25,023 results match your criteria disease conversion


NfL predicts relapse-free progression in a longitudinal multiple sclerosis cohort study: Serum NfL predicts relapse-free progression.

EBioMedicine 2021 Sep 24;72:103590. Epub 2021 Sep 24.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn(2)), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. Electronic address:

Background: Easily accessible biomarkers enabling the identification of those patients with multiple sclerosis (MS) who will accumulate irreversible disability in the long term are essential to guide early therapeutic decisions. We here examine the utility of serum neurofilament light chain (sNfL) for forecasting relapse-free disability progression and conversion to secondary progressive MS (SPMS) in the prospective Neurofilamentandlongtermoutcome inMS (NaloMS) cohort.

Methods: The predictive ability of sNfL at Baseline and sNfL follow-up (FU)/ Baseline (BL) ratio with regard to disability progression was assessed within a development cohort (NaloMS, n=196 patients with relapsing-remitting MS (RRMS) or clinically isolated syndrome) and validated with an external independent cohort (Düsseldorf, Essen, n=204). Read More

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September 2021

Criteria and definitions for the radiological and clinical diagnosis of bronchiectasis in adults for use in clinical trials: international consensus recommendations.

Lancet Respir Med 2021 Sep 24. Epub 2021 Sep 24.

Department of Pneumology Dr Josep Trueta Hospital, Biomedical Research Institute of Girona, Universitat de Girona, Girona, Spain.

Bronchiectasis refers to both a clinical disease and a radiological appearance that has multiple causes and can be associated with a range of conditions. Disease heterogeneity and the absence of standardised definitions have hampered clinical trials of treatments for bronchiectasis and are important challenges in clinical practice. In view of the need for new therapies for non-cystic fibrosis bronchiectasis to reduce the disease burden, we established an international taskforce of experts to develop recommendations and definitions for clinically significant bronchiectasis in adults to facilitate the standardisation of terminology for clinical trials. Read More

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September 2021

Biliary Tract Instrumentations Prior to Elective Cholecystectomy: Effect on Biliary Microbiome.

Surg Infect (Larchmt) 2021 Sep 27. Epub 2021 Sep 27.

Department of General Surgery, Hillel Yaffe Medical Center, affiliated with The Rapaport School of Medicine, Technion Haifa, Israel.

Calculus biliary disease is a common condition that requires invasive procedures in complicated cases. The effect of biliary instrumentation on the biliary microbiome and its impact on surgical complications after elective cholecystectomy remains unclear. This study aimed to assess the impact of prior biliary instrumentation on the biliary microbiome, as well as on the clinical outcomes of cholecystectomy. Read More

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September 2021

Interferon gamma immunotherapy in five critically ill COVID-19 patients with impaired cellular immunity: a case series.

Med (N Y) 2021 Sep 21. Epub 2021 Sep 21.

Department of Internal Medicine and Radboud Centre for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.

Background: Prolonged SARS-CoV-2 shedding has been described in immunocompromised COVID-19 patients, resulting in protracted disease and poor outcome. Specific therapy to improve viral clearance and outcome for this group of patients is currently unavailable.

Methods: Five critically ill COVID-19 patients with severe defects in cellular immune responses, high SARS-CoV-2 viral RNA loads, and no respiratory improvement were treated with interferon gamma, 100 μg subcutaneously, thrice weekly. Read More

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September 2021

Acetabular Fractures with Central Hip Dislocation: A Retrospective Consecutive 50 Case Series Study Based on AO/OTA 2018 Classification in Midterm Follow-Up.

Biomed Res Int 2021 17;2021:6659640. Epub 2021 Sep 17.

Department of Orthopedics, China Medical University Hospital, Taichung, Taiwan.

Introduction: Management of acetabular fractures is challenging, especially when a medial acetabular fracture is complicated by central hip dislocation. We retrospectively investigated the clinical outcome and risk factors of secondary hip osteoarthritis requiring total hip arthroplasty after the surgical treatment of acetabular fractures with central hip dislocation.

Materials And Methods: The medical records of all patients who had acetabular medial wall fractures with central hip dislocation treated with open reduction and internal fixation by a single surgeon between January 2015 and June 2017 were reviewed. Read More

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September 2021

Adipose/Connective Tissue From Thyroid-Associated Ophthalmopathy Uncovers Interdependence Between Methylation and Disease Pathogenesis: A Genome-Wide Methylation Analysis.

Front Cell Dev Biol 2021 8;9:716871. Epub 2021 Sep 8.

Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.

In response to pathological stimulation, methylation status conversion of the genome drives changes of cell feature and is able to promote disease development. Yet the role of methylation in the development of thyroid-associated ophthalmopathy (TAO) remains to be evaluated. Overexpansion of orbital tissue is the key feature of TAO. Read More

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September 2021

Disease-Associated Gut Microbiota Reduces the Profile of Secondary Bile Acids in Pediatric Nonalcoholic Fatty Liver Disease.

Front Cell Infect Microbiol 2021 9;11:698852. Epub 2021 Sep 9.

Department of Pediatric Infectious Disease, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Children with nonalcoholic fatty liver disease (NAFLD) display an altered gut microbiota compared with healthy children. However, little is known about the fecal bile acid profiles and their association with gut microbiota dysbiosis in pediatric NAFLD. A total of 68 children were enrolled in this study, including 32 NAFLD patients and 36 healthy children. Read More

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September 2021

The 96-week clinical outcomes after cessation of nucleos(t)ide analog treatment in chronic hepatitis B patients.

Gastroenterol Rep (Oxf) 2021 Aug 10;9(4):313-322. Epub 2021 Apr 10.

Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P. R. China.

Background: Chronic hepatitis B (CHB) patients have a high virological relapse rate after cessation of nucleos(t)ide analog (NA) treatment, but the clinical outcome remains unclear. This study aimed to investigate the 96-week clinical outcomes and the risk factors for relapse in CHB after cessation of NAs.

Methods: This study was a prospective trial; 74 eligible patients were enrolled. Read More

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Transient Impact of Dysglycemia on Sputum Conversion among Smear-Positive Tuberculosis Patients in a Tertiary Care Facility in Ghana.

Clin Med Insights Circ Respir Pulm Med 2021 20;15:11795484211039830. Epub 2021 Sep 20.

University of Ghana, Accra, Greater Accra, Ghana.

Background: Apart from increasing the risk of tuberculosis (TB), diabetes may be associated with more severe disease and lower rates of sputum conversion among TB patients.

Methods: We conducted a baseline cross-sectional study with a longitudinal follow-up of newly diagnosed smear-positive TB patients for 6 months. Sputum conversion rates between those with dysglycemia and those without were compared at 2 months (end of the intensive phase) and 6 months (end of the treatment). Read More

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September 2021

Generation of human chronic wasting disease in transgenic mice.

Acta Neuropathol Commun 2021 Sep 26;9(1):158. Epub 2021 Sep 26.

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.

Chronic wasting disease (CWD) is a cervid prion disease caused by the accumulation of an infectious misfolded conformer (PrP) of cellular prion protein (PrP). It has been spreading rapidly in North America and also found in Asia and Europe. Although bovine spongiform encephalopathy (i. Read More

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September 2021

Molecular Insights into the Inhibitory Effect of GV971 Components Derived from Marine Acidic Oligosaccharides against the Conformational Transition of Aβ42 Monomers.

ACS Chem Neurosci 2021 Sep 27. Epub 2021 Sep 27.

Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, P. R. China.

GV971 derived from marine acidic oligosaccharides has been used to cure Alzheimer's disease (AD). However, the molecular mechanism of its inhibition of the conformational transition of amyloid β-proteins (Aβ) is still unclear. Herein, molecular dynamics simulations were used to explore the molecular mechanism of the main GV971 components including DiM, TetraM, HexaM, and OctaM to inhibit the conformational conversion of the Aβ42 monomer. Read More

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September 2021

Short- and medium-term outcomes after uniportal and multiportal video-assisted thoracic surgery lobectomy in elderly patients with non-small cell lung cancer.

J BUON 2021 Jul-Aug;26(4):1453-1459

Pingxiang People's Hospital, Pingxiang, Jiangxi, People's Republic of China.

Purpose: To investigate the short- and medium-term outcomes following treatment with uniportal video-assisted thoracic surgery lobectomy (uniportal VATS) in elderly patients with non-small cell lung cancer (NSCLC).

Methods: We conducted a retrospective analysis on the clinical and follow-up data of 74 elderly patients with NSCLC who underwent uniportal VATS between January 2015 and January 2020. One-to-one propensity score matching (PSM) was employed to select 71 elderly patients with NSCLC who underwent multiportal video-assisted thoracoscopic lobectomy (multiportal VATS) during the same period. Read More

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September 2021

MRI-based Alzheimer's disease prediction via distilling the knowledge in multi-modal data.

Neuroimage 2021 Sep 23:118586. Epub 2021 Sep 23.

School of Computer Science, The University of Sydney, Australia; JD Explore Academy, China. Electronic address:

Mild cognitive impairment (MCI) conversion prediction, i.e., identifying MCI patients of high risks converting to Alzheimer's disease (AD), is essential for preventing or slowing the progression of AD. Read More

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September 2021

Adjunctive interleukin-2 for the treatment of drug-susceptible tuberculosis: a randomized control trial in China.

Infection 2021 Sep 25. Epub 2021 Sep 25.

Fuyang No.2 Hospital, Fuyang, China.

Purpose: Evaluation of the efficacy and safety of IL-2 in the treatment of drug-susceptible tuberculosis.

Methods: First, the cases of diagnosed drug-susceptible tuberculosis were randomized into two groups-the control group that received the background regimen of isoniazid, rifampin, pyrazinamide, and ethambutol, and the experimental group that received the background regimen plus IL-2. The efficacy and safety evaluations were performed throughout the therapy process as well as 12 months after the treatment completion. Read More

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September 2021

Long-Term Outcomes After an Individualized Strategy in Patients with Pulmonary Atresia and Intact Ventricular Septum.

Pediatr Cardiol 2021 Sep 24. Epub 2021 Sep 24.

Department of Cardiovascular Surgery, Kyushu Hospital, Japan Community Healthcare Organization, Kitakyushu, Japan.

This retrospective cohort study aimed to explore the long-term outcomes of an individualized strategy in patients with pulmonary atresia and intact ventricular septum (PAIVS). We analyzed survival and reintervention rates and identified risk factors for outcomes in patients with PAIVS treated based on individual right heart structures between 1979 and 2019. Ninety-five patients were included in this study. Read More

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September 2021

Project extension for community healthcare outcomes improves care and treatment for multidrug-resistant tuberculosis patients in Tanzania.

Int J Mycobacteriol 2021 Apr-Jun;10(2):182-187

Division of Infectious Diseases, The ECHO Institute, University of New Mexico Health Sciences Centre, New Mexico, United States.

Background: Project Extension for Community Healthcare Outcomes (Project ECHO) is a telementoring, case based virtual community of practice training and education model connecting experts to primary care clinicians (PCCs). Project ECHO has good evidence for favorable treatment outcomes on wide range of diseases. Since 2017, Tanzania hosts multidrug resistant tuberculosis (MDR TB) ECHO with hub at Kibong'oto Infectious Diseases Hospital. Read More

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September 2021

Early safety and efficacy of linezolid-based combination therapy among patients with drug-resistant tuberculosis in North-western Nigeria.

Int J Mycobacteriol 2021 Apr-Jun;10(2):129-135

Department of Medicine, College of Health Sciences, Bayero University, Kano, Kano State, Nigeria.

Background: The emergence of drug-resistant tuberculosis (DRTB) has continued to pose a threat to public health in sub-Saharan Africa and globally. Despite the high burden of tuberculosis (TB) in Nigeria, there are paucity of data on the safety and efficacy of newer agents and repurposed drugs used in the treatment of DRTB.

Methods: This prospective cohort study was conducted at a regional DRTB treatment center in Kano, Northwestern Nigeria. Read More

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September 2021

ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling.

J Cell Sci 2021 Sep 24. Epub 2021 Sep 24.

Max-Delbrueck-Center for Molecular Medicine, 13125 Berlin, Germany.

Sortilin is a neuronal receptor for apolipoprotein E. Sortilin-dependent uptake of lipidated apoE promotes conversion of polyunsaturated fatty acids (PUFA) into neuromodulators that induce anti-inflammatory gene expression in the brain. This neuroprotective pathway works with apoE3 but is lost with apoE4, the main risk factor for Alzheimer's disease (AD). Read More

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September 2021

Repeated centralized multidisciplinary team assessment of resectability, clinical behavior, and outcomes in 1086 Finnish metastatic colorectal cancer patients (RAXO): A nationwide prospective intervention study.

Lancet Reg Health Eur 2021 Apr 29;3:100049. Epub 2021 Jan 29.

Department of Transplantation and Liver Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Background: Resection of colorectal cancer (CRC) metastases provides good survival but is probably underused in real-world practice.

Methods: A prospective Finnish nationwide study enrolled treatable metastatic CRC patients. The intervention was the assessment of resectability upfront and twice during first-line therapy by the multidisciplinary team (MDT) at Helsinki tertiary referral centre. Read More

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Monitoring of chronic wasting disease using real-time quaking-induced conversion assay in Japan.

J Vet Med Sci 2021 Sep 24. Epub 2021 Sep 24.

Laboratory of Veterinary Hygiene, Faculty of Veterinary Medicine, Graduate School of Infectious Diseases, Hokkaido University.

There has been no report on Chronic wasting disease (CWD) cases in Japan to date; however, there is concern about the geographic spread of CWD. To clarify the CWD status in Japan, we conducted CWD monitoring using real-time quaking-induced conversion (RT-QuIC) assay which can detect the low level of CWD prions. A total of 690 obex samples collected from sika deer and Reeves's muntjac in Hokkaido and Honshu was tested for CWD prions. Read More

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September 2021

Synthesis of Nanoparticles Fully Made of Hemoglobin with Antioxidant Properties: A Step toward the Creation of Successful Oxygen Carriers.

Langmuir 2021 Sep 23. Epub 2021 Sep 23.

Department of Health Technology, Centre for Nanomedicine and Theranostics, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.

Transfusion of donor red blood cells (RBCs) is a crucial and widely employed clinical procedure. However, important constraints of blood transfusions include the limited availability of blood, the need for typing and cross-matching due to the RBC membrane antigens, the limited storage lifetime, or the risk for disease transmission. Hence, a lot of effort has been devoted to develop RBC substitutes, which are free from the limitations of donor blood. Read More

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September 2021

Quantification of balanced SSFP myocardial perfusion imaging at 1.5 T: Impact of the reference image.

Magn Reson Med 2021 Sep 23. Epub 2021 Sep 23.

School of Biomedical Engineering and Imaging Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.

Purpose: To investigate the use of a high flip-angle (HFA) balanced SSFP (bSSFP) reference image (in comparison to conventional proton density [PD]-weighted reference images) for conversion of bSSFP myocardial perfusion images into dynamic T maps for improved myocardial blood flow (MBF) quantification at 1.5 T.

Methods: The HFA-bSSFP (flip angle [FA] = 50°), PD gradient-echo (PD-GRE; FA = 5°), and PD-bSSFP (FA = 8°) reference images were acquired before a dual-sequence bSSFP perfusion acquisition. Read More

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September 2021

Outcomes following out-of-hours acute cholecystectomy: A systematic review and meta-analysis.

J Trauma Acute Care Surg 2021 Sep 20. Epub 2021 Sep 20.

Department of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.

Background: Cholecystectomy is one of the most commonly performed abdominal operations. Rising demands on acute operating theatre availability and resource utilization in the daytime have led to acute cholecystectomy being performed out-of-hours (in the evenings, at night, or on weekends), although it remains unknown whether outcomes differ between out-of-hours and in-hours (during the daytime on weekdays) acute cholecystectomy. This systematic review and meta-analysis aimed to compare outcomes following out-of-hours versus in-hours acute cholecystectomy. Read More

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September 2021

The review of alpha-linolenic acid: Sources, metabolism, and pharmacology.

Phytother Res 2021 Sep 22. Epub 2021 Sep 22.

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

α-linolenic acid (ALA, 18:3n-3) is a carboxylic acid composed of 18 carbon atoms and three cis double bonds, and is an essential fatty acid indispensable to the human body. This study aims to systematically review related studies on the dietary sources, metabolism, and pharmacological effects of ALA. Information on ALA was collected from the internet database PubMed, Elsevier, ResearchGate, Web of Science, Wiley Online Library, and Europe PMC using a combination of keywords including "pharmacology," "metabolism," "sources. Read More

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September 2021

The Effects of Diosgenin on Hypolipidemia and Its Underlying Mechanism: A Review.

Diabetes Metab Syndr Obes 2021 15;14:4015-4030. Epub 2021 Sep 15.

Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, People's Republic of China.

Hyperlipidemia is a disorder of lipid metabolism, which is a major cause of coronary heart disease. Although there has been considerable progress in hyperlipidemia treatment, morbidity and risk associated with the condition continue to rise. The first-line treatment for hyperlipidemia, statins, has multiple side effects; therefore, development of safe and effective drugs from natural products to prevent and treat hyperlipidemia is necessary. Read More

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September 2021

Conversion from intravenous maxacalcitol to oral vitamin D in secondary hyperparathyroidism management.

Clin Exp Nephrol 2021 Sep 21. Epub 2021 Sep 21.

Dialysis Unit, Shin-Kuki General Hospital, Saitama, Japan.

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September 2021

Predictors of unfavorable responses to therapy in rifampicin-sensitive pulmonary tuberculosis using an integrated approach of radiological presentation and sputum mycobacterial burden.

PLoS One 2021 20;16(9):e0257647. Epub 2021 Sep 20.

Department of Clinical Research, National Institute for Research in Tuberculosis (formerly Tuberculosis Research Centre), Indian Council of Medical Research, Chennai, Tamil Nadu, India.

Introduction: Despite the exalted status of sputum mycobacterial load for gauging pulmonary tuberculosis treatment and progress, Chest X-rays supplement valuable information for taking instantaneous therapeutic decisions, especially during the COVID-19 pandemic. Even though literature on individual parameters is overwhelming, few studies have explored the interaction between radiographic parameters denoting severity with mycobacterial burden signifying infectivity. By using a sophisticated approach of integrating Chest X-ray parameters with sputum mycobacterial characteristics, evaluated at all the three crucial time points of TB treatment namely pre-treatment, end of intensive phase and completion of treatment, utilizing the interactive Cox Proportional Hazards model, we aimed to precisely deduce predictors of unfavorable response to TB treatment. Read More

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September 2021

The inhibitor miR-21 regulates macrophage polarization in an experimental model of chronic obstructive pulmonary disease.

Tob Induc Dis 2021 2;19:69. Epub 2021 Sep 2.

Department of Respiratory Medicine, The Third XiangYa Hospital of Central South University, Changsha, People's Republic of China.

Introduction: In chronic obstructive pulmonary disease (COPD), macrophages play an indispensable role. In the lung tissues of COPD patients and smokers, macrophages can be observed to polarize towards M2 phenotype. The molecular mechanism of this process is unclear, and it has not been fully elucidated in COPD. Read More

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September 2021

Prediction on Transmission Trajectory of COVID-19 based on Particle Swarm Algorithm.

Pattern Recognit Lett 2021 Sep 15. Epub 2021 Sep 15.

School of Computer Science, Hubei Polytechnic University, Huangshi 435003, China.

This study aimed to predict the transmission trajectory of the 2019 Corona Virus Disease (COVID-19). The particle swarm optimization (PSO) algorithm was combined with the traditional susceptible exposed infected recovered (SEIR) infectious disease prediction model to propose a SEIR-PSO prediction model on the COVID-19. In addition, the domestic epidemic data from February 25, 2020 to March 20, 2020 in China were selected as the training set for analysis. Read More

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September 2021

Duration of infectious virus shedding in patients with severe coronavirus disease 2019 who required mechanical ventilation.

J Infect Chemother 2021 Sep 10. Epub 2021 Sep 10.

Department of Infectious Diseases, Hiroshima University Hospital, 1-2-3 Kasumi, Minamiku, Hiroshima, 734-8551, Japan.

Background: Approximately 5% of patients with coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 develop severe COVID-19. Severe COVID-19 requires respiratory management with mechanical ventilation and an extended period of treatment. Prolonged infectious virus shedding is a concern in severe COVID-19 cases, but few reports have examined the duration of infectious virus shedding. Read More

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September 2021