14,308 results match your criteria disease stabilization

A Case of a 49-Year-Old Man with Nonclassical Fabry Disease Diagnosed by Renal Biopsy.

Nephron 2021 Sep 14:1-4. Epub 2021 Sep 14.

Department of Nephrology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, China.

Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by mutations in the galactosidase A (GLA) gene that result in deficiency of α-GLA activity, leading to major organ failure and premature mortality. According to different disease courses, FD can be divided into classical and nonclassical phenotypes. The nonclassical FD phenotype is always absent of characteristic symptoms, which makes identifying it challenging. Read More

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September 2021

Impact of enzalutamide on patient-reported fatigue in patients with prostate cancer: data from the pivotal clinical trials.

Prostate Cancer Prostatic Dis 2021 Sep 13. Epub 2021 Sep 13.

Urology, University of Montréal Hospital Center, Montréal, QC, Canada.

Background: Fatigue is a multifactorial symptom commonly reported by patients with prostate cancer as a result of disease and treatment. This study assesses the impact enzalutamide has on patient-reported fatigue ("fatigue") by using patient-reported outcomes from four pivotal, placebo-controlled trials of enzalutamide (ARCHES (NCT02677896), PROSPER (NCT02003924), PREVAIL (NCT01212991), and AFFIRM (NCT00974311)).

Methods: Fatigue was assessed in the individual studies using the Functional Assessment of Cancer Therapy-Prostate item GP1 at baseline, weeks 13 or 17, and every 12 weeks until disease progression. Read More

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September 2021

Congenital Diaphragmatic Hernia: Core Review and Novel Updates.

Neonatal Netw 2021 Aug;40(5):305-312

Congenital diaphragmatic hernia (CDH) is a developmental defect in the diaphragm that allows abdominal viscera to herniate into the thoracic cavity. Pulmonary hypoplasia and pulmonary hypertension are consequences of this disease process. The incidence is approximately 2. Read More

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Acute Pancreatitis as the Index Manifestation of Parathyroid Adenoma.

Cureus 2021 Aug 6;13(8):e16948. Epub 2021 Aug 6.

Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.

Acute pancreatitis is one of the most common clinical emergencies encountered in our day-to-day practice. Although gallstones are the most common cause worldwide, alcohol consumption remains the leading cause of acute pancreatitis in the Indian population. We report a rare case of parathyroid adenoma, which presented with acute pancreatitis as its initial manifestation in an elderly patient. Read More

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Accelerated Recovery Program for Patients with Polysegmental Degenerative Lumbar Spine Disease.

Sovrem Tekhnologii Med 2021 1;13(2):74-81. Epub 2021 Jan 1.

Professor, Head of the Department of Neurosurgery and Innovative Medicine, Irkutsk State Medical University, 1 Krasnogo Vosstaniya St., Irkutsk, 664003, Russia; Chief of the Neurosurgery Center, Road Clinical Hospital, 10 Botkin St., Irkutsk, 664005, Russia; Professor, Department of Traumatology, Orthopedics, and Neurosurgery, Irkutsk State Medical Academy for Postgraduate Education, 100 Yubileyny Microdistrict, Irkutsk, 664049, Russia.

was to evaluate the effectiveness of the accelerated recovery program for patients with polysegmental degenerative diseases of the lumbar spine.

Materials And Methods: This prospective study included 53 patients who underwent two-level transforaminal interbody fusion in the L-S segments. Two groups were identified: in group 1 (n=24), operations were performed using the accelerated recovery program; in group 2 (n=29), open rigid stabilization was used under traditional intravenous anesthesia. Read More

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January 2021

Adapting Disease Prevention Protocols for Human Spaceflight During COVID-19.

Aerosp Med Hum Perform 2021 Jul;92(7):597-602

The National Aeronautics and Space Administration (NASA) Flight Crew Health Stabilization Program (HSP) was historically implemented to minimize infectious disease transmission to astronauts in the immediate prelaunch period. The first ever commercial application and adaptation of the NASA HSP was implemented during the Crew Demo-2 mission in the time of the Coronavirus disease 2019 (COVID-19) pandemic. This article details and discusses the first commercial implementation and adaptation of the HSP prior to the Crew Demo-2 launch. Read More

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S1P Stimulates Erythropoietin Production in Mouse Renal Interstitial Fibroblasts by S1P and S1P Receptor Activation and HIF-2α Stabilization.

Int J Mol Sci 2021 Aug 31;22(17). Epub 2021 Aug 31.

Institute of Pharmacology, University of Bern, Inselspital, INO-F, CH-3010 Bern, Switzerland.

Erythropoietin (Epo) is the critical hormone for erythropoiesis. In adults, Epo is mainly produced by a subset of interstitial fibroblasts in the kidney, with minor amounts being produced in the liver and the brain. In this study, we used the immortalized renal interstitial fibroblast cell line FAIK F3-5 to investigate the ability of the bioactive sphingolipid sphingosine 1-phosphate (S1P) to stimulate Epo production and to reveal the mechanism involved. Read More

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Tau Protein Interaction Partners and Their Roles in Alzheimer's Disease and Other Tauopathies.

Int J Mol Sci 2021 Aug 26;22(17). Epub 2021 Aug 26.

Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska Cesta 9, 845 10 Bratislava, Slovakia.

Tau protein plays a critical role in the assembly, stabilization, and modulation of microtubules, which are important for the normal function of neurons and the brain. In diseased conditions, several pathological modifications of tau protein manifest. These changes lead to tau protein aggregation and the formation of paired helical filaments (PHF) and neurofibrillary tangles (NFT), which are common hallmarks of Alzheimer's disease and other tauopathies. Read More

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Role of regulatory C-terminal motifs in synaptic confinement of LRRTM2.

Biol Cell 2021 Sep 9. Epub 2021 Sep 9.

Interdisciplinary Institute for Neuroscience, Centre National de la Recherche Scientifique, Bordeaux, 33077, France.

Leucine Rich Repeat Transmembrane proteins (LRRTMs) are neuronal cell adhesion molecules involved in synapse development and plasticity. LRRTM2 is the most synaptogenic isoform of the family, and its expression is strongly restricted to excitatory synapses in mature neurons. However, the mechanisms by which LRRTM2 is trafficked and stabilized at synapses remain unknown. Read More

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September 2021

HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells.

Aging (Albany NY) 2021 Sep 8;13(undefined). Epub 2021 Sep 8.

The Division of Ophthalmology and Vision Science, Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.

The senescence of retinal pigment epithelial (RPE) cells is associated with age-related macular degeneration (AMD), a leading cause of blindness in the world. HSP90 is a predominant chaperone that regulates cellular homeostasis under divergent physio-pathological conditions including senescence. However, the role of HSP90 in senescent RPE cells still remains unclear. Read More

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September 2021

Nucleic Acid Delivery for Therapeutic Applications.

Adv Drug Deliv Rev 2021 Sep 4:113834. Epub 2021 Sep 4.

David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

Recent medical advances have exploited the ability to address a given disease at the underlying level of transcription and translation. These treatment paradigms utilize nucleic acids - including short interfering RNA (siRNA), microRNA (miRNA), antisense oligonucleotides (ASO), and messenger RNA (mRNA) - to achieve a desired outcome ranging from gene knockdown to induced expression of a selected target protein. Towards this end, numerous strategies for encapsulation or stabilization of various nucleic acid structures have been developed in order to achieve intracellular delivery. Read More

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September 2021

Electrostatic Drivers of GPx4 Interactions with Membrane, Lipids, and DNA.

Biochemistry 2021 Sep 7. Epub 2021 Sep 7.

Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284, United States.

Glutathione peroxidase 4 (GPx4) serves as the only enzyme that protects membranes through the reduction of lipid hydroperoxides, preventing membrane oxidative damage and cell death through ferroptosis. Recently, GPx4 has gained attention as a therapeutic target for cancer through inhibition and as a target for inflammatory diseases through activation. In addition, GPx4 isoforms perform several distinct moonlighting functions including cysteine cross-linking of protamines during sperm cell chromatin remodeling, a function for which molecular and structural details are undefined. Read More

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September 2021

Crash Landing of Thyroid Storm: A Case Report and Review of the Role of Extra-Corporeal Systems.

Front Endocrinol (Lausanne) 2021 20;12:725559. Epub 2021 Aug 20.

Division of Endocrinology, Department of Medicine, National University Hospital, Singapore, Singapore.

Thyroid storm is a rare but life-threatening endocrinological emergency with significant mortality ranging from 10-30% with multi-organ involvement and failure. In view of the rarity of this condition and efficacy of established first line medical treatment, use of extra-corporeal treatments are uncommon, not well-studied, and its available evidence exists only from case reports and case series. We describe a 28-year-old man who presented with an out-of-hospital cardiac arrest secondary to thyroid storm. Read More

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The Course of Carotid Plaque Vulnerability Assessed by Advanced Neurosonology.

Front Neurol 2021 20;12:702657. Epub 2021 Aug 20.

Department of Neurology, Haukeland University Hospital, Bergen, Norway.

Carotid artery atherosclerosis is a major risk factor for ischemic stroke. This risk is related to plaque vulnerability and is characterized by plaque morphology, intraplaque neovascularization, and cerebral microembolization. Advanced neurosonology can identify vulnerable plaques and aid in preventing subsequent stroke. Read More

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Staged surgical management of sinus tarsi syndrome: our experience of 273 cases.

Ann Palliat Med 2021 Aug;10(8):8909-8918

Department of Orthopedics, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Background: The sinus tarsi syndrome (STS) is a common foot and ankle disease with controversial pathogenesis and treatment procedures. This long-term study aimed to analyze the effect of a staged surgical strategy for STS.

Methods: Clinical data were retrospectively analyzed in 273 STS patients [129 men and 144 women; mean age: 36 years (10-60 years)] treated between 2006 and 2016. Read More

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CRISPR/SpCas9-mediated double knockout of barley Microrchidia MORC1 and MORC6a reveals their strong involvement in plant immunity, transcriptional gene silencing and plant growth.

Plant Biotechnol J 2021 Sep 6. Epub 2021 Sep 6.

Institute of Phytopathology, Research Centre for BioSystems, Land Use and Nutrition, Justus Liebig University Giessen, D-35392, Giessen, Germany.

The Microrchidia (MORC) family proteins are important nuclear regulators in both animals and plants with critical roles in epigenetic gene silencing and genome stabilization. In the crop plant barley (Hordeum vulgare) seven MORC gene family members have been described. While barley HvMORC1 has been functionally characterized, very little information is available about other HvMORC paralogs. Read More

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September 2021

A Rapidly Stabilizing Water-Gated Field-Effect Transistor Based on Printed Single-Walled Carbon Nanotubes for Biosensing Applications.

ACS Appl Electron Mater 2021 Jul 1;3(7):3106-3113. Epub 2021 Jul 1.

Center for Nano Science and Technology @PoliMi, Istituto Italiano di Tecnologia, Via Giovanni Pascoli, 70/3, 20133 Milano, Italy.

Biosensors are expected to revolutionize disease management through provision of low-cost diagnostic platforms for molecular and pathogenic detection with high sensitivity and short response time. In this context, there has been an ever-increasing interest in using electrolyte-gated field-effect transistors (EG-FETs) for biosensing applications owing to their expanding potential of being employed for label-free detection of a broad range of biomarkers with high selectivity and sensitivity while operating at sub-volt working potentials. Although organic semiconductors have been widely utilized as the channel in EG-FETs, primarily due to their compatibility with cost-effective low-temperature solution-processing fabrication techniques, alternative carbon-based platforms have the potential to provide similar advantages with improved electronic performances. Read More

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Perioperative management of von Willebrand patients at the time of implant placement: Case report.

Clin Case Rep 2021 Sep 30;9(9):e04755. Epub 2021 Aug 30.

Department of Oral and Maxillofacial Surgery Nagoya City University Graduate School of Medical Sciences Nagoya Japan.

In the management of patients with type 1 von Willebrand disease, supplementation with Con Facto F as well as hemodynamic stabilization with appropriate analgesia and sedation may be important to reduce the risk of bleeding. Read More

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September 2021

Spontaneous massive hemothorax as a complication of necrotizing pneumonia in a patient with severe acute respiratory syndrome coronavirus 2 induced acute respiratory distress syndrome: a case report.

J Med Case Rep 2021 Sep 3;15(1):444. Epub 2021 Sep 3.

Department of Anaesthesiology and Intensive Care Medicine, Medical School Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Background: We present an unusual bleeding complication in a patient with severe acute respiratory distress syndrome in coronavirus disease 2019.

Case Presentation: The patient, a 63-year-old Caucasian man, received venovenous extracorporeal membrane oxygenation support after rapid deterioration of lung function on day 6 after admission to hospital. After initial stabilization on lung protective ventilation and prone positioning, he started to develop mild bleeding complications until he went into occult profound hemorrhagic shock. Read More

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September 2021

Structural Basis for Anti-non-alcoholic Fatty Liver Disease and Diabetic Dyslipidemia Drug Saroglitazar as a PPAR α/γ Dual Agonist.

Biol Pharm Bull 2021 ;44(9):1210-1219

Department of Health Chemistry, Showa Pharmaceutical University.

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor-type transcription factors that consist of three subtypes (α, γ, and β/δ) with distinct functions and PPAR dual/pan agonists are expected to be the next generation of drugs for metabolic diseases. Saroglitazar is the first clinically approved PPARα/γ dual agonist for treatment of diabetic dyslipidemia and is currently in clinical trials to treat non-alcoholic fatty liver disease (NAFLD); however, the structural information of its interaction with PPARα/γ remains unknown. We recently revealed the high-resolution co-crystal structure of saroglitazar and the PPARα-ligand binding domain (LBD) through X-ray crystallography, and in this study, we report the structure of saroglitazar and the PPARγ-LBD. Read More

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January 2021

An Overview of Potential Therapeutic Agents Targeting WNT/PCP Signaling.

Handb Exp Pharmacol 2021 Sep 1. Epub 2021 Sep 1.

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.

Since the discovery of the proto-oncogene Wnt1 (Int1) in 1982, WNT signaling has been identified as one of the most important pathways that regulates a wide range of fundamental developmental and physiological processes in multicellular organisms. The canonical WNT signaling pathway depends on the stabilization and translocation of β-catenin and plays important roles in development and homeostasis. The WNT/planar cell polarity (WNT/PCP) signaling, also known as one of the β-catenin-independent WNT pathways, conveys directional information to coordinate polarized cell behaviors. Read More

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September 2021

Promoting athero-protective immunity by vaccination with low density lipoprotein-derived antigens.

Atherosclerosis 2021 Aug 25. Epub 2021 Aug 25.

Oppenheimer Atherosclerosis Research Center, Department of Cardiology and Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA, 90048, USA.

Immune responses activated by LDL particles that have been trapped and oxidized in the arterial wall play an important role in atherosclerosis. Some of these immune responses are protective by facilitating the removal of pro-inflammatory and toxic lipid species formed as result of LDL oxidation. However, should these protective immune responses be insufficient, other more potent pro-inflammatory immune responses instead contributing to disease progression will gradually become dominant. Read More

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Formin Activity and mDia1 Contribute to Maintain Axon Initial Segment Composition and Structure.

Mol Neurobiol 2021 Aug 30. Epub 2021 Aug 30.

Instituto Cajal, CSIC, 28002, Madrid, Spain.

The axon initial segment (AIS) is essential for maintaining neuronal polarity, modulating protein transport into the axon, and action potential generation. These functions are supported by a distinctive actin and microtubule cytoskeleton that controls axonal trafficking and maintains a high density of voltage-gated ion channels linked by scaffold proteins to the AIS cytoskeleton. However, our knowledge of the mechanisms and proteins involved in AIS cytoskeleton regulation to maintain or modulate AIS structure is limited. Read More

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Surgical stabilization of rib fractures in symptomatic COVID-19: A case report.

Trauma Case Rep 2021 Oct 24;35:100522. Epub 2021 Aug 24.

OhioHealth Riverside Methodist Hospital, USA.

Severe chest wall injury following trauma is a significant contributing factor to respiratory failure and need for mechanical ventilation in multiply injured patients. Surgical stabilization of rib fractures (SSRF) is increasingly considered to be advantageous in this population. Surgical stabilization has been shown to improve multiple outcomes including ventilator avoidance, liberation from mechanical ventilation, and diminished pulmonary complications in the trauma population, particularly when performed early. Read More

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October 2021

Partial Inhibition of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 (PFKFB3) Enzyme in Myeloid Cells Does Not Affect Atherosclerosis.

Front Cell Dev Biol 2021 12;9:695684. Epub 2021 Aug 12.

Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, Netherlands.

Background: The protein 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) is a key stimulator of glycolytic flux. Systemic, partial PFKFB3 inhibition previously decreased total plaque burden and increased plaque stability. However, it is unclear which cell type conferred these positive effects. Read More

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Phytofabricated zinc oxide nanoparticles as a nanofungicide for management of Alternaria blight of Brassica.

Biometals 2021 Aug 29. Epub 2021 Aug 29.

Amity Institute of Microbial Technology, Amity University Uttar Pradesh, Noida, 201301, India.

Plant pathogens resistant to the commercially available fungicides and bactericides even at higher concentrations are the biggest challenge for the farmers to control the losses due to plant diseases. The antibacterial and antifungal potential of nanomaterials makes them a suitable candidate for the control of plant diseases. Thus, the present study reports the phytofabricated zinc oxide nanoparticles (ZnO Np's) using aqueous plant leaf extract of Terminalia bellerica (Baheda). Read More

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A phase I trial of lurbinectedin in combination with cisplatin in patients with advanced solid tumors.

Invest New Drugs 2021 Aug 28. Epub 2021 Aug 28.

Medical Oncology, Oncology Institute of Southern Switzerland, EOC, Bellinzona, Switzerland.

Background In vitro/in vivo data showed synergism of cisplatin and lurbinectedin in ovarian cancer cells and grafts. This phase I trial investigated the recommended phase II dose (RD) of cisplatin and lurbinectedin combination, with (Group A) or without aprepitant (Group B), in patients with advanced solid tumors. Patients and Methods All patients received 60 mg/m cisplatin 90-min intravenous (i. Read More

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Distinctive Supramolecular Features of β-Cyclodextrin Inclusion Complexes with Antidepressants Protriptyline and Maprotiline: A Comprehensive Structural Investigation.

Thammarat Aree

Pharmaceuticals (Basel) 2021 Aug 18;14(8). Epub 2021 Aug 18.

Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.

Depression, a global mental illness, is worsened due to the coronavirus disease 2019 (COVID-2019) pandemic. Tricyclic antidepressants (TCAs) are efficacious for the treatment of depression, even though they have more side effects. Cyclodextrins (CDs) are powerful encapsulating agents for improving molecular stability, water solubility, and lessening the undesired effects of drugs. Read More

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Posterior petrous face meningiomas presenting with Ménière's-like syndrome: a case series and review of the literature.

J Neurosurg 2021 Aug 27:1-8. Epub 2021 Aug 27.

Departments of1Neurological Surgery and.

Objective: Ménière's disease is an inner ear disorder classically characterized by fluctuating hearing loss, tinnitus, and aural fullness accompanied by episodic vertigo. While the pathogenesis of Ménière's remains under debate, histopathological analyses implicate endolymphatic sac dysfunction with inner ear fluid homeostatic dysregulation. Little is known about whether external impingement of the endolymphatic sac by tumors may present with Ménière's-like symptoms. Read More

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MACF1 controls skeletal muscle function through the microtubule-dependent localization of extra-synaptic myonuclei and mitochondria biogenesis.

Elife 2021 Aug 27;10. Epub 2021 Aug 27.

INSERM U1217,CNRS UMR5310, Université Claude Bernard Lyon I, INMG, Lyon, France.

Skeletal muscles are composed of hundreds of multinucleated muscle fibers (myofibers) whose myonuclei are regularly positioned all along the myofiber's periphery except the few ones clustered underneath the neuromuscular junction (NMJ) at the synaptic zone. This precise myonuclei organization is altered in different types of muscle disease, including centronuclear myopathies (CNMs). However, the molecular machinery regulating myonuclei position and organization in mature myofibers remains largely unknown. Read More

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