Semin Cell Dev Biol 2021 Mar 26. Epub 2021 Mar 26.
Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, United States; Heart and Vascular Institute, Cellular and Molecular Medicine, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Biomedical Engineering, Department of Cell Biology, Johns Hopkins University, Baltimore, MD, United States. Electronic address:
Organoids, or miniaturized organs formed in vitro, hold potential to revolutionize how researchers approach and answer fundamental biological and pathological questions. In the context of cardiac biology, development of a bona fide cardiac organoid enables study of heart development, function, and pathogenesis in a dish, providing insight into the nature of congenital heart disease and offering the opportunity for high-throughput probing of adult heart disease and drug discovery. Recently, multiple groups have reported novel methods for generating in vitro models of the heart; however, there are substantial conceptual and methodological differences. Read More