FEBS J 2021 May 11. Epub 2021 May 11.
Departments of Psychiatry, Neurology, Pharmacology, Biology, Columbia University: Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, USA, 10032.
The synaptic pathways in the striatum are central to basal ganglia functions including motor control, learning, and organization, action selection, the acquisition of motor skills, cognitive function, and emotion. Here we review the role of the striatum and its connections in motor learning and performance. The development of new techniques to record neuronal activity and animal models of motor disorders using neurotoxin, pharmacological, and genetic manipulations are revealing pathways that underlie motor performance and motor learning, as well as how they are altered by pathophysiological mechanisms. Read More