17,875 results match your criteria disease mimic

Human pluripotent stem cells: an alternative for 3D in vitro modelling of skin disease.

Exp Dermatol 2021 Apr 17. Epub 2021 Apr 17.

Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

To effectively study the skin and its pathology, various platforms have been used to date, with in vitro 3D skin models being considered the future gold standard. These models have generally been engineered from primary cell lines. However, their short life span leading to the use of various donors, imposes issues with genetic variation. Read More

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A prognostic dynamic model applicable to infectious diseases providing easily visualized guides: a case study of COVID-19 in the UK.

Sci Rep 2021 Apr 16;11(1):8412. Epub 2021 Apr 16.

Department of Pharmacology, University of Oxford, Oxford, OX1 3QT, UK.

A reasonable prediction of infectious diseases' transmission process under different disease control strategies is an important reference point for policy makers. Here we established a dynamic transmission model via Python and realized comprehensive regulation of disease control measures. We classified government interventions into three categories and introduced three parameters as descriptions for the key points in disease control, these being intraregional growth rate, interregional communication rate, and detection rate of infectors. Read More

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Airway Epithelial Inflammation Augments the Rescue of Mutant CFTR by Current CFTR Modulator Therapies.

Front Pharmacol 2021 30;12:628722. Epub 2021 Mar 30.

Marsico Lung Institute and Cystic Fibrosis Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, United States.

In cystic fibrosis (CF), defective biogenesis and activity of the cystic fibrosis transmembrane conductance regulator (CFTR) leads to airway dehydration and impaired mucociliary clearance, resulting in chronic airway infection and inflammation. The most common CFTR mutation, F508del, results in a processing defect in which the protein is retained in the endoplasmic reticulum and does not reach the apical surface. CFTR corrector compounds address this processing defect to promote mutant CFTR transfer to the apical membrane. Read More

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Human umbilical cord mesenchymal stem cell-derived small extracellular vesicles ameliorate collagen-induced arthritis via immunomodulatory T lymphocytes.

Mol Immunol 2021 Apr 12;135:36-44. Epub 2021 Apr 12.

Department of Rheumatology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital Affiliated to Shanxi Medical University, Taiyuan, 030032, China. Electronic address:

Background: Rheumatoid arthritis (RA) is an autoimmune disease for which there are currently no effective therapies. Although mesenchymal stem cells (MSCs) can prevent arthritis through immunomodulatory mechanisms, there are several associated risks. Alternatively, MSC-derived small extracellular vesicles (sEVs) can mimic the effects of MSCs, while reducing the risk of adverse events. Read More

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Validation of Withings ScanWatch as a Wrist-Worn Reflective Pulse Oximeter: Hypoxia Study.

J Med Internet Res 2021 Apr 11. Epub 2021 Apr 11.

Withings, 2 rue Maurice Hartmann, Issy-Les-Moulineaux, FR.

Background: A decrease in the pulse oxygen saturation (SpO2) level is an indicator of hypoxemia that may occur in various respiratory diseases such as chronic obstructive pulmonary disease (COPD), sleep apnea syndrome (SAS) and COVID-19. There is currently no mass-market wrist-worn SpO2 monitor meeting the medical standards for pulse oximeters.

Objective: The main objective of this monocentric and prospective clinical study with single-blind analysis was to test and validate the accuracy of the Withings ScanWatch's reflective pulse oximeter function to measure SpO2 levels at different stages of hypoxia. Read More

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Priming mesenchymal stem cells with uric acid enhances neuroprotective properties in parkinsonian models.

J Tissue Eng 2021 Jan-Dec;12:20417314211004816. Epub 2021 Mar 30.

Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.

Mesenchymal stem cells (MSCs) are a potential source of cell-based disease-modifying therapy in Parkinsonian disorders. A promising approach to develop in vitro culture methods that mimic natural MSC niche is cell priming. Uric acid (UA), a powerful antioxidant, scavenges reactive oxygen species, which has a vital role in maintaining self-renewal and differentiation potential of MSCs. Read More

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Circ-OSBPL2 Contributes to Smoke-Related Chronic Obstructive Pulmonary Disease by Targeting miR-193a-5p/BRD4 Axis.

Int J Chron Obstruct Pulmon Dis 2021 7;16:919-931. Epub 2021 Apr 7.

Department of Respiratory and Critical Care Medicine, The First People's Hospital of Lianyungang, Lianyungang, People's Republic of China.

Background: Circular RNAs (circRNAs) have been identified to play roles in the respiratory diseases. Here, this study aimed to elucidate the function of circRNA oxysterol binding protein like 2 (circOSBPL2) in the development of smoke-related chronic obstructive pulmonary diseases (COPD).

Methods: The expression of circ-OSBPL2, microRNA (miR)-193a-5p, and bromodomain-containing protein 4 (BRD4) was detected using qRT-PCR and Western blot assays. Read More

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Acute lung toxicity by nitrofurantoin.

BMJ Case Rep 2021 Apr 14;14(4). Epub 2021 Apr 14.

Department of Internal Medicine, Midland Inpatient Medical Associates, Midland Memorial Hospital, Midland, Texas, USA.

Nitrofurantoin is a synthetic derivative of imidazolinedione, used to treat uncomplicated urinary tract infections. It acts by inhibiting bacterial DNA, RNA and cell wall protein synthesis. It is used prophylactically as a urinary anti-infective agent against most gram-positive organism and for long-term suppression of infections. Read More

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Human alpha-synuclein overexpressing MBP29 mice mimic functional and structural hallmarks of the cerebellar subtype of multiple system atrophy.

Acta Neuropathol Commun 2021 04 14;9(1):68. Epub 2021 Apr 14.

Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.

Multiple system atrophy (MSA) is a rare, but fatal atypical parkinsonian disorder. The prototypical pathological hallmark are oligodendroglial cytoplasmic inclusions (GCIs) containing alpha-synuclein (α-syn). Currently, two MSA phenotypes are classified: the parkinsonian (MSA-P) and the cerebellar subtype (MSA-C), clinically characterized by predominant parkinsonism or cerebellar ataxia, respectively. Read More

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Identifying medical mimics for late-life mania: A case of prion disease.

Int J Psychiatry Med 2021 Apr 14:912174211010529. Epub 2021 Apr 14.

Union Hospital Family Medicine Residency, Terre Haute, IN, USA.

Sporadic Creutzfeld Jakob Disease is a rare disease with diagnostic challenges. While there is very little human data regarding this disease, some studies have indicated that certain medications may be useful in slowing its progression. Case study data implies psychiatric and cognitive symptoms preceding the diagnosis. Read More

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Cannabidiol-dihydroartemisinin conjugates for ameliorating neuroinflammation with reduced cytotoxicity.

Bioorg Med Chem 2021 Apr 2;39:116131. Epub 2021 Apr 2.

Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China; Department of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China. Electronic address:

Cannabidiol (CBD) and dihydroartemisinin (DHA) can alleviate neuroinflammatory responses. However, they show cytotoxicity, which severely limits their therapeutic windows. Therefore, there is a great need to develop neuroprotective agents with improved safety. Read More

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Sinonasal teratocarcinosarcoma mimicking chronic invasive fungal disease of paranasal sinuses.

Ann R Coll Surg Engl 2021 Apr 14. Epub 2021 Apr 14.

Anesthesiology, Clinical Research Office, Ataturk University, Erzurum, Turkey.

Sinonasal teratoid carcinosarcoma or teratocarcinoma is an extremely rare aggressive tumour. It usually arises in the nasal cavity and paranasal sinuses. In this study, the authors described magnetic resonance imaging and computed tomography findings from a patient with sinonasal teratocarcinoma. Read More

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Engineering Advanced In Vitro Models of Systemic Sclerosis for Drug Discovery and Development.

Adv Biol (Weinh) 2021 04 15;5(4):e2000168. Epub 2021 Feb 15.

Dr. A. De Pieri, Prof. K. Wuertz-Kozak, Department of Biomedical Engineering, Rochester Institute of Technology (RIT), 106 Lomb Memorial Rd., Rochester, NY, 14623, USA.

Systemic sclerosis (SSc) is a complex multisystem disease with the highest case-specific mortality among all autoimmune rheumatic diseases, yet without any available curative therapy. Therefore, the development of novel therapeutic antifibrotic strategies that effectively decrease skin and organ fibrosis is needed. Existing animal models are cost-intensive, laborious and do not recapitulate the full spectrum of the disease and thus commonly fail to predict human efficacy. Read More

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Development of a Novel Human CD147 Transgenic NSG Mouse Model to test SARS-CoV-2 Infection and Immune Responses.

Res Sq 2021 Apr 7. Epub 2021 Apr 7.

An animal model that can mimic the SARS-CoV-2 infection in humans is critical to understanding the newly emerged, rapidly spreading SARS-CoV-2 and development of therapeutic strategies. Studies show that the spike (S) proteins of SARS-CoV (SARS-CoV-S-1-S) and SARS-CoV-2 (SARS-CoV-2-S) bind to human angiotensin-converting enzyme 2 (hACE2, a well-recognized, functional receptor for SARS-CoV and SARS-CoV-2) to mediate viral entry. Several hACE2 transgenic (hACE2Tg) mouse models are being widely used, which is clearly invaluable. Read More

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miR-20a-5p inhibits endometrial cancer progression by targeting janus kinase 1.

Oncol Lett 2021 May 30;21(5):427. Epub 2021 Mar 30.

Emergency Department, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075000, P.R. China.

Endometrial cancer (EC) is a multi-factorial disease of which pathogenesis has not been fully elucidated. The function and underlying mechanism of microRNA-20a-5p (miR-20a-5p) in EC remain poorly understood. The present study aimed to analyze the association between miR-20a-5p expression and the clinicopathological characteristics of patients with EC. Read More

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The virtual physiological human gets nerves! How to account for the action of the nervous system in multiphysics simulations of human organs.

J R Soc Interface 2021 Apr 14;18(177):20201024. Epub 2021 Apr 14.

Centre for Computational Engineering Sciences, Cranfield University, Bedford MK43 0AL, UK.

This article shows how to couple multiphysics and artificial neural networks to design computer models of human organs that autonomously adapt their behaviour to environmental stimuli. The model simulates motility in the intestine and adjusts its contraction patterns to the physical properties of the luminal content. Multiphysics reproduces the solid mechanics of the intestinal membrane and the fluid mechanics of the luminal content; the artificial neural network replicates the activity of the enteric nervous system. Read More

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A Prediction Model for Assessing Prognosis in Critically Ill Patients With Sepsis-Associated Acute Kidney Injury.

Shock 2021 Mar 3. Epub 2021 Mar 3.

*Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China †Department of Pathophysiology, Guangdong Provincial Key Laboratory of Shock and Microcirculation, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China ‡Department of Biostatistics, School of Public Health, Southern Medical University, Guangzhou 510515, China.

Background: Sepsis-associated acute kidney injury (SA-AKI) is a common problem in critically ill patients and is associated with high morbidity and mortality. Early prediction of the survival of hospitalized patients with SA-AKI is necessary, but a reliable and valid prediction model is still lacking.

Methods: We conducted a retrospective cohort analysis based on a training cohort of 2066 patients enrolled from the Multiparameter Intelligent Monitoring in Intensive Care Database III (MIMIC III) and a validation cohort of 102 patients treated at Nanfang Hospital of Southern Medical University. Read More

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CTHRC1 Knockdown Promotes Inflammatory Responses Partially by p38 MAPK Activation in Human Periodontal Ligament Cells.

Inflammation 2021 Apr 12. Epub 2021 Apr 12.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST KLOS) & Key Laboratory of Oral Biomedicine Ministry of Education (KLOBME), School & Hospital of Stomatology, Wuhan University, Wuhan, China.

Collagen triple helix repeat containing 1 (CTHRC1), a secreted glycoprotein, is widely expressed in many tissues. It has been recently defined as a novel marker for rheumatoid arthritis (RA), a systemic inflammatory disorder. However, the precise role of CTHRC1 in other chronic inflammatory diseases, like periodontal disease, remains unclear. Read More

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The white matter is a pro-differentiative niche for glioblastoma.

Nat Commun 2021 04 12;12(1):2184. Epub 2021 Apr 12.

Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, WC1E 6DD, UK.

Glioblastomas are hierarchically organised tumours driven by glioma stem cells that retain partial differentiation potential. Glioma stem cells are maintained in specialised microenvironments, but whether, or how, they undergo lineage progression outside of these niches remains unclear. Here we identify the white matter as a differentiative niche for glioblastomas with oligodendrocyte lineage competency. Read More

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Abdominal tuberculosis in a tertiary care centre in Saudi Arabia.

Indian J Tuberc 2021 Apr 12;68(2):236-241. Epub 2020 Sep 12.

Infectious Diseases Unit, Prince Sultan Military Medical City (PSMMC), Riyadh, Saudi Arabia.

Objectives: Abdominal tuberculosis (ATB) is the second most common type of extra-pulmonary tuberculosis. Though it does not usually pose a significant risk of infectivity, ATB can go unidentified and progress to disseminated infection. The aim of this study is to highlight the incidence and outcome of this infection in a tertiary care centre in the Kingdom of Saudi Arabia (KSA). Read More

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Improved characterisation of clinical text through ontology-based vocabulary expansion.

J Biomed Semantics 2021 04 12;12(1). Epub 2021 Apr 12.

Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.

Background: Biomedical ontologies contain a wealth of metadata that constitutes a fundamental infrastructural resource for text mining. For several reasons, redundancies exist in the ontology ecosystem, which lead to the same entities being described by several concepts in the same or similar contexts across several ontologies. While these concepts describe the same entities, they contain different sets of complementary metadata. Read More

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MicroRNA-200b-3p promotes endothelial cell apoptosis by targeting HDAC4 in atherosclerosis.

BMC Cardiovasc Disord 2021 Apr 12;21(1):172. Epub 2021 Apr 12.

Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Background: Epicardial adipose tissue (EAT) shares the same microcirculation with coronary arteries through coronary arteries branches, and contributes to the development of atherosclerosis. MicroRNAs (miRNAs) are involved in the formation of atherosclerosis. However, the alteration of miRNA profile in EAT during atherosclerosis is still uncovered. Read More

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An Orthotopic Mouse Model of Ovarian Cancer using Human Stroma to Promote Metastasis.

J Vis Exp 2021 Mar 23(169). Epub 2021 Mar 23.

Division of Hematology/Oncology, Department of Medicine, Hillman Cancer Center, University of Pittsburgh; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens' Hospital, University of Pittsburgh Medical Center;

Ovarian cancer is characterized by early, diffuse metastasis with 70% of women having metastatic disease at the time of diagnosis. While elegant transgenic mouse models of ovarian cancer exist, these mice are expensive and take a long time to develop tumors. Intraperitoneal injection xenograft models lack human stroma and do not accurately model ovarian cancer metastasis. Read More

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Triggered micropore-forming bioprinting of porous viscoelastic hydrogels.

Mater Horiz 2020 Sep 16;7(9):2336-2347. Epub 2020 Jul 16.

Department of Mechanical Engineering, McGill University, 817 Sherbrooke St W, Montreal, QC H3A 0C3, Canada.

Cell-laden scaffolds of architecture and mechanics that mimic those of the host tissues are important for a wide range of biomedical applications but remain challenging to bioprint. To address these challenges, we report a new method called triggered micropore-forming bioprinting. The approach can yield cell-laden scaffolds of defined architecture and interconnected pores over a range of sizes, encompassing that of many cell types. Read More

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September 2020

The Influenza A Virus H3N2 Triggers the Hypersusceptibility of Airway Inflammatory Response via Activating the lncRNA TUG1/miR-145-5p/NF-κB Pathway in COPD.

Front Pharmacol 2021 22;12:604590. Epub 2021 Feb 22.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Patients with chronic obstructive pulmonary disease (COPD) are more susceptible to influenza A virus (IAV) with more severe symptoms, yet the underlying molecular mechanisms of the hypersusceptibility of airway inflammatory response remain unclear. The primary human bronchial epithelial cells (pHBECs) were isolated from normal and COPD bronchial tissues (NHBE and DHBE) and cultured with/without IAV infection . DHBE cells were exposed to IAV for 24 h after knockdown of lncRNA TUG1 with short hairpin RNA (shRNA). Read More

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February 2021

Mesenchymal stem cells accelerated growth and metastasis of neuroblastoma and preferentially homed towards both primary and metastatic loci in orthotopic neuroblastoma model.

BMC Cancer 2021 Apr 10;21(1):393. Epub 2021 Apr 10.

Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Special Administrative Region, China.

Background: Majority of neuroblastoma patients develop metastatic disease at diagnosis and their prognosis is poor with current therapeutic approach. Major challenges are how to tackle the mechanisms responsible for tumorigenesis and metastasis. Human mesenchymal stem cells (hMSCs) may be actively involved in the constitution of cancer microenvironment. Read More

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Effects of dim artificial light at night on locomotor activity, cardiovascular physiology, and circadian clock genes in a diurnal songbird.

Environ Pollut 2021 Mar 31;282:117036. Epub 2021 Mar 31.

Department of Biology, University of Nevada, Reno, Reno, NV, USA.

Artificial light is transforming the nighttime environment and quickly becoming one of the most pervasive pollutants on earth. Across taxa, light entrains endogenous circadian clocks that function to synchronize behavioral and physiological rhythms with natural photoperiod. Artificial light at night (ALAN) disrupts these photoperiodic cues and has consequences for humans and wildlife including sleep disruption, physiological stress and increased risk of cardiovascular disease. Read More

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Calcium supplementation relieves high-fat diet-induced liver steatosis by reducing energy metabolism and promoting lipolysis.

J Nutr Biochem 2021 Apr 7:108645. Epub 2021 Apr 7.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Animal Science and Technology, Guangxi University, Nanning 530004, P.R. China. Electronic address:

Nonalcoholic fatty liver disease (NAFLD) is a chronic disease affecting the health of many people worldwide. Previous studies have shown that dietary calcium supplementation may alleviate NAFLD, but the underlying mechanism is not clear. In this study investigating the effect of calcium on hepatic lipid metabolism, 8-week-old male C57BL/6J mice were divided into four groups (n = 6): (a) mice given a normal chow containing 0. Read More

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The effect of methotrexate monotherapy on treatment-resistant idiopathic granulomatous mastitis patients.

Surgeon 2021 Apr 6. Epub 2021 Apr 6.

Istanbul University-Cerrahpasa, Cerrahpaşa Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Turkey. Electronic address:

Background: Idiopathic granulomatous mastitis (IGM) is a disease of unknown etiology, involving a chronic inflammatory process, characterized by noncaseating granuloma formation. IGM can mimic a tumor clinically and radiologically. Since we are a tertiary referral center, most of our patients (n = 56, 87. Read More

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In-vitro Immunomodulatory activity of Azadirachta indica A.Juss. Ethanol: water mixture against HIV associated chronic CD4 T-cell activation/ exhaustion.

BMC Complement Med Ther 2021 Apr 9;21(1):114. Epub 2021 Apr 9.

Makerere University, Walter Reed Project, P.O Box 16524, Kampala, Uganda.

Background: In Sub-Saharan Africa, herbal therapy continues to be utilized for HIV-1 disease management. However, the therapeutic benefits of these substances remain ambiguous. To date, little is known about the effects of these plant extracts on chronic CD4 + T-cell activation and exhaustion which is partly driven by HIV-1 associated microbial translocation. Read More

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