547,074 results match your criteria diseases vascular


Controlling nutritional status score as a new indicator of overt hepatic encephalopathy in cirrhotic patients following transjugular intrahepatic portosystemic shunt.

Clin Nutr 2022 Jan 4;41(2):560-566. Epub 2022 Jan 4.

Department of Oncology and Vascular Intervention, First Hospital of Shanxi Medical University, Jiefang South Road 8, Taiyuan, 030001, China. Electronic address:

Background & Aims: The Controlling Nutritional Status (CONUT) score is designed to assess the immune-nutritional status of patients. Poor nutritional status and inflammation may facilitate the development of hepatic encephalopathy (HE) in cirrhotic patients. However, it remains unknown whether the CONUT score is related to and can be used as a predictive marker for HE. Read More

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January 2022

The VASCERN European Reference Network: An overview.

Eur J Med Genet 2022 Jan 12:104420. Epub 2022 Jan 12.

VASCERN Coordination Team, Hopital Bichat, Paris, France.

Established since 2017 and co-funded by the European commission, VASCERN is the European Reference Network aiming at improving and homogenizing care of patients with rare multisystemic vascular diseases throughout Europe. It gathers 31 expert teams from 26 highly specialized multidisciplinary HCPs, plus 7 Affiliated Partner centers, from 16 EU Member States, as well as more than 65 patient organisations (ePAG). It is structured around 5 main RDWGs, each specialized in a specific disease or group of diseases. Read More

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January 2022

Optical coherence tomography angiography of subclinical ocular features in pediatric Behçet disease.

J AAPOS 2022 Jan 12. Epub 2022 Jan 12.

Department of Pediatric Rheumatology, Division of Pediatrics, Kocaeli University, Kocaeli, Turkey.

Purpose: To investigate macular and optic nerve head (ONH) vascular density (VD), foveal avascular zone (FAZ) area, choroidal thickness, outer retina and choriocapillaris flow, and morphological changes of foveal microvasculature in pediatric Behçet disease (BD) without ocular involvement using optical coherence tomography angiography (OCTA).

Methods: We analyzed 22 eyes of 22 pediatric patients diagnosed with BD without ocular involvement and 24 age- and sex-matched healthy controls in this prospective, cross-sectional study. The superficial capillary plexus (SCP) and the deep capillary plexus (DCP), FAZ parameters, the flow area of the outer retina, and choriocapillaris were evaluated using OCTA. Read More

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January 2022

Myocardial inflammation and sudden death in the inherited cardiomyopathies.

Can J Cardiol 2022 Jan 12. Epub 2022 Jan 12.

Cardiology, Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Padova, Italy.

The best studied of the inherited cardiomyopathies, hypertrophic (HCM), dilated (DCM) and arrhythmogenic (ACM), present overlapping clinical phenotypes with varying, often unrecognized risk of sudden death. Risk assessment is informed by patient sex and by the specific disease-causing variant. HCM and arrhythmogenic right ventricular cardiomyopathy (ARVC) remain important causes of sudden death. Read More

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January 2022

An adapted passive model of anti-MPO dependent crescentic glomerulonephritis reveals matrix dysregulation and is amenable to modulation by CXCR4 inhibition.

Matrix Biol 2022 Jan 12. Epub 2022 Jan 12.

Department of Pathology, Medical University of Vienna, Vienna, Austria. Electronic address:

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are severe inflammatory disorders that often involve focal necrotizing glomerulonephritis (FNGN) and consequent glomerular scarring, interstitial fibrosis, and chronic kidney disease. Robust murine models of scarring in FNGN that may help to further our understanding of deleterious processes are still lacking. Here, we present a murine model of severe FNGN based on combined administration of antibodies against the glomerular basement membrane (GBM) and myeloperoxidase (MPO), and bacterial lipopolysaccharides (LPS), that recapitulates acute injury and was adapted to investigate subsequent glomerular and interstitial scarring. Read More

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January 2022

Cerebral embolic protection devices in TAVR: All, none, or selective?

Ann Thorac Surg 2022 Jan 12. Epub 2022 Jan 12.

Division of Cardiac Surgery, University of Pittsburgh, Center for Heart Valve Disease, Heart and Vascular Institute, University of Pittsburgh Medical Center, 5200 Centre Ave, Suite 715, Pittsburgh, PA 15232.

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January 2022

Eukaryotic elongation factor 2 kinase regulates foam cell formation via translation of CD36.

FASEB J 2022 Feb;36(2):e22154

Vascular Research Centre, Heart and Vascular Program, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

Eukaryotic elongation factor 2 kinase (eEF2K) is an atypical protein kinase that controls protein synthesis in cells under stress. Although well studied in cancer, less is known about its roles in chronic inflammatory diseases. Here, we examined its regulation of macrophage cholesterol handling in the context of atherosclerosis. Read More

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February 2022

Sacrectomy with Ilio-Lumbar Stabilization Due to Low-Grade Chondrosarcoma of Sacrum and Iliac Wing. Case Report of the First Surgery Performed in the Republic of North Macedonia.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2021 Dec 30;42(3):71-78. Epub 2021 Dec 30.

University Clinic for Gastroenterohepatology - Skopje, Republic of North Macedonia.

Low - grade chondrosarcomas are primary malignant bone tumors that are resistant to chemo- and radiotherapy and are treated surgically. Sacral localization makes surgical resection technically difficult due to position, anatomic structures involved, and large tumor size at detection. The risk of complications is high. Read More

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December 2021

Postmortem brain 7T MRI with minimally invasive pathological correlation in deceased COVID-19 subjects.

Insights Imaging 2022 Jan 15;13(1). Epub 2022 Jan 15.

Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.

Background: Brain abnormalities are a concern in COVID-19, so we used minimally invasive autopsy (MIA) to investigate it, consisting of brain 7T MR and CT images and tissue sampling via transethmoidal route with at least three fragments: the first one for reverse transcription polymerase chain reaction (RT-PCR) analysis and the remaining fixed and stained with hematoxylin and eosin. Two mouse monoclonal anti-coronavirus (SARS-CoV-2) antibodies were employed in immunohistochemical (IHC) reactions.

Results: Seven deceased COVID-19 patients underwent MIA with brain MR and CT images, six of them with tissue sampling. Read More

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January 2022

Predictors of optimal procedural result after transcatheter edge-to-edge mitral valve repair in secondary mitral regurgitation.

Catheter Cardiovasc Interv 2022 Jan 15. Epub 2022 Jan 15.

Cardiology and Cardiac Catheterization Laboratory, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.

Background: Procedural success after transcatheter edge-to-edge mitral valve repair (TEER) is defined as a reduction of mitral regurgitation (MR) degree to
Aim: To evaluate predictors and prognostic impact of optimal procedural result (MR 0/1+) after TEER. Read More

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January 2022

Adult oncology patients' experiences of living with a central venous catheter: a systematic review and meta-synthesis.

Support Care Cancer 2022 Jan 14. Epub 2022 Jan 14.

Department of Health Professions, Campus Bio-Medico of Rome University Hospital, Via Alvaro del Portillo, 200, 00128, Rome, Italy.

Background: The incidence of cancer is increasing globally, and a greater number of patients will receive treatments though central vascular access devices (CVADs). Only a few qualitative studies describe the experience of adult oncology patients living with CVADs, and no systematic review of literature has been published on this topic. We therefore aimed to systematically synthesize the evidence of the qualitative studies on the experience of adult oncology patients with CVADs to report the implications of living with this device, and to inform healthcare professionals (HCPs) about problematic aspects of care for this population. Read More

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January 2022

Updated systematic review of the approach to pelvic exenteration for locally advanced primary rectal cancer.

Eur J Surg Oncol 2022 Jan 5. Epub 2022 Jan 5.

Centre for Graduate Research, University College Dublin, Belfield, Dublin, 4, Ireland; Centre for Colorectal Disease, St. Vincent's University Hospital, Elm Park, Dublin, 4, Ireland.

Objectives: To review the evidence regarding surgical advances in the management of primary locally advanced rectal cancer.

Background: The management of rectal cancer has evolved significantly in recent decades, with improved (neo)adjuvant treatment strategies and enhanced perioperative protocols. Centralization of care for complex, advanced cases has enabled surgeons in these units to undertake more ambitious surgical procedures. Read More

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January 2022

Preoperative N-terminal pro-brain natriuretic peptide is associated with Fontan outcomes.

J Thorac Cardiovasc Surg 2021 Dec 10. Epub 2021 Dec 10.

Department of Pediatrics, National Taiwan University Children's Hospital, Taipei, Taiwan. Electronic address:

Objective: The role of preoperative N-terminal pro-brain natriuretic peptide level in patient outcomes after the Fontan operation remains unclear.

Methods: The medical records of all patients who underwent their first Fontan operation from June 2011 to October 2019 in our tertiary referral pediatric cardiac center were retrospectively reviewed. Preoperative hemodynamic factors and N-terminal pro-brain natriuretic peptide were analyzed to test the association of mortality and morbidity. Read More

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December 2021

Anatomical and clinical risk stratification tool for mortality risk assessment following revascularization for multivessel coronary artery disease.

J Thorac Cardiovasc Surg 2021 Dec 23. Epub 2021 Dec 23.

Department of Cardiac Surgery, Leviev Cardiothoracic and Vascular Center, Sheba Medical Center affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel.

Objective: This study aimed to assess the prognostic ability of SYNTAX score II in left main and/or 3-vessel disease patients undergoing revascularization either by coronary artery bypass grafting or percutaneous coronary intervention in a national registry.

Methods: This prospective registry included consecutive patients with multivessel disease enrolled between January and April 2013 from all 22 hospitals in Israel that perform coronary angiography. Of the 1112 study patients, 368 patients (33%) had a low (<25), 372 (33%) had an intermediate (25-35) and 372 patients (33%) a high (≥35) SYNTAX score II. Read More

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December 2021

A Validated Model to Identify Patients With Low Likelihood of High-Risk Coronary Artery Disease Anatomy.

Am J Cardiol 2022 Jan 11. Epub 2022 Jan 11.

Department of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio; Center for Value-Based Care Research, Cleveland Clinic, Cleveland, Ohio. Electronic address:

In stable coronary artery disease (CAD), revascularization improves outcomes only for patients with high-risk coronary anatomy (HRCA). We sought to derive and validate a prediction model, incorporating clinical and exercise stress test characteristics, to identify patients with HRCA. We conducted a retrospective analysis of patients undergoing exercise stress testing at Cleveland Clinic (2005 to 2014), followed by invasive coronary angiography within 3 months. Read More

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January 2022

Transitory ischemic attack associated with a rare fenestration of the cervical segment of the internal carotid artery: a case report.

J Med Case Rep 2022 Jan 15;16(1):13. Epub 2022 Jan 15.

Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.

Background: Fenestration of the cervical segment of the internal carotid artery is a very rare finding, and its origin is still not fully understood. Explanations of its genesis range from dissections leading to the fenestration to the more common interpretation as a developmental vascular variant. However, most reported cases were symptomatic and presented with dissections, where even endovascular treatment of the fenestration of the cervical segment of the internal carotid artery became necessary. Read More

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January 2022

Neurotrophin-3 and neurotrophin-4: The unsung heroes that lies behind the meninges.

Neuropeptides 2022 Jan 7;92:102226. Epub 2022 Jan 7.

Department of Anatomy, Universiti Kebangsaan Malaysia Medical Centre, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia. Electronic address:

Neurotrophin is a growth factor that regulates the development and repair of the nervous system. From all factors, two pioneer groups, the nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF), have been widely explored for their role in disease pathogenesis and potential use as therapeutic agents. Nonetheless, neurotrophin-3 (NT3) and neurotrophin-4 (NT4) also have promising potential, albeit less popular than their counterparts. Read More

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January 2022

Physical exercise promotes integration of grafted cells and functional recovery in an acute stroke rat model.

Stem Cell Reports 2022 Jan 3. Epub 2022 Jan 3.

Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, China. Electronic address:

Human neural progenitor cell (hNPC) transplantation holds great potential to treat neurological diseases. However, hNPC grafts take a long time to differentiate into mature neurons due to their intrinsically prolonged developmental timetable. Here, we report that postoperative physical exercise (PE), a prevailing rehabilitation intervention, promotes the neuronal commitment, maturation, and integration of engrafted hNPCs, evidenced by forming more synapses, receiving more synaptic input from host neurons, and showing higher neuronal activity levels. Read More

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January 2022

Mesenchymal Neoplasms of the Prostate and Seminal Vesicles: Spectrum of Disease with Radiologic-Pathologic Correlation.

Radiographics 2022 Jan 14:210084. Epub 2022 Jan 14.

From the Department of Abdominal Imaging, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1473, Houston, TX 77030-4009 (L.P.M., V.R.S., S.R.P.); Department of Pathology, Michael E. DeBakey VA Medical Center, Houston, Tex (N.S.R.); Department of Radiology, University of Texas Health Science Center, San Antonio, Tex (V.S.K.); and Department of Radiology, Case Western Reserve University, Cleveland, Ohio (R.M.P.).

There is a wide spectrum of benign and malignant mesenchymal neoplasms of the prostate, which account for less than 1% of all prostatic tumors. These include distinctive tumors that arise from the specialized prostatic stroma and site-agnostic neoplasms such as smooth muscle tumors, fibrous or myofibroblastic neoplasms, neurogenic tumors, vascular tumors, and a plethora of sarcomas. Select tumors show classic sites of origin within the prostate. Read More

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January 2022

Arterial Atherosclerosis: Vascular Surgery Interventions.

Am Fam Physician 2022 Jan;105(1):65-72

East Carolina University and East Carolina Heart Institute, Greenville, NC, USA.

Atherosclerotic vascular disease is a leading cause of death worldwide. Atherosclerotic stenosis of the internal carotid or intracranial arteries causes up to 15% of strokes. Peripheral artery disease affects up to one in five people in the United States who are 60 years and older and nearly one-half of those who are 85 years and older. Read More

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January 2022

Diagnostic method for malignant pleural effusion distinguishing malignant mesothelioma from lung cancer using pleural carcinoembryonic antigen and hyaluronic acid levels.

Medicine (Baltimore) 2022 Jan;101(1):e28517

Kyorin University School of Medicine, Department of Respiratory Medicine, Japan.

Abstract: Malignant mesothelioma (MM) is difficult to diagnose because of the lack of parenchymal opacities, often revealing minimal or absent pleural thickening. Furthermore, pleural effusion has diverse differential diagnoses, including malignancies, infections, as well as collagen vascular and other benign diseases. In general practice, lung cancer (LC) is the most common malignancy causing pleural effusion; therefore, a simple method using pleural diagnostic markers to differentiate between LC and mesothelioma is crucial. Read More

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January 2022

Dabrafenib- and trametinib-associated glomerular toxicity: A case report.

Authors:
Eunmi Jo Harin Rhee

Medicine (Baltimore) 2022 Jan;101(1):e28485

Department of Nephrology, Pusan National University School of Medicine, Busan, Republic of Korea.

Rationale: Combined treatment with dabrafenib, a B-RAF inhibitor, and trametinib, a mitogen-activated protein kinase inhibitor, is an effective option for patients with metastatic melanoma. A few cases of acute kidney injury associated with tubulointerstitial nephritis and 1 case of nephrotic syndrome have been reported in patients on this drug combination; however, progressive renal injury has not been reported. In this case study, we report a patient with metastatic melanoma who developed glomerular capillary endothelial toxicity and progressive glomerular sclerosis during combination therapy. Read More

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January 2022

Association of the VEGFR2 single nucleotide polymorphism rs2305948 with glioma risk.

Medicine (Baltimore) 2022 Jan;101(1):e28454

Department of Neurosurgery, Weifang People's Hospital, Weifang, China.

Background: Many studies have reported a relationship between the vascular endothelial growth factor receptor 2 single nucleotide polymorphism (SNP) rs2305948 and glioma, but their conclusions have been controversial. A meta-analysis was performed to assess the association between rs2305948 and glioma susceptibility.

Methods: Inclusion criteria and a strategy for screening of original literature were created. Read More

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January 2022

Molecular mechanisms of cognitive impairment associated with stroke.

Metab Brain Dis 2022 Jan 14. Epub 2022 Jan 14.

School of Pharmaceutical Sciences, CT University, Ludhiana, Punjab, India.

Stroke is the second leading cause of death after coronary heart disease in developed countries and is the greatest cause of disability and cognitive impairment. Risk factors for cognitive impairment and dementia after stroke are multifactorial including older age, family history, hypertension, arterial fibrillation, diabetes, genetic variants, low educational status, vascular comorbidities, prior transient ischaemic attack or recurrent stroke, depressive illness duration of a stroke, location, volume, intensity, and degree of neuronal degeneration, location and size of infarction after stroke, time interval after stroke other cerebral dysfunctions. The pathophysiology of stroke associated cognitive impairment is complex and recent molecular, cellular, and animal models studies have revealed that multiple cellular changes have been implicated, including altered redox state, mitochondrial dysfunction, disruption of the blood-brain barrier, perivascular spacing, glymphatic system impairment, microglia activation and amyloid-β deposition in the parenchyma of the brain. Read More

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January 2022

The essential anti-angiogenic strategies in cartilage engineering and osteoarthritic cartilage repair.

Cell Mol Life Sci 2022 Jan 14;79(1):71. Epub 2022 Jan 14.

Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, 64 Medical Center Drive, PO Box 9196, Morgantown, WV, 26506-9196, USA.

In the cartilage matrix, complex interactions occur between angiogenic and anti-angiogenic components, growth factors, and environmental stressors to maintain a proper cartilage phenotype that allows for effective load bearing and force distribution. However, as seen in both degenerative disease and tissue engineering, cartilage can lose its vascular resistance. This vascularization then leads to matrix breakdown, chondrocyte apoptosis, and ossification. Read More

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January 2022

[Avoiding mistakes in anti-VEGF intravitreal injection therapy].

Ophthalmologe 2022 Jan 14. Epub 2022 Jan 14.

Universitäts-Augenklinik, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30652, Hannover, Deutschland.

Intravitreal injection (IVI) of drugs for treatment of various macular diseases is now one of the most frequently performed surgical procedures worldwide. As mostly chronic diseases are treated, the indications for treatment often mean a continuous treatment over years with a corresponding effort regarding spatial, personnel and financial resources. The diagnosis and indications for treatment are nowadays mainly made by spectral domain optical coherence tomography (SD-OCT). Read More

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January 2022

[Biologics for connective tissue diseases and vasculitides].

Internist (Berl) 2022 Jan 14. Epub 2022 Jan 14.

Zentrum für Interdisziplinäre Klinische Immunologie, Rheumatologie und Autoimmunerkrankungen (INDIRA), Universitätsklinikum Tübingen, Tübingen, Deutschland.

Despite therapy with glucocorticoids (GC) and conventional immunosuppressants, patients with connective tissue diseases and vasculitides often develop functionally relevant and prognostically unfavourable internal organ damage. Based on new pathogenetic insights, biologics and small molecules have recently been studied as targeted therapies for collagen vascular diseases and vasculitides. The B lymphocyte stimulator antagonist belimumab has been used for the treatment of systemic lupus erythematosus (SLE) for several years and has recently also been approved as an add-on therapy for lupus nephritis. Read More

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January 2022

Burn Injuries in People Who Used Drug, 2009-2017: A Case-Control Study in Shiraz, Southern Iran.

J Burn Care Res 2022 Jan 13. Epub 2022 Jan 13.

Department of Burn and Wound Healing Research Center, Plastic and Reconstructive Surgery Ward, Shiraz University of Medical Science, Shiraz, Iran.

Background: Burn injury is a critical health issue, which is associated with several morbidities and mortalities. Substance abuse, which is an important public health problem in Iran, can affect burn injury outcomes and etiologies in victims. This study was aimed to evaluate different aspects of burn injuries in people who used drug (PWUD) in two referral centers in the south of Iran. Read More

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January 2022

First Report of Causing Blackleg and Soft Rot on Potato in Hebei and Fujian Province, China.

Plant Dis 2022 Jan 14. Epub 2022 Jan 14.

Inner Mongolia University, 12576, Inner Mongolia Potato Engineering & Technology Research Center, hohhot, Hohhot, Inner Mongolia, China, 021000;

Pectobacterium spp. and Dickeya spp. cause blackleg and soft rot on potato worldwide (Charkowski, 2018). Read More

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January 2022

Relationship between blood-brain permeability and antibodies against aquaporins in neuromyelitis optica spectrum disorders and multiple sclerosis patients.

Neurol Neurochir Pol 2022 Jan 14. Epub 2022 Jan 14.

Department of Neurochemistry and Neuropathology, Poznan University of Medical Sciences, Poznan, Poland.

Aim Of The Study: To evaluate serum anti-aquaporin antibodies profile, to measure serum levels of cell-cell adhesion molecules as potential markers of blood-brain barrier (BBB) permeability, and to assess their relationship in neuromyelitis optica spectrum disorders (NMOsd) and multiple sclerosis (MS).

Clinical Rationale For The Study: Serum levels of cell-cell adhesion molecules could provide information about BBB disruption in demyelinating diseases of the central nervous system. Improved knowledge about differences in their profile in NMOsd and MS patients, as well as about their relationship with antibody serostatus, would facilitate early and accurate diagnosis. Read More

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January 2022