1,251 results match your criteria diseased segment


Laparoscopic Surgeries in Urology: Initial Burgeoning Experience at National Transplant Centre, Nepal.

Kathmandu Univ Med J (KUMJ) 2021 Apr-Jun;19(74):160-163

Department of Urology and Kidney Transplantation, Shahid Dharma Bhakta National Transplant Centre(SDNTC), Bhaktapur, Nepal.

Background This study focuses on experience of laparoscopic surgery at Shahid Dharma Bhakta National Transplant Centre (SDNTC), Nepal; which could enable us to gain knowledge regarding its benefits over conventional surgery. The present study revealed the frequency of various forms of laparoscopic surgeries done at our centre. Moreover, this study accomplishes laparoscopic donor nephrectomy "a historical milestone achieved in Nepal for kidney transplantation on 18th November 2018" which was the first Laparoscopic donor nephrectomy done in Nepal by Nepalese team. Read More

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November 2021

Relative strain is a novel predictor of aneurysmal degeneration of the thoracic aorta: An ex vivo mechanical study.

JVS Vasc Sci 2021 8;2:235-246. Epub 2021 Oct 8.

Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford University, Stanford, Calif.

Objective: Current guidelines for prophylactic replacement of the thoracic aorta, primarily based on size alone, may not be adequate in identifying patients at risk for either progression of disease or aortic catastrophe. We undertook the current study to determine whether the mechanical properties of the aorta might be able to predict aneurysmal dilatation of the aorta using a clinical database and benchtop mechanical testing of human aortic tissue.

Methods: Using over 400 samples from 31 patients, mechanical properties were studied in (a) normal aorta and then (b) between normal and diseased aorta using linear mixed-effects models. Read More

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October 2021

Cone photoreceptor dysfunction in retinitis pigmentosa revealed by optoretinography.

Proc Natl Acad Sci U S A 2021 Nov;118(47)

School of Optometry, Indiana University, Bloomington, IN 47405

Retinitis pigmentosa (RP) is the most common group of inherited retinal degenerative diseases, whose most debilitating phase is cone photoreceptor death. Perimetric and electroretinographic methods are the gold standards for diagnosing and monitoring RP and assessing cone function. However, these methods lack the spatial resolution and sensitivity to assess disease progression at the level of individual photoreceptor cells, where the disease originates and whose degradation causes vision loss. Read More

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November 2021

Toe pressure and toe brachial index are predictive of cardiovascular mortality regardless of the most diseased arterial segment in symptomatic lower-extremity artery disease-A retrospective cohort study.

PLoS One 2021 15;16(11):e0259122. Epub 2021 Nov 15.

Faculty of Medicine, University of Turku, Turku, Finland.

Objective: Although lower extremity arterial disease (LEAD) is most often multisegmental, the predominant disease location and risk factors differ between patients. Ankle-brachial index (ABI), toe-brachial index (TBI), and toe pressure (TP) are predictive of outcome in LEAD patients. Previously, we reported a classification method defining the most diseased arterial segment (MDAS); crural (CR), femoropopliteal (FP), or aortoiliac (AOI). Read More

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November 2021

Computational simulation of rheological blood flow containing hybrid nanoparticles in an inclined catheterized artery with stenotic, aneurysmal and slip effects.

Comput Biol Med 2021 Nov 2;139:105009. Epub 2021 Nov 2.

Department of Mathematics, School of Advanced Sciences, VIT University, Vellore, 632014, India.

Influenced by nano-drug delivery applications, the present article considers the collective effects of hybrid biocompatible metallic nanoparticles (Silver and Copper), a stenosis and an aneurysm on the unsteady blood flow characteristics in a catheterized tapered inclined artery. The non-Newtonian Carreau fluid model is deployed to represent the hemorheological characteristics in the arterial region. A modified Tiwari-Das volume fraction model is adopted for nanoscale effects. Read More

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November 2021

Isolation and reconstruction of cardiac mitochondria from SBEM images using a deep learning-based method.

J Struct Biol 2021 Nov 3;214(1):107806. Epub 2021 Nov 3.

Institute for Engineering in Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0412, USA.

Mitochondrial morphological defects are a common feature of diseased cardiac myocytes. However, quantitative assessment of mitochondrial morphology is limited by the time-consuming manual segmentation of electron micrograph (EM) images. To advance understanding of the relation between morphological defects and dysfunction, an efficient morphological reconstruction method is desired to enable isolation and reconstruction of mitochondria from EM images. Read More

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November 2021

Survival after Resuscitated Out-of-Hospital Cardiac Arrest in Patients with Paramedic-Identified ST-Segment Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention.

Prehosp Emerg Care 2021 Nov 3:1-8. Epub 2021 Nov 3.

ST-segment elevation myocardial infarction (STEMI) is a common cause of out-of-hospital cardiac arrest (OHCA). For these patients, urgent angiography and revascularization is an important treatment goal. There is a lack of data on the prognosis of STEMI patients after OHCA, who are diagnosed and treated by paramedics prior to hospital transport for primary percutaneous coronary intervention (PCI). Read More

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November 2021

Epicardial adipocyte-derived TNF-α modulates local inflammation in patients with advanced coronary artery disease.

Curr Vasc Pharmacol 2021 Oct 29. Epub 2021 Oct 29.

Department of Cardiac Surgery, Euroclinic of Athens, Athens. Greece.

Background: Epicardial adipose tissue (EAT) surrounds the epicardium and can mediate harmful effects related to coronary artery disease (CAD).

Objective: We explored the regional differences between adipose stores surrounding diseased and non-diseased segments of coronary arteries in patients with advanced CAD.

Methods: We enrolled 32 patients with known CAD who underwent coronary artery bypass graft (CABG) surgery. Read More

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October 2021

Time to think beyond door to balloon time: significance of total ischemic time in STEMI.

Egypt Heart J 2021 Oct 29;73(1):95. Epub 2021 Oct 29.

National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.

Background: Significance of total ischemic time (TIT) in the context of ST-segment elevation myocardial infarction (STEMI) is still controversial. Therefore, in this study, we have evaluate the association of TIT with immediate outcomes in STEMI patients in whom recommended door to balloon (DTB) time of less than 90 min was achieved.

Results: A total of 5730 patients were included in this study, out of which 80. Read More

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October 2021

Concentric ballooned catheterization to the fractional non-newtonian hybrid nano blood flow through a stenosed aneurysmal artery with heat transfer.

Sci Rep 2021 Oct 14;11(1):20379. Epub 2021 Oct 14.

Institute of Engineering Mathematics, Faculty of Applied and Human Sciences, Universiti Malaysia Perlis, Pauh Putra Campus, 02600, Arau, Perlis, Malaysia.

The current work analyzes the effects of concentric ballooned catheterization and heat transfer on the hybrid nano blood flow through diseased arterial segment having both stenosis and aneurysm along its boundary. A fractional second-grade fluid model is considered which describes the non-Newtonian characteristics of the blood. Governing equations are linearized under mild stenosis and mild aneurysm assumptions. Read More

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October 2021

Impact of persistent subclinical hypothyroidism on clinical outcomes in non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention.

Clin Endocrinol (Oxf) 2021 Oct 12. Epub 2021 Oct 12.

The Eighth Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.

Background: Data on the association of subclinical hypothyroidism (SCH) with the severity of coronary artery disease and major adverse cardiovascular and cerebral events (MACCE) in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) after percutaneous coronary intervention (PCI) are limited and conflicting.

Objective: We established the baseline rate of SCH and followed the trajectory of thyroid-stimulating hormone (TSH) values during and after hospitalisation for PCI for up to six months and determined whether persistent SCH was associated with the severity of coronary artery disease and MACCE in patients with NSTE-ACS after PCI.

Design: Population-based prospective cohort study. Read More

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October 2021

Lipoprotein(a) has no major impact on calcification activity in patients with mild to moderate aortic valve stenosis.

Heart 2021 Sep 30. Epub 2021 Sep 30.

Department of Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands

Objective: To assess whether patients with aortic valve stenosis (AS) with elevated lipoprotein(a) (Lp(a)) are characterised by increased valvular calcification activity compared with those with low Lp(a).

Methods: We performed F-sodium fluoride (F-NaF) positron emission tomography/CT in patients with mild to moderate AS (peak aortic jet velocity between 2 and 4 m/s) and high versus low Lp(a) (>50 mg/dL vs <50 mg/dL, respectively). Subjects were matched according to age, gender, peak aortic jet velocity and valve morphology. Read More

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September 2021

Greater plaque burden and cholesterol content may explain an increased incidence of non-culprit events in diabetic patients: a Lipid-Rich Plaque substudy.

Eur Heart J Cardiovasc Imaging 2021 Sep 26. Epub 2021 Sep 26.

Cardiovascular Department, MedStar Washington Hospital Center, Washington, DC, USA.

Aims : Diabetes mellitus (DM) is associated with increased cardiovascular morbidity and mortality. The multicentre, prospective Lipid-Rich Plaque trial (LRP) examined non-culprit (NC) non-obstructive coronary segments with a combined near-infrared spectroscopy (NIRS)-intravascular ultrasound (IVUS) catheter. This study assessed the differences in NC plaque characteristics and their influence on major adverse cardiac events (MACE) in diabetic and non-diabetic patients. Read More

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September 2021

Comparison of angiographic and intravascular ultrasound vessel measurements in infra-popliteal endovascular interventions: The below-the-knee calibration study.

Cardiovasc Revasc Med 2021 Sep 16. Epub 2021 Sep 16.

Cardiology, NC Heart and Vascular Research, LLC, UNC School of Medicine, Raleigh, NC, USA. Electronic address:

Background: Endovascular revascularization (ER) via percutaneous transluminal angioplasty (PTA) and stenting are viable options for revascularization in below-the-knee (BTK) peripheral arterial disease. Two-dimensional angiography has been the standard of practice for estimating vessel size and selecting treatment devices during ER. However, in other vascular territories, intravascular ultrasound (IVUS) offers better visualization of the lumen dimensions. Read More

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September 2021

Analysis of the Therapeutic Effects of Staged Posterior-Anterior Combined Surgery for Cervicothoracic Segmental Tuberculosis with Kyphosis in Pediatric Patients.

Int J Gen Med 2021 26;14:4847-4855. Epub 2021 Aug 26.

Department of Spine Surgery, XinJiang Medical University Affiliated First Hosptial, Urumqi, XinJiang, People's Republic of China.

Objective: The present study aimed to investigate the surgical efficacy of staged posterior-anterior combined surgery for the treatment of cervicothoracic segmental tuberculosis (TB) with kyphosis in pediatric patients.

Methods: The clinical data of 15 pediatric patients admitted to our hospital from January 2010 to December 2017 who underwent staged posterior-anterior combined surgery for cervicothoracic segmental TB with kyphosis were collected. A posterior median incision was made for patients after general anesthesia. Read More

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Enterosalpingeal fistula complicating Crohn's disease: Report of two cases and review of the literature.

Ann Med Surg (Lond) 2021 Sep 17;69:102734. Epub 2021 Aug 17.

Surgery Department A - La Rabta Hospital of Tunis, University of Tunis El Manar, Faculty of Medicine of Tunis, Tunisia.

Introduction And Importance: Reports of enterosalpingeal fistulae complicating Crohn's disease are scarce. They involve the last ileal loop and lead to a progressive destruction of the salpinx. Usually, no genital symptoms are found. Read More

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September 2021

A 2-Year-Old Boy Who Developed an Aortoesophageal Fistula After Swallowing a Button Battery, Managed Using a Novel Procedure with Vascular Plug Device as a Bridge to Definitive Surgical Repair.

Am J Case Rep 2021 Aug 18;22:e931013. Epub 2021 Aug 18.

Department of Pediatric Surgery, Maternity and Children's Hospital, Madinah, Saudi Arabia.

BACKGROUND Button batteries (BBs) can be inhaled or swallowed accidentally, particularly by infants and children, who can present as a surgical emergency with a fatal outcome. This report is of a case of a 2-year-old boy who developed an aortoesophageal fistula (AEF) after swallowing a button battery and was successfully treated using a novel vascular plug device as a bridge to definitive surgical repair. AEF is diagnosed using computed tomography angiography (CTA), after laparotomy, and using aortography. Read More

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End-diastolic segmentation of intravascular ultrasound images enables more reproducible volumetric analysis of atheroma burden.

Catheter Cardiovasc Interv 2021 Aug 17. Epub 2021 Aug 17.

Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust, London, UK.

Background: Volumetric intravascular ultrasound (IVUS) analysis is currently performed at a fixed frame interval, neglecting the cyclic changes in vessel dimensions occurring during the cardiac cycle that can affect the reproducibility of the results. Analysis of end-diastolic (ED) IVUS frames has been proposed to overcome this limitation. However, at present, there is lack of data to support its superiority over conventional IVUS. Read More

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A deep semantic segmentation correction network for multi-model tiny lesion areas detection.

BMC Med Inform Decis Mak 2021 07 30;21(Suppl 2):89. Epub 2021 Jul 30.

Center for Medical Artificial Intelligence, Shandong University of Traditional Chinese Medicine, Qingdao, 266112, China.

Background: Semantic segmentation of white matter hyperintensities related to focal cerebral ischemia (FCI) and lacunar infarction (LACI) is of significant importance for the automatic screening of tiny cerebral lesions and early prevention of LACI. However, existing studies on brain magnetic resonance imaging lesion segmentation focus on large lesions with obvious features, such as glioma and acute cerebral infarction. Owing to the multi-model tiny lesion areas of FCI and LACI, reliable and precise segmentation and/or detection of these lesion areas is still a significant challenge task. Read More

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Twin Giant Intracranial Aneurysms.

World Neurosurg 2021 10 24;154:64-66. Epub 2021 Jul 24.

The First People's Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan Province, China. Electronic address:

Giant aneurysms of the intracranial vertebral artery and posterior inferior cerebellar artery are challenging to treat as they often necessitate direct sacrifice of the diseased segment, which is thought to carry high morbidity due to brainstem and cerebellar stroke. Here, we report images of twin giant aneurysms of the left posterior inferior cerebellar artery at the brainstem and cerebellopontine angle region in a young child. Read More

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October 2021

[Study on the safety and effectiveness of low-dose tranexamic acid in operation of multi-level continuous thoracic ossification of ligament flavum].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jul;35(7):873-877

Department of Orthopedics, Affiliated Hospital of North Sichuan Medical College, Nanchong Sichuan, 637000, P.R.China.

Objective: To investigate the safety and effectiveness of low-dose tranexamic acid (TXA) in operation of multi-level continuous thoracic ossification of ligament flavum (TOLF).

Methods: A clinical data of 26 patients who underwent operation for multi-level continuous TOLF and met the selection criteria between July 2015 and January 2019 was retrospectively analyzed. Among them, 13 cases (group A) were received intravenous infusion of TXA (10 mg/kg) at 15 minutes before operation, and maintained the infusion at 1 mg/(kg·h) until the end of the operation; 13 cases (group B) were received the same dose of normal saline before and during operation. Read More

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Need for a holistic approach to treat TB contacts and extrapulmonary (ocular) tuberculosis.

BMJ Case Rep 2021 Jul 21;14(7). Epub 2021 Jul 21.

Ophthalmology, All India Institute of Medical Sciences, Patna, Bihar, India

We aim to highlight the ignorance and incidences of deliberate hiding of medical facts in society. The cause of it can be, the associated taboo with these diseases. The fear of social outcasts is the major barrier preventing diseased from accepting the diagnosis as well as treatment. Read More

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Experience Summary of Laparoscopic Treatment for Pediatric Ureteral Polyps.

Front Pediatr 2021 30;9:689842. Epub 2021 Jun 30.

Department of Pediatric Surgery, Qilu Hospital of Shandong University, Jinan, China.

To investigate surgical techniques and challenges of laparoscopic in treating pediatric ureteral polyps under laparoscopy. The clinical data of 7 of pediatric ureteral polyps patients who were admitted to the hospital from July 2015 to January 2020 were analyzed retrospectively. There were 6 males and 1 female from 7. Read More

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A Magnetic Resonance Imaging Index to Predict Crohn's Disease Postoperative Recurrence: The MONITOR Index.

Clin Gastroenterol Hepatol 2021 Jun 30. Epub 2021 Jun 30.

Department of Hepatogastroenterology, Nancy University Hospital, Vandoeuvre-lès-Nancy; INSERM U1256, Nutrition-Génétique et Exposition aux Risques Environnementaux, Faculté de Médecine, Université de Lorraine, Vandoeuvre-les-Nancy, France. Electronic address:

Background & Aims: We developed and validated a magnetic resonance imaging-based index to predict Crohn's disease (CD) postoperative recurrence (POR).

Methods: Patients with CD who underwent a postoperative evaluation for recurrence (with colonoscopy and MRI no longer than 105 days apart) were included between 2006 and 2016 in University Hospital of Nancy, France. MRI items with good levels of intra-rater and inter-rater agreement (Gwet's coefficient ≥0. Read More

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Automated segmentation and quantification of the healthy and diseased aorta in CT angiographies using a dedicated deep learning approach.

Eur Radiol 2021 Jun 25. Epub 2021 Jun 25.

Department of Radiology and Nuclear Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.

Objectives: To develop and validate a deep learning-based algorithm for segmenting and quantifying the physiological and diseased aorta in computed tomography angiographies.

Methods: CTA exams of the aorta of 191 patients (68.1 ± 14 years, 128 male), performed between 2015 and 2018, were retrospectively identified from our imaging archive and manually segmented by two investigators. Read More

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Characteristics of high-resolution magnetic resonance vessel wall imaging of cervicocerebral artery dissection and the influential factors of vascular recanalization.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 May;46(5):467-474

Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China.

Objectives: Cervicocerebral artery dissection (CAD) is one of the important causes for ischemic stroke in young and middle-aged people. CAD is dangerous and untimely diagnosis and treatment are likely to result in severe disability. Early diagnosis and timely intervention can greatly improve the prognosis of patients. Read More

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Acute atrial ischemia associates with early but not late new-onset atrial fibrillation in STEMI patients treated with primary PCI: relationship with in-hospital outcomes.

J Cardiol 2021 11 12;78(5):368-374. Epub 2021 Jun 12.

Department of Clinical Internal, Anesthesiological, and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy; Department of Systems Medicine, University of Rome Tor Vergata, Italy.

Background: New-onset atrial fibrillation (NOAF), both early (EAF) or late (LAF), may complicate ST-segment elevation myocardial infarction (STEMI). The mechanisms underlying EAF or LAF are poorly described. We investigated atrial branch occlusion and EAF or LAF onset in STEMI patients undergoing primary percutaneous coronary intervention. Read More

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November 2021

Living donor liver transplantation for Budd‒Chiari syndrome with right posterior segment graft and patch plasty using the superficial femoral vein: a case report.

Surg Case Rep 2021 Jun 4;7(1):136. Epub 2021 Jun 4.

Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan.

Background: In living donor liver transplantation (LDLT) for patients with Budd‒Chiari syndrome (BCS), there are several concerns about reconstruction of the inferior vena cava (IVC) and hepatic veins. Herein, we report the case of a patient with BCS who underwent LDLT with right posterior segment graft (RPSG) and patch plasty for reconstruction of the hepatic venous outflow, using the patient's own superficial femoral vein (SFV).

Case Presentation: A 19-year-old man, who was diagnosed with primary BCS, underwent LDLT. Read More

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Hybrid repair versus conventional open repair for thoracic aortic arch aneurysms.

Cochrane Database Syst Rev 2021 06 4;6:CD012923. Epub 2021 Jun 4.

School of Nursing and Midwifery, National University of Ireland Galway, Galway, Ireland.

Background: Thoracic aortic arch aneurysms (TAAs) can be a life-threatening condition due to the potential risk of rupture. Treatment is recommended when the risk of rupture is greater than the risk of surgical complications. Depending on the cause, size and growth rate of the TAA, treatment may vary from close observation to emergency surgery. Read More

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Clinical Observations of Kümmell Disease Treatment Through Percutaneous Fixation Combined with Vertebroplasty.

Orthop Surg 2021 Jul 2;13(5):1505-1512. Epub 2021 Jun 2.

First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.

Objective: To explore the safety and efficacy of percutaneous pedicle screw fixation combined with vertebroplasty for the treatment of stage III Kümmell disease.

Methods: The clinical data and follow-up results of 22 patients with Kümmell disease who were admitted to our department from 2014 to 2018 were analyzed. There were 14 females and eight males, and the Age range was 58-81 years. Read More

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