4,874,147 results match your criteria disease progression


Non-steroidal anti-inflammatory drugs (NSAIDs) for trigger finger.

Cochrane Database Syst Rev 2021 Apr 14;4:CD012789. Epub 2021 Apr 14.

Cochrane Singapore, Singapore, Singapore.

Background: Trigger finger is a common hand condition that occurs when movement of a finger flexor tendon through the first annular (A1) pulley is impaired by degeneration, inflammation, and swelling. This causes pain and restricted movement of the affected finger. Non-surgical treatment options include activity modification, oral and topical non-steroidal anti-inflammatory drugs (NSAIDs), splinting, and local injections with anti-inflammatory drugs. Read More

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iNetModels 2.0: an interactive visualization and database of multi-omics data.

Nucleic Acids Res 2021 Apr 13. Epub 2021 Apr 13.

Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm SE-171 21, Sweden.

It is essential to reveal the associations between various omics data for a comprehensive understanding of the altered biological process in human wellness and disease. To date, very few studies have focused on collecting and exhibiting multi-omics associations in a single database. Here, we present iNetModels, an interactive database and visualization platform of Multi-Omics Biological Networks (MOBNs). Read More

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Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer.

Nucleic Acids Res 2021 Apr 13. Epub 2021 Apr 13.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.

Castration-resistant prostate cancer (CRPC) is a terminal disease and the molecular underpinnings of CRPC development need to be better understood in order to improve its treatment. Here, we report that a transcription factor Yin Yang 1 (YY1) is significantly overexpressed during prostate cancer progression. Functional and cistrome studies of YY1 uncover its roles in promoting prostate oncogenesis in vitro and in vivo, as well as sustaining tumor metabolism including the Warburg effect and mitochondria respiration. Read More

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Caregiver experiences of paediatric inpatient cardiac services: A qualitative systematic review.

Eur J Cardiovasc Nurs 2021 Apr;20(2):147-159

Newcastle Upon Tyne Hospitals NHS Foundation Trust, UK.

Background: Advances in paediatric care have contributed to an increasing survival of children with complex heart disease. Yet, life-saving management demands prolonged inpatient admissions, which contribute to emotional and psychological distress for parents and other caregivers in a role of main custody.

Aim: The purpose of this study was to identify, appraise and synthesise qualitative studies exploring caregivers' experiences of paediatric inpatient cardiac services, generating an understanding of their needs in hospital and informing priorities for change in healthcare delivery. Read More

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Age-Stratified Outcome in Treatment of Left Main Coronary Artery Stenosis: A NOBLE Trial Substudy.

Cardiology 2021 Apr 13:1-10. Epub 2021 Apr 13.

Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark.

Background: In the treatment of left main coronary artery (LMCA) disease, patients' age may affect the clinical outcome after percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). This study stratified the clinical outcome according to the age of patients treated for LMCA stenosis with PCI or CABG in the Nordic-Baltic-British Left Main Revascularization (NOBLE) study.

Methods: Patients with LMCA disease were enrolled in 36 centers in northern Europe and randomized 1:1 to treatment by PCI or CABG. Read More

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Antithrombotic Management in Ischemic Stroke with Essential Thrombocythemia: Current Evidence and Dilemmas.

Med Princ Pract 2021 Apr 13. Epub 2021 Apr 13.

Thrombotic diseases like ischemic stroke are common complications of essential thrombocythemia (ET) due to abnormal megakaryopoiesis and platelet dysfunction. Ischemic stroke in ET can occur as a result of both cerebral arterial and venous thrombosis. Management of ET is aimed at preventing vascular complications including thrombosis. Read More

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Machine Learning Algorithms for Predicting Fatty Liver Disease.

Ann Nutr Metab 2021 Apr 13:1-8. Epub 2021 Apr 13.

Department of Geriatrics, The First People's Hospital of Xiangtan City, Xiangtan, China.

Background: Fatty liver disease (FLD) has become a rampant condition. It is associated with a high rate of morbidity and mortality in a population. The condition is commonly referred as FLD. Read More

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The Streetlight Effect: Reappraising the Study of Addiction in Light of the Findings of Genome-wide Association Studies.

Brain Behav Evol 2021 Apr 13:1-17. Epub 2021 Apr 13.

Department of Pharmacology and Experimental Therapeutics, College of Pharmacology and Pharmacological Science, University of Toledo, Toledo, Ohio, USA.

Drug dependence has long been thought to have a genetic component. Research seeking to identify the genetic basis of addiction has gone through important transitions over its history, in part based upon the emergence of new technologies, but also as the result of changing perspectives. Early research approaches were largely dictated by available technology, with technological advancements having highly transformative effects on genetic research, but the limitations of technology also affected modes of thinking about the genetic causes of disease. Read More

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Long-Term Medical Therapy after Laparoscopic Excision of Ovarian Endometriomas: Can We Reduce and Predict the Risk of Recurrence?

Gynecol Obstet Invest 2021 Apr 13:1-7. Epub 2021 Apr 13.

Gynecology and Human Reproduction Physiopathology, Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Objectives: Up to 32% of women experience anatomic recurrence after conservative surgery for endometriomas, while pain recurs in 10-40% of cases. Long-term postoperative hormonal therapy is recommended to prevent disease recurrence. We evaluated the efficacy of long-term therapy with estroprogestins (EPs) or progestins (Ps) in preventing endometrioma recurrence, as identifiable cysts and subjective symptoms, after laparoscopic excision. Read More

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Multidimensional Prognostic Index Predicts Clinical Outcome and Mortality in Hospitalised Older Patients with Diverticular Disease.

Gerontology 2021 Apr 13:1-9. Epub 2021 Apr 13.

Department of Internal Medicine, IRCCS San Matteo Hospital Foundation, University of Pavia, Pavia, Italy.

Introduction: The Multidimensional Prognostic Index (MPI) is a validated tool for assessing mortality risk in hospitalised patients. We aimed to evaluate whether the MPI predicted mortality and the risk of developing diverticular disease (DD) complications in older patients.

Methods: This is a multicentre study conducted in January 2016-March 2018. Read More

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Association between 10-Year Atherosclerotic Cardiovascular Disease Risk and Vascular Endothelial Function in Patients with Vasospastic Angina.

Cardiology 2021 Apr 13:1-7. Epub 2021 Apr 13.

Department of Physiology, College of Medicine, Hallym University, Chuncheon, Republic of Korea.

Background: Endothelial dysfunction is a predictor of atherosclerotic cardiovascular disease (ASCVD) and plays an important role in vasospastic angina (VA).

Objectives: This study evaluated whether flow-mediated dilation (FMD) is also a good marker of 10-year ASCVD risk (10Y-ASCVDR) in patients with VA.

Methods: Based on their clinical history and coronary artery diameter stenosis (DS), patients were retrospectively enrolled into VA (DS <50% and positive ergonovine provocation), minor coronary artery disease (mCAD, DS <30%), and significant coronary artery disease (sCAD, DS ≥50%) groups. Read More

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Current Reality of Treating Advanced Soft Tissue Sarcoma as Illustrated by Case Studies.

Oncology 2021 Apr 13:1-9. Epub 2021 Apr 13.

Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom.

In the first-line setting of advanced soft tissue sarcomas (STS), the treatment aim generally drives decision-making. Anthracycline combinations with ifosfamide or dacarbazine are more appropriate when the aim is tumour shrinkage, and doxorubicin monotherapy is suitable for tumour control. In patients who progress on anthracycline-based regimens, scope exists for tumour shrinkage with trabectedin and concurrent low-dose radiotherapy. Read More

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Innate Immune Cells in the Adipose Tissue in Health and Metabolic Disease.

J Innate Immun 2021 Apr 13:1-27. Epub 2021 Apr 13.

Institute for Clinical Chemistry and Laboratory Medicine, Medical Faculty, Technische Universität Dresden, Dresden, Germany.

Metabolic disorders, such as obesity, type 2 diabetes mellitus, and nonalcoholic fatty liver disease, are characterized by chronic low-grade tissue and systemic inflammation. During obesity, the adipose tissue undergoes immunometabolic and functional transformation. Adipose tissue inflammation is driven by innate and adaptive immune cells and instigates insulin resistance. Read More

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Stapedial Reflex: A Possible Novel Biomarker of Early Bulbar Involvement in Amyotrophic Lateral Sclerosis Patients.

Audiol Neurootol 2021 Apr 13:1-8. Epub 2021 Apr 13.

ENT Unit, Department of Surgical Sciences, University of Turin, Turin, Italy.

Background And Aim: Amyotrophic lateral sclerosis (ALS) is a neuromuscular progressive disorder, characterized by limb and bulbar muscle wasting and weakness. 30% of patients present a bulbar onset, while 70% a spinal outbreak, although most of them develop bulbar impairment later on. Due to the lack of an early biomarker of bulbar involvement, we chose to evaluate the role of stapedial reflex (SR) in order to predict preclinical bulbar impairment in ALS. Read More

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An engineered neurovascular unit for modeling neuroinflammation.

Biofabrication 2021 Apr 13. Epub 2021 Apr 13.

Brain Science Institute, Korea Institute of Science and Technology Brain Science Institute, 5, Hwarang-ro 14 gil, Seongbuk-gu, Seoul, Seongbok-gu, 02792, Korea (the Republic of).

The neurovascular unit (NVU) comprises multiple types of brain cells, including brain endothelial cells, astrocytes, pericytes, neurons, microglia, and oligodendrocytes. Each cell type contributes to the maintenance of the molecular transport barrier and brain tissue homeostasis. Several disorders and diseases of the central nervous system, including neuroinflammation, Alzheimer's disease, stroke, and multiple sclerosis, have been associated with dysfunction of the NVU. Read More

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Automatic classification of idiopathic Parkinson's disease and atypical parkinsonian syndromes combining [C]raclopride PET uptake and MRI grey matter morphometry.

J Neural Eng 2021 Apr 13. Epub 2021 Apr 13.

Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), ICNAS Polo 3, Coimbra, 3000-548, PORTUGAL.

Objective: To explore the viability of developing a computer-aided diagnostic system for Parkinsonian syndromes using dynamic [11C]raclopride PET and T1-weighted MRI data.

Approach: The biological heterogeneity of Parkinsonian syndromes renders their statistical classification a challenge. The unique combination of structural and molecular imaging data allowed different classifier designs to be tested. Read More

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Dual activation of Hedgehog and Wnt/β-catenin signaling pathway caused by downregulation of SUFU targeted by miRNA-150 in human gastric cancer.

Aging (Albany NY) 2021 Apr 12;13. Epub 2021 Apr 12.

Guangdong Key Laboratory for Genome Stability and Disease Prevention, Department of Pathology, Shenzhen University School of Medicine, Shenzhen 518060, Guangdong, P.R. China.

Mounting evidence has shown that miRNA-150 expression is upregulated in gastric cancer (GC) and is associated with gastric carcinogenesis, but the underlying oncogenic mechanism remains elusive. Here, we discovered that miRNA-150 targets the tumor suppressor SUFU to promote cell proliferation, migration, and the epithelial-mesenchymal transition (EMT) via the dual activation of Hedgehog (Hh) and Wnt signaling. MiRNA-150 was highly expressed in GC tissues and cell lines, and the level of this miRNA was negatively related to that of SUFU. Read More

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Deep CNN-Based CAD System for COVID-19 Detection Using Multiple Lung CT Scans.

J Med Internet Res 2021 Apr 3. Epub 2021 Apr 3.

Department of Computer Engineering, Faculty of Electrical and Computer Engineering, Shiraz University, Shiraz, IR.

Background: Due to the COVID-19 pandemic and the imminent collapse of healthcare systems following the excessive consumption of financial, hospital, and medicinal resources, the WHO changed the alert level on the COVID-19 pandemic from high to very high. Meanwhile, the world began to favor less expensive and more precise COVID-19 detection methods.

Objective: Machine vision-based COVID-19 detection methods especially Deep learning as a diagnostic technique in the early stages of the disease have found great importance during the pandemic. Read More

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Screening for inborn errors of metabolism in psychotic patients using Next Generation Sequencing.

J Psychiatr Res 2021 Apr 1;138:125-129. Epub 2021 Apr 1.

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health and Life Sciences (FHML), Maastricht University, Maastricht, the Netherlands.

Inborn errors of metabolism (IEMs) are a group of rare genetic disorders which, when emerging later in life, are often characterized by neuropsychiatric manifestations including psychosis. This study aimed to determine whether it would be useful to screen patients presenting with a psychotic disorder for IEMs by a single blood sample using Next Generation Sequencing (NGS), in order to detect rare, treatable causes of psychotic disorders. Blood was drawn from 60 patients with a psychotic disorder, with a duration of illness of less than 5 years. Read More

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Bovine mastitis inflammatory assessment using silica coated ZnO-NPs induced fluorescence of NAGase biomarker assay.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 1;257:119769. Epub 2021 Apr 1.

Institute of Agricultural Engineering, ARO, the Volcani Center, Bet Dagan 50250, Israel. Electronic address:

Bovine mastitis (BM) is the most common inflammatory disease in the dairy sector worldwide, originated from bacterial invasion onto the mammary gland. Early BM detection is crucial for identifying new pathogenic infections within the dairy herd, which can be alleviated by antimicrobial therapy. N-acetyl-β-D-glucosaminidase (NAGase) is a prominent BM inflammatory biomarker secreted onto the blood circulation upon pathogenesis and then released into milk, capable of separating healthy quarters from subclinical and clinical BM cases. Read More

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Understanding the biology of volumetric muscle loss for an individualized exercise rehabilitation approach in breast cancer patients.

Curr Opin Pharmacol 2021 Apr 10;58:27-34. Epub 2021 Apr 10.

Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy; Division of Pathology, IEO, European Institute of Oncology IRCCS, Milan, Italy. Electronic address:

Muscle maintenance relies on a multidimensional biologic balance that is extremely delicate in breast cancer patients, particularly those with advanced-stage disease. The biology that underpins breast cancer tumorigenesis, tumor progression and response to pharmacotherapies can modify muscle homeostasis, resulting in volumetric muscle loss. This condition dramatically increases the overall patients' frailty, leading to reduced survival and impaired quality of life. Read More

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Targeting intramuscular adipose tissue expansion to preserve contractile function in volumetric muscle loss: A potentially novel therapy?

Curr Opin Pharmacol 2021 Apr 10;58:21-26. Epub 2021 Apr 10.

Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, VIC, Australia; Department of Medicine-Western Health, Melbourne Medical School, The University of Melbourne, St. Albans, VIC, Australia.

In volumetric muscle loss (VML), the severity of trauma exceeds a muscle's regenerative capacity. VML causes permanent functional impairments for which there are no rehabilitative, pharmacological, or regenerative medicine interventions. Driving failed regeneration in VML is a hostile microenvironment characterized by heightened inflammation, fibrosis, and denervation, which may reduce the remaining muscle tissue's quality, and stimulate intramuscular adipose tissue (IMAT) expansion. Read More

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Chronic bronchitis in the 50-year follow-up of the European cohorts of the Seven Countries Study: prevalence, mortality and association with cardiovascular diseases.

Respir Med 2021 Apr 2;181:106385. Epub 2021 Apr 2.

Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.

Objectives: To study prevalence of chronic bronchitis (CB) in residential populations and its relationship with mortality in a 50-year follow-up.

Material And Methods: In the late 1950's-early 1960's, 7047 men aged 40-59 years were enrolled in 10 European cohorts of the Seven Countries Study (in Finland, the Netherlands, Italy, Serbia and Greece). After baseline examination, follow-up for mortality was extended during 50 years (45 year in the Serbian cohorts). Read More

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Paediatric long term continuous positive airway pressure and noninvasive ventilation in France: A cross-sectional study.

Respir Med 2021 Apr 3;181:106388. Epub 2021 Apr 3.

Pediatric Pulmonology and Allergology Unit, Hospices Civils de Lyon, 69677, Bron, France; Sorbonne Université, INSERM UMR-S 938, Centre de Recherche Saint-Antoine (CRSA), F-75014, Paris, France; Centre de Pneumologie de l'enfant, Ramsay Générale de Santé, 92100, Boulogne-Billancourt, France.

Objective: To describe the characteristics of children treated with long term continuous positive airway pressure (CPAP) or noninvasive ventilation (NIV) in France.

Design: Cross-sectional national survey.

Setting: Paediatric CPAP/NIV teams of 28 tertiary university hospitals in France. Read More

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The estimations of the COVID-19 incubation period: A scoping reviews of the literature.

J Infect Public Health 2021 Feb 8;14(5):638-646. Epub 2021 Feb 8.

College of Engineering and Information Technology, Ajman University.

Background: A novel coronavirus (COVID-19) has taken the world by storm. The disease has spread very swiftly worldwide. A timely clue which includes the estimation of the incubation period among COVID-19 patients can allow governments and healthcare authorities to act accordingly. Read More

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February 2021

Reactivation of SARS-CoV-2 infection following recovery from COVID-19.

J Infect Public Health 2021 Feb 8;14(5):620-627. Epub 2021 Feb 8.

Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, No. 8, Jingshun East Street, Chaoyang District, Beijing 100015, PR China. Electronic address:

Introduction: Many individuals test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA after recovering from the coronavirus disease (COVID-19), but the incidence of reactivation is unknown. We, therefore, estimated the incidence of reactivation among individuals who had recovered from COVID-19 and determined its predictors.

Methods: In this retrospective cohort study, patients with COVID-19 were followed up for at least 14 days after two consecutive negative SARS-CoV-2 polymerase chain reaction test results obtained ≥24 h apart, and the frequency of SARS-CoV-2 reactivation was assessed. Read More

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February 2021

Essential oils as an effective alternative for the treatment of COVID-19: Molecular interaction analysis of protease (M) with pharmacokinetics and toxicological properties.

J Infect Public Health 2021 Feb 10;14(5):601-610. Epub 2021 Feb 10.

Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea. Electronic address:

Background: The current health concern to the entire world is the chronic respiratory disease caused by coronavirus 2 (COVID-19). A specific treatment or proper therapy is still lacking, and the investigations from across the world for proper drug/vaccine development towards disease control are in progress. The Coronavirus replication takes place by the conversion of the polypeptide into functional protein and this occurs due to the key enzyme Main protease (M). Read More

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February 2021

Context matters: Examining the factors impacting the implementation of tuberculosis infection prevention and control guidelines in health settings in seven high tuberculosis burden countries.

J Infect Public Health 2021 Feb 8;14(5):588-597. Epub 2021 Feb 8.

School of Public Health and Community Medicine, University of New South Wales, Room 212, Samuels Building, Sydney, Australia.

Background: Healthcare workers (HCWs) in high tuberculosis (TB) burden countries are at increased risk of TB infection due to increased exposures to TB patients and inadequate implementation of TB infection prevention and control (TB IPC) measures in health settings. While various guidelines on TB IPC exist, there is little understanding of the content of these guidelines, whether they are relevant to the context and are being appropriately implemented in low-and middle-income high TB burden countries. This study aimed to critically examine the implementation of TB IPC guidelines, along with factors impacting TB IPC implementation in health settings in seven high TB burden countries. Read More

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February 2021