4,331 results match your criteria discussing current


The 'wave sign' in hip arthroscopy: a systematic review of epidemiological factors, current diagnostic methods and treatment options.

J Hip Preserv Surg 2020 Aug 22;7(3):410-422. Epub 2020 Dec 22.

Department of Orthopaedic Surgery, Maroondah Hospital, Ringwood, Victoria, Australia.

This study aims to present a systematic review and synthesized evidence on the epidemiological factors, diagnostic methods and treatment options available for this phenomenon. A multi-database search (OVID Medline, EMBASE and PubMed) was performed according to PRISMA guidelines on 18 June 2019. All studies of any study design discussing on the epidemiological factors, diagnostic methods, classification systems and treatment options of the wave sign were included. Read More

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Short- and long-term outcomes of aortic root-sparing repair and replacement in acute type A aortic dissection repair.

Asian Cardiovasc Thorac Ann 2021 May 4:2184923211015087. Epub 2021 May 4.

Aortovascular Surgery, Barts Heart Centre, St. Bartholomew's Hospital, London, UK.

Acute type A aortic dissection is a surgical emergency with a high mortality rate if left untreated. Management of the aortic root in this setting constitutes an intricate decision-making framework, further complicated by the emergent nature of the dissection. There exists much controversy regarding pursuit of the aggressive aortic root replacement versus a conservative root-sparing repair, alongside considerations for valve-sparing root replacement. Read More

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Ideas prevented from becoming conscious: On Freud's unconscious and the theory of psychoanalytic technique.

Authors:
David Tuckett

Int J Psychoanal 2019 Dec 23;100(6):1068-1083. Epub 2019 Dec 23.

The Psychoanalysis Unit and Centre for the Study of Decision-Making Uncertainty, University College London, London, UK; Institute of Psychoanalysis, London, UK.

This contribution to honour the Journal's centenary elaborates the classical view that what is primarily at stake in a psychoanalysis are ideas patients and analysts have that are prevented from becoming conscious. It is argued, drawing on a "bare bones" or parsimonious model of psychoanalytic treatment, that the ideas concerned are mainly the worrying unconscious beliefs patients have about their experience with their analysts. These are ideas saturated with feeling and derived from the internal templates that patients use to respond to current experience, based on ways they have registered experience from the beginning of their lives. Read More

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December 2019

The Substance and Circumstances of Race and Immigration Talk in High School Gender and Sexuality Alliances.

Am J Community Psychol 2021 May 4. Epub 2021 May 4.

San Diego State University School of Public Health, San Diego, CA, USA.

Gender & Sexuality Alliances (GSAs) are school-based clubs that support youth of diverse sexual orientations and gender identities. As identity-centered spaces, GSAs could also foster discussions related to race and immigration (i.e. Read More

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How, when, and for whom: decisions regarding remote neuropsychological assessment during the 2020 COVID-19 pandemic.

Isr J Health Policy Res 2021 05 3;10(1):31. Epub 2021 May 3.

Department of Education and Psychology, The Open University, Ra'anana, Israel.

Neuropsychological assessment provides crucial information about cognitive, behavioral, and socioemotional functioning in medical, educational, legal, and social contexts. During the 2020 COVID-19 pandemic, the Israeli Ministry of Health initially mandated that all psychological assessments be postponed. However, as referrals to time-sensitive, high-need, and high-stakes assessments began to accumulate, it became necessary to consider remote solutions. Read More

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Potential impact of a COVID-19 and smoking paper on Twitter users' attitudes toward smoking: Observational Study.

JMIR Form Res 2021 Apr 22. Epub 2021 Apr 22.

Roswell Park Comprehensive Cancer Center, Buffalo, US.

Background: A cross-sectional study conducted by French researchers showed that the rate of current daily smoking was significantly lower in COVID-19 patients than in the French general population.

Objective: We aim to examine the dissemination of this Miyara et al. study among Twitter users and whether a shift in their attitudes towards smoking occurred after its publication on April 21st, 2020. Read More

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CON: Pulmonary artery catheter use should be forgone in modern clinical practice.

Ann Card Anaesth 2021 Jan-Mar;24(1):8-11

Department of Anesthesia, Pain Management and Perioperative Medicine, Divisions of Cardiothoracic Anesthesia and Critical Care Anesthesiology, Henry Ford Hospital, Detroit, Michigan, USA.

The pulmonary artery catheter (PAC) and its role in the practice of modern medicine remains to be questioned and has experienced a substantial decline in its use in the most recent decades. The complications associated to its use, the lack of consistency of the interpretation provided by the PAC among clinicians, the development of new hemodynamic methods, and the deleterious cost profile associated to the PAC are some of the reasons behind the decrease in its use. Since its introduction into clinical practice, the PAC and the data obtained from its use became paramount in the management of critically ill patients as well as for the high-risk/invasive procedures. Read More

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Deep Learning in Neuroradiology: A Systematic Review of Current Algorithms and Approaches for the New Wave of Imaging Technology.

Radiol Artif Intell 2020 Mar 4;2(2):e190026. Epub 2020 Mar 4.

Warren Alpert Medical School of Brown University, Box G-9280, 222 Richmond St, Providence, RI (A.D.Y., D.L.C., I.P.); and Department of Diagnostic Imaging, Universidade Federal de São Paulo, São Paulo, Brazil (F.K.).

Purpose: To systematically review and synthesize the current literature and to develop a compendium of technical characteristics of existing deep learning applications in neuroradiology.

Materials And Methods: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses systematic review was conducted through September 1, 2019, using PubMed, Cochrane, and Web of Science databases. A total of 155 articles discussing deep learning applications in neuroimaging were identified, divided by imaging modality, and characterized by imaging task, data source, algorithm type, and outcome metrics. Read More

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"Is there a doctor on board?": willingness and confidence of physicians in the Kingdom of Saudi Arabia in assisting with in-flight medical emergencies.

BMC Emerg Med 2021 Apr 30;21(1):54. Epub 2021 Apr 30.

Department of Family and Community Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Background: In-flight medical emergencies (IMEs) are common, and for a traveling physician, it is very likely to encounter such a condition. Data discussing this issue are limited. Thus, this study aimed to evaluate the willingness and confidence of physicians in the Kingdom of Saudi Arabia (KSA) in responding to IMEs. Read More

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Public health risks associated with chronic, low-level domoic acid exposure: A review of the evidence.

Pharmacol Ther 2021 Apr 27:107865. Epub 2021 Apr 27.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA; Center on Human Development and Disability, University of Washington, Seattle, WA, USA; Infant Primate Research Laboratory, Washington National Primate Research Center, Seattle,WA, USA. Electronic address:

Domoic acid (DA), the causative agent for the human syndrome Amnesic Shellfish Poisoning (ASP), is a potent, naturally occurring neurotoxin produced by common marine algae. DA accumulates in seafood, and humans and wildlife alike can subsequently be exposed when consuming DA-contaminated shellfish or finfish. While strong regulatory limits protect people from the acute effects associated with ASP, DA is an increasingly significant public health concern, particularly for coastal dwelling populations, and there is a growing body of evidence suggesting that there are significant health consequences following repeated exposures to levels of the toxin below current safety guidelines. Read More

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Regulatory Role of Sex Hormones in Cardiovascular Calcification.

Int J Mol Sci 2021 Apr 28;22(9). Epub 2021 Apr 28.

The Roslin Institute & R(D)SVS, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.

Sex differences in cardiovascular disease (CVD), including aortic stenosis, atherosclerosis and cardiovascular calcification, are well documented. High levels of testosterone, the primary male sex hormone, are associated with increased risk of cardiovascular calcification, whilst estrogen, the primary female sex hormone, is considered cardioprotective. Current understanding of sexual dimorphism in cardiovascular calcification is still very limited. Read More

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Current Trends of Enterococci in Dairy Products: A Comprehensive Review of Their Multiple Roles.

Foods 2021 Apr 10;10(4). Epub 2021 Apr 10.

LEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, 420-465 Porto, Portugal.

As a genus that has evolved for resistance against adverse environmental factors and that readily exchanges genetic elements, enterococci are well adapted to the cheese environment and may reach high numbers in artisanal cheeses. Their metabolites impact cheese flavor, texture, and rheological properties, thus contributing to the development of its typical sensorial properties. Due to their antimicrobial activity, enterococci modulate the cheese microbiota, stimulate autolysis of other lactic acid bacteria (LAB), control pathogens and deterioration microorganisms, and may offer beneficial effects to the health of their hosts. Read More

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New Evidence on the Distribution of the Highly Endangered and Implications for Its Conservation.

Animals (Basel) 2021 Apr 9;11(4). Epub 2021 Apr 9.

Terra Cypria, The Cyprus Conservation Foundation, Agiou Andreou 341, Limassol 3035, Cyprus.

The critically endangered Cyprus grass snake () has been studied for the past 25 years. Although the need for a complete survey on the distribution of its population, outside the strict boundaries of the known mountainous localities, had been stressed, such an effort has not been conducted to date. In this study, we used a rapid survey approach to investigate possible sightings of the species upstream of the known distribution in the Troodos Mountains. Read More

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Dissecting FGF Signalling to Target Cellular Crosstalk in Pancreatic Cancer.

Cells 2021 Apr 8;10(4). Epub 2021 Apr 8.

Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis with a 5 year survival rate of less than 8%, and is predicted to become the second leading cause of cancer-related death by 2030. Alongside late detection, which impacts upon surgical treatment, PDAC tumours are challenging to treat due to their desmoplastic stroma and hypovascular nature, which limits the effectiveness of chemotherapy and radiotherapy. Pancreatic stellate cells (PSCs), which form a key part of this stroma, become activated in response to tumour development, entering into cross-talk with cancer cells to induce tumour cell proliferation and invasion, leading to metastatic spread. Read More

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MRI-Based Radiomics and Radiogenomics in the Management of Low-Grade Gliomas: Evaluating the Evidence for a Paradigm Shift.

J Clin Med 2021 Apr 1;10(7). Epub 2021 Apr 1.

Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA.

Low-grade gliomas (LGGs) are tumors that affect mostly adults. These neoplasms are comprised mainly of oligodendrogliomas and diffuse astrocytomas. LGGs remain vexing to current management and therapeutic modalities although they exhibit more favorable survival rates compared with high-grade gliomas (HGGs). Read More

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Adolescents Treated for Attention-Deficit/Hyperactivity Disorder in Pediatric Primary Care: Characterizing Risk for Stimulant Diversion.

J Dev Behav Pediatr 2021 Apr 27. Epub 2021 Apr 27.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA; University of Pittsburgh Medical Center, Pittsburgh, PA; Department of Psychology and Neuroscience, University of North Carolina, Chapel Hill, NC; National Institute on Drug Abuse, Bethesda, MD.

Objective: To describe the clinical and psychosocial characteristics, and their hypothesized interrelations, as it pertains to risk for stimulant diversion (sharing, selling, or trading) for adolescents in pediatric primary care treatment for attention-deficit/hyperactivity disorder.

Methods: Baseline data for 341 adolescents in a cluster-randomized controlled trial of stimulant diversion prevention in pediatric primary care (NCT_03080259) were used to (1) characterize diversion and newly measured risk factors, (2) examine their associations with age and sex, and (3) test whether associations among risk factors were consistent with model-implied predictions. Data were collected through multi-informant electronic surveys from adolescents and parents. Read More

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Modelling the impact of vector control on lymphatic filariasis programmes: current approaches and limitations.

Clin Infect Dis 2021 Apr 27. Epub 2021 Apr 27.

Big Data Institute, University of Oxford, UK.

Vector control is widely considered an important tool for lymphatic filariasis (LF) elimination but is not usually included in programme budgets and has often been secondary to other policy questions in modelling studies. Evidence from the field demonstrates that vector control can have a large impact on programme outcomes and even halt transmission entirely, but implementation is expensive. Models of LF have the potential to inform where and when resources should be focused, but often simplify vector dynamics and focus on capturing human prevalence trends, making them comparatively ill-designed for direct analysis of vector control measures. Read More

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The Necessity to Recognize Processes of Radicalization from a Socio-cultural Perspective.

Integr Psychol Behav Sci 2021 Apr 26. Epub 2021 Apr 26.

İstanbul Bilgi University, European Institute, İstanbul, Turkey.

The current paper investigates Psychoanalytic, Cognitive, Behaviorist, and Socio-cultural theories and critiques how they have (or might have) contributed to the study of radicalization. The paper asserts two arguments that lack emphasis in the current radicalization research: 1) radicalization refers to a process, and does not always refer to violent behavior; 2) radicalization research needs to pay tribute to socio-cultural, political, and historical context while designing research and discussing findings. These two points are essential to extend the concept of radicalization and to be sensitive to different research contexts and populations. Read More

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Ecological Modelling of Insect Movement in Cropping Systems.

Neotrop Entomol 2021 Apr 26. Epub 2021 Apr 26.

Dept of Entomology and Acarology, Luiz de Queiroz College of Agriculture, Univ of São Paulo, Piracicaba, São Paulo, Brazil.

The spatio-temporal dynamics of insect pests in agricultural landscapes involves the potential of species to move, invade, colonise, and establish in different areas. This study revised the dispersal of the important crop pests Diabrotica speciosa Germar and Spodoptera frugiperda (J.E. Read More

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Introduction to Health Systems Science: Experiential Learning Through Patient Interviews in the Emergency Department.

AEM Educ Train 2021 Apr 11;5(2):e10512. Epub 2020 Aug 11.

UC Davis School of Medicine Sacramento CA USA.

Increased complexity in health care delivery is now a problem of national proportions. Traditional medical education fails to sufficiently prepare students for the realities of practicing medicine in the 21st century. To address this critical problem, health systems science (HSS), which focuses on the broader system of care, has emerged as the "third pillar" of undergraduate medical education complementing the basic and clinical sciences. Read More

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A Model for an Online Learning Management System for Simulation-Based Acquisition of Psychomotor Skills in Health Professions Education.

Cureus 2021 Mar 23;13(3):e14055. Epub 2021 Mar 23.

Computer Science, Ontario Tech University, Oshawa, CAN.

The current coronavirus disease (COVID-19) pandemic has shifted traditional educational approaches in health professions education (HPE) from in-person to remote learning. Although pedagogical strategies have been developed and implemented rapidly to support cognitive and affective domains of learning in HPE, less progress has occurred in psychomotor skills acquisition. Psychomotor skills, referred to as technical skills training, are underpinned by educational theories and conceptual frameworks. Read More

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Experiences of Transgender and Nonbinary Physicians During Medical Residency Program Application.

J Grad Med Educ 2021 Apr 15;13(2):201-205. Epub 2021 Mar 15.

is a Researcher, Doctoral Candidate, Denver Health and Hospital Authority, Department of Health and Behavioral Sciences, University of Colorado Denver.

Background: Increasing numbers of transgender and nonbinary (TNB) people seek careers in medicine, but little is known about their experiences and the effect of their gender identity during residency application.

Objective: This project sought to evaluate the experiences and needs of TNB individuals during the residency application and Match process in order to inform the practice of residency programs.

Methods: An online survey was distributed in 2019 via social media, professional groups, and snowball sampling to TNB persons, who were current residents or recent graduates (within the past 3 years) of a US residency program. Read More

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Advanced Therapies and Regulatory Framework in Different Areas of the Globe: Past, Present, and Future.

Clin Ther 2021 Apr 20. Epub 2021 Apr 20.

Public Health Program, University of Brasília, DF, Brazil; Genomic Sciences and Biotechnology Program, Catholic University of Brasília, DF, Brazil. Electronic address:

Purpose: The field of human medicine is in a constant state of evolution, developing and incorporating technological advances from diverse scientific fields. In recent years, cellular and gene therapies have come of age, challenging regulatory agencies to define the path for commercial registration. Approval necessarily demands robust evidence for safety and efficacy, but these exigencies must not be such that they render unviable the development and testing of the therapeutic agent. Read More

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Hospital Mortality and Current Trends in Liver Transplantation in Germany-a Systematic Analysis of Standardized Hospital Discharge Data, 2008-2017.

Dtsch Arztebl Int 2021 Jul 26;118(Forthcoming). Epub 2021 Jul 26.

Background: Liver transplantation (LT) has undergone dynamic developments in recent decades. In Germany, the Federal Joint Committee (G-BA) recently tightened the guidelines regarding the minimum number of transplantations a center should perform annually. The aim of the study presented here, was to analyze recent trends in hospital mortality due to LT in Germany. Read More

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Systematic review of three-dimensional printing for simulation training of interventional radiology trainees.

3D Print Med 2021 Apr 21;7(1):10. Epub 2021 Apr 21.

UF Health Jacksonville, Jacksonville, FL, USA.

Rationale And Objectives: Three-dimensional (3D) printing has been utilized as a means of producing high-quality simulation models for trainees in procedure-intensive or surgical subspecialties. However, less is known about its role for trainee education within interventional radiology (IR). Thus, the purpose of this review was to assess the state of current literature regarding the use of 3D printed simulation models in IR procedural simulation experiences. Read More

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Post-COVID syndrome: A reflection and opinion paper

Rev Esp Quimioter 2021 04 20. Epub 2021 Apr 20.

Servicio de Microbiología Clínica y Enfermedades Infecciosas del Hospital General Universitario Gregorio Marañón, Universidad Complutense. CIBERES. Ciber de Enfermedades Respiratorias. Madrid, Spain.

A high proportion of people who have suffered from COVID-19 report, after recovery from the acute phase of the disease, clinical manifestations, both subjective and objective, that continue beyond 3 weeks or even 3 months after the original clinical disease. There is still no agreed nomenclature to refer to this condition, but perhaps the most commonly used is post-COVID syndrome. The Scientific Committee on COVID of the Madrid College of Physicians (ICOMEM) has discussed this problem with a multidisciplinary approach in which internists, infectious disease specialists, psychiatrists, pneumologists, surgeons, geriatricians, pediatricians, microbiologists, family physicians and other specialists have participated, trying to gather the existing information and discussing it in the group. Read More

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A key review on oxadiazole analogs as potential methicillin-resistant Staphylococcus aureus (MRSA) activity: Structure-activity relationship studies.

Eur J Med Chem 2021 Apr 17;219:113442. Epub 2021 Apr 17.

Department of Studies in Chemistry, Manasagangotri, University of Mysore, Mysuru, 570006, India. Electronic address:

Methicillin-resistant Staphylococcus aureus (MRSA) is becoming dangerous to human beings due to easy transmission mode and leading to the difficult-to-treat situation. The rapid resistance development of MRSA to many approved antibiotics is of major concern. There is a lot of scope to develop novel, efficient, specific, and nontoxic drug candidates to fight against MRSA isolates. Read More

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Insulin Actions on the Vascular Tissues: Physiological Effects and Pathophysiological Contributions to Vascular Complications of Diabetes.

Mol Metab 2021 Apr 17:101236. Epub 2021 Apr 17.

Dianne Nunnally Hoppes Laboratory for Diabetes Complications, Section of Vascular Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215 USA. Electronic address:

Background: Insulin has been demonstrated to exert direct and indirect effects on vascular tissues. Its actions in vascular cells are mediated by two major pathways: The insulin receptor substrate 1/2-phosphoinositide-3 kinase/Akt (IRS1/2/PI3K/Akt) pathway and the Src/mitogen-activated protein kinase (MAPK) pathway, both of which contribute to the expression and distribution of metabolites, hormones and cytokines.

Scope Of Review: In this review, we summarize the current understanding on insulin's physiological and pathophysiological actions and associated signaling pathways in vascular cells, mainly in endothelial cells (EC) and vascular smooth muscle cells (VSMC), and how these processes lead to selective insulin resistance. Read More

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MR-Guided Radiotherapy for Liver Malignancies.

Front Oncol 2021 1;11:616027. Epub 2021 Apr 1.

Radiation Medicine Program, Princess Margaret Cancer Centre, Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

MR guided radiotherapy represents one of the most promising recent technological innovations in the field. The possibility to better visualize therapy volumes, coupled with the innovative online adaptive radiotherapy and motion management approaches, paves the way to more efficient treatment delivery and may be translated in better clinical outcomes both in terms of response and reduced toxicity. The aim of this review is to present the existing evidence about MRgRT applications for liver malignancies, discussing the potential clinical advantages and the current pitfalls of this new technology. Read More

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Predictors and Correlates of Depression in Retired Elite Level Rugby League Players.

Front Neurol 2021 1;12:655746. Epub 2021 Apr 1.

Priority Research Centre for Stroke and Brain Injury, School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia.

There is considerable interest in determining whether later-in-life depression is associated with lifetime history of concussions or the duration of a career in professional contact and collision sports. Rugby league is a high-intensity collision sport involving a large number of tackles per game and a high rate of concussions. We examined predictors and correlates of depression in retired elite level rugby league players in Australia. Read More

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