195,357 results match your criteria disease recurrence

Increased Body Mass Index Is a Risk Factor for Poor Clinical Outcomes after Radical Prostatectomy in Men with International Society of Urological Pathology Grade Group 1 Prostate Cancer Diagnosed with Systematic Biopsies.

Urol Int 2021 Jun 24:1-8. Epub 2021 Jun 24.

Department of Emergency and Organ Transplantation-Urology, Andrology and Kidney Transplantation Unit, University of Bari, Bari, Italy.

Introduction: The association between obesity and clinically significant prostate cancer (PCa) is still a matter of debate. In this study, we evaluated the effect of body mass index (BMI) on the prediction of pathological unfavorable disease (UD), positive surgical margins (PSMs), and biochemical recurrence (BCR) in patients with clinically localized (≤cT2c) International Society of Urological Pathology (ISUP) grade group 1 PCa at biopsy.

Methods: 427 patients with ISUP grade group 1 PCa who have undergone radical prostatectomy and BMI evaluation were included. Read More

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Minimally invasive surgery and abdominal radical hysterectomy in patients with early-stage cervical cancer: A meta-analysis.

Int J Gynaecol Obstet 2021 Jun 24. Epub 2021 Jun 24.

Department of Oncology, The First People's Hospital of Chenzhou, 423002, Hunan, China.

Objective: Risk of recurrence and death related to minimally invasive surgery (MIS) and abdominal radical hysterectomy (ARH) in with early-stage cervical cancer (CC) patients were compared.

Methods: All relevant literatures in databases were retrieved from the built time of databases to October, 2020. Observational studies comparing MIS and ARH in early-stage CC patients were involved. Read More

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Core outcome set for surgical trials in gastric cancer (GASTROS study): international patient and healthcare professional consensus.

Br J Surg 2021 Jun 24. Epub 2021 Jun 24.

Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Background: Surgery is the primary treatment that can offer potential cure for gastric cancer, but is associated with significant risks. Identifying optimal surgical approaches should be based on comparing outcomes from well designed trials. Currently, trials report different outcomes, making synthesis of evidence difficult. Read More

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Effect of Postoperative Radiotherapy for Patients With pIIIA-N2 Non-Small Cell Lung Cancer After Complete Resection and Adjuvant Chemotherapy: The Phase 3 PORT-C Randomized Clinical Trial.

JAMA Oncol 2021 Jun 24. Epub 2021 Jun 24.

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Importance: The role of postoperative radiotherapy (PORT) has not been well defined in resected pIIIA-N2 non-small cell lung cancer (NSCLC).

Objective: To evaluate the effect of PORT using modern techniques on survival and safety in patients with pIIIA-N2 NSCLC after complete resection and adjuvant chemotherapy.

Design, Setting, And Participants: The PORT-C randomized clinical trial was conducted in 394 patients with pIIIA-N2 NSCLC treated with complete resection and 4 cycles of platinum-based chemotherapy between January 2009 and December 2017. Read More

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Preventive and therapeutic effects of SHA113 and its culture supernatant on alcoholic gastric ulcers.

Food Funct 2021 Jun 24. Epub 2021 Jun 24.

Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyi West Road, Xi'an, Shanxi Province 710072, China.

Background: Alcoholic gastric ulcers are currently a common upper gastrointestinal disease with a high recurrence rate, causing gastric perforation or even gastric cancer in severe cases. Lactobacillus rhamnosus was previously found to prevent alcoholic gastric ulcers, but its therapeutic effects were not illustrated.

Aims: This study aims to illustrate the preventive and therapeutic effects of L. Read More

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Two decades of experience on ablation in children with Ebstein's anomaly.

Cardiol Young 2021 Jun 21:1-7. Epub 2021 Jun 21.

Department of Paediatric Cardiology, American Hospital, İstanbul, Turkey.

Introduction: Accessory pathways are commonly seen due to delamination of tricuspid valve leaflets. In addition to accessory pathways, an enlarged right atrium due to tricuspid regurgitation and incisional scars creates substrates for atrial re-entries and ectopic tachycardia. We sought to describe our experience with catheter ablation in children with Ebstein's anomaly. Read More

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Atrial fibrillation recurrence and spontaneous conversion to sinus rhythm after cardiac surgery: Insights from 426 patients with continuous rhythm monitoring.

J Cardiovasc Electrophysiol 2021 Jun 23. Epub 2021 Jun 23.

Department of Diagnostics and Monitoring Research, Medtronic plc, Mounds View, Minnesota, USA.

Introduction: Cardiac surgery may influence occurrence and persistence of atrial fibrillation (AF). In patients with a history of cardiac surgery and postoperative pacemaker or implantable cardioverter defibrillator implantation we attempted to quantify AF characteristics and investigate factors that influence AF recurrence.

Methods: In 426 patients (319 male; age: 73 SD: 9 years) with a history of cardiac surgery (364 CABG; 69 mitral valve; 57 aortic valve and 59 combination procedures) the heart rhythm history (mean: 351 days SD: 54 days) was reconstructed and investigated for AF recurrence patterns. Read More

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Bi-atrial or left atrial ablation of atrial fibrillation during concomitant cardiac surgery: A Bayesian network meta-analysis of randomized controlled trials.

J Cardiovasc Electrophysiol 2021 Jun 23. Epub 2021 Jun 23.

Department of Cardiac Surgery, Yunnan Fuwai Cardiovascular Hospital, Kunming Medical University, Kunming, China.

Objective: Surgical ablation of atrial fibrillation (AF) has became a routine procedure during concomitant cardiac surgery, however, the extension of lesion sets remained controversial. We sought to compare the relative benefit and risk of different lesion sets through a Bayesian network meta-analysis (NMA).

Methods: Pubmed, Embase and Cochrane Trials databases were searched for randomized controlled trials (RCTs) comparing the rhythm outcome of AF patients undergoing pulmonary vein isolation (PVI), left atrial Maze (LAM), bi-atrial Maze (BAM) or no ablation during concomitant cardiac surgery. Read More

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Prevalence and correlates of psychological distress, unmet supportive care needs, and fear of cancer recurrence among haematological cancer patients during the COVID-19 pandemic.

Support Care Cancer 2021 Jun 23. Epub 2021 Jun 23.

Leukaemia Foundation, Brisbane, QLD, Australia.

Background: The COVID-19 pandemic has had a disruptive effect on people with haematological cancers, who represent a high-risk population due to the nature of their disease and immunosuppressive treatments. We aimed to identify the psychological impacts of the COVID-19 pandemic on haematology patients and identify correlated factors to inform the development of appropriate supportive interventions.

Methods: Three hundred and ninety-four respondents volunteered their participation in response to a study advertisement distributed online through established haematology groups. Read More

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Paraesophageal hernia: to fundoplicate or not?

Ann Transl Med 2021 May;9(10):902

Department of General Surgery, Rabin Medical Center, Campus Beilinson, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, Petach-Tikva, Israel.

The need for an antireflux procedure during repair of a paraesophageal hernia (PEH) has been the subject of a long-standing controversy. With most centers now performing routine fundoplication during PEH repair, high-quality data on whether crural repair alone or using a mesh may provide adequate anti-reflux effect is still scarce. We sought to answer to the question: "Is fundoplication routinely needed during PEH repair?". Read More

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Surgical reconstruction of massive scrotal lymphedema associated with hidradenitis suppurativa: a case report.

Gland Surg 2021 May;10(5):1800-1805

Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory cutaneous disease affecting apocrine glands. It can be associated with lymphedema of the surrounding tissues and most commonly affects scrotum. As a debilitating complication of HS, lymphedema can cause significant morbidity and further exacerbate HS condition, thus causing a vicious cycle. Read More

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Complete disease remission in a and co-mutated brain oligometastatic lung cancer patient after immuno-chemotherapy and surgical resection: a case report.

Transl Lung Cancer Res 2021 May;10(5):2298-2305

Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin, China.

Lung cancer is the most common primary malignancy and tends to metastasize to the brain. A multimodal approach, including systematic therapy (targeted therapy, chemotherapy, immunotherapy) and local consolidative therapy (surgical intervention, radiation therapy, ablation therapy), is essential for treatment of oligometastatic lung cancer. The systemic immunotherapy has been shown to increase response rate and survival, which then has the potential benefit of making localized treatment more feasible for some cases of oligometastatic cancer. Read More

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Hippocampal avoidance in prophylactic cranial irradiation for small cell lung cancer: benefits and pitfalls.

J Thorac Dis 2021 May;13(5):3235-3245

Department of Radiation Oncology, Cross Cancer Institute, Edmonton, Canada.

Small cell lung cancers (SCLC) are a group of cancers that are clinically and pathologically different from other lung cancers. They are associated with high recurrence rates and mortality, and many patients present with metastatic disease. Approximately ten percent of SCLC patients have brain metastases at time of diagnosis, and the cumulative incidence of brain metastases increases to more than fifty percent at two years, even with optimal treatment. Read More

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Decreased expression of Dlg5 is associated with a poor prognosis and epithelial-mesenchymal transition in squamous cell lung cancer.

J Thorac Dis 2021 May;13(5):3115-3125

Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Background: Discs large homolog 5 (Dlg5) is a newly discovered member of the membrane-associated guanylate kinase superfamily (MAGUK) that is involved in several important processes, including the maintenance of epithelial cell polarity, cell proliferation control, and cell migration and invasion. Decreased expression of Dlg5 has been reported in malignancies arising from different organs. In the present study, we analyzed Dlg5 expression and its prognostic value in squamous cell lung cancer (SqCLC). Read More

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Preoperative inflammation-based scores predict early recurrence after lung cancer resection.

J Thorac Dis 2021 May;13(5):2812-2823

Department of Surgery, Yokohama City University, Yokohama, Japan.

Background: Inflammation in the tumor microenvironment is hypothesized to have a major role in cancer invasiveness, progression, and metastases. The purpose of this study was to evaluate the prognostic value of preoperative inflammation-based scores in terms of estimating the timing of recurrence by hazard curves in a cohort of operable, early-stage non-small cell lung cancer (NSCLC) patients.

Methods: A total of 387 patients with NSCLC who underwent complete pulmonary resection from 2010 to 2019 had their C-reactive protein-to-albumin ratio (CAR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), Glasgow prognostic score (GPS), modified GPS, systemic immune-inflammation index (SII), and advance lung cancer inflammation index (ALI) measurements taken before surgery. Read More

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Yield of surgery in solid pseudopapillary neoplasms of the pancreas: A case series and literature review.

World J Gastrointest Oncol 2021 Jun;13(6):589-599

Department of Surgery of the Upper Digestive System, São Rafael Hospital/Rede D'Or Hospital Group, Salvador 41253-190, Bahia, Brazil.

Background: Solid pseudopapillary neoplasms (SPN) of the pancreas represents approximately 2% of non-endocrine tumors of the pancreas. It is described in the literature as a rare and predominant tumor in young women.

Aim: To report a case series with SPN and analyzing clinical, surgical, anatomopathological characteristics, as well as the prognosis and review of literature. Read More

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Recurrent Miller Fisher: A Case Report Along With a Literature and an EMG/NCS Review.

Neurohospitalist 2021 Jul 19;11(3):263-266. Epub 2021 Jan 19.

Department of Neurology, The Ohio State University, Columbus, OH, USA.

MFS has been reported to recur in 10-12% of patients. There may be a genetic component related to HLA-DR2. Anti-GAD antibodies can be present in MFS along with anti-GQ1b. Read More

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Identifying the 'Active Ingredients' of an Effective Psychological Intervention to Reduce Fear of Cancer Recurrence: A Process Evaluation.

Front Psychol 2021 7;12:661190. Epub 2021 Jun 7.

Cincinnati Children's Center for Heart Disease and Mental Health, Heart Institute and the Division of Behavioral Medicine & Clinical Psychology, Cincinnati Children's Hospital, Cincinnati, OH, United States.

Psychological interventions targeting fear of cancer recurrence (FCR) are effective in reducing fear and distress. Process evaluations are an important, yet scarce adjunct to published intervention trials, despite their utility in guiding the interpretation of study outcomes and optimizing intervention design for broader implementation. Accordingly, this paper reports the findings of a process evaluation conducted alongside a randomized controlled trial of a psychological intervention for melanoma patients. Read More

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Combination of Pertuzumab and Trastuzumab in the Treatment of HER2-Positive Early Breast Cancer: A Review of the Emerging Clinical Data.

Breast Cancer (Dove Med Press) 2021 14;13:393-407. Epub 2021 Jun 14.

Department of Solid Tumor Oncology and Investigational Therapeutics, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.

Human epidermal growth factor receptor type 2 (HER2) is a relevant and effective target in breast cancer. The development of monoclonal antibodies against HER2 has revolutionized the treatment of HER2-positive breast cancer. The humanized monoclonal antibody, trastuzumab, was the first in its class to be widely adopted. Read More

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Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma.

Sci Rep 2021 Jun 23;11(1):13192. Epub 2021 Jun 23.

School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW, Australia.

Perineural invasion (PNI) is frequently associated with aggressive clinical behaviour in head and neck cutaneous squamous cell carcinoma (HNcSCC) leading to local recurrence and treatment failure. This study evaluates the gene expression profiles of HNcSCC with PNI using a differential expression analysis approach and constructs a tailored gene panel for sensitivity and specificity analysis. 45 cases of HNcSCC were stratified into three groups (Extensive, Focal and Non PNI) based on predefined clinicopathological criteria. Read More

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Salvage re-irradiation using stereotactic body radiation therapy for locally recurrent prostate cancer: the impact of castration sensitivity on treatment outcomes.

Radiat Oncol 2021 Jun 23;16(1):114. Epub 2021 Jun 23.

Radiation Oncology Department, Sheba Medical Center, 52621, Ramat-Gan, Israel.

Background: Advances in imaging, biomaterials and precision radiotherapy provide new opportunities to salvage locally recurrent prostate cancer (PC). This study evaluates the efficacy and safety of re-irradiation using stereotactic body radiation therapy (SBRT). We hypothesized that patients with castrate-resistant PC (CRPC) would benefit less from local salvage. Read More

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Ga-prostate-specific membrane antigen (PSMA) PET/CT as a clinical decision-making tool in biochemically recurrent prostate cancer.

Asia Pac J Clin Oncol 2021 Jun 23. Epub 2021 Jun 23.

Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.

Objective: PSMA PET/CT has demonstrated superior sensitivity over conventional imaging in the detection of local and distant recurrence in biochemically relapsed (BCR) prostate cancer. We prospectively investigated the management impact of Ga-PSMA PET/CT imaging in men with BCR, with the aim of identifying baseline clinicopathological predictors for management change.

Patients And Methods: Men with BCR who met eligibility criteria underwent Ga-PSMA-11 PET/CT at Monash Health (Melbourne, Australia). Read More

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The impact of fertility preservation on the timing of breast cancer treatment, recurrence, and survival.

Cancer 2021 Jun 23. Epub 2021 Jun 23.

Center for Infertility and Reproductive Surgery, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, Massachusetts.

Background: Many young women with breast cancer undergo fertility preservation (FP) before cancer treatment. This study examined the impact of FP on breast cancer outcomes.

Methods: The authors performed a retrospective cohort study of 272 women aged 20 to 45 years with newly diagnosed stage 0 to III breast cancer who underwent an FP consultation between 2005 and 2017. Read More

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Clinical Characteristics, Classification, and Management of Adult Nasopharyngolaryngeal Hemangioma.

Laryngoscope 2021 Jun 23. Epub 2021 Jun 23.

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, People's Republic of China.

Objectives/hypothesis: To analyze the clinical features, classification, and treatment of adult nasopharyngolaryngeal hemangioma (ANPLH).

Study Design: Retrospective study.

Methods: From February 2009 to May 2020, 101 patients with ANPLH were reviewed and analyzed. Read More

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Clinical implications of age and excellent response to therapy in patients with high-risk differentiated thyroid carcinoma.

Clin Endocrinol (Oxf) 2021 Jun 23. Epub 2021 Jun 23.

Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 0550.

Background: Patients with American Thyroid Association (ATA) high-risk differentiated thyroid carcinoma (DTC) have poor clinical outcomes. This study aimed to evaluate the clinical implications of age and response to therapy classification in patients with ATA high-risk DTC.

Design And Patients: This study included 222 patients with high-risk DTC who initially underwent therapy between 2000 and 2010 in a single tertiary center in Korea. Read More

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Treatment and survival outcomes of ceruminous carcinomas of the external auditory canal: a SEER database analysis and literature review.

Arch Dermatol Res 2021 Jun 23. Epub 2021 Jun 23.

Division of Dermatology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Ohio State Officenter Gahanna, 540 Officenter Place Suite 240, Columbus, OH, 43230, USA.

Ceruminous carcinomas of the external auditory canal (EAC), encompassing adenoid cystic carcinoma (ACC), ceruminous adenocarcinoma (CA), and mucoepidermoid carcinoma (MEC), are extremely rare with little known regarding the influence of demographics, tumor characteristics, and treatment on survival. This study aimed to summarize existent data and describe prognostic factors affecting survival in ceruminous carcinoma. Cases of ceruminous carcinoma of the EAC in the Surveillance, Epidemiology, and End Results (SEER) database were analyzed to provide demographic, cancer-related, and treatment data and assess their influence on disease-specific and overall survival. Read More

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Recurrent neonatal sepsis and progressive white matter injury in a premature newborn culture-positive for group B Streptococcus: A case report.

Medicine (Baltimore) 2021 Jun;100(25):e26387

Department of Pediatrics, Incheon Worker's Compensation Hospital, Incheon.

Rationale: Group B Streptococcus (GBS) remains a principal pathogen causing neonatal sepsis and meningitis, particularly in premature infants with relatively insufficient immunity. Recurrence may occur uncommonly, largely associated with subclinical mucosal persistence or repetitive exposure to exogenous sources. White matter injury (WMI) including cystic periventricular leukomalacia (PVL) has been associated with intrauterine infection/inflammation, and neonatal infection as a more significant predictor including postnatal sepsis and recurrent infection, even without microbial neuroinvasion. Read More

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Graves disease and metastatic hormonal-active Hürthle cell thyroid cancer: A case report.

Medicine (Baltimore) 2021 Jun;100(25):e26384

Faculty of Medicine Ljubljana.

Rationale: A hormone-active metastatic Hürthle cell thyroid carcinoma (HCTC) and Graves disease (GD) present a therapeutic challenge and is rarely reported.

Patient Concerns: We present a 64-year-old male patient, who had dyspnea and left hip pain lasting 4 months. He had clinical signs of hyperthyroidism and a tumor measuring 9 cm in diameter of the left thyroid lobe, metastatic neck lymph node and metastases in the lungs, mediastinum, and bones. Read More

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Novel Treatment for Glioblastoma Delivered by a Radiation Responsive and Radiopaque Hydrogel.

ACS Biomater Sci Eng 2021 Jun 23. Epub 2021 Jun 23.

Department of Radiology, University of Pennsylvania, 3400 Spruce Street, 1 Silverstein Philadelphia, Pennsylvania 19104, United States.

Successful treatment of glioblastoma (GBM) is hampered by primary tumor recurrence after surgical resection and poor prognosis, despite adjuvant radiotherapy and chemotherapy. In search of improved outcomes for this disease, quisinostat appeared as a lead compound in drug screening. A delivery system was devised for this drug and to exploit current clinical methodology: an injectable hydrogel, loaded with both the quisinostat drug and radiopaque gold nanoparticles (AuNP) as contrast agent, that can release these payloads as a response to radiation. Read More

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Wiad Lek 2021 ;74(6):1331-1335


Objective: The aim: The purpose of research is to improve the effectiveness of treatment by applying laser in complex treatment in patients with herpetic stomatitis.

Patients And Methods: Materials and methods: Were examined 47 people (22 men and 25 women) with acute herpetic stomatitis. The patіents' age was from 20 to 72 years. Read More

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