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[Application and value of excimer laser ablation in the treatment of lower limb atherosclerotic obliterans].

Zhonghua Yi Xue Za Zhi 2021 Apr;101(14):1026-1030

Department of Vascular Surgery, Zhongshan Hospital, Fudan University,Shanghai 200032, China.

To evaluate the results of excimer laser ablation (ELA) in the treatment of lower limb atherosclerotic obliterans (ASO). From June 2019 to March 2020, patients who underwent ELA combined with drug-coated balloon (DCB) for lower limb atherosclerotic obliterans (ASO) were enrolled. Demographics, lesion characteristics, procedure-related outcomes and complications were collected and analyzed. Read More

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Fragmentation of Ventricular Extrasystoles: A Potential New Electrocardiographic Window to Uncover Patients at Risk.

Cureus 2021 Mar 7;13(3):e13748. Epub 2021 Mar 7.

Cardiovascular Medicine, University of Missouri Kansas City, Kansas City, USA.

Fragmented QRS (fQRS) is a marker of conduction block due to myocardial scar that presents in electrocardiography (ECG) as an additional one or more R wave (R') or notching in the S wave nadir in contiguous leads. However, fQRS description on premature ventricular contractions (PVCs) has not been previously described. We describe a case of a 67-year-old male with a past medical history of prediabetes, hypertension and coronary artery disease who presented after an ophthalmic procedure with asymptomatic PVCs and episodes of bigeminy. Read More

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Robotic mitral valve surgery: a review and tips for safely negotiating the learning curve.

J Thorac Dis 2021 Mar;13(3):1971-1981

The Liverpool Heart & Chest Hospital, Liverpool, UK.

Totally endoscopic robotic mitral valve repair represents the least invasive surgical therapy for mitral valve disease. Comparative results for robotic mitral valve surgery against sternotomy are impressive, repeatedly demonstrating shorter hospital stay, faster return to normal activities, less morbidity and equivalent mortality and mid-term durability. We lack data comparing robotic approaches to totally endoscopic minimally invasive mitral valve surgery using 3D vision platforms. Read More

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A randomized clinical trial evaluating the immunomodulatory effect of convalescent plasma on COVID-19-related cytokine storm.

Intern Emerg Med 2021 Apr 10. Epub 2021 Apr 10.

Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Evaluating the effect of convalescent plasma (CP) on some cytokine storm indices in severe COVID-19 patients. Totally, 62 patients were randomly assigned into two groups for this clinical trial. Patients in the intervention group received one unit (500 mL) plasma on the admission day plus standard drugs while the controls merely received standard treatments. Read More

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[Serpins as important protective factors in the pathogenesis of acute lung injury/acute respiratory distress syndrome].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Mar;33(3):368-372

Department of Abdominal Emergency Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China.

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a common respiratory disease in clinic, and with a pathological manifestation of pulmonary edema, decreased pulmonary compliance as well as pulmonary epithelial/endothelial cells injury. At present, it was suggested that systemic inflammatory response syndrome (SIRS) caused by various causes which play an important role in the occurrence and development of ALI/ARDS. Widely activated neutrophils can migrate to lung tissue and release plenty of proteases in the procedure of SIRS, including neutrophil serine proteases (NSPs), lysozyme, myeloperoxidase and collagenase, which can induce severe lung injury. Read More

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Psychosocial Risk Factors in Cardiac Rehabilitation: Time to Screen Beyond Anxiety and Depression.

Glob Heart 2021 Feb 19;16(1):16. Epub 2021 Feb 19.

Graduate School for Health Sciences and Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, CH.

Background: Although it is well acknowledged that psychosocial risk factors (PSRF) such as low socio-economic status, stress, social isolation, negative emotions and negative personality patterns may contribute to the development and adverse outcome of cardiovascular disease (CVD), screening for PSRF in CVD patients is usually limited to anxiety and depression, mainly for feasibility reasons. We therefore aimed to develop a user-friendly screening battery for routine assessment of PSRFs and to evaluate this instrument regarding feasibility of application, PSRF results and attendance of psychological counselling if recommended to cardiac rehabilitation (CR) patients.

Methods: This is a prospective single center cohort study including 609 consecutive CR patients. Read More

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February 2021

A Fear of COVID-19 and PTSD Symptoms in Pathological Personality: The Mediating Effect of Dissociation and Emotion Dysregulation.

Front Psychiatry 2021 23;12:590021. Epub 2021 Mar 23.

Department of Dynamic and Clinical Psychology, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.

The 2019 coronavirus disease (COVID-19) outbreak is currently putting a strain on the mental health resilience of the world's population. Specifically, it is likely to elicit an intense response to fear and to act as a risk factor for the onset of posttraumatic stress disorder (PTSD). Some individuals may be more at risk than others, with pathological personality variables being a potential candidate as a central vulnerability factor. Read More

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Pulmonary rehabilitation focusing on the regulation of respiratory movement can improve prognosis of severe patients with COVID-19.

Ann Palliat Med 2021 Mar 23. Epub 2021 Mar 23.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Background: Since the coronavirus disease 2019 (COVID-19) emerged in Wuhan, China, it has become a global public health emergency. Besides conventional care, pulmonary rehabilitation (PR) is an equally important treatment for patients with COVID-19 suffering from respiratory, physical and psychological disease. The aim of this study is to investigate the role of PR on the inpatients with severe COVID-19. Read More

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Identification of a potentially novel LncRNA-miRNA-mRNA competing endogenous RNA network in pulmonary arterial hypertension via integrated bioinformatic analysis.

Life Sci 2021 Apr 5;277:119455. Epub 2021 Apr 5.

Department of Physiology, Basic Medical Science School, Wenzhou Medical University, Wenzhou, PR China. Electronic address:

Aims: Pulmonary arterial hypertension (PAH) is a fatal cardiovascular disease with a cancer-like phenotype. Competing endogenous RNA (ceRNA) networks extensively involve in its pathological processes. But rare ceRNA networks and profound molecular mechanisms have been revealed in PAH. Read More

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Isolation, identification and some characteristics of two lytic bacteriophages against Salmonella enterica serovar Paratyphi B and Salmonella enterica serovar Typhimurium from various food sources.

FEMS Microbiol Lett 2021 Apr 8. Epub 2021 Apr 8.

Department of Biology, Faculty of Sciences, University of Isfahan. Isfahan, Iran.

Salmonellosis is an important worldwide food-borne disease. Increasing resistance to Salmonella spp. has been reported in recent years and now, the prevalence of multidrug resistant (MDR) Salmonella spp. Read More

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Drug-eluting bead bronchial arterial chemoembolization vs. chemotherapy in treating advanced non-small cell lung cancer: comparison of treatment efficacy, safety and quality of life.

Eur Rev Med Pharmacol Sci 2021 Mar;25(6):2554-2566

Department of Nuclear Medicine, The Eighth Medical Center of PLA General Hospital, Beijing, P.R. China.

Objective: This present study aimed to compare the treatment response, survival profile, quality of life (QoL), and safety between drug-eluting bead bronchial arterial chemoembolization (DEB-BACE) and chemotherapy in the treatment of advanced non-small-cell lung cancer (NSCLC).

Patients And Methods: Totally, 44 advanced NSCLC patients were analyzed retrospectively and were divided into DEB-BACE group (n=23) and chemotherapy group (n=21). Treatment response, European Organization for Research and Treatment of Cancer QoL Questionnaire-Core 30 (EORTC QLQ-C30), progression-free survival (PFS), overall survival (OS), and adverse events were assessed during the follow-up. Read More

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Mitochondria are involved in bronchial smooth muscle remodeling in severe preschool wheezers.

J Allergy Clin Immunol 2021 Apr 2. Epub 2021 Apr 2.

Univ-Bordeaux, Centre de Recherche Cardio-thoracique de Bordeaux, U1045, CIC 1401, F-33000 Bordeaux, France; INSERM, Centre de Recherche Cardio-thoracique de Bordeaux, U1045, CIC 1401, F-33000 Bordeaux, France; CHU de Bordeaux, Service d'exploration fonctionnelle respiratoire, Service de Pédiatrie médicale, Bordeaux, France. Electronic address:

Background: Bronchial remodeling is a key feature of asthma already present in preschool wheezers. Moreover, bronchial smooth muscle (BSM) remodeling at preschool age is predictive of asthma at school age. However, the mechanism responsible for BSM remodeling in preschool wheezers remains totally unknown. Read More

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COVID-19 Vaccine for Elderly: Should We Be Reactive or Proactive?

Acta Med Indones 2021 Jan;53(1):1-4

1. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia. 2. Clinical Epidemiology and Evidence-Based Medicine, Cipto Mangunkusumo Hospital, Jakarta, Indonesia..

It has been a year since the Indonesian government announced its first COVID-19 identified in Jakarta. Since then, there have been more than 900,000 cases in Indonesia with case fatality rate (CFR) of 2.9%. Read More

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January 2021

Venous thromboembolism in COVID-19: A systematic review and meta-analysis.

Vasc Med 2021 Apr 4:1358863X21995566. Epub 2021 Apr 4.

Third Department of Medicine, National and Kapodistrian University of Athens, School of Medicine, Sotiria Hospital, Athens, Greece.

Severe coronavirus disease 2019 (COVID-19) is associated with increased risk of venous thromboembolism events (VTE). This study performed a systematic review in PubMed/EMBASE of studies reporting the prevalence of VTE in patients with COVID-19 who were totally screened/assessed for deep vein thrombosis (DVT) and/or for pulmonary embolism (PE). Among 47 candidate studies ( = 6459; 33 in Europe), 17 studies ( = 3973; weighted age 63. Read More

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Application of Mixture Cure with the Doubly Censoring Model in Estimation of Initiation Age and Prevalence of Water-Pipe Smoking in Iran: a New Approach in Population-Based Studies.

Tanaffos 2020 Jul;19(3):243-249

Department of Epidemiology and Biostatistics, School of Public health, Tehran University of Medical Sciences, Tehran, Iran.

Background: The initiation age and prevalence of smoking water-pipe are two important parameters for establishing preventive policies. Thus, the present study was conducted to introduce a new approach for estimating and evaluating the effect of demographic variables on the initiation age and prevalence of smoking water-pipe.

Materials And Methods: The STEPwise approach for non-communicable disease risk factors surveillance (STEPS) 2011 data were used and daily smokers and non-smokers with the age range of 16 to 70 years were included in the study. Read More

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New ethical challenges in the management of rare pediatric diseases with innovative therapies.

Arch Pediatr 2021 Apr 1. Epub 2021 Apr 1.

Pediatric Neurology Department, Hôpital Timone Enfant, APHM, 263, rue Saint-Pierre, 13385 Marseille cedex 5, France; CNRS, EFS, UMR 7268 ADéS, Aix Marseille University, Marseille, France.

Introduction: Rare diseases, despite their low individual prevalence, affect a large number of children. Their management has considerably improved recently due to new treatments, modifying the diseases evolution without being totally curative. Since this raises many ethical dilemmas, we present a study about respecting the principles of medical ethics in the management of rare diseases in pediatrics. Read More

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In vivo effects of AZD4547, a novel fibroblast growth factor receptor inhibitor, in a mouse model of endometriosis.

Pharmacol Res Perspect 2021 Apr;9(2):e00759

NorthWest Centre for Advanced Drug Delivery (NoWCADD), School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

Endometriosis is a chronic disease, characterized by the growth of endometrial-like cells outside the uterine cavity. Due to its complex pathophysiology, a totally resolving cure is yet to be found. The aim of this study was to compare the therapeutic efficacy of AZD4547, a novel fibroblast growth factor receptor inhibitor (FGFRI), with a well-characterized progestin, etonogestrel (ENG) using a validated in vivo mouse model of endometriosis. Read More

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Pharmaceuticals Market, Consumption Trends and Disease Incidence Are Not Driving the Pharmaceutical Research on Water and Wastewater.

Int J Environ Res Public Health 2021 Mar 4;18(5). Epub 2021 Mar 4.

Tecnologico de Monterrey, School of Engineering and Science, Av. Eugenio Garza Sada Sur No. 2501, Col. Tecnológico, Monterrey 64849, Mexico.

Pharmaceuticals enhance our quality of life; consequently, their consumption is growing as a result of the need to treat ageing-related and chronic diseases and changes in the clinical practice. The market revenues also show an historic growth worldwide motivated by the increase on the drug demand. However, this positivism on the market is fogged because the discharge of pharmaceuticals and their metabolites into the environment, including water, also increases due to their inappropriate management, treatment and disposal; now, worldwide, this fact is recognized as an environmental concern and human health risk. Read More

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Managing Osteoporosis and Joint Damage in Patients with Rheumatoid Arthritis: An Overview.

Authors:
Yoshiya Tanaka

J Clin Med 2021 Mar 17;10(6). Epub 2021 Mar 17.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Kitakyushu 807-8555, Japan.

In rheumatoid arthritis, a representative systemic autoimmune disease, immune abnormality and accompanying persistent synovitis cause bone and cartilage destruction and systemic osteoporosis. Biologics targeting tumor necrosis factor, which plays a central role in the inflammatory process, and Janus kinase inhibitors have been introduced in the treatment of rheumatoid arthritis, making clinical remission a realistic treatment goal. These drugs can prevent structural damage to bone and cartilage. Read More

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[Protective function of electroacupuncture on young mouse model of Alzheimer's disease and proteomic study].

Zhongguo Zhen Jiu 2021 Mar;41(3):295-302

School of Basic Medicine, Henan University of CM, Zhengzhou 450046, China.

Objective: To screen protein target in prevention and treatment with electroacupuncture (EA) for Alzheimer's disease (AD) and explore the potential mechanism of EA in prevention of AD.

Methods: A total of 40 APP/PS1 transgenic young male mice, 1.5-month old, were randomized into an EA group and a model group, 20 mice in each one, and 20 C57BL/6J mice were chosen as the normal control group. Read More

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Not all anosmia and fever was COVID-19 infection: a case report.

Pan Afr Med J 2020 23;37:371. Epub 2020 Dec 23.

Neurosurgery Department, Mohamed V Military Training Hospital, Rabat, Morocco.

COVID-19 pandemic touch all part of world to the date more than fifteen millions of patients are infected by virus including about 1,388,926 deaths (European Centre for Disease Prevention and Control an agency of the European Union). Morocco has put in place strict containment measures to control the disease and prevent the saturation of health systems. One of the great difficulties is to quickly identify asymptomatic and paucisymptomatic cases which function as an important vector of contagion. Read More

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An Analysis of the Psychosocial Challenges Faced by the University Students During COVID-19 Pandemic, and the Students' Knowledge, Attitudes, and Practices Toward the Disease.

Noro Psikiyatr Ars 2021 Mar 15;58(1):3-10. Epub 2021 Feb 15.

Marmara University School of Medicine, Department of Psychiatry, Istanbul, Turkey.

Introduction: The aims of the present study were 1) to identify the major psychosocial challenges faced by students of a university in Istanbul, during the initial period of the COVID-19 outbreak, 2) to assess how these interacted with their level of knowledge, attitudes, and practices toward COVID-19 and the related health measures in place.

Methods: As part of an international research, a total of 2583 university students from Istanbul participated in an online survey, which included questions in several domains including their studies and daily life before and after the outbreak, their concerns and worries about the pandemic, their level of knowledge on COVID-19, their views on the policies implemented by the government and their institution, their attitude and practices toward the protective measures.

Results: Majority of the students reported to suffer from financial adversities due to the outbreak. Read More

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[Therapeutic effect of acupuncture combined with medication on chronic prostatitis of damp and heat stasis].

Zhongguo Zhen Jiu 2021 Feb;41(2):149-52

Zhongshan Hospital Affiliated to Guangzhou University of CM.

Objective: To observe the clinical therapeutic effect of electroacupuncture (EA) combined with tamsulosin hydrochloride sustained release capsule on chronic prostatitis (CP) of damp and heat stasis.

Methods: A total of 70 patients with CP of damp and heat stasis were randomized into an acupuncture plus medication group (35 cases, 4 cases dropped off) and a medication group (35 cases, 5 cases dropped off). In the medication group, tamsulosin hydrochloride sustained release capsule was given orally, 0. Read More

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February 2021

Relationship between CT Severity Score and Capillary Blood Oxygen Saturation in Patients with COVID-19 Infection.

Indian J Crit Care Med 2021 Mar;25(3):279-283

Department of Infectious Diseases, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

COVID-19 pneumonia is responsible for the latest pandemic. Usage of pulmonary computed tomography (CT) scan is known to be an important method in the diagnosis of COVID-19. Here, we aimed to evaluate the relationship between CT severity score and capillary blood oxygen saturation in patients with COVID-19 infection. Read More

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Risk Factors for Totally Implantable Central Venous Access Port-related Infection in Patients With Malignancy.

Anticancer Res 2021 Mar;41(3):1547-1553

Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Background: We sought to identify the risk factors of totally implantable central venous access port (TICVAP)-related infections in patients with malignant disease.

Patients And Methods: Overall, 324 consecutive patients who received a TICVAP at our institution were retrospectively analysed. We further analysed cases of TICVAP-related complications. Read More

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Reciprocal Correlations of Inflammatory and Calcium Signaling in Asthma Pathogenesis.

Adv Exp Med Biol 2021 ;1303:319-331

Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA.

Asthma is a chronic disease characterized by airway hyperresponsiveness, which can be caused by exposure to an allergen, spasmogen, or be induced by exercise. Despite its prevalence, the exact mechanisms by which the airway becomes hyperresponsive in asthma are not fully understood. There is evidence that myosin light-chain kinase is overexpressed, with a concomitant downregulation of myosin light-chain phosphatase in the airway smooth muscle, leading to sustained contraction. Read More

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