454,371 results match your criteria disease progression


Progression-Free Survival at 24 Months as A Landmark After Autologous Stem Cell Transplant in Relapsed or Refractory Diffuse Large B-cell Lymphoma.

Transplant Cell Ther 2022 Jun 22. Epub 2022 Jun 22.

Division of Hematology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL) who achieve progression-free survival (PFS) at 24 months (PFS24) following immunochemotherapy (IC) have excellent overall survival (OS) comparable to that of the age- and sex-matched general population. However, a similar landmark has not been established for patients with relapsed or refractory (RR) DLBCL following frontline IC who are subsequently treated with salvage therapy followed by autologous stem cell transplant (ASCT).

Objective: To evaluate the role of PFS24 as a landmark after ASCT in patients with RR DLBCL. Read More

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Impact of operability and total metastatic ablation on outcomes after stereotactic ablative radiotherapy (SABR) for oligometastases.

Int J Radiat Oncol Biol Phys 2022 Jun 22. Epub 2022 Jun 22.

Department of Radiation Oncology, Peter MacCallum Cancer Centre, Victoria, Australia.

Purpose: Medical operability is prognostic for survival after SABR in primary malignancies. This study investigates the prognostic significance of medical operability and total versus subtotal ablation of all oligometastatic disease sites.

Material/methods: Consecutive patients with 1-5 sites of active extracranial oligometastases had medical operability status and presence of subtotal versus total metastatic ablation recorded prospectively on an institutional database. Read More

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Polyol Pathway and Redox Balance in Diabetes.

Pharmacol Res 2022 Jun 22:106326. Epub 2022 Jun 22.

Department of Biochemistry, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab, India. Electronic address:

Diabetes is a major public health disease that is globally approaching epidemic proportions. One of the major causes of type 2 diabetes is either a defect in insulin secretion or insulin action which is usually caused by a combination of genetic and environmental factors. Not only these factors but others such as deregulation of various pathways, and oxidative stress are also known to trigger the redox imbalance in diabetics. Read More

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Results from a national-wide retrospective cohort measure the impact of C3 and soluble C5b-9 levels on kidney outcomes in C3 glomerulopathy.

Kidney Int 2022 Jun 22. Epub 2022 Jun 22.

INSERM UMRS1138, Centre de Recherche des Cordeliers, Team "Inflammation, Complement and cancer", Paris, France; Assistance Publique-Hôpitaux de Paris, Hopital Européen Georges Pompidou, Department of Immunology, Paris, France.

C3 glomerulopathy (C3G) is a rare complement-mediated disease. Specific treatments are not yet available and factors predictive of kidney survival such as age, kidney function and proteinuria are not specific to C3G. The prognostic value of biomarkers of complement activation, which are pathognomonic of the diseases, remain unknown. Read More

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3D printing of a controlled fluoride delivery device for the prevention and treatment of tooth decay.

J Control Release 2022 Jun 22. Epub 2022 Jun 22.

Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland. Electronic address:

Dental decay is a highly prevalent chronic disease affecting people from all ages. Clinically, fluoride supplementation is the primary strategy in the prevention of dental decay. However, the current existing self-application formulations such as gels or mouthwashes are rapidly cleared after administration, resulting in modest efficacy even after repeated applications. Read More

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Characteristics of tumor infiltrating lymphocytes in sinonasal mucosal melanoma and prognosis for patients.

Curr Probl Cancer 2022 Jun 11;46(4):100878. Epub 2022 Jun 11.

Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Electronic address:

The significance of tumor infiltrating lymphocytes (TILs) in melanoma has been studied for a long time, but, to date, there has been insufficient research on TILs in sinonasal mucosal melanoma. The purpose of this study was to analyze the correlation between TILs and prognosis for Chinese patients with sinonasal mucosal melanoma, and to clarify the significance of TILs in prognosis. As a retrospective cohort study, 44 cases of malignant melanoma in head and neck mucosa were studied by immunohistochemical staining. Read More

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Artemisia Leaf Extract protects against neuron toxicity by TRPML1 activation and promoting autophagy/mitophagy clearance in both in vitro and in vivo models of MPP+/MPTP-induced Parkinson's disease.

Phytomedicine 2022 Jun 15;104:154250. Epub 2022 Jun 15.

Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan. Electronic address:

Background: Parkinson's disease (PD) is a neurodegenerative disorder involving the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Cellular clearance mechanisms, including the autophagy-lysosome pathway, are commonly affected in the pathogenesis of PD. The lysosomal Ca channel mucolipin TRP channel 1 (TRPML1) is one of the most important proteins involved in the regulation of autophagy. Read More

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Riociguat attenuates left ventricular proteome and microRNA profile changes after experimental aortic stenosis in mice.

Br J Pharmacol 2022 Jun 25. Epub 2022 Jun 25.

German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.

Background And Purpose: Development and progression of heart failure (HF) involve endothelial and myocardial dysfunction as well as a dysregulation of the nitric oxide - soluble guanylyl cyclase - cyclic guanosine monophosphate (NO-sGC-cGMP) signalling pathway. Recently, we reported that the sGC stimulator riociguat (RIO) has beneficial effects on cardiac remodelling and progression of HF in response to chronic pressure overload. Here, we examined if these favourable RIO effects are also reflected in alterations of the myocardial proteome and microRNA profiles. Read More

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Adipokines and coronary artery calcification in incident dialysis participants.

Endocrine 2022 Jun 25. Epub 2022 Jun 25.

Kidney and Hypertension Unit, Joslin Diabetes Center, Boston, MA, USA.

Purpose: Adipokines have been associated with increased risk of cardiovascular disease. Our aim was to determine if adipokine levels are associated with coronary artery calcification (CAC) as well as all-cause mortality in incident dialysis patients.

Methods: In patients new to dialysis, we prospectively investigated the association of adiponectin, leptin and resistin with coronary artery calcification measured by ECG-gated computer tomography. Read More

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A Narrative Review of Diabetic Kidney Disease: Previous and Current Evidence-Based Therapeutic Approaches.

Authors:
Akira Mima

Adv Ther 2022 Jun 25. Epub 2022 Jun 25.

Department of Nephrology, Osaka Medical and Pharmaceutical University, Osaka, 569-8686, Japan.

Diabetic kidney disease (DKD) is one of the most important diabetic complications. DKD is also the most common cause of chronic kidney disease (CKD) and end-stage renal disease. This review focused on potential therapeutic drugs for which there is established evidence of treatment for DKD. Read More

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Investigating the use of plasma pTau181 in retired contact sports athletes.

J Neurol 2022 Jun 25. Epub 2022 Jun 25.

Tanz Centre for Research in Neurodegenerative Diseases, Krembil Discovery Tower, University of Toronto, 60 Leonard Avenue, 6th floor 6KD-407, Toronto, ON, M5T 2S8, Canada.

Background: Considering the wide range of outcomes following sport-related concussions, biomarkers are needed to detect underlying pathological changes. The objective was to analyze the use of plasma phosphorylated tau 181 (pTau181) as a non-invasive measure of underlying brain changes in a cohort of retired contact sports athletes at risk of neurodegeneration.

Methods: Fifty-four retired contact sport athletes and 27 healthy controls whose blood plasma was analyzed for pTau181 were included. Read More

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Olfactory Bulb Amyloid-β Correlates With Brain Thal Amyloid Phase and Severity of Cognitive Impairment.

J Neuropathol Exp Neurol 2022 Jun 25. Epub 2022 Jun 25.

Department of Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona, USA.

The Alzheimer disease (AD) neuropathological hallmarks amyloid β (Aβ) and tau neurofibrillary (NF) pathology have been reported in the olfactory bulb (OB) in aging and in different neurodegenerative diseases, which coincides with frequently reported olfactory dysfunction in these conditions. To better understand when the OB is affected in relation to the hierarchical progression of Aβ throughout the brain and whether OB pathology might be an indicator of AD severity, we assessed the presence of OB Aβ and tau NF pathology in an autopsy cohort of 158 non demented control and 173 AD dementia cases. OB Aβ was found in less than 5% of cases in lower Thal phases 0 and 1, in 20% of cases in phase 2, in 60% of cases in phase 3 and in more than 80% of cases in higher Thal phases 4 and 5. Read More

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The relationship between fatigue severity and mild cognitive impairment in Saudi patients with type 2 diabetes mellitus.

J Pak Med Assoc 2022 Jun;72(6):1255-1259

Department of Physiology, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Type 2 Diabetes Mellitus (T2DM) is a major health issue in Saudi Arabia, with a prevalence of 23.7% in 2015. Several factors contribute to the occurrence of Mild Cognitive Impairment (MCI) and its progression to Alzheimer's disease in patients with T2DM. Read More

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Automatic cyst and kidney segmentation in autosomal dominant polycystic kidney disease: Comparison of U-Net based methods.

Comput Biol Med 2022 Jul 9;146:105431. Epub 2022 Apr 9.

Department of Management, Information and Production and Engineering, University of Bergamo, Dalmine, BG, Italy. Electronic address:

Autosomal Dominant Polycystic Kidney Disease is a genetic disease that causes uncontrolled growth of fluid-filled cysts in the kidney. Kidney enlargement resulting from the expansion of cysts is continuous and often associated with decreased renal function and kidney failure. Mouse and rat models are necessary to discover new drugs able to halt the progression of the disease. Read More

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Hereditary transthyretin amyloidosis: a case report.

J Med Case Rep 2022 Jun 25;16(1):248. Epub 2022 Jun 25.

Division of Neurology, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: Hereditary transthyretin amyloidosis is an uncommon multisystem disorder caused by mutation of the transthyretin protein, leading to peripheral neuropathy often with autonomic features, cardiomyopathy, or a mixed phenotype. Multiple other organ systems can be involved with ophthalmologic, renal, hematologic, gastrointestinal, and/or genitourinary symptoms and signs. This often results in assessments by multiple specialists and significant delays before the diagnosis is recognized. Read More

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Endotracheal tube microbiome in hospitalized patients defined largely by hospital environment.

Respir Res 2022 Jun 24;23(1):168. Epub 2022 Jun 24.

Corporación CorpoGen Research Center, Bogotá, Colombia.

Background: Studies of the respiratory tract microbiome primarily focus on airway and lung microbial diversity, but it is still unclear how these microbial communities may be affected by intubation and long periods in intensive care units (ICU), an aspect that today could aid in the understanding of COVID19 progression and disease severity. This study aimed to explore and characterize the endotracheal tube (ETT) microbiome by analyzing ETT-associated microbial communities.

Methods: This descriptive study was carried out on adult patients subjected to invasive mechanical ventilation from 2 to 21 days. Read More

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Blastic plasmacytoid dendritic cell neoplasm and cerebral toxoplasmosis: a case report.

BMC Neurol 2022 Jun 24;22(1):233. Epub 2022 Jun 24.

Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark.

Background: The present case contributes to the limited literature on central nervous system involvement of blastic plasmacytoid dendritic cell neoplasm (BPDCN).  CASE PRESENTATION : A 63-year-old male presented to the department of neurology with a three-day history of rapidly progressing headache, fatigue, and confusion. Physical examination revealed multiple bruise-like skin lesions. Read More

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Association of underlying comorbidities and progression of COVID-19 infection amongst 2586 patients hospitalised in the National Capital Region of India: a retrospective cohort study.

Mol Cell Biochem 2022 Jun 25. Epub 2022 Jun 25.

Department of Research, Sir Ganga Ram Hospital, New Delhi, 110060, India.

This study is conducted to observe the association of diabetes (DM), hypertension (HTN) and chronic kidney disease (CKD) on the prognosis and mortality of COVID-19 infection in hospital admitted patients with above mentioned comorbidities. This is a single centre, observational, retrospective study carried out at Sir Ganga Ram Hospital, Delhi, India. The burden of comorbidities on the prognosis and clinical outcome of COVID-19 patients admitted patients from April 8, 2020, to October 4, 2020. Read More

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Signalling mechanisms and cellular functions of SUMO.

Nat Rev Mol Cell Biol 2022 Jun 24. Epub 2022 Jun 24.

Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.

Sumoylation is an essential post-translational modification that is catalysed by a small number of modifying enzymes but regulates thousands of target proteins in a dynamic manner. Small ubiquitin-like modifiers (SUMOs) can be attached to target proteins as one or more monomers or in the form of polymers of different types. Non-covalent readers recognize SUMO-modified proteins via SUMO interaction motifs. Read More

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Bone-specific response according to MDA criteria predicts immunotherapy efficacy among advanced non-small cell lung cancer (NSCLC) patients.

J Cancer Res Clin Oncol 2022 Jun 24. Epub 2022 Jun 24.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via Giuseppe Massarenti, 9, 40138, Bologna, Italy.

Purpose: The presence of bone metastasis at baseline has been associated with dismal prognosis under immunotherapy in advanced non-small cell lung cancer (NSCLC). Response Evaluation Criteria in Solid Tumors (RECIST) criteria may be limited for bone-specific response evaluation. Whether their assessment through MD Anderson (MDA) criteria predict immunotherapy efficacy is unknown. Read More

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The microbiome-gut-brain axis in Parkinson disease - from basic research to the clinic.

Nat Rev Neurol 2022 Jun 24. Epub 2022 Jun 24.

Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, Toronto, Ontario, Canada.

Evidence for a close bidirectional link between the brain and the gut has led to a paradigm shift in neurology, especially in the case of Parkinson disease (PD), in which gastrointestinal dysfunction is a prominent feature. Over the past decade, numerous high-quality preclinical and clinical publications have shed light on the highly complex relationship between the gut and the brain in PD, providing potential for the development of new biomarkers and therapeutics. With the advent of high-throughput sequencing, the role of the gut microbiome has been specifically highlighted. Read More

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Salvage I brachytherapy for liver metastases of colorectal cancer in anatomically challenging locations after failure of systemic chemotherapy-A retrospective study.

Brachytherapy 2022 Jun 21. Epub 2022 Jun 21.

Department of Interventional Radiology, Hospital of Jiangnan University, Jiangsu Province, Wuxi, China.

Purpsoe: Colorectal cancer liver metastasis (CCLM) in anatomically challenging locations is difficult to treat. This retrospective study aimed to evaluate the effectiveness and safety of permanent I seeds implantation (ISI) for treatment of CCLM in anatomically challenging locations after failure of systemic chemotherapy.

Methods And Materials: A total of 31 liver metastases (in 25 patients) were treated by ISI under computerized tomography guidance from January 2011 to December 2017. Read More

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Salvage image-guided freehand interstitial brachytherapy for pelvic sidewall recurrence after hysterectomy for uterine malignancies.

Brachytherapy 2022 Jun 21. Epub 2022 Jun 21.

Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.

Purpose: Pelvic sidewall recurrence after hysterectomy for uterine malignances has a poor prognosis, and the salvage therapy for this type of recurrence is still challenging. The purpose of this study was to investigate the efficacy of freehand high-dose-rate interstitial brachytherapy (HDR-ISBT) through the perineum using transrectal ultrasonography for this disease.

Methods And Materials: We retrospectively evaluated 42 patients with pelvic sidewall recurrence after hysterectomy for uterine cervical and endometrial cancers. Read More

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Prognostic Impact of Adiposity in Hematological Malignancies: A Systematic Review and Meta-analysis.

Clin Lymphoma Myeloma Leuk 2022 May 29. Epub 2022 May 29.

Sarah Cannon - Nashville TN.

It has been proposed that direct measurement of adiposity has a greater accuracy as a prognostic factor in various malignancies than anthropometric measures such as BMI. We evaluated the association of visceral and subcutaneous adiposity with outcomes in patients with hematological malignancies with a systematic review and meta-analysis. This systematic review included patients with hematological malignancies who had the analysis of overall mortality and progression-free survival according to their adiposity status. Read More

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Quantitative Muscle Analysis in FSHD Using Whole-Body Fat-Referenced MRI: Composite Scores for Longitudinal and Cross-Sectional Analysis.

Neurology 2022 Jun 24. Epub 2022 Jun 24.

Fulcrum Therapeutics, Cambridge, MA.

Background And Objectives: Facioscapulohumeral muscular dystrophy (FSHD) is a rare, debilitating disease characterized by progressive muscle weakness. MRI is a sensitive assessment of disease severity and progression. We developed a quantitative whole-body (WB) musculoskeletal MRI (WB-MSK-MRI) protocol analyzing muscles in their entirety. Read More

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Sjögren's syndrome as a cause of both lymphoid interstitial pneumonia and light chain deposition disease in a single patient.

BMJ Case Rep 2022 Jun 24;15(6). Epub 2022 Jun 24.

Department of Respiratory Medicine, Royal Devon and Exeter NHS Foundation Trust, Exeter, Devon, UK.

A man in his 70s presents with 12 months of progressive dyspnoea, sicca symptoms and Raynaud's phenomenon. Serological testing and tear duct biopsy confirm Sjögren's syndrome (SS). Bilateral nodular-cystic appearances highly suggestive of lymphoid interstitial pneumonia (LIP) are noted on high-resolution computed tomography (HRCT), supported by a 40% lymphocytosis on bronchoalveolar lavage. Read More

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Use of circulating tumour DNA in nasopharyngeal carcinoma to detect minimal residual disease.

BMJ Case Rep 2022 Jun 24;15(6). Epub 2022 Jun 24.

Hematology and Medical Oncology, Oakland University William Beaumont School of Medicine, Troy, Michigan, USA.

Circulating tumour DNA (ctDNA) is defined as short DNA sequences shed by tumour cells into the systemic circulation. A promising use of ctDNA includes the detection of minimal residual disease (MRD) and is currently being studied in multiple types of solid tumours. Literature for the use of individualised ctDNA in nasopharyngeal carcinoma (NPC) is not available, although circulating Epstein-Barr virus DNA level is validated as a prognostic factor. Read More

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Nivolumab in patients with relapsed or refractory peripheral T-cell lymphoma: modest activity and cases of hyperprogression.

J Immunother Cancer 2022 Jun;10(6)

Division of Hematology, Mayo Clinic, Rochester, MN, USA.

Peripheral T-cell lymphomas (PTCL), a heterogeneous group of mature aggressive non-Hodgkin's lymphomas, carry a worse prognosis for most subtypes when compared with their B-cell counterparts. Despite recent approval of newer therapies, the outlook for patients with relapsed/refractory (RR) PTCL remains poor and new treatment strategies are clearly needed. Targeting the profoundly immunosuppressive tumor microenvironment in PTCL is one such approach. Read More

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Is essential tremor a family of diseases or a syndrome? A family of diseases.

Int Rev Neurobiol 2022 23;163:7-29. Epub 2022 Mar 23.

The Marlene and Paolo Fresco Institute for Parkinson's and Movement Disorders, New York University Langone Health, New York, NY, United States. Electronic address:

It is now well-established that essential tremor (ET) can manifest with different clinical presentations and progressions (i.e., upper limb tremor, head tremor, voice tremor, lower limb tremor, task- or position-specific tremor, or a combination of those). Read More

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Is essential tremor a degenerative or an electrical disorder? Electrical disorder.

Authors:
Hyun Joo Cho

Int Rev Neurobiol 2022 21;163:103-128. Epub 2022 Mar 21.

Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States. Electronic address:

Essential tremor (ET) is one of the most common movement disorders, yet we do not have a complete understanding of its pathophysiology. From a phenomenology standpoint, ET is an isolated tremor syndrome of bilateral upper limb action tremor with or without tremor in other body locations. ET is a pathological tremor that arises from excessive oscillation in the central motor network. Read More

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