15,426 results match your criteria disease manifest

Dietary astaxanthin augments disease resistance of Asian seabass, Lates calcarifer (Bloch, 1790) against Vibrio alginolyticus infection.

Fish Shellfish Immunol 2021 Apr 7. Epub 2021 Apr 7.

Department of Aquaculture, Faculty of Agriculture, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia; International Institute of Aquaculture and Aquatic Sciences, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia.

This investigation describes the impacts of dietary provisioning with astaxanthin on hemato-biochemistry, non-specific immunity, and disease resistance of the Asian seabass, Lates calcarifer against the virulent Vibrio alginolyticus, with specific reference to dose-response associations and variations over different post-infection periods (0-, 7-, and 14-day). Triplicate groups of fish weighing 28 g, on average, were fed various diets (C, the control or astaxanthin-free; AXT50, 50 mg astaxanthin kg diet; AXT100, 100 mg astaxanthin kg diet; and AXT150, 150 mg astaxanthin kg diet) for 90 days and subsequently challenged with V. alginolyticus at the end of the feeding period. Read More

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Early initiation of ambroxol treatment diminishes neurological manifestations of type 3 Gaucher disease: A long-term outcome of two siblings.

Eur J Paediatr Neurol 2021 Mar 31;32:66-72. Epub 2021 Mar 31.

Department of Pediatrics, University Hospital Centre Zagreb, Zagreb, Croatia; University of Zagreb, School of Medicine, Zagreb, Croatia. Electronic address:

Gaucher disease type 3 (GD3) is a severely debilitating disorder characterized by multisystemic manifestations and neurodegeneration. Enzyme replacement therapy alleviates visceral signs and symptoms but has no effect on neurological features. Ambroxol has been suggested as an enzyme enhancement agent. Read More

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Pathomechanism and Management of Stroke in COVID-19: Review of Immunopathogenesis, Coagulopathy, Endothelial Dysfunction, and Downregulation of ACE2.

J Clin Neurol 2021 Apr;17(2):155-163

Department of Neurology, Udayana University, Udayana University Hospital, Bali, Indonesia.

Coronavirus disease 2019 (COVID-19) can reportedly manifest as an acute stroke, with most cases presenting as large vessel ischemic stroke in patients with or without comorbidities. The exact pathomechanism of stroke in COVID-19 remains ambiguous. The findings of previous studies indicate that the most likely underlying mechanisms are cerebrovascular pathological conditions following viral infection, inflammation-induced endothelial dysfunction, and hypercoagulability. Read More

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The Long Arm of Conflict: How Timing Shapes the Impact of Childhood Exposure to War.

Demography 2021 Apr 9. Epub 2021 Apr 9.

Department of Sociology and Criminology, Pennsylvania State University, State College, PA, USA.

This paper examines how the timing of childhood exposure to armed conflict influences both the magnitude of the impact it has on later-life health and the pathways through which those impacts manifest. Utilizing the Survey of Health and Retirement in Europe, we examine cohorts of children during World War II. We find that cohorts born during the war show the largest negative effects of exposure on health in later life. Read More

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Necrotising Fasciitis: Appearances Can Be Deceptive.

World J Plast Surg 2021 Jan;10(1):43-52

Plastic Surgeon, Bangalore, India.

Background: Necrotizing fasciitis is a potentially fatal infection of β hemolytic Group-A Streptococcus, often occurring in patients with other comorbidities, but can occur in healthy individuals as well. It commonly affects the extremities, perineum, and abdominal wall. The aim of this study was to highlight various presentations of necrotizing fasciitis in unusual anatomical sites with delayed diagnosis and treatment. Read More

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January 2021

Neurologic and Neuroscientific Evidence in Aged COVID-19 Patients.

Front Aging Neurosci 2021 23;13:648662. Epub 2021 Mar 23.

Department of Emergency Medicine, University of Wisconsin Hospitals and Clinics, Madison, WI, United States.

The COVID-19 pandemic continues to prevail as a catastrophic wave infecting over 111 million people globally, claiming 2. 4 million lives to date. Aged individuals are particularly vulnerable to this disease due to their fraility, immune dysfunction, and higher rates of medical comorbidities, among other causes. Read More

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[Epidemiology for alcohol-related liver disease].

Ugeskr Laeger 2021 Apr;183(14)

Alcohol is the dominant cause of liver disease in Denmark. Around 1,000 persons, usually of 40 to 70 years of age, are diagnosed with alcohol-related liver disease (ALD) each year in Denmark. ALD is usually preceded by several years of heavy drinking, during which alcohol cessation could have prevented manifest ALD as argued in this review. Read More

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Assessment and Management of Acute Disseminated Encephalomyelitis (ADEM) in the Pediatric Patient.

Cynthia X Wang

Paediatr Drugs 2021 Apr 8. Epub 2021 Apr 8.

Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical School, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA.

Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system that typically presents in childhood and is associated with encephalopathy and multifocal brain lesions. Although ADEM is thought to be a post-infectious disorder, the etiology is still poorly understood. ADEM is often a monophasic disorder, in contrast to other demyelinating disorders such as multiple sclerosis and neuromyelitis optica spectrum disorder. Read More

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[Hypothesis regarding the connections between severe COVID-19 in children and nutrition: a narrative review].

Nutr Hosp 2021 Apr 8. Epub 2021 Apr 8.

Department of Research Methodology. Instituto Nacional de Pediatría.

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Compared with adults, children with SARS-CoV-2 infection may have fewer and less severe symptoms. Gastrointestinal symptoms are commonly reported in children, sometimes as the only manifestation of the disease, and most often manifest as anorexia, diarrhea, nausea and vomiting, or abdominal pain. Read More

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Clinical and Pathophysiologic Spectrum of Neuro-COVID.

Mol Neurobiol 2021 Apr 8. Epub 2021 Apr 8.

Disciplina de Neurociência, Universidade Federal de São Paulo/Escola Paulista de Medicina (UNIFESP/EPM), São Paulo, Brasil.

Though the lungs are predominantly affected in SARS-CoV-2-infected patients, extra-pulmonary manifestations can occur. Extra-pulmonary manifestations of the central and peripheral nervous system need to be recognised as they can strongly determine the outcome. This mini-review summarises and discusses previous and recent findings about neuro-COVID. Read More

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Primary localized gastric amyloidosis: A scoping review of the literature from clinical presentations to prognosis.

World J Gastroenterol 2021 Mar;27(12):1132-1148

Department of Gastroenterology, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.

Localized gastric amyloidosis (LGA) is a rare disease characterized by abnormal extracellular deposition of amyloid protein restricted to the stomach and it is confirmed by positive results of Congo red staining. Over decades, only a few cases have been reported and studies or research focusing on it are few. Although LGA has a low incidence, patients may suffer a lot from it and require proper diagnosis and management. Read More

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Early onset calciphylaxis following acute kidney injury secondary to anti-glomerular basement membrane antibody disease.

BMJ Case Rep 2021 Apr 7;14(4). Epub 2021 Apr 7.

Nephrology and Hypertension, Albany Medical Center Hospital, Albany, New York, USA.

Calciphylaxis is commonly associated with end-stage renal disease (ESRD) and renal transplant. We present a rare case of early onset calciphylaxis in a patient presenting with acute kidney injury (AKI) secondary to anti-glomerular basement membrane (anti-GBM) antibody disease. A 65-year-old obese Caucasian woman with type 2 diabetes mellitus and hypertension presented with a 1-month history of painless gross haematuria and worsening lower extremity oedema. Read More

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J Zoo Wildl Med 2021 Apr;52(1):200-205

Laboratory of Wildlife Biology and Medicine, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan,

Piroplasms, which include spp. and spp., are protozoan parasites carried by ticks and commonly cause disease in animals and humans. Read More

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Cardiovascular autonomic neuropathy in patients with schizophrenia.

Nord J Psychiatry 2021 Apr 7:1-6. Epub 2021 Apr 7.

Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

Background: Cardiovascular autonomic neuropathy (CAN) is an independent predictor of cardiovascular disease (CVD) in patients with diabetes as well as in patients with pre-diabetes and metabolic syndrome. Patients with schizophrenia have an increased rate of metabolic syndrome, pre-diabetes and diabetes as compared to the general population. Despite of this, occurrence CAN has not been investigated in patient with schizophrenia. Read More

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Association of blood pressure, obesity and physical activity with arterial stiffness in children: a systematic review and meta-analysis.

Pediatr Res 2021 Apr 6. Epub 2021 Apr 6.

Department of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.

Central pulse wave velocity (cPWV) is a biomarker for cardiovascular (CV) risk and a predictor for CV events in adulthood. Alterations of arterial stiffness have also been associated with CV risk in childhood. The study aimed to systematically review and meta-analyze the association of blood pressure (BP), body mass index (BMI), and cardiorespiratory fitness (CRF) with cPWV in children. Read More

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Impact of COVID-19 on the Gut: A Review of the Manifestations, Pathology, Management, and Challenges.

Acta Med Indones 2021 Jan;53(1):96-104

Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/ Dr. Cipto Mangunkusumo General Hospital National Hospital, Jakarta.

SARS-CoV-2 is a virus that can enter its hosts through the Angiotensin Converting Enzyme-2 (ACE2) receptor. ACE2 is mainly expressed in cells of the gastrointestinal tract, such as the esophageal epithelium and enterocytes from the ileum-colon. Coronavirus Disease 2019 (COVID-19) has varying clinical symptoms and presents differently in individuals, ranging from asymptomatic carriers to moderate clinical spectrum with mild pneumonia clinical features, and to a severe clinical presentation with dyspnea and hypoxia, leading to death due to respiratory or multi-organ failure. Read More

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January 2021

Converging evidence in support of omega-3 polyunsaturated fatty acids as a potential therapy for Huntington's disease symptoms.

Rev Neurosci 2021 Apr 5. Epub 2021 Apr 5.

Intellectual and Developmental Disabilities Research Center, Jane and Terry Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA90095, USA.

Huntington's disease (HD) is a genetic, inexorably fatal neurodegenerative disease. Patient average survivability is up to 20 years after the onset of symptoms. Those who suffer from the disease manifest motor, cognitive, and psychiatric impairments. Read More

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Sympathetic context of the disease - a new era in glaucoma management.

Rom J Ophthalmol 2021 Jan-Mar;65(1):15-19

Ophthalmology Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Primary open angle glaucoma (POAG) is a multifactorial optic neuropathy, which progresses in a chronic manner. Several etiological factors are involved, including genetic factors, race, age, IOP or vascular, systemic factors. IOP has an established role in the initiation and evolution of glaucoma, but its interactions with additional risk factors are complex. Read More

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Sex Differences in Huntington's Disease: Evaluating the Enroll-HD Database.

Mov Disord Clin Pract 2021 Apr 8;8(3):420-426. Epub 2021 Mar 8.

McGovern Medical School, The University of Texas Health Science Center (UTHealth) Houston Texas USA.

Background: Identifying sex-related differences is critical for enhancing our understanding of factors that may impact prognosis and advance treatments in Huntington's disease (HD).

Objectives: To investigate if sex-related differences exist in clinical HD.

Methods: Longitudinal study of the Enroll-HD database. Read More

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Multidimensional Apathy: The Utility of the Dimensional Apathy Scale in Huntington's Disease.

Mov Disord Clin Pract 2021 Apr 12;8(3):361-370. Epub 2021 Feb 12.

School of Psychological Sciences, Turner Institute for Brain and Mental Health Monash University Melbourne Victoria Australia.

Background: Apathy is a disorder of motivation common to Huntington's disease (HD). Recent conceptual frameworks suggest that apathy is not unitary but consists of discrete subtypes ("dimensions"). Which of the proposed dimensions are preferentially affected in HD, and how these dimensions evolve with disease progression is unknown. Read More

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Disease Onset in Huntington's Disease: When Is the Conversion?

Mov Disord Clin Pract 2021 Apr 31;8(3):352-360. Epub 2021 Jan 31.

Department of Neurology Leiden University Medical Center Leiden The Netherlands.

Background: Determination of disease onset in Huntington's disease is made by clinical experience. The diagnostic confidence level is an assessment regarding the certainty about the clinical diagnosis based on motor signs. A level of 4 means the rater has ≥99% confidence motor abnormalities are unequivocal signs of disease. Read More

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AON-based degradation of c.151C>T mutant transcripts associated with dominantly inherited hearing impairment DFNA9.

Mol Ther Nucleic Acids 2021 Jun 1;24:274-283. Epub 2021 Mar 1.

Department of Otorhinolaryngology, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.

The c.151C>T founder mutation in is a frequent cause of late-onset, dominantly inherited hearing impairment and vestibular dysfunction (DFNA9) in the Dutch/Belgian population. The initial clinical symptoms only manifest between the 3rd and 5th decade of life, which leaves ample time for therapeutic intervention. Read More

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GEORGE ®: A Pilot Study of a Smartphone Application for Huntington's Disease.

J Huntingtons Dis 2021 Mar 30. Epub 2021 Mar 30.

Center for Health+Technology, University of Rochester Medical Center, Rochester, NY, USA.

Background: Current Huntington's disease (HD) measures are limited to subjective, episodic assessments conducted in clinic. Smartphones can enable the collection of objective, real-world data but their use has not been extensively evaluated in HD.

Objective: Develop and evaluate a smartphone application to assess feasibility of use and key features of HD in clinic and at home. Read More

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Possible Role of Activin in the Adiponectin Paradox-Induced Progress of Alzheimer's Disease.

J Alzheimers Dis 2021 Apr 2. Epub 2021 Apr 2.

Division of Neuroscience, National Institute on Aging, Bethesda, MD, USA.

Accumulating evidence suggests that the adiponectin (APN) paradox might be involved in promoting aging-associated chronic diseases such as Alzheimer's disease (AD). In human brain, APN regulation of the evolvability of amyloidogenic proteins (APs), including amyloid-β (Aβ) and tau, in developmental/reproductive stages, might be paradoxically manifest as APN stimulation of AD through antagonistic pleiotropy in aging. The unique mechanisms underlying APN activity remain unclear, a better understanding of which might provide clues for AD therapy. Read More

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Associations between Genotypes, Phenotypes, and Clinical Parameters of Human Disease: A Review.

J Fungi (Basel) 2021 Mar 30;7(4). Epub 2021 Mar 30.

Division of Infectious Diseases, Department of Medicine, Duke University, Durham, NC 27710, USA.

The genus contains two primary species complexes that are significant opportunistic human fungal pathogens: and C. In humans, cryptococcosis can manifest in many ways, but most often results in either pulmonary or central nervous system disease. Patients with cryptococcosis can display a variety of symptoms on a spectrum of severity because of the interaction between yeast and host. Read More

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Deterioration, Compensation and Motor Control Processes in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease.

Geriatrics (Basel) 2021 Mar 23;6(1). Epub 2021 Mar 23.

INSERM U1093-CAPS, Université Bourgogne Franche-Comté, UFR des Sciences du Sport, F-21000 Dijon, France.

Aging is associated with modifications of several brain structures and functions. These modifications then manifest as modified behaviors. It has been proposed that some brain function modifications may compensate for some other deteriorated ones, thus maintaining behavioral performance. Read More

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Longitudinal Evaluation of the Effect of Tricyclic Antidepressants and Neuroleptics on the Course of Huntington's Disease-Data from a Real World Cohort.

Brain Sci 2021 Mar 25;11(4). Epub 2021 Mar 25.

Huntington Center North Rhine-Westphalia, Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital Bochum, Gudrunstraße 56, 44791 Bochum, Germany.

Reducing the progress of neurodegeneration is a key goal in Huntington´s disease (HD). A previously performed systematic screening for medications with neuroprotective features identified tricyclic antidepressants and neuroleptics as neuroprotective and mitochondrioprotective agents. Here, we analyzed the characteristics of disease manifestation, progression and potential beneficial effects in HD patients treated with afore-mentioned medications compared to un- and otherwise treated motor-manifest patients in a large real-world cohort over two years. Read More

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Overcoming the Elusiveness of Neurosarcoidosis: Learning from Five Complex Cases.

Neurol Int 2021 Mar 25;13(2):130-142. Epub 2021 Mar 25.

Department of Neurology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26505, USA.

The involvement of the central nervous system in sarcoidosis can manifest with a variety of neurological symptoms, and most of them can be nonspecific. The diagnosis of neurosarcoidosis (NS) can therefore be very challenging without a tissue biopsy. Both computed tomography (CT) and magnetic resonance imaging (MRI) are important imaging modalities in the diagnosis of NS, and MRI is the modality of choice due to its superior soft-tissue contrast resolution. Read More

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Genetics of Acromegaly and Gigantism.

J Clin Med 2021 Mar 29;10(7). Epub 2021 Mar 29.

Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.

Growth hormone (GH)-secreting pituitary tumours represent the most genetically determined pituitary tumour type. This is true both for germline and somatic mutations. Germline mutations occur in several known genes (, , , , , , , ) as well as familial cases with currently unknown genes, while somatic mutations in are present in up to 40% of tumours. Read More

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Asthma and Chronic Rhinosinusitis: How Similar Are They in Pathogenesis and Treatment Responses?

Int J Mol Sci 2021 Mar 24;22(7). Epub 2021 Mar 24.

Immunoallergology Unit, University Hospital Careggi, 50134 Florence, Italy.

Severe asthma and rhinosinusitis represent frequent comorbidities, complicating the overall management of the disease. Both asthma and chronic rhinosinusitis (CRS) can be differentiated into endotypes: those with type 2 eosinophilic inflammation and those with a non-type 2 inflammation. A correct definition of phenotype/endotype for these diseases is crucial, taking into account the availability of novel biological therapies. Read More

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