7,515,955 results match your criteria diseases

In vitro models of the canine digestive tract as an alternative to in vivo assays: Advances and current challenges.

ALTEX 2022 Jan 13. Epub 2022 Jan 13.

Université Clermont Auvergne, UMR 454 MEDIS UCA-INRAE, Clermont-Ferrand, France.

Dogs occupy a full place in the family and their well-being is of paramount importance to their owners. Digestion, a complex process involving physicochemical, mechanical, and microbial parameters, plays a central in maintaining animals healthy. As in vivo studies in dogs are more and more restricted by ethical, regulatory, societal, and cost reasons, an alternative option resides in the use of in vitro models simulating the different parts of the canine gastrointestinal tract. Read More

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January 2022

COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop.

ALTEX 2022 Jan 3. Epub 2022 Jan 3.

US Consumer Product Safety Commission, Bethesda, MD, USA.

On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project "Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework" aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome, such as respiratory distress, anosmia or multiorgan failure. Read More

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January 2022

Determinants of early antibody responses to COVID-19 mRNA vaccines in a cohort of exposed and naïve healthcare workers.

EBioMedicine 2022 Jan 11;75:103805. Epub 2022 Jan 11.

ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Catalonia, Spain; CIBER de Enfermedades Infecciosas, Madrid, Spain. Electronic address:

Background: Two doses of mRNA vaccination have shown >94% efficacy at preventing COVID-19 mostly in naïve adults, but it is not clear if the second dose is needed to maximize effectiveness in those previously exposed to SARS-CoV-2 and what other factors affect responsiveness.

Methods: We measured IgA, IgG and IgM levels against SARS-CoV-2 spike (S) and nucleocapsid (N) antigens from the wild-type and S from the Alpha, Beta and Gamma variants of concern, after BNT162b2 (Pfizer/BioNTech) or mRNA-1273 (Moderna) vaccination in a cohort of health care workers (N=578). Neutralizing capacity and antibody avidity were evaluated. Read More

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January 2022

COVID-19-associated pulmonary aspergillosis in a tertiary care center in Shenzhen City.

J Infect Public Health 2022 Jan 6;15(2):222-227. Epub 2022 Jan 6.

The Third People's Hospital of Shenzhen, Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, Shenzhen, China. Electronic address:

Objectives: The severe coronavirus disease 2019 (COVID-19) is characterized by acute respiratory distress syndrome (ARDS) and risk of fungal co-infection, pulmonary aspergillosis in particular. However, COVID-19 associated pulmonary aspergillosis (CAPA) cases remain limited due to the difficulty in diagnosis.

Methods: We describe presumptive invasive aspergillosis in eight patients diagnosed with COVID-19 in a single center in Shenzhen, China. Read More

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January 2022

MMV560185 from pathogen box induces extrinsic pathway of apoptosis in Theileria annulata infected bovine leucocytes.

Int J Parasitol Drugs Drug Resist 2022 Jan 4;18:20-31. Epub 2022 Jan 4.

National Institute of Animal Biotechnology (NIAB), Hyderabad, India; Adjunct Assistant Professor, Regional Centre for Biotechnology (RCB), Faridabad, India. Electronic address:

Tropical theileriosis is a lymphoproliferative disease caused by the intracellular schizonts of Theileria annulata, an apicomplexan parasite. It causes severe infection in cattle and the untreated cattle would possibly die within 3-4 weeks of infection. The chemotherapy for this disease is largely dependent on the use of hydroxynaphthoquinone, namely buparvaquone. Read More

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January 2022

Combined influence of medication and symptom severity on visual processing in bipolar disorder.

J Psychiatr Res 2022 Jan 5;147:135-141. Epub 2022 Jan 5.

Department of Psychology, Federal University of Paraiba, Joao Pessoa, Brazil; Perception, Neuroscience and Behaviour Laboratory, Federal University of Paraiba, Brazil.

Previous studies have reported visual impairments in patients with bipolar disorder (BPD), but unclear were whether clinical variables would be associated with those disturbances. Here, we investigate the relationship between visual functioning, in terms of color discrimination, and the impact of BPD duration, mood state, and the patients' medication. Forty-five participants (25-45 years old) were recruited for this study. Read More

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January 2022

Experiences of pregnant women and healthcare professionals of participating in a digital antenatal CMV education intervention.

Midwifery 2022 Jan 6;106:103249. Epub 2022 Jan 6.

Paediatric Infectious Diseases Research Group, St George's, University of London, London, United Kingdom; Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton and NIHR Southampton Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Room LF102, F Level, South Academic Block,Tremona Road, Southampton SO16 6YD, United Kingdom. Electronic address:

Objective: The study aimed to explore the perspectives of participating pregnant women and Health Care Professionals (HCPs) towards receiving and providing cytomegalovirus (CMV) education so that barriers and facilitators towards incorporating CMV in routine antenatal care could be better understood.

Design: This process evaluation phase employed a qualitative design using individual, semi-structured, face-to-face interviews.

Setting: Recruitment and interviews took place within a large teaching hospital from an ethnically diverse area of South-west London PARTICIPANTS: The study sample included 20 participants: 15 pregnant women, and five HCPs. Read More

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January 2022

miR-424-5p overexpression inhibits LPS-stimulated inflammatory response in bovine endometrial epithelial cells by targeting IRAK2.

J Reprod Immunol 2021 Dec 28;150:103471. Epub 2021 Dec 28.

Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, PR China. Electronic address:

Endometritis is inflammation of endometrium due to various factors and is a common cause of infertility. Several remedies used for endometritis like antibiotics, hormones, and herbs. Studies confirm that microRNAs play a significant role in various inflammatory diseases. Read More

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December 2021

All-solid-state SARS-CoV-2 protein biosensor employing colloidal quantum dots-modified electrode.

Biosens Bioelectron 2022 Jan 8;202:113974. Epub 2022 Jan 8.

School of Optical and Electronic Information, Wuhan National Laboratory for Optoelectronics, Optics Valley Laboratory, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, 430074, China. Electronic address:

Rapid and reliable detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody can provide immunological evidence in addition to nucleic acid test for the early diagnosis and on-site screening of coronavirus disease 2019 (COVID-19). All-solid-state biosensor capable of rapid, quantitative SARS-CoV-2 antibody testing is still lacking. Herein, we propose an electronic labelling strategy of protein molecules and demonstrate SARS-CoV-2 protein biosensor employing colloidal quantum dots (CQDs)-modified electrode. Read More

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January 2022

Economic burden of public health care and hospitalisation associated with COVID-19 in China.

Public Health 2022 Jan 12;203:65-74. Epub 2022 Jan 12.

Department of Clinical Epidemiology and Biostatistics, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China. Electronic address:

Objectives: This study aimed to evaluate the socio-economic burden imposed on the Chinese healthcare system during the coronavirus disease 2019 (COVID-19) pandemic.

Study Design: A cross-sectional study was used to investigate how COVID-19 impacted health and medical costs in China. Data were derived from a subdivision of the Centers for Disease control and Prevention of China. Read More

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January 2022

Investigation of the prevalence of non-COVID-19 infectious diseases during the COVID-19 pandemic.

C Tanislav K Kostev

Public Health 2021 Dec 11;203:53-57. Epub 2021 Dec 11.

Epidemiology, IQVIA, Frankfurt Am Main, Germany.

Objectives: This study aimed to investigate non-COVID-19-related upper respiratory tract infections (URTIs), gastrointestinal infections (GIIs) and urinary tract infections (UTIs) during the COVID-19 pandemic in Germany.

Study Design: Cross-sectional study.

Methods: Patients with diagnoses of URTIs, GIIs and UTIs from 994 general practitioners (GP) and 192 paediatric practices that routinely send anonymous data to the Disease Analyzer database (IQVIA) were investigated. Read More

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December 2021

Long-term trends in the incidence of congenital anomalies in Central China from 1997 to 2019.

Public Health 2022 Jan 12;203:47-52. Epub 2022 Jan 12.

College of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, China. Electronic address:

Objective: The aim of the study was to investigate the incidence of, and trends in, congenital anomalies in Central China from 1997 to 2019.

Study Design: This was a descriptive study.

Methods: We collected data describing 4,134,098 births from 75 hospital monitoring sites in Henan Province, Central China, from 1997 to 2019. Read More

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January 2022

HRPIF data mining based on data-dependent/independent acquisition for Rhei Radix et Rhizoma metabolite screening in rats.

J Chromatogr B Analyt Technol Biomed Life Sci 2022 Jan 10;1190:123095. Epub 2022 Jan 10.

Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cell Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China. Electronic address:

In traditional Chinese medicine (TCM), components with identical nuclei often share structural similarity, indicating the possibility of similar second-level mass spectrometry (MS/MS) fragments. High-resolution product-ion filter (HRPIF) technique can be utilized to identify metabolites, with similar fragments, in vivo. In principle, this technique applies to TCM; however, its application has been restricted due to the limitations of traditional MS/MS data acquisition. Read More

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January 2022

Pediatric GAD-65 Autoimmune Encephalitis: Assessing Clinical Characteristics and Response to Therapy With a Novel Assessment Scale.

Pediatr Neurol 2021 Dec 24;128:25-32. Epub 2021 Dec 24.

Division of Rheumatology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina. Electronic address:

Background: Glutamic acid decarboxylase (GAD) encephalitis is a neuroinflammatory disease characterized by a broad range of symptoms including cognitive deficits, behavioral changes, and seizures. Children with this disorder have heterogeneous presentations, and little is known about symptom progression over time and response to immunotherapy.

Methods: This study reports 10 pediatric GAD encephalitis cases and symptoms found at presentation and follow-up. Read More

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December 2021

Quality of life of patients with multiple sclerosis and neuromyelitis optica spectrum disorders: Cross-sectional and longitudinal analysis.

Mult Scler Relat Disord 2022 Jan 5;58:103500. Epub 2022 Jan 5.

University of Ulsan, College of Medicine, Seoul, South Korea; Department of Neurology, Asan Medical Center, University of Ulsan, College of Medicine, 88 Olympic-Ro 43-Gil, Songpa-Gu, Seoul 05505, South Korea.

Background: Multiple sclerosis (MS) and aquaporin-4 antibody-positive neuromyelitis optica spectrum disorders (NMOSD), which have different pathogenic mechanisms, both negatively affect patients during their lifetime. We aimed to analyze and compare the quality of life (QoL) of patients with MS and NMOSD, its longitudinal course, and associated factors between the two diseases.

Methods: Between June 2018 and April 2020, patients with MS and NMOSD who visited a tertiary hospital were prospectively enrolled. Read More

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January 2022

Evaluation of the times of disability progression and related factors in patients with primary progressive multiple sclerosis from Argentina.

Mult Scler Relat Disord 2022 Jan 2;58:103483. Epub 2022 Jan 2.

Centro Universitario de Esclerosis Múltiple -CUEM, Hospital Ramos Mejía, Buenos Aires, Argentina. Electronic address:

Background PPMS (primary progressive multiple sclerosis) patients represent less than 10% of MS patients in Argentina, men and women were similarly affected and most of them had a severe functional impairment. More rapid progression has been reported in males, but this is not the case in all datasets. The main objective of our study was to determine the time to EDSS (Expanded disability Status Scale) 4, 6 and 7 in PPMS patients. Read More

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January 2022

Reduced GABA levels in the medial prefrontal cortex are associated with cognitive impairment in patients with NMOSD.

Mult Scler Relat Disord 2022 Jan 4;58:103496. Epub 2022 Jan 4.

Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215000, China; Institute of Medical Imaging, Soochow University, Suzhou, Jiangsu 215000, China; National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000, China. Electronic address:

Background: Cognitive impairment is a symptom present in part of patients with neuromyelitis optica spectrum disorder (NMOSD) and its pathophysiology is unknown. Dysfunction of the GABAergic/glutamatergic pathways involving inhibitory and excitatory neurotransmitters have been implicated in several neurological disorders. This study aimed to investigate the changes in inhibitory gamma-aminobutyric acid (GABA) and excitatory glutamate and glutamine (Glx) neurotransmitter levels and their correlations with cognitive functions in patients with NMOSD. Read More

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January 2022

Pediatric anti-N-methyl-D-aspartate receptor encephalitis with MOG-Ab co-existence: Relapse propensity and treatability.

Mult Scler Relat Disord 2021 Dec 15;58:103447. Epub 2021 Dec 15.

Beijing Children's Hospital, Capital Medical University, National Center for Children's Health China, 56 South Lishi Road Xicheng District, Beijing, China. Electronic address:

Objectives: To investigate the clinical characteristics of the anti-N-methyl-D-aspartate receptor(NMDAR)encephalitis with anti-myelin oligodendrocyte glycoprotein antibody(MOG-Ab)positivity serostatus in pediatric patients.

Methods: The clinical manifestations, treatments, and outcomes of patients with anti-NMDAR encephalitis with positive MOG-Ab were elaborated. The annualized relapse rates (ARRs) were compared before and during treatment with disease-modifying drugs (DMDs). Read More

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December 2021

Neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio are associated with a 2-year relapse in patients with multiple sclerosis.

Mult Scler Relat Disord 2022 Jan 10;58:103514. Epub 2022 Jan 10.

Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

Background: The association between increased neutrophil-to-lymphocyte ratio (NLR) and multiple sclerosis has been demonstrated in several studies. The monocyte-to-lymphocyte ratio (MLR) is an emerging biomarker for disease monitoring. Moreover, there has not been a published Taiwanese study to date. Read More

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January 2022

Real world comparison of teriflunomide and dimethyl fumarate in naïve relapsing multiple sclerosis patients: Evidence from the Italian MS register.

Mult Scler Relat Disord 2022 Jan 2;58:103489. Epub 2022 Jan 2.

Department "G.F. Ingrassia", MS Center University of Catania, Italy. Electronic address:

Background: Teriflunomide (TERI) and dimethyl fumarate (DMF) are licensed as first-line disease-modifying treatments (DMTs) for relapsing remitting Multiple Sclerosis (RRMS) and are largely replacing injectable DMTs.

Methods: All RRMS patients starting TERI or DMF between January 1, 2013, and December 31, 2017, were included in the analysis. Time to first relapse, time to confirmed disability progression (CDP), and time to DMT discontinuation have been investigated. Read More

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January 2022

Comparison of SARS-CoV-2 antibody response after two doses of mRNA and inactivated vaccines in multiple sclerosis patients treated with disease-modifying therapies.

Mult Scler Relat Disord 2022 Jan 10;58:103486. Epub 2022 Jan 10.

Department of Neurology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.

Background: Disease-modifying therapy could weaken the immune system and decrease the immune response to vaccines. It is essential to know which vaccine is more protective against SARS-CoV-2 in the multiple sclerosis population.

Objective: To assess immune response after messenger RNA BNT162b2 (Pfizer/BioNTech) and inactivated Sinovac vaccines in people with multiple sclerosis (pwMS) treated with a disease-modifying therapy (DMT) compared to healthy controls. Read More

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January 2022

A comparison between subjective and objective measurements of spasticity in neuromyelitis optica spectrum disorder patients.

Mult Scler Relat Disord 2022 Jan 10;58:103517. Epub 2022 Jan 10.

Division of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok, 10700, Thailand; Siriraj Neuroimmunology Center, Division of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok, 10700, Thailand; Bumrungrad International Hospital, Bangkok, 10110, Thailand. Electronic address:

Background: Spasticity is a common and disabling problem in multiple sclerosis (MS), but its effect in other CNS inflammatory demyelinating diseases (CNSIDDs), such as neuromyelitis optica spectrum disorder (NMOSD) is not widely studied. This study aims to compare subjective and objective measurements of spasticity in NMOSD patients and determine associated factors.

Methods: A prospective cross-sectional study was performed on CNSIDD patients attending the Multiple Sclerosis and Related Disorders Clinic at Siriraj Hospital, a tertiary hospital in Thailand, from June to November 2020 was performed. Read More

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January 2022

Super-refractory status epilepticus (SRSE): A case series of 22 pediatric patients.

Eur J Paediatr Neurol 2022 Jan 7;37:25-31. Epub 2022 Jan 7.

Department of Neuroscience, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. Electronic address:

Background: Super-refractory Status Epilepticus (SRSE) is a rare condition in which SE persists or recurs ≥24 h after the onset of anesthesia. Although its characteristics are well defined in adulthood, only few studies on children are available.

Methods: we retrospectively analyzed the population of patients with SRSE aged <18 years treated in the Pediatric Intensive Care Unit of the Bambino Gesù Pediatric Hospital. Read More

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January 2022

Induction of thymic atrophy and loss of thymic output by type-I interferons during chronic viral infection.

Virology 2021 Dec 24;567:77-86. Epub 2021 Dec 24.

Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, 98101, USA; Department of Pediatrics, Division of Hematology and Oncology, University of Washington, Seattle, WA, 98195, USA. Electronic address:

Type-I interferon (IFN-I) signals exert a critical role in disease progression during viral infections. However, the immunomodulatory mechanisms by which IFN-I dictates disease outcomes remain to be fully defined. Here we report that IFN-I signals mediate thymic atrophy in viral infections, with more severe and prolonged loss of thymic output and unique kinetics and subtypes of IFN-α/β expression in chronic infection compared to acute infection. Read More

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December 2021

Rift Valley fever virus Gn V5-epitope tagged virus enables identification of UBR4 as a Gn interacting protein that facilitates Rift Valley fever virus production.

Virology 2022 Jan 7;567:65-76. Epub 2022 Jan 7.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, USA; National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, USA; Center for Zoonotic and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University, USA. Electronic address:

Rift Valley fever virus (RVFV) is an arbovirus that was first reported in the Rift Valley of Kenya which causes significant disease in humans and livestock. RVFV is a tri-segmented, negative-sense RNA virus consisting of a L, M, and S segments with the M segment encoding the glycoproteins Gn and Gc. Host factors that interact with Gn are largely unknown. Read More

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January 2022

Pregnancy exposure to phthalates and DNA methylation in male placenta - An epigenome-wide association study.

Environ Int 2022 Jan 13;160:107054. Epub 2022 Jan 13.

University Grenoble Alpes, Inserm, CNRS, Team of Environmental Epidemiology applied to Development and Respiratory Health, Institute for Advanced Biosciences, Grenoble, France.

Background: Exposure to phthalates during pregnancy may alter DNA methylation in the placenta, a crucial organ for the growth and development of the fetus.

Objectives: We studied associations between urinary concentrations of phthalate biomarkers during pregnancy and placental DNA methylation.

Methods: We measured concentrations of 11 phthalate metabolites in maternal spot urine samples collected between 22 and 29 gestational weeks in 202 pregnant women. Read More

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January 2022

Galectin-3 levels and inflammatory response in patients undergoing bariatric surgery.

Cytokine 2022 Jan 12;151:155793. Epub 2022 Jan 12.

Department of General Surgery, University of Health Sciences, Tepecik Training and Research Hospital, Izmir, Turkey.

Purpose: Obesity, a low-grade systemic inflammatory disease, causes inflammation in metabolic tissues. Galectin-3(Gal-3) is one of the lectin molecules involved in inflammatory processes. We evaluated the possible relationship between Gal-3 level and the metabolic inflammatory process before and after obesity surgery. Read More

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January 2022

Controlling nutritional status score as a new indicator of overt hepatic encephalopathy in cirrhotic patients following transjugular intrahepatic portosystemic shunt.

Clin Nutr 2022 Jan 4;41(2):560-566. Epub 2022 Jan 4.

Department of Oncology and Vascular Intervention, First Hospital of Shanxi Medical University, Jiefang South Road 8, Taiyuan, 030001, China. Electronic address:

Background & Aims: The Controlling Nutritional Status (CONUT) score is designed to assess the immune-nutritional status of patients. Poor nutritional status and inflammation may facilitate the development of hepatic encephalopathy (HE) in cirrhotic patients. However, it remains unknown whether the CONUT score is related to and can be used as a predictive marker for HE. Read More

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January 2022

Electrochemiluminescent emission potential tunable Cu-Zn-In-S/ZnS nanocrystals for multiplex microRNAs potential-resolved detection.

Biosens Bioelectron 2022 Jan 8;201:113980. Epub 2022 Jan 8.

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, Shaanxi, 710069, PR China. Electronic address:

The development of a multi-target simultaneous detection electrochemiluminescence (ECL) strategy remains a great research interest, however, the limited choice of ECL luminophores is the main limitation holding the field back. In this study, a band gap tunable Cu-Zn-In-S/ZnS nanocrystals (CZIS/ZnS NCs) was synthesized and applied to a potential-resolved ECL detection strategy. By changing the Cu ratio in the precursor, the CZIS/ZnS NCs ECL emission spectrum and emission potential were tuned from 480 to 750 nm and -2. Read More

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January 2022

Differential diagnosis of hereditary anemias from a fraction of blood drop by digital holography and hierarchical machine learning.

Biosens Bioelectron 2022 Jan 4;201:113945. Epub 2022 Jan 4.

Istituto di Scienze Applicate e Sistemi Intelligenti "Eduardo Caianiello" (ISASI-CNR), via Campi Flegrei 34, 80078, Pozzuoli, Napoli, Italy.

Anemia affects about the 25% of the global population and can provoke severe diseases, ranging from weakness and dizziness to pregnancy problems, arrhythmias and hearth failures. About 10% of the patients are affected by rare anemias of which 80% are hereditary. Early differential diagnosis of anemia enables prescribing patients a proper treatment and diet, which is effective to mitigate the associated symptoms. Read More

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January 2022