More

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