426,222 results match your criteria disease severity


The Current Status of Granulocyte-Colony Stimulating Factor to Treat Acute-on-Chronic Liver Failure.

Semin Liver Dis 2021 May 15. Epub 2021 May 15.

Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.

Patients with acute-on-chronic liver failure (ACLF) have a devastating prognosis and therapeutic options are limited. Granulocyte-colony stimulating factor (G-CSF) mobilizes immune and stem cells and possess immune-modulatory and proregenerative capacities. In this review, we aim to define the current evidence for the treatment with G-CSF in end-stage liver disease. Read More

View Article and Full-Text PDF

Sleep disturbance in school-aged children with atopic dermatitis: prevalence and severity in a cross-sectional sample.

J Allergy Clin Immunol Pract 2021 May 12. Epub 2021 May 12.

Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611.

Rationale: Atopic dermatitis(AD) causes sleep disturbance, yet the epidemiology is not known.

Objective: Estimate the US prevalence of sleep disturbance and its impact on psychological and neurocognitive function.

Methods: Cross-sectional survey of 180 parent-child dyads with AD, using stratified sampling based on disease severity(POEM,Patient Oriented Eczema Measure,mild(n=30)/moderate(n=75)/severe (n=75)), age, and race (White/Black or African American/Other). Read More

View Article and Full-Text PDF

QTL mapping in Fusarium graminearum identified an allele of FgVe1 involved in reduced aggressiveness.

Fungal Genet Biol 2021 May 12:103566. Epub 2021 May 12.

INRAE, MycSA, F-33882, Villenave d'Ornon, France. Electronic address:

Fusarium graminearum is one of the most frequent causal agents of the Fusarium Head Blight, a cereal disease spread throughout the world, reducing grain production and quality. F. graminearum isolates are genetically and phenotypically highly diverse. Read More

View Article and Full-Text PDF

Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis.

J Hepatol 2021 May 12. Epub 2021 May 12.

Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, UK; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust and the University of Oxford, Oxford, UK. Electronic address:

Background And Aims: Vibration-controlled transient elastography (VCTE), point shear wave elastography (pSWE), two-dimensional shear wave elastography (2DSWE), magnetic resonance elastography (MRE), and magnetic resonance imaging (MRI) are proposed as non-invasive tests for patients with non-alcoholic fatty liver disease (NAFLD). This study evaluated their diagnostic accuracy for liver fibrosis and non-alcoholic steatohepatitis (NASH).

Methods: PubMED/MEDLINE, EMBASE and the Cochrane Library were searched for studies examining the diagnostic accuracy of these index tests against histology as the reference standard, in adult patients with NAFLD. Read More

View Article and Full-Text PDF

Structure-guided design of ultrapotent disruptive IgE inhibitors to rapidly terminate acute allergic reactions.

J Allergy Clin Immunol 2021 May 12. Epub 2021 May 12.

Department of Structural Biology, Stanford University School of Medicine, Stanford California 94305; Progam in Immunology, Stanford University School of Medicine, Stanford California 94305; Sean N. Parker Center for Allergy Research at Stanford University. Electronic address:

Background: Anaphylaxis represents one of the most severe and fatal forms of allergic reactions. Like most other allergies, it is caused upon activation of basophils and mast cells by allergen-mediated cross-linking of immunoglobulin E (IgE) bound to its high affinity receptor FcεRI on the cell surface. The systemic release of soluble mediators induces an inflammatory cascade rapidly causing symptoms with peak severity in minutes to hours after allergen exposure. Read More

View Article and Full-Text PDF

Gut Microbiome Composition is Associated with COVID-19 Disease Severity.

Gastroenterology 2021 May 12. Epub 2021 May 12.

Department of Medicine, Division of Gastroenterology, Duke University, Durham, North Carolina.

View Article and Full-Text PDF

Nurr1 deficiency shortens free running period, enhances photoentrainment to phase advance, and disrupts circadian cycling of the dopamine neuron phenotype.

Behav Brain Res 2021 May 12:113347. Epub 2021 May 12.

East Carolina University, Department of Anatomy and Cell Biology, Brody School of Medicine, Greenville, NC, USA. Electronic address:

Neurological and neuropsychiatric disorders, including addiction, schizophrenia, and Parkinson's disease (PD), involve dysfunction in midbrain dopamine (DA) neurotransmission with severity of disease symptoms and progression associated with disrupted circadian rhythms. The nuclear transcription factor Nurr1, essential for DA neuron (DAN) development, survival, and maintenance, is also known to interact with circadian rhythm regulating clock proteins. In the Nurr1-null heterozygous (+/-) mice, a Nurr1 deficient model which reproduces some of the alterations in DA function found in schizophrenia and PD, we measured, using wheel-running activity, the free running period (tau) and photoperiod entrainment. Read More

View Article and Full-Text PDF

Dynamics of B cell repertoires and emergence of cross-reactive responses in patients with different severities of COVID-19.

Cell Rep 2021 May 9:109173. Epub 2021 May 9.

HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China; The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address:

Individuals with the 2019 coronavirus disease (COVID-19) show varying severity of the disease, ranging from asymptomatic to requiring intensive care. Although monoclonal antibodies specific to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been identified, we still lack an understanding of the overall landscape of B cell receptor (BCR) repertoires in individuals with COVID-19. We use high-throughput sequencing of bulk and plasma B cells collected at multiple time points during infection to characterize signatures of the B cell response to SARS-CoV-2 in 19 individuals. Read More

View Article and Full-Text PDF

Myosteatosis in NAFLD patients correlates with plasma Cathepsin D.

Biomol Concepts 2021 May 15;12(1):27-35. Epub 2021 May 15.

Department of Molecular Genetics, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Universiteitssingel 50, 6229ERMaastricht, the Netherlands.

Previously, we have shown that hepatic lipid accumulation induces the secretion of cathepsin D (CTSD), and that plasma CTSD levels are associated with increased inflammation and disease severity in nonalcoholic fatty liver disease (NAFLD). Although it is clear that the liver is a major source of plasma CTSD, it is unknown whether other metabolically active organs such as the muscle, also associate with plasma CTSD levels in NAFLD patients. Therefore, the aim of this study was to explore the relation between lipid accumulation in the muscle (myosteatosis) and plasma CTSD levels in forty-five NAFLD patients. Read More

View Article and Full-Text PDF

Incidence, characteristics and clinical profile of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in patients with pre-existing primary immune thrombocytopenia (ITP) in Spain.

Br J Haematol 2021 May 15. Epub 2021 May 15.

Hospital Universitario Virgen del Rocío, Sevilla, Spain.

Infections are one of the well-known precipitating factors for relapses in patients with immune thrombocytopenia (ITP). Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection can sometimes lead to or be associated with thrombocytopenia due to an increase in peripheral platelet destruction from inflammatory hyperactivation. Currently, we do not know if SARS-CoV-2 infection modifies the natural evolution of chronic or persistent ITP or if previous immunosuppression of patients with ITP influences the incidence and severity of coronavirus disease 2019 (COVID-19) in this group. Read More

View Article and Full-Text PDF

Tetracyclines and photosensitive skin reactions: a narrative review.

Dermatol Ther 2021 May 15:e14978. Epub 2021 May 15.

Department of Medical Sciences, Section of Dermatology and Infectious Diseases, University of Ferrara, Italy.

Tetracyclines are a group of broad-spectrum antibiotics largely employed in infectious, dermatological and surgical fields. Some adverse events may occur during treatment, including photosensitivity reactions, which are divided in phototoxic or photoallergic. We performed a systematic search on Pubmed, Cochrane and Embase from database inception to 9 Aug 2020 aim to summarize all available papers on photosensitive reactions related to Tetracyclines in all clinical settings where they are used on human being. Read More

View Article and Full-Text PDF

Assessment of Imaging Modalities Against Liver Biopsy in Nonalcoholic Fatty Liver Disease: The Amsterdam NAFLD-NASH Cohort.

J Magn Reson Imaging 2021 May 15. Epub 2021 May 15.

Department of Internal and Vascular Medicine, Amsterdam University Medical Centres, Amsterdam, The Netherlands.

Background: Noninvasive diagnostic methods are urgently required in disease stratification and monitoring in nonalcoholic fatty liver disease (NAFLD). Multiparametric magnetic resonance imaging (MRI) is a promising technique to assess hepatic steatosis, inflammation, and fibrosis, potentially enabling noninvasive identification of individuals with active and advanced stages of NAFLD.

Purpose: To examine the diagnostic performance of multiparametric MRI for the assessment of disease severity along the NAFLD disease spectrum with comparison to histological scores. Read More

View Article and Full-Text PDF

Characterizing Quality of Life in Caregivers of People with Parkinson's Disease and Dysphagia.

Dysphagia 2021 May 15. Epub 2021 May 15.

Laboratory for the Study of Upper Airway Dysfunction, Teachers College, Columbia University, New York, NY, USA.

Caring for a family member with dysphagia can negatively impact caregiver wellbeing, although little is known about how dysphagia severity or specific symptoms influence this. The purpose of this study was to examine how objective measures of dysphagia in people with Parkinson's disease influenced their caregivers' quality of life. Fifty caregivers (mainly spouses) of people with Parkinson's disease completed a caregiver quality of life survey. Read More

View Article and Full-Text PDF

Diabetes coexistent with Charcot-Marie-Tooth disease presenting as a recurrent foot ulcer misdiagnosed as diabetic foot: a case report.

J Diabetes Investig 2021 May 15. Epub 2021 May 15.

Innovation Center for Wound Repair, Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, P. R. China.

Both diabetes mellitus (DM) and Charcot-Marie-Tooth disease (CMT) can lead to severe peripheral neuropathy. The differential diagnosis of peripheral neuropathy is difficult due to the similar clinical features. There are still some clues, such as unusual muscle atrophy, unmatched severity of peripheral neurogenic damage with nephropathy or retinopathy, which could alert clinicians to make differential diagnosis. Read More

View Article and Full-Text PDF

Clinical and trichoscopic features in various forms of scalp psoriasis.

J Eur Acad Dermatol Venereol 2021 May 15. Epub 2021 May 15.

Dermatology -IRCCS Policlinico di Sant'Orsola - Department of Experimental, Diagnostic and Specialty Medicine (DIMES) Alma Mater, Studiorum University of Bologna, Italy.

Background: Scalp psoriasis is often undiagnosed or inadequately treated. The patient himself underestimates the seriousness of this hair disease and consults too late to a dermatologist.

Objectives: The aim of our study was to create a correlation between the clinical patterns and trichoscopy of scalp psoriasis such in a way to help the clinician to make the diagnosis and select the appropriate therapy. Read More

View Article and Full-Text PDF

Long-term efficacy and safety of intravenous injection of clonal mesenchymal stem cells derived from bone marrow in five adults with moderate to severe atopic dermatitis.

J Dermatol 2021 May 14. Epub 2021 May 14.

Department of Dermatology, Inha University School of Medicine, Incheon, Republic of Korea.

Atopic dermatitis is a chronic and relapsing inflammatory skin disease that is treated with immunosuppressants. However, long-term use of immunosuppressants may cause toxicity and severe side-effects. To confirm the long-term efficacy and safety of clonal mesenchymal stem cell therapy, we performed investigator-initiated clinical trials and long-term observation in five adult patients with moderate to severe atopic dermatitis that was refractory to conventional treatments. Read More

View Article and Full-Text PDF

Prevalence and genetic diversity of gastroenteritis viruses in hospitalized children < 5 years of age in Maharashtra state, Western India, 2017-2019.

J Med Virol 2021 May 15. Epub 2021 May 15.

King Edward Memorial Hospital, Pune, India.

Four gastroenteritis viruses were responsible for 54% of the acute gastroenteritis (AGE) cases in children hospitalized between May 2017 and December 2019 in Pune city of Maharashtra state, Western India. The majority (79%) of the children were < 2 years of age. The prevalence of Rotavirus A was 30. Read More

View Article and Full-Text PDF

Immunological aspects and gender bias during respiratory viral infections including novel Coronavirus disease-19 (COVID-19): a scoping review.

J Med Virol 2021 May 15. Epub 2021 May 15.

Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, 243 122, Uttar Pradesh, India.

The human immune system is not adequately equipped to eliminate new microbes, and could result in serious damage on first exposure. This is primarily attributed to the exaggerated immune response (inflammatory disease), which may prove detrimental to the host, as evidenced by SARS-CoV-2 infection. From the experiences of COVID-19 to date, male patients are likely to suffer from high-intensity inflammation and disease severity than the female population. Read More

View Article and Full-Text PDF

Vitamin D and COVID-19: Role of ACE2, Age, Gender and Ethnicity.

J Med Virol 2021 May 14. Epub 2021 May 14.

Howard University, College of Medicine, Department of Pharmacology, Washington DC, 20059.

COVID-19, caused by SARS-CoV-2 virus, disproportionally targets older people, particularly men, ethnic minorities and individuals with underlying diseases such as compromised immune system, cardiovascular disease and diabetes. The discrepancy in COVID-19 incidence and severity is multifaceted and likely involves biological, social, as well as nutritional status. Vitamin D deficiency, notably common in Black and Brown people and elderly, is associated with an increased susceptibility to many of the diseases comorbid with COVID-19. Read More

View Article and Full-Text PDF

Molecular identification of triticale introgression lines carrying leaf rust resistance genes transferred from Aegilops kotschyi Boiss. and Ae. tauschii Coss.

J Appl Genet 2021 May 14. Epub 2021 May 14.

Department of Genomics, Institute of Plant Genetics of the Polish Academy of Sciences, Strzeszyńska 34, 60-479, Poznań, Poland.

Triticale (× Triticosecale Wittmack) is a commercial hybrid harboring wheat (Triticum sp.) and rye (Secale cereale L.) genomes. Read More

View Article and Full-Text PDF

Severe COVID-19 and coagulopathy: A systematic review and meta-analysis.

Ann Acad Med Singap 2021 Apr;50(4):325-335

Cardiothoracic Intensive Care Unit, National University Heart Centre, National University Hospital, Singapore.

Introduction: Coronavirus disease 2019 (COVID-19)-induced coagulopathy (CIC) has been widely reported in the literature. However, the spectrum of abnormalities associated with CIC has been highly variable.

Methods: We conducted a systematic review of the literature (until 1 June 2020) to assess CIC and disease severity during the early COVID-19 pandemic. Read More

View Article and Full-Text PDF

Edmonton Obesity Staging System: an improvement by cardiopulmonary exercise testing.

Int J Obes (Lond) 2021 May 14. Epub 2021 May 14.

Center for the Study and Integrated Treatment of Obesity (CeSTIO), Internal Medicine 3, Department of Medicine, University of Padova, Padova, Italy.

Background/objectives: Different approaches are used to classify obesity severity. Beyond classical anthropometric measurements, the Edmonton Obesity Staging System (EOSS) considers medical, physical and psychological parameters. However, this method has some limitations, principally due to the absence of an objective measure for physical impairment. Read More

View Article and Full-Text PDF

G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis.

Commun Biol 2021 May 14;4(1):585. Epub 2021 May 14.

Johns Hopkins University, Department of Medicine, Division of Infectious Diseases, Baltimore, MD, USA.

G protein-coupled receptor (GPR)35 is highly expressed in the gastro-intestinal tract, predominantly in colon epithelial cells (CEC), and has been associated with inflammatory bowel diseases (IBD), suggesting a role in gastrointestinal inflammation. The enterotoxigenic Bacteroides fragilis (ETBF) toxin (BFT) is an important virulence factor causing gut inflammation in humans and animal models. We identified that BFT signals through GPR35. Read More

View Article and Full-Text PDF

JAK-inhibitors for coronavirus disease-2019 (COVID-19): a meta-analysis.

Leukemia 2021 May 14. Epub 2021 May 14.

Department of Hematologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

We analyzed reports on safety and efficacy of JAK-inhibitors in patients with coronavirus infectious disease-2019 (COVID-19) published between January 1st and March 6th 2021 using the Newcastle-Ottawa and Jadad scales for quality assessment. We used disease severity as a proxy for time when JAK-inhibitor therapy was started. We identified 6 cohort studies and 5 clinical trials involving 2367 subjects treated with ruxolitinib (N = 3) or baricitinib 45 (N = 8). Read More

View Article and Full-Text PDF

Predictive SNPs for β-thalassemia/HbE disease severity.

Sci Rep 2021 May 14;11(1):10352. Epub 2021 May 14.

Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand.

β-Thalassemia/HbE disease has a wide spectrum of clinical phenotypes ranging from asymptomatic to dependent on regular blood transfusions. Ability to predict disease severity is helpful for clinical management and treatment decision making. A thalassemia severity score has been developed from Mediterranean β-thalassemia patients. Read More

View Article and Full-Text PDF

The effect of levodopa on bilateral coordination and gait asymmetry in Parkinson's disease using inertial sensor.

NPJ Parkinsons Dis 2021 May 14;7(1):42. Epub 2021 May 14.

Department of Orthopaedic Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

This study aimed to evaluate the effect of levodopa on the phase coordination index (PCI) and gait asymmetry (GA) of patients with Parkinson's disease (PD) and to investigate correlations between the severity of motor symptoms and gait parameters measured using an inertial sensor. Twenty-six patients with mild-to-moderate-stage PD who were taking levodopa participated in this study. The Unified Parkinson's Disease Rating Scale part III (UPDRS III) was used to assess the severity of motor impairment. Read More

View Article and Full-Text PDF

Loss of the WNT9a ligand aggravates the rheumatoid arthritis-like symptoms in hTNF transgenic mice.

Cell Death Dis 2021 May 15;12(5):494. Epub 2021 May 15.

Department of Bone and Skeletal Research, Institute of Musculoskeletal Medicine, Medical Faculty of the Westphalian Wilhelm University, 48149, Münster, Germany.

Agonists and antagonists of the canonical Wnt signaling pathway are modulators of pathological aspects of rheumatoid arthritis (RA). Their activity is primarily modifying bone loss and bone formation, as shown in animal models of RA. More recently, modulation of Wnt signaling by the antagonist Sclerostin has also been shown to influence soft-tissue-associated inflammatory aspects of the disease pointing towards a role of Wnt signaling in soft-tissue inflammation as well. Read More

View Article and Full-Text PDF

Blastomycosis in 64 Wisconsin Children: Unanticipated Infection Risk and Severity in Urban Residents.

Pediatr Infect Dis J 2021 May 7. Epub 2021 May 7.

From the Department of Pediatrics, Medical College of Wisconsin, Wauwatosa, Wisconsin; Department of Pediatrics, Washington University in St. Louis, St. Louis, Missouri; Department of Pediatrics, Quantitative Health Sciences, Medical College of Wisconsin, Wauwatosa, Wisconsin; and Department of Pathology, Medical College of Wisconsin, Wauwatosa, Wisconsin.

Background: Blastomycosis, an endemic mycosis of immunocompetent individuals, is typically seen after exposure to waterways within rural wooded regions. It is not considered a disease of urban environments. Infection can be solely pneumonic or disseminate to skin, bone or central nervous system. Read More

View Article and Full-Text PDF

Coronavirus disease 2019, vitamin D and kidney function.

Curr Opin Nephrol Hypertens 2021 May 11. Epub 2021 May 11.

Columbia University Vagelos College of Physicians & Surgeons Division of Endocrinology Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.

Purpose Of Review: The purpose of this review is to summarize the emerging studies analyzing the association between vitamin D and risk of COVID-19 infection and severity, as well as the early interventional studies investigating the protective effect of vitamin D supplementation against COVID-19.

Recent Findings: Studies investigating the association between vitamin D levels and risk of COVID-19 infection and risk of severe disease and mortality among those infected have yielded mixed results. Thus far, the majority of studies investigating the association between vitamin D and COVID-19 have been observational and rely on vitamin D levels obtained at the time of admission, limiting causal inference. Read More

View Article and Full-Text PDF

WSM419 genes that improve symbiosis between Rm1021 and Jemalong A17 and in other symbiotic systems.

Appl Environ Microbiol 2021 May 14. Epub 2021 May 14.

Institute of Biological Chemistry and School of Molecular Biosciences, Washington State University, Pullman, WA 99164 USA

Some soil bacteria called rhizobia can interact symbiotically with legumes in which they form nodules on the plant roots where they can reduce atmospheric dinitrogen to ammonia, a form of nitrogen that can be used by growing plants. Rhizobia/plant combinations can differ in how successful this symbiosis is- Rm1021 forms a relatively ineffective symbiosis with Jemalong A17 but WSM419 is able to support more vigorous plant growth. Using proteomic data from free-living and symbiotic WSM419, we previously identified a subset of proteins that were not closely related to any Rm1021 proteins and speculated that adding one or more of these proteins to Rm1021 would increase its effectiveness on A17. Read More

View Article and Full-Text PDF