2,700 results match your criteria disease-free subjects


Clinical Outcomes of Endoscopic Treatment for Type 1 Gastric Neuroendocrine Tumor.

J Gastrointest Surg 2021 Apr 6. Epub 2021 Apr 6.

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Although the rate of early detection and endoscopic treatment of gastric neuroendocrine tumors (NETs) is steadily increasing, there are insufficient studies on the long-term outcomes of endoscopic treatment. Therefore, we aimed to investigate the clinical features and long-term outcomes of endoscopic treatment for type 1 gastric NETs.

Methods: Subjects who underwent endoscopic treatment for gastric NETs between March 1997 and December 2015 were included. Read More

View Article and Full-Text PDF

Long-term oncological outcome in patients with cervical cancer after 3 trimodality treatment (radiotherapy, platinum-based chemotherapy, and robotic surgery).

Medicine (Baltimore) 2021 Apr;100(13):e25271

Carol Davila University of Medicine and Pharmacy.

Abstract: Cervical cancer represents a general health issue spread all over the globe, which prompts the surge of scientific survey toward the rise of survival and condition of life of these patients. American and European guidelines suggest the open surgery, laparoscopic, and robotic surgery are the main therapeutic approaches for radical hysterectomy for patients with cervical cancer. This is the first survey to analyze the long-term oncological outcome of an extensive series of subjects cared for with multimodality treatment, here comprising robotic surgery. Read More

View Article and Full-Text PDF

[Object and action naming in a sentence context in people with Parkinson's disease free of dementia].

Rev Neurol 2021 Apr;72(7):223-230

Universidad Complutense de Madrid, Madrid, España.

Introduction: Difficulties in action language processing (e.g. verbs) have been described in Parkinson's disease (PD). Read More

View Article and Full-Text PDF

Effect and limitation of neoadjuvant chemotherapy for pancreatic ductal adenocarcinoma: consideration from a new perspective.

World J Surg Oncol 2021 Mar 22;19(1):85. Epub 2021 Mar 22.

Department of Diagnostic Pathology, Ota Memorial Hospital, SUBARU Health Insurance Society, 455-1 Oshima, Gunma, 373-8585, Japan.

Background: Effect of neoadjuvant chemotherapy (NAC) for pancreatic ductal adenocarcinoma (PDAC) has remained under investigation. We investigated its effect from a unique perspective and discussed its application.

Patients And Methods: We retrospecively analyzed consecutive 131 PDAC patients who underwent pancreatoduodenectomy and distal pancreatectomy. Read More

View Article and Full-Text PDF

Malignant peripheral nerve sheath tumor with analysis of various prognostic factors: A single-institutional experience.

J Cancer Res Ther 2021 Jan-Mar;17(1):106-113

Department of Radiotherapy, The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India.

Context: Malignant peripheral nerve sheath tumor (MPNST) is a rare and aggressive soft-tissue sarcoma.

Aims: The aim of this study was to analyze various prognostic factors and treatment outcome of patients with MPNST.

Settings And Design: This was a retrospective study. Read More

View Article and Full-Text PDF

The Significance of HOXC11 and LSH in Survival Prediction in Gastric Adenocarcinoma.

Onco Targets Ther 2021 1;14:1517-1529. Epub 2021 Mar 1.

Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education; Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, People's Republic of China.

Purpose: Gastric adenocarcinoma is one of the most important causes of cancer death and lacks effective treatment. Eighty-four gastric adenocarcinoma tissue samples along with the clinical information were collected. After analyzing the expression of HOXC11 and LSH in the gastric adenocarcinoma tissues, we explored the prognosis of patients and its correlation with clinical characteristics. Read More

View Article and Full-Text PDF

Preoperative EUS evaluation of the response to neoadjuvant therapy for gastric and esophagogastric junction cancer is correlated with survival: A single retrospective study of 97 patients.

Endosc Ultrasound 2021 Mar 3. Epub 2021 Mar 3.

Department of Endoscopy, Institut Paoli-Calmettes, Marseille, France.

Background And Objectives: The European Society for Medical Oncology suggests performing EUS staging for esophagogastric junction and gastric cancers to further assess the T and N stages. The use of EUS after neoadjuvant therapy (NT) is still under debate. We aimed to evaluate the contribution of EUS after NT to staging, therapeutic choices, and prognosis prediction. Read More

View Article and Full-Text PDF

Recent advances in neoadjuvant therapy for breast cancer.

Fac Rev 2021 4;10. Epub 2021 Jan 4.

University of Minnesota, Minneapolis, MN, USA.

Neoadjuvant trials for early breast cancer have accelerated the identification of novel active agents, enabling streamlined conduct of registration trials with fewer subjects. Measurement of neoadjuvant drug effects has also enabled the identification of patients with high risk of distant recurrence and has justified development of additional adjuvant approaches to improve outcomes. Neoadjuvant evaluation of new drugs was significantly improved by the introduction of pathologic complete response (pCR) rate as a quantitative surrogate endpoint for distant disease-free survival (DDFS) and event free survival (EFS). Read More

View Article and Full-Text PDF
January 2021

Tumor cell proliferation (Ki-67) expression and its prognostic significance in histological subtypes of lung adenocarcinoma.

Lung Cancer 2021 Apr 16;154:69-75. Epub 2021 Feb 16.

Department of Thoracic Surgery, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. Electronic address:

Objectives: Ki-67 is a key molecular marker to indicate the proliferative activity of tumor cells in lung cancer. However, Ki-67 expression and its prognostic significance in histological subtypes of lung adenocarcinoma (LUAD) remain unclear.

Materials And Methods: We retrospectively analyzed 1028 invasive LUAD patients who underwent surgery treatment between January 2012 and April 2020 in our department. Read More

View Article and Full-Text PDF

Trophoblast cell surface antigen 2 expression predicts outcome in oral squamous cell carcinomas.

Oral Dis 2021 Feb 22. Epub 2021 Feb 22.

Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.

Background: Trophoblast cell surface antigen 2 (TROP2) has unclear clinical role in oral squamous cell carcinomas (OSCC). Here, we investigated the association of TROP2 immunoexpression with clinicopathological parameters and survival of OSCC patients.

Subjects And Methods: Cancer-specific survival (CSS) and disease-free survival (DFS) were assessed in a cohort composed of 266 OSCC. Read More

View Article and Full-Text PDF
February 2021

Efficacy and safety of systematic corticosteroids among severe COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.

Signal Transduct Target Ther 2021 02 21;6(1):83. Epub 2021 Feb 21.

Department of Anesthesiology, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China.

The benefits and harms of corticosteroids for patients with severe coronavirus disease 2019 (COVID-19) remain unclear. We systematically searched PubMed, Embase, and Cochrane Central Register of Controlled Trials from December 31, 2019 to October 1, 2020 to identify randomized controlled trials (RCTs) that evaluated corticosteroids in severe COVID-19 patients. The primary outcome was all-cause mortality at the longest follow-up. Read More

View Article and Full-Text PDF
February 2021

[Idea of Treatment Method for Upper and Lower Rectal Cancer Avoiding Irradiation to Internal and External Sphincter].

Gan To Kagaku Ryoho 2021 Feb;48(2):239-241

Dept. of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.

Background: Preoperative chemoradiotherapy(CRT)followed by total mesorectal excision(TME)is used for locally advanced rectal cancer, but it can induce postoperative anorectal function. The primary objective of this study is to confirm the efficacy and safety of preoperative CRT and TME without irradiation to the internal and external sphincter muscles.

Subjects And Methods: Patients were eligible for this study if they met the following inclusion criteria: histologically proven rectal cancer, clinical T3T4N0-2 disease, and a distance between anal margin of tumor and the rental line is more than 2 cm. Read More

View Article and Full-Text PDF
February 2021

[Analysis on Clinical Characteristics and Prognosis of 47 Patients with Extranodal NK/T Cell Lymphoma].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Feb;29(1):86-90

Department of Hematology, Peking University Third Hospital, Beijing 100191, China,E-mail:

Objective: To investigate the clinical features and prognostic factors of patients with extranodal NK/T cell lymphoma (ENKTL).

Methods: The clinical data of patients with ENKTL from November 2009 to November 2019 was collected and retrospectively analyzed to clarify the clinical features of ENKTL, and evaluate the factors that affected survival and prognosis.

Results: Forty-seven patients with ENKTL were collected, median age was 40 (12-82) years old, and more common in males than females, at the ratio of 1. Read More

View Article and Full-Text PDF
February 2021

A comparative cross-sectional study on sleep quality in patients with a history of differentiated thyroid carcinoma and its correlation with quality of life.

Endocrine 2021 Feb 3. Epub 2021 Feb 3.

Endocrinology Unit, Department of Internal Medicine & Medical Specialties (DiMI), University of Genoa, Genoa, Italy.

Purpose: To evaluate sleep quality in differentiated thyroid carcinoma (DTC) patients and correlate sleep disturbances with quality of life (QoL).

Methods: 119 DTC patients were enrolled (DTC group). The Pittsburgh Sleep Quality Index (PSQI) and the Insomnia Severity Index (ISI) inventories were administered. Read More

View Article and Full-Text PDF
February 2021

Postprandial effects of macronutrient composition meals on the metabolic responses and arterial stiffness indices of lean and obese male adults: a protocol of a pilot study.

Pilot Feasibility Stud 2021 Feb 3;7(1):41. Epub 2021 Feb 3.

Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Prior studies have shown that meal composition may affect the metabolic responses and arterial stiffness indices, and these responses may be different in lean and obese adults. The primary objective of this study is to determine the feasibility of conducting a trial to compare the effect of three test meals in lean and obese men. Due to the lack of a comprehensive study that concurrently compares metabolic responses and vascular stiffness indices after receiving three different meals in lean and obese men, this pilot study will be conducted with a three-phase parallel design, aiming to investigate the effects of meal composition on the metabolic parameters and arterial stiffness indices of lean and obese adults. Read More

View Article and Full-Text PDF
February 2021

Role of 18F-FDG PET/CT in the Assessment of Response to Antitubercular Chemotherapy and Identification of Treatment Endpoint in Patients With Tuberculosis of the Joints: A Pilot Study.

Clin Nucl Med 2021 Jan 28. Epub 2021 Jan 28.

From the Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India Nepalgunj Medical College, Nepalgunj, Nepal Department of Nuclear Medicine Department of Pathology Diagnostic Division, Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

Aims: The aim of this study was to explore the utility of 18F-FDG PET/CT in the assessment of response to antitubercular treatment (ATT) and identification of treatment endpoint.

Patients And Methods: Forty patients (mean age, 35.3 years; 27 men) with clinically, radiologically, and histopathologically proven joint tuberculosis prospectively underwent clinical, biochemical, and PET/CT evaluation at baseline and after ~6, 12, and 18 months of ATT. Read More

View Article and Full-Text PDF
January 2021

Suspicious adrenal incidentaloma in a patient with Congenital Adrenal Hyperplasia: A case report.

Urol Case Rep 2021 May 12;36:101569. Epub 2021 Jan 12.

Department of Urology, Bellevue Medical Center, Mansourieh, Lebanon.

Congenital Adrenal Hyperplasia has been associated with an increased prevalence of adrenal masses. It is still unknown whether incidentalomas in CAH* patients are more frequent or if the risk of adrenal carcinoma is higher than the general population. Therefore, the management CAH subjects presenting with suspicious adrenal masses remains problematic. Read More

View Article and Full-Text PDF

Body Composition Analysis of 10 Years versus 5 Years of Adjuvant Endocrine Therapy in Patients with Nonmetastatic Breast Cancer.

J Oncol 2021 16;2021:6659680. Epub 2021 Jan 16.

Thyroid Breast Surgery Department, Hubei Ezhou Central Hospital, Ezhou, Hubei, China.

Objective: Our study aims to investigate the association of extended adjuvant endocrine therapy with disease-free survival (DFS), muscle mass, muscle strength, and visceral adipose tissue in patients with nonmetastatic breast cancer and the effect of extended endocrine therapy on body composition. . Patients ( = 90) with nonmetastatic breast cancer aged between 60 and 65 years old were prospectively recruited in this study, compromising a cohort of subjects rece iving 5 years or 10 years of adjuvant endocrine therapy. Read More

View Article and Full-Text PDF
January 2021

Clinical features, prognosis, and influencing factors of contralateral prophylactic mastectomy in 58 patients with breast cancer.

Ann Transl Med 2020 Dec;8(24):1665

Department of General Surgery, First Medical Center of the People's Liberation Army (PLA) General Hospital, Beijing, China.

Background: The past two decades have witnessed the increasing application of contralateral prophylactic mastectomy (CPM) for women with breast cancer in the western countries. Over 30% of young patients choose to underwent CPM up to 2015. However, the adoption rate of CPM has not shown a remarkably increasing in Asian countries. Read More

View Article and Full-Text PDF
December 2020

Outcome of Children with Wilms' Tumor in Developing Countries.

J Med Life 2020 Oct-Dec;13(4):484-489

Department of Pediatrics, Ali-Asghar Children Hospital, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Wilms' tumor is the most common kidney tumor of childhood. The outcome of this malignant tumor has improved due to the improvement of therapeutic strategies. The most important factor in determining the prognosis of these patients is the histopathology subtype of the tumor; unfavorable histopathology is seen in only 11. Read More

View Article and Full-Text PDF
January 2021

The role of postoperative radiotherapy for thymomas: a multicentric retrospective evaluation from three Italian centers and review of the literature.

J Thorac Dis 2020 Dec;12(12):7518-7530

Department of Radiation Oncology, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence, Italy.

Background: Thymoma is a rare mediastinal neoplasia. Surgery is the backbone of the treatment, but the role of postoperative radiotherapy (PORT) remains controversial. We aimed to obtain data on survival and safety in patients treated with PORT in three different Italian institutions. Read More

View Article and Full-Text PDF
December 2020

The incidence and presumed aetiologies of fourth cranial nerve palsy in Korea: a 10-year nationwide cohort study.

Eye (Lond) 2021 Jan 7. Epub 2021 Jan 7.

Department of Ophthalmology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.

Aims: To investigate the incidence and presumed aetiologies of fourth cranial nerve (CN4) palsy in Korea METHODS: Using the nationally representative dataset of the Korea National Health Insurance Service-National Sample Cohort from 2006 to 2015, newly developed CN4 palsy cases confirmed by a preceding disease-free period of ≥4 years were identified. The presumed aetiology of CN4 palsy was evaluated based on comorbidities around the CN4 palsy diagnosis.

Results: Among the 1,108,292 cohort subjects, CN4 palsy newly developed in 390 patients during 10-year follow-up, and the overall incidence of CN4 palsy was 3. Read More

View Article and Full-Text PDF
January 2021

Phase II study of the histone deacetylase inhibitor vorinostat (Suberoylanilide Hydroxamic Acid; SAHA) in recurrent or metastatic transitional cell carcinoma of the urothelium - an NCI-CTEP sponsored: California Cancer Consortium trial, NCI 6879.

Invest New Drugs 2021 Jan 6. Epub 2021 Jan 6.

City of Hope Comprehensive Cancer Center, Duarte, CA, USA.

Background: Until the advent of T cell check point inhibitors standard second-line therapy for patients with metastatic urothelial cancer (mUC) was undefined. Histone deacetylase inhibitors (HDACi) have anti-cancer activity in a variety of tumor models including modulation of apoptosis in bladder cancer cell lines. We evaluated the efficacy and toxicity of the HDACi vorinostat in patients with mUC failing first-line platinum-based therapy either in the adjuvant/neoadjuvant setting or for recurrent/advanced disease. Read More

View Article and Full-Text PDF
January 2021

Impact of Lymphovascular Invasion in Patients With Stage II Colorectal Cancer: A Propensity Score-matched Study.

In Vivo 2021 Jan-Feb;35(1):525-531

Department of Gastrointestinal Surgery, Saitama Medical University International Medical Center, Saitama, Japan.

Background/aim: Whether lymphovascular invasion (LVI) is a high-degree risk factor in stage II colorectal cancer has not been fully clarified, as different results have been reported in the literature. If LVI is a risk factor, postoperative chemotherapy may be recommended. The purpose of this study was to evaluate the impact of lymphovascular invasion on disease recurrence and patient prognosis in conjunction with stage II colorectal cancer (CRC). Read More

View Article and Full-Text PDF
October 2020

Impact of xenobiotic-metabolizing gene polymorphisms on breast cancer risk in South Indian women.

Breast Cancer Res Treat 2021 Apr 4;186(3):823-837. Epub 2021 Jan 4.

Cancer Genomics Laboratory, Department of Biotechnology, School of Chemical and Biotechnology, SASTRA - Deemed University, Thanjavur, 613 401, India.

Background: Functional variants of the xenobiotic-metabolizing genes (XMG) might modulate breast cancer (BC) risk by altering the rate of metabolism and clearance of myriad types of potent carcinogens from the breast tissue. Despite mounting evidence on the role of XMG variants on BC risk, the current knowledge regarding their influence on BC development is still fragmentary.

Methods: The present study examined the candidate genetic variants in CYP1A1, NQO1, GST-T1, GST-M1, and GST-P1 in 1002 subjects (502 BC patients and 500 disease-free women). Read More

View Article and Full-Text PDF

Radical antegrade modular pancreatosplenectomy (RAMPS) versus conventional distal pancreatosplenectomy (CDPS) for left-sided pancreatic ductal adenocarcinoma.

Surg Today 2021 Jan 3. Epub 2021 Jan 3.

Department of General Surgery, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

Purpose: The insufficient clearance of regional lymph nodes and unsatisfactory R0 resection rate may result in the metastasis of left-sided pancreatic ductal adenocarcinoma (PDAC) after conventional distal pancreatosplenectomy (CDPS). Radical antegrade modular pancreatosplenectomy (RAMPS) was designed to achieve R0 resection more successfully with better lymph-node clearance; however, there is still insufficient evidence of its short- and long-term results to confirm its superiority. We conducted this study to compare the efficiency of these two procedures. Read More

View Article and Full-Text PDF
January 2021

Human papillomavirus infection and p53 mutation in esophageal squamous cell carcinoma and its impact on treatment outcome.

J Cancer Res Ther 2020 Dec;16(Supplement):S150-S155

Department of Radiation Oncology, Cancer Research Institute, Swami Rama Himalayan University, Dehradun, Uttarakhand, India.

Introduction: Human papillomavirus (HPV) is emerging as a risk factor for esophageal squamous carcinoma. The prognostic value of the HPV status has been investigated. However, the results are much controversial. Read More

View Article and Full-Text PDF
December 2020

Serum Krebs von den Lungen-6 level predicts disease progression in interstitial lung disease.

PLoS One 2020 17;15(12):e0244114. Epub 2020 Dec 17.

Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Disease progression (DP) in interstitial lung disease (ILD) is variable and difficult to predict. In previous reports, serum Krebs von den Lungen-6 (KL-6) was suggested to be useful in diagnosing and predicting survival in ILD. The aim of our study was to investigate the usefulness of serum KL-6 as a predictor of DP in ILD. Read More

View Article and Full-Text PDF

Second-Line Conservative Device-Assisted Intravesical Treatment in Selected Patients With Recurrent High-Risk Non-Muscle-Invasive Bladder Cancer.

Clin Genitourin Cancer 2020 Nov 13. Epub 2020 Nov 13.

Department of Urology, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Università Cattolica del Sacro Cuore di Roma, Rome, Italy.

Introduction: In cases of recurrent high-risk non-muscle-invasive bladder cancer, radical cystectomy (RC) is recommended. We compared oncologic and treatment-related outcomes of second-line conservative device-assisted therapy to RC.

Patients And Methods: In a retrospective cohort study, we analyzed 209 consecutive patients with recurrent bacillus Calmette-Guérin-unresponsive high-risk non-muscle-invasive bladder cancer; 107 subjects refused RC and were offered electromotive drug administration (n = 44) or chemohyperthermia (n = 63) (group A), and 102 patients underwent RC (group B). Read More

View Article and Full-Text PDF
November 2020

Measurable Residual Disease Assessment and Allogeneic Transplantation as Consolidation Therapy in Adult Acute Lymphoblastic Leukemia in Colombia.

Clin Lymphoma Myeloma Leuk 2021 Apr 14;21(4):e365-e372. Epub 2020 Nov 14.

Department of Hematology, Clínica Reina Sofía, Bogotá, Colombia.

Introduction: Detectable minimal residual disease (MRD) after therapy for acute lymphoblastic leukemia (ALL) is the strongest predictor of hematologic relapse. The objective of the study was to assess disease-free survival (DFS) and overall survival (OS) of patients with ALL according with MRD status at the end of induction therapy in a Colombian population.

Patients And Methods: We assessed a retrospective cohort to compare DFS and OS in adults with de novo ALL according to MRD status at the end of induction chemotherapy, and the type of postinduction consolidation strategy used. Read More

View Article and Full-Text PDF