558 results match your criteria discussions 200


Liver health events: an indigenous community-led model to enhance HCV screening and linkage to care.

Health Promot Int 2021 Jun 13. Epub 2021 Jun 13.

Wellness Wheel Regina General Hospital, 2nd Floor Medical Office Wing c/o Infectious Diseases Clinic 1440-14th Avenue, Regina, SK, S4P 0W5, Canada.

Despite high prevalence of hepatitis C virus (HCV), linkage to care and treatment for Indigenous people is low. In an Indigenous community in Saskatchewan, Canada a retrospective review identified 200 individuals (∼12% prevalence) had HCV antibodies though majority lacked ribonucleic acid (RNA) testing, and few received treatment despite availability of an effective cure. Following Indigenous oral traditions, focus group discussions were held with key community members and leadership. Read More

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Counseling at all contacts for postpartum contraceptive use: can paper-based tools help community health workers improve continuity of care? A qualitative study from Ethiopia.

Gates Open Res 2019 29;3:1652. Epub 2021 Apr 29.

Jhpiego, Conakry, Immeuble Guinomar, 5ème étage, Guinea.

Globally, there has been a resurgence of interest in postpartum family planning (PPFP) to advance reproductive health outcomes. Few programs have systematically utilized all contacts a woman and her baby have with the health system, from pregnancy through the first year postpartum, to promote PPFP. Nested into a larger study covering two districts, this study assessed the use, acceptability, and feasibility of tools for tracking women's decision-making and use of PPFP in the community health system in Oromia region, Ethiopia. Read More

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The Leeds Infant Mental Health Service: early relationships matter.

J Reprod Infant Psychol 2020 Oct 8:1-14. Epub 2020 Oct 8.

Formerly Infant Mental Health Service, Leeds Community Healthcare NHS Trust, UK.

Introduction: Infants' experience of the early caregiving environment is fundamental to the development of positive social and emotional functioning. The Leeds Infant Mental Health Service was established to provide early intervention to infantsunder two and their caregivers, where there are concerns about the attachment relationship. This paper describes preliminary data to evaluate its effectiveness. Read More

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October 2020

Some lessons for malaria from the Global Polio Eradication Initiative.

Malar J 2021 May 1;20(1):210. Epub 2021 May 1.

ISGlobal, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain.

The Global Polio Eradication Initiative (GPEI) was launched in 1988 with the aim of completely clearing wild polio viruses by 2000. More than three decades later, the goal has not been achieved, although spectacular advances have been made, with wild polio virus reported in only 2 countries in 2019. In spite of such progress, novel challenges have been added to the equation, most importantly outbreaks of vaccine-derived polio cases resulting from reversion to neurovirulence of attenuated vaccine virus, and insufficient coverage of vaccination. Read More

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Uganda's response to sexual harassment in the public health sector: from "Dying Silently" to gender-transformational HRH policy.

Hum Resour Health 2021 May 1;19(1):59. Epub 2021 May 1.

Uganda Ministry of Health, Plot 6, Lourdel Road, Wandegeya, P.O Box 7272, Kampala, Uganda.

Introduction: Sexual harassment is a ubiquitous problem that prevents women's integration and retention in the workforce. Its prevalence had been documented in previous health sector studies in Uganda, indicating that it affected staffing shortages and absenteeism but was largely unreported. To respond, the Ministry of Health needed in-depth information on its employees' experiences of sexual harassment and non-reporting. Read More

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Insights about Screen-Use Conflict from Discussions between Mothers and Pre-Adolescents: A Thematic Analysis.

Int J Environ Res Public Health 2021 04 28;18(9). Epub 2021 Apr 28.

Department of Psychology, Queens University, Kingston, ON K7L 3N6, Canada.

Digital screens have become an integral part of everyday life. In the wake of the digital swell, pre-adolescents and their parents are learning to navigate seemingly new terrain regarding digital media use. The present study aimed to investigate parent and pre-adolescent perceptions of screen use and the source of conflict surrounding digital media. Read More

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Comparing older nonmedical and medical cannabis users: health-related characteristics, cannabis use patterns, and cannabis sources.

Am J Drug Alcohol Abuse 2021 Apr 29:1-11. Epub 2021 Apr 29.

Steve Hicks School of Social Work, University of Texas at Austin, Austin, TX, USA.

: US epidemiologic data show that nearly one in 10 individuals aged 50+ report past-year cannabis use, and nearly one in five users report medical use. However, research on older cannabis users, especially medical cannabis users, is scant.: We examined medical and nonmedical cannabis users aged 50+ on health-related characteristics, cannabis use patterns, and cannabis sources. Read More

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Optimizing language for effective communication of gene therapy concepts with hemophilia patients: a qualitative study.

Orphanet J Rare Dis 2021 Apr 28;16(1):189. Epub 2021 Apr 28.

BioMarin Pharmaceutical Inc., Novato, CA, USA.

Background: For communities of people living with hemophilia and other genetic conditions, gene therapy could represent a paradigm shift in treatment strategies. As investigational therapeutic modalities such as gene therapy become more widely used and discussed, there is a critical need for all stakeholders to communicate using a lexicon that is intelligible, accurate, consistent, and representative of novel treatments. In doing so, expectations can be more carefully managed and potential risks, benefits, and limitations better understood. Read More

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Development and validation of a questionnaire for assessing preventive practices and barriers among health care workers in COVID-19 pandemic.

Indian J Med Microbiol 2021 Apr 23;39(2):200-211. Epub 2021 Apr 23.

Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.

Objectives: COVID-19 has affected thousands of health care workers worldwide. Suboptimal infection control practices have been identified as important risk factors. The objective of this study was to develop and validate a questionnaire to holistically assess the preventive practices of health care workers related to COVID-19 and identify the reasons for shortcomings therein. Read More

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Perceptions of Ghanaian traditional health practitioners, primary health care workers, service users and caregivers regarding collaboration for mental health care.

BMC Health Serv Res 2021 Apr 23;21(1):375. Epub 2021 Apr 23.

Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Background: In low- and middle-income countries, the paucity of conventional health services means that many people with mental health problems rely on traditional health practitioners (THPs). This paper examines the possibility of forging partnerships at the Primary Health Care (PHC) level in two geopolitical regions of Ghana, to maximize the benefits to both health systems.

Methods: The study was a qualitative cross-sectional survey. Read More

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The Status of Quality Improvement Programs for Pediatric Traumatic Brain Injury Care in Argentina.

J Surg Res 2021 Apr 19;265:71-78. Epub 2021 Apr 19.

Harborview Injury Prevention and Research Center, Box 359960, Harborview Medical Center, Seattle, Washington. Electronic address:

Introduction: Trauma quality improvement (QI) programs improve care and outcomes for injured patients. Information about QI programs for pediatric traumatic brain injury (TBI) is sparse in Latin America.

Methods: We gathered data on the status of QI programs and activities that encompass pediatric TBI at 15 Argentine hospitals. Read More

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Combining quantitative ADF STEM with SiN membrane-based MEMS devices: A simulation study with Pt nanoparticles.

Ultramicroscopy 2021 Apr 6:113270. Epub 2021 Apr 6.

Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons and Peter Grünberg Institute, Forschungszentrum Jülich, 52425 Jülich, Germany.

Computer simulations are used to assess the influence of a 20-nm-thick SiN membrane on the quantification of atomic-resolution annular dark-field (ADF) scanning transmission electron microscopy images of Pt nanoparticles. The discussions include the effect of different nanoparticle/membrane arrangements, accelerating voltage, nanoparticle thickness and the presence of adjacent atomic columns on the accuracy with which the number of Pt atoms in each atom column can be counted. The results, which are based on the use of ADF scattering cross-sections, show that an accuracy of better than a single atom is attainable at 200 and 300 kV. Read More

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Digital Health during COVID-19: Informatics Dialogue with the World Health Organization.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

eHealth Development Association, Amman, Jordan.

Background: On December 16, 2020 representatives of the International Medical Informatics Association (IMIA), a Non-Governmental Organization in official relations with the World Health Organization (WHO), along with its International Academy for Health Sciences Informatics (IAHSI), held an open dialogue with WHO Director General (WHO DG) Tedros Adhanom Ghebreyesus about the opportunities and challenges of digital health during the COVID-19 global pandemic.

Objectives: The aim of this paper is to report the outcomes of the dialogue and discussions with more than 200 participants representing different civil society organizations (CSOs).

Methods: The dialogue was held in form of a webinar. Read More

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Assessment and management of disease burden and quality of life in patients with hereditary angioedema: a consensus report.

Allergy Asthma Clin Immunol 2021 Apr 19;17(1):40. Epub 2021 Apr 19.

University of California San Diego, 8899 University Center Ln, San Diego, CA, 92122, USA.

Background: Hereditary angioedema (HAE) is a rare disease characterized by unpredictable, potentially life-threatening attacks, resulting in significant physical and emotional burdens for patients and families. To optimize care for patients with HAE, an individualized management plan should be considered in partnership with the physician, requiring comprehensive assessment of the patient's frequency and severity of attacks, disease burden, and therapeutic control. Although several guidelines and consensus papers have been published concerning the diagnosis and treatment of HAE, there has been limited specific clinical guidance on the assessment of disease burden and quality of life (QoL) in this patient population. Read More

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GRADE guidelines 32: GRADE offers guidance on choosing targets of GRADE certainty of evidence ratings.

J Clin Epidemiol 2021 Apr 20;137:163-175. Epub 2021 Apr 20.

Department of Health Research Methods, Evidence and Impact, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada, L8S 4L8; Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada, L8S 4K1.

Objective: To provide practical principles and examples to help GRADE users make optimal choices regarding their ratings of certainty of evidence using a minimally or partially contextualized approach.

Study Design And Setting: Based on the GRADE clarification of certainty of evidence in 2017, a project group within the GRADE Working Group conducted iterative discussions and presentations at GRADE Working Group meetings to refine this construct and produce practical guidance.

Results: Systematic review and health technology assessment authors need to clarify what it is in which they are rating their certainty of evidence (i. Read More

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A Framework for Sharing Radiation Dose Distribution Maps in the Electronic Medical Record for Improving Multidisciplinary Patient Management.

Radiol Imaging Cancer 2021 03 12;3(2):e200075. Epub 2021 Mar 12.

Departments of Radiation Oncology (R.R.S., J.D., M.M., S.T., N.A., J.H., T.K.) and Radiology (N.S.), UCLA David Geffen School of Medicine, 200 UCLA Medical Plaza, Suite B265, Los Angeles, CA 90095.

Radiation oncology practices use a suite of dedicated software and hardware that are not common to other medical subspecialties, making radiation treatment history inaccessible to colleagues. A radiation dose distribution map is generated for each patient internally that allows for visualization of the dose given to each anatomic structure volumetrically; however, this crucial information is not shared systematically to multidisciplinary medical, surgery, and radiology colleagues. A framework was developed in which dose distribution volumes are uploaded onto the medical center's picture archiving and communication system (PACS) to rapidly retrieve and review exactly where, when, and to what dose a lesion or structure was treated. Read More

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A learning process towards person-centred care: A second-year follow-up of guideline implementation.

Int J Older People Nurs 2021 Mar 19:e12373. Epub 2021 Mar 19.

Division of Occupational Therapy, Department of Neurobiology, Caring Sciences and Society, Karolinska Institutet, Huddinge, Sweden.

Background: Research claims that 'learning by doing' creates new thinking, often leading to new practice.

Objectives: The aim was to explore and describe the staff learning process from the first to the second year when adopting person-centred care into clinical practice in a nursing home for persons with dementia.

Method: The data consisted of poster texts from staff and written notes by researchers obtained from the group discussions. Read More

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Developing Visual Messages to Support Liquefied Petroleum Gas Use in Intervention Homes in the Household Air Pollution Intervention Network (HAPIN) Trial in Rural Guatemala.

Health Educ Behav 2021 Mar 18:1090198121996280. Epub 2021 Mar 18.

Emory University, Atlanta, GA, USA.

Background: Household air pollution adversely affects human health and the environment, yet more than 40% of the world still depends on solid cooking fuels. The House Air Pollution Intervention Network (HAPIN) randomized controlled trial is assessing the health effects of a liquefied petroleum gas (LPG) stove and 18-month supply of free fuel in 3,200 households in rural Guatemala, India, Peru, and Rwanda.

Aims: We conducted formative research in Guatemala to create visual messages that support the sustained, exclusive use of LPG in HAPIN intervention households. Read More

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Ex vivo gene modification therapy for genetic skin diseases-recent advances in gene modification technologies and delivery.

Exp Dermatol 2021 Mar 3. Epub 2021 Mar 3.

Infection, Immunity and Inflammation Research & Teaching Department, Immunobiology Section, UCL Great Ormond Street Institute of Child Health, London, UK.

Genetic skin diseases, also known as genodermatoses, are inherited disorders affecting skin and constitute a large and heterogeneous group of diseases. While genodermatoses are rare with the prevalence rate of less than 1 in 50,000 - 200,000, they frequently occur at birth or early in life and are generally chronic, severe, and could be life-threatening. The quality of life of patients and their families are severely compromised by the negative psychosocial impact of disease, physical manifestations, and the lack or loss of autonomy. Read More

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It helps to talk: A guiding framework (TRUST) for peer support in delivering mental health care for adolescents living with HIV.

PLoS One 2021 3;16(3):e0248018. Epub 2021 Mar 3.

Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Introduction: Adolescents living with HIV have poor treatment outcomes, including lower rates of viral suppression, than other age groups. Emerging evidence suggests a connection between improved mental health and increased adherence. Strengthening the focus on mental health could support increased rates of viral suppression. Read More

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Knowledge About COVID-19 in Brazil: Cross-Sectional Web-Based Study.

JMIR Public Health Surveill 2021 01 21;7(1):e24756. Epub 2021 Jan 21.

Laboratory of Immunology and Bioinformatics, Institute of Biological and Natural Sciences, Federal University of Triangulo Mineiro, Uberaba, Brazil.

Background: COVID-19 is a highly transmissible illness caused by SARS-CoV-2. The disease has affected more than 200 countries, and the measures that have been implemented to combat its spread, as there is still no vaccine or definitive medication, have been based on supportive interventions and drug repositioning. Brazil, the largest country in South America, has had more than 140,000 recorded deaths and is one of the most affected countries. Read More

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January 2021

Consult and procedure incidence outcomes following establishment of a fertility preservation program for children with cancer.

J Assist Reprod Genet 2021 Feb 3;38(2):495-501. Epub 2021 Jan 3.

Division of Pediatric and Adolescent Gynecology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.

Purpose: Fertility is a quality of life outcome adversely affected by cancer therapy. Many childhood cancer patients, however, are not offered options to preserve their fertility. Providers acknowledge difficulty discussing impaired fertility to patients due to lack of knowledge of available options. Read More

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February 2021

Trajectories of PrEP Adherence Among Young Women Aged 16 to 25 in Cape Town, South Africa.

AIDS Behav 2021 Jul 2;25(7):2046-2053. Epub 2021 Jan 2.

Women's Global Health Imperative, RTI International, 2150 Shattuck avenue, Berkeley, CA, 94104, USA.

Despite demonstrated efficacy for HIV prevention, substantial challenges remain for the successful rollout of oral pre-exposure prophylaxis (PrEP), especially among adolescent girls and young women (AGYW). We characterized trajectories of PrEP adherence among 200 AGYW in South Africa and analyzed data from 22 qualitative interviews and 3 focus group discussions for explanatory purposes. Two adherence trajectory groups were identified: 52% with high early adherence that declined after month three and 48% with low adherence throughout. Read More

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2020 Food and Drug Law Institute (FDLI) Annual Conference (October 6-8, 2020 - Virtual Meeting).

Authors:
D Komlos

Drugs Today (Barc) 2020 Dec;56(12):795-802

Clarivate, Philadelphia, Pennsylvania, USA.

This year's annual conference of the Food and Drug Law Institute (FDLI) drew more than 700 attendees, including over 200 from the U.S. Food and Drug Administration (FDA), and featured 93 speakers. Read More

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December 2020

Treatment of HF in an Era of Multiple Therapies: Statement From the HF Collaboratory.

JACC Heart Fail 2021 01 9;9(1):1-12. Epub 2020 Dec 9.

Department of Medicine, University of Mississippi, Jackson, Mississippi, USA. Electronic address:

The treatment of heart failure with reduced ejection fraction (HFrEF) has changed considerably over time, particularly with the sequential development of therapies aimed at antagonism of maladaptive biologic pathways, including inhibition of the sympathetic nervous system and the renin-angiotensin aldosterone system. The sequential nature of earlier HFrEF trials allowed the integration of new therapies tested against the background therapy of the time. More recently, multiple heart failure therapies are being evaluated simultaneously, and the number of therapeutic choices for treating HFrEF has grown considerably. Read More

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January 2021

Seroprevalence of anti-SARS-CoV-2 IgG Antibodies in the Staff of a Public School System in the Midwestern United States.

medRxiv 2020 Oct 27. Epub 2020 Oct 27.

Harvard Medical School, Boston, MA.

Background: Since March 2020, the United States has lost over 200,000 lives to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. A growing body of literature describes population-level SARS-CoV-2 exposure, but studies of antibody seroprevalence within school systems are critically lacking, hampering evidence-based discussions on school reopenings. The Lake Central School Corporation (LCSC), a public school system in suburban Indiana, USA, assessed SARS-CoV-2 seroprevalence in its staff and identified correlations between seropositivity and subjective histories and demographics. Read More

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October 2020

Developing trustworthy recommendations as part of an urgent response (1-2 weeks): a GRADE concept paper.

J Clin Epidemiol 2021 Jan 30;129:1-11. Epub 2020 Sep 30.

American College of Physicians, 190 N Independence Mall West, Philadelphia, PA 19087, USA.

Objectives: The aim of this study is to propose an approach for developing trustworthy recommendations as part of urgent responses (1-2 week) in the clinical, public health, and health systems fields.

Study Design And Setting: We conducted a review of the literature, outlined a draft approach, refined the concept through iterative discussions, a workshop by the Grading of Recommendations Assessment, Development and Evaluation Rapid Guidelines project group, and obtained feedback from the larger Grading of Recommendations Assessment, Development and Evaluation working group.

Results: A request for developing recommendations within 2 week is the usual trigger for an urgent response. Read More

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January 2021

Scabies: Diagnostic and Therapeutic Update.

J Cutan Med Surg 2021 Jan-Feb;25(1):95-101. Epub 2020 Sep 30.

8613 Departments of Medicine, North York General Hospital and Baycrest Health Sciences, Courtesy Staff Dermatology, Toronto, ON, Canada.

Background: Scabies is globally ubiquitous and is a significant health issue for institutions, the economically disenfranchised, resource-poor areas, and for those with weakened immune systems. Topicals are usually effective, but are cumbersome and expensive to use in large populations and for those nonadherent to topicals. Oral ivermectin became available in Canada for the off-label treatment of scabies in the fall 2018. Read More

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September 2020

Novel Use of Telepalliative Care in a New York City Emergency Department During the COVID-19 Pandemic.

J Emerg Med 2020 11 4;59(5):714-716. Epub 2020 Aug 4.

Department of Emergency Medicine, Columbia University Irving Medical Center, New York, New York.

Background: Coronavirus-2 (COVID-19) is a global pandemic. As of August 21, mortality from COVID-19 has reached almost 200,000 people, with the United States leading the globe in levels of morbidity and mortality. Large volumes of high-acuity patients, particularly those of advanced age and with chronic comorbidities, have significantly increased the need for palliative care resources beyond usual capacity. Read More

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November 2020