19,350 results match your criteria discrimination training


A step forward, but still inadequate: Australian health professionals' views on the genetics and life insurance moratorium.

J Med Genet 2021 Sep 20. Epub 2021 Sep 20.

School of Public Health and Preventive Medicine, Monash University, Faculty of Medicine, Nursing and Health Sciences, Melbourne, Victoria, Australia.

Background: In 2019, the Australian life insurance industry introduced a partial moratorium (ban) limiting the use of genetic test results in life insurance underwriting. The moratorium is industry self-regulated and applies only to policies below certain financial limits (eg, $500 000 of death cover).

Methods: We surveyed Australian health professionals (HPs) who discuss genetic testing with patients, to assess knowledge of the moratorium; reported patient experiences since its commencement; and HP views regarding regulation of genetic discrimination (GD) in Australia. Read More

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September 2021

A passive and objective measure of recognition memory in Alzheimer's disease using Fastball memory assessment.

Brain 2021 Sep 20. Epub 2021 Sep 20.

Bristol Medical School, University of Bristol, Bristol, UK.

Earlier diagnosis of Alzheimer's disease requires biomarkers sensitive to associated structural and functional changes. While considerable progress has been made in the development of structural biomarkers, functional biomarkers of early cognitive change, unconfounded by effort, practice and level of education, are still needed. We present Fastball, a new EEG method for the passive and objective measurement of recognition memory, that requires no behavioural memory response or comprehension of the task . Read More

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September 2021

Palindromic-assisted self-annealing transcription amplification for reliable genotyping of epidermal growth factor receptor exon mutations.

Biosens Bioelectron 2021 Sep 13;194:113633. Epub 2021 Sep 13.

Center of Smart Laboratory and Molecular Medicine, School of Medicine, Chongqing University, Chongqing, 400044, PR China. Electronic address:

Reliable discrimination of specific epidermal growth factor receptor (EGFR) gene mutations plays a critical role in guiding lung cancer therapeutics. Until now, convenient and accurate recognition of the specific deletion of EGFR exons has remained particularly challenging. Herein, we propose a palindromic-assisted self-annealing transcription amplification (PASTA) strategy for the reliable detection of circulating EGFR exon mutations. Read More

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September 2021

Development and validation of a nomogram for predicting overall survival in pediatric patients with atypical teratoid/rhabdoid tumors.

Turk Neurosurg 2021 May 3. Epub 2021 May 3.

Lishui Municipal Central Hospital, Department of Orthopedics, Lishui, China.

Aim: The clinical outcomes of patients with atypical teratoid/rhabdoid tumors (ATRTs) are heterogeneous, making it difficult to predict prognosis. This study aimed to construct a reliable prediction model for pediatric ATRT patients.

Material And Methods: Population-based data of patients diagnosed with intracranial ATRT were extracted from the National Cancer Institute\'s Surveillance, Epidemiology, and End Results database. Read More

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Perceived Racial Discrimination and Mental Health in Diverse Groups of Asian Americans: The Differing Impacts by Age, Education, and Ethnicity.

J Immigr Minor Health 2021 Sep 20. Epub 2021 Sep 20.

Edward R. Roybal Institute on Aging, University of Southern California, 669 West 34th Street, Los Angeles, CA, 90089-0411, USA.

The aim of this study was to examine how perceived racial discrimination is associated with mental distress among diverse Asian Americans and to explore the potential moderators in the relationship. Based on the 2015 Asian American Quality of Life (AAQoL) survey (n = 2609), direct influences were tested of the contextual (demographic, health-related, and immigration-related) variables and perceived racial discrimination on mental distress, as well as their interactions. About 30% of the sample reported perceived racial discrimination, and 44% fell into the category of having mental distress. Read More

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September 2021

Intergroup Discrimination as a Predictor of Conflict within the Same Organization. The Role of Organizational Identity.

Eur J Investig Health Psychol Educ 2019 May 29;10(1):1-9. Epub 2019 May 29.

Social and Organizational Psychology Department, The National Distance Education University, 28015 Madrid, Spain.

The main purpose of this research is to shed light upon how perception of intergroup discrimination is related to perception of organizational conflict. This phenomenon is mediated by group identification and moderated by organizational identification. The sample was constituted by 466 employees belonging to the staff of Administration and Service of a Spanish public University. Read More

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Gender-Affirmative Eating Disorder Care: Clinical Considerations for Transgender and Gender Expansive Children and Youth.

Pediatr Ann 2021 Sep 1;50(9):e371-e378. Epub 2021 Sep 1.

Transgender and gender expansive (TGE) children and youth suffer staggering rates of discrimination and are at higher risk of developing eating disorder symptoms and behaviors than cisgender youth. This article presents an overview of current research on identified risk factors for the development of eating disorders for TGE children and youth; provides clinical considerations for professionals in providing gender-affirming, collaborative eating disorder care; outlines specific concepts for staff training and for developing gender-affirming systems of care including policies and practices; and identifies numerous resources for TGE children and youth and their families. The clinical considerations and suggested practices reflect current research and clinical practice. Read More

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September 2021

The Mental Health of Refugees during a Pandemic: Striving toward Social Justice through Social Determinants of Health and Human Rights.

Asian Bioeth Rev 2021 Sep 13:1-15. Epub 2021 Sep 13.

Northeast Ohio Medical University, Rootstown, OH USA.

This paper is the second of two in a series. In our first paper, we presented a social justice framework emerging from an extensive literature review and incorporating core social determinants specific to mental health in the age of COVID-19 and illustrated specific social determinants impacting mental health (SDIMH) of our resettled Bhutanese refugee population during the pandemic. This second paper details specific barriers to the SDIMH detrimental to the basic human rights and social justice of this population during this pandemic. Read More

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September 2021

Intervention Stigma toward Medications for Opioid Use Disorder: A Systematic Review.

Subst Use Misuse 2021 Sep 20:1-20. Epub 2021 Sep 20.

Utah State University Extension, Utah State University, Logan, Utah, USA.

Introduction: Medications for opioid use disorder (MOUD) are evidence-based treatments, yet can be controversial among some populations. This study provides a systematic review of prejudice and discrimination toward MOUD, a form of "intervention stigma," or stigma associated with a particular medical treatment.

Methods: A systematic search strategy was used in PsychInfo and PubMed to identify studies published between 1998 and 2018. Read More

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September 2021

Dangers of residual confounding: a cautionary tale featuring cognitive ability, socioeconomic background, and education.

BMC Psychol 2021 Sep 18;9(1):145. Epub 2021 Sep 18.

Division of Psychology, Department of Clinical Neuroscience, Karolinska Institutet, 171 77, Stockholm, Sweden.

Background: Cognitive ability and socioeconomic background (SEB) have been previously identified as determinants of achieved level of education. According to a "discrimination hypothesis", higher cognitive ability is required from those with lower SEB in order to achieve the same level of education as those with higher SEB. Support for this hypothesis has been claimed from the observation of a positive association between SEB and achieved level of education when adjusting for cognitive ability. Read More

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September 2021

Development, verification, and comparison of a risk stratification model integrating residual cancer burden to predict individual prognosis in early-stage breast cancer treated with neoadjuvant therapy.

ESMO Open 2021 Sep 16;6(5):100269. Epub 2021 Sep 16.

Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, PR China. Electronic address:

Background: A favorable model for predicting disease-free survival (DFS) and stratifying prognostic risk in breast cancer (BC) treated with neoadjuvant chemotherapy (NAC) is lacking. The aim of the current study was to formulate an excellent model specially for predicting prognosis in these patients.

Patients And Methods: Between January 2012 and December 2015, 749 early-stage BC patients who received NAC in Xijing hospital were included. Read More

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September 2021

Challenges, coping responses and supportive interventions for international and migrant students in academic nursing programs in major host countries: a scoping review with a gender lens.

BMC Nurs 2021 Sep 18;20(1):174. Epub 2021 Sep 18.

Faculty of Nursing, University of Montreal, Montreal, Canada.

Background: International and migrant students face specific challenges which may impact their mental health, well-being and academic outcomes, and these may be gendered experiences. The purpose of this scoping review was to map the literature on the challenges, coping responses and supportive interventions for international and migrant students in academic nursing programs in major host countries, with a gender lens.

Methods: We searched 10 databases to identify literature reporting on the challenges, coping responses and/or supportive interventions for international and migrant nursing students in college or university programs in Canada, the United-States, Australia, New Zealand or a European country. Read More

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September 2021

The sexual health, orientation, and activity of autistic adolescents and adults.

Autism Res 2021 Sep 18. Epub 2021 Sep 18.

Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.

Small studies suggest significant differences between autistic and nonautistic individuals regarding sexual orientation and behavior. We administered an anonymized, online survey to n = 2386 adults (n = 1183 autistic) aged 16-90 years to describe sexual activity, risk of sexually transmitted infections (STIs), and sexual orientation. Autistic individuals are less likely to report sexually activity or heterosexuality compared to nonautistic individuals, but more likely to self-report asexuality or an 'other' sexuality. Read More

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September 2021

Work situation of rheumatologists and residents in times of COVID-19 : Findings from a survey in Germany.

Z Rheumatol 2021 Sep 17. Epub 2021 Sep 17.

Klinik für Rheumatologie und Immunologie, Medizinische Hochschule Hannover, OE 6830, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Background And Objective: The work situation is an important dimension of professional life and wellbeing, and a policy lever to strengthen recruitment and retention. This study aims to explore the work situation of physicians and residents in internal medical rheumatology, considering the impact of the coronavirus pandemic COVID-19.

Methods: A questionnaire-based online survey was conducted in early 2021 at the Hannover Medical School, supported by the German Society of Rheumatology. Read More

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September 2021

Changes in patients' outlook, behaviors, and attitudes toward COVID-19 after hospitalization and their experiences of discrimination and harassment.

BMC Res Notes 2021 Sep 17;14(1):362. Epub 2021 Sep 17.

Department of Internal Medicine, Hyogo Prefectural Tamba Medical Center, Tanba, Japan.

Objective: This study aims to examine changes in patients' perspectives and outlooks regarding the disease and their health after hospitalization for COVID-19 and investigate their discrimination and harassment experiences. This prospective observational study surveyed discharged patients who had been admitted to Hyogo Prefectural Tamba Medical Center in Japan for COVID-19. Patient characteristics, changes in outlook and behaviors after discharge, and incidents of discrimination and harassment were examined. Read More

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September 2021

Lessons from the life of Asia's first female neurosurgeon for modern neurosurgical trainees and educators worldwide.

J Neurosurg 2021 Sep 17:1-9. Epub 2021 Sep 17.

3Department of Neurosurgery, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey.

Surgical specialties, and particularly neurosurgery, have historically had and continue to have poor representation of female trainees. This is especially true of South Asia, considering the added social and cultural expectations for women in this region. Yet it was in India, with its difficult history of gender relations, that Asia's first fully qualified female neurosurgeon, Dr. Read More

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September 2021

COVID-19 dimensions and psychotic experiences among US college students: Findings from the Healthy Mind Study 2020.

Schizophr Res 2021 Sep 14;237:148-152. Epub 2021 Sep 14.

Fordham University, Graduate School of Social Service, United States of America.

Background: The COVID-19 pandemic has caused tremendous changes in daily living, which may be related to mental health problems, including psychotic experiences, though research has only begun to assess these associations.

Methods: We analyzed data from the Healthy Minds Survey (Fall Semester Cohort 2020), which is a non-probability sample of students attending one of 36 universities in the United States, who completed an online survey during the COVID-19 pandemic (September-December 2020). We used multivariable logistic regression to examine the associations between several COVID-19 dimensions (anxiety, discrimination, financial distress, infection, illness of loved one, death of loved one, caregiving) and 12-month psychotic experiences, adjusting for age, gender, race/ethnicity, and international student status. Read More

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September 2021

A Radiomics Signature-Based Nomogram to Predict the Progression-Free Survival of Patients With Hepatocellular Carcinoma After Transcatheter Arterial Chemoembolization Plus Radiofrequency Ablation.

Front Mol Biosci 2021 31;8:662366. Epub 2021 Aug 31.

Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention, Fifth Affiliated Hospital, Wenzhou Medical University, Lishui, China.

The study aims to establish an magnetic resonance imaging radiomics signature-based nomogram for predicting the progression-free survival of intermediate and advanced hepatocellular carcinoma (HCC) patients treated with transcatheter arterial chemoembolization (TACE) plus radiofrequency ablation A total of 113 intermediate and advanced HCC patients treated with TACE and RFA were eligible for this study. Patients were classified into a training cohort ( = 78 cases) and a validation cohort ( = 35 cases). Radiomics features were extracted from contrast-enhanced T1W images by analysis kit software. Read More

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The Development and Validation of a CT-Based Radiomics Nomogram to Preoperatively Predict Lymph Node Metastasis in High-Grade Serous Ovarian Cancer.

Front Oncol 2021 31;11:711648. Epub 2021 Aug 31.

Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.

Purpose: To develop and validate a radiomics model for predicting preoperative lymph node (LN) metastasis in high-grade serous ovarian cancer (HGSOC).

Materials And Methods: From May 2008 to January 2018, a total of 256 eligible HGSOC patients who underwent tumor resection and LN dissection were divided into a training cohort (n=179) and a test cohort (n=77) in a 7:3 ratio. A Radiomics Model was developed based on a training cohort of 179 patients. Read More

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Schooling and Nigerian Children with Asthma: A Review of Challenges, Risk and Prospects.

Authors:
B P Kuti

Niger J Clin Pract 2021 Sep;24(9):1268-1276

Department of Paediatrics and Child Health, Faculty of Clinical Sciences, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.

Epidemiologic studies have reported increasing prevalence of childhood asthma in Nigeria and other developing countries where there are parallel increases in school enrolments. Children with asthma face lots of challenges in school which can affect their academic performance and quality of life. This narrative review highlights the challenges and the risks of schooling encountered by Nigerian children with asthma and the prospects of utilizing the School Health Programme (SHP) to overcome these challenges. Read More

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September 2021

Development and validation of a novel classification scheme for combining pathological T stage and log odds of positive lymph nodes for colon cancer.

Eur J Surg Oncol 2021 Sep 9. Epub 2021 Sep 9.

Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, China; Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan. Electronic address:

Aim: Log Odds of Positive Lymph Nodes (LODDS) have a better predictive ability than N stage for colon cancer. However, the prognostic value of developing a novel prognostic classification by combining T stage and LODDS (TLODDS) for colon cancer remains unknown. Therefore, in the present study, we aimed to develop a TLODDS classification for colon cancer, and assess whether or not the novel TLODDS classification could improve survival stratification by comparing its discrimination, model-fitting, and net benefits, with the American Joint Committee on Cancer (AJCC) Tumor/Node/Metastasis (TNM) classification. Read More

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September 2021

Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR.

Epigenetics Chromatin 2021 Sep 16;14(1):44. Epub 2021 Sep 16.

Department of Genetics/Epigenetics, Saarland University, Saarbrücken, Germany.

Background: Understanding the influence of genetic variants on DNA methylation is fundamental for the interpretation of epigenomic data in the context of disease. There is a need for systematic approaches not only for determining methylation quantitative trait loci (methQTL), but also for discriminating general from cell type-specific effects.

Results: Here, we present a two-step computational framework MAGAR ( https://bioconductor. Read More

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September 2021

Discrimination of active and inactive substances in cytotoxicity based on Tox21 10K compound library: Structure alert and mode of action.

Toxicology 2021 Sep 13;462:152948. Epub 2021 Sep 13.

Center for Environmental and Human Toxicology, Department of Physiological Sciences, College of Veterinary Medicine, UF Genetics Institute, Interdisciplinary Program in Biomedical Sciences Neuroscience, University of Florida, Gainesville, FL, 32611, USA.

In vitro cytotoxicity assay is an ideal alternative method for the in vivo toxicity in the risk assessment of pollutants in environment. However, modes of action (MOAs) of cytotoxicity have not been investigated for a wide range of compounds. In this paper, binomial and recursive partitioning analysis were carried out between the cytotoxicity and molecular descriptors for 8981 compounds. Read More

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September 2021

Geographical socioeconomic inequalities in healthy life expectancy in Japan, 2010-2014: An ecological study.

Lancet Reg Health West Pac 2021 Sep 15;14:100204. Epub 2021 Jul 15.

Department of Medical Statistics, Research & Development Center Osaka Medical and Pharmaceutical University.

Background: Area differences in life expectancy (LE) and healthy life expectancy (HLE) in large geographical units have been monitored around the world. Area characteristics may be based on culture, history, socioeconomic status and discrimination in smaller geographical units, so it is important to consider these when looking at health inequality. We aimed to evaluate LE, HLE, and non-healthy life expectancy (NHLE) in 1707 municipalities using Areal Deprivation Index (ADI) in Japan for the first time. Read More

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September 2021

Development and Validation of an Esophageal Squamous Cell Carcinoma Risk Prediction Model for Rural Chinese: Multicenter Cohort Study.

Front Oncol 2021 30;11:729471. Epub 2021 Aug 30.

Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.

Background: There are rare prediction models for esophageal squamous cell carcinoma (ESCC) for rural Chinese population. We aimed to develop and validate a prediction model for ESCC based on a cohort study for the population.

Methods: Data of 115,686 participants were collected from esophageal cancer (EC) early diagnosis and treatment of cancer program as derivation cohort while data of 54,750 participants were collected as validation cohort. Read More

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Development and validation of nomograms for predicting survival and recurrence in patients with parotid gland cancer.

Gland Surg 2021 Aug;10(8):2398-2407

Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Background: To develop nomograms for predicting recurrence risk and long-term survival in patients with parotid gland cancer (PGC).

Methods: A total of 301 consecutive patients with PGC who underwent surgery were enrolled and randomly divided into a training cohort (n=210) and a validation cohort (n=91). Predictive nomograms were constructed based on the independent indicators of overall survival (OS) and disease-free survival (DFS) as determined by multivariate Cox regression analysis. Read More

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Prognostic Value of Glucose-to-Lymphocyte Ratio in Critically Ill Patients with Acute Pancreatitis.

Int J Gen Med 2021 8;14:5449-5460. Epub 2021 Sep 8.

Department of Gastroenterology, Qianjiang Central Hospital of Chongqing Municipality, Chongqing, 409000, People's Republic of China.

Background: Glucose metabolism and systemic inflammation have been associated with prognosis in acute pancreatitis (AP) patients. However, the possible value as a prognostic marker of the glucose-to-lymphocyte ratio (GLR) has not been evaluated in critically ill patients with AP.

Methods: This study included 1,133 critically ill patients with AP from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database, who were randomly divided into the training cohort (n=806) and the validation cohort (n=327) at a ratio of 7:3. Read More

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September 2021

Assessment of health equity consideration in masking/PPE policies to contain COVID-19 using PROGRESS-plus framework: a systematic review.

BMC Public Health 2021 09 16;21(1):1682. Epub 2021 Sep 16.

School of Pharmacy, University of Utah, Salt Lake City, UT, USA.

Introduction: There is increasing evidence that COVID-19 has unmasked the true magnitude of health inequity worldwide. Policies and guidance for containing the infection and reducing the COVID-19 related deaths have proven to be effective, however the extent to which health inequity factors were considered in these policies is rather unknown. The aim of this study is to measure the extent to which COVID-19 related policies reflect equity considerations by focusing on the global policy landscape around wearing masks and personal protection equipment (PPE). Read More

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September 2021

A hypertension risk score for adults: a population-based cross-sectional study from Dubai Household Survey 2019.

Epidemiol Health 2021 Sep 8:e2021064. Epub 2021 Sep 8.

Department of Data Analysis, Research and Studies, Dubai Health Authority, Dubai, United Arab Emirates.

Objectives: To develop a risk score model for predicting hypertension specific to Dubai population in the United Arab Emirates (UAE) to facilitate prevention and early intervention.

Methods: A retrospective analysis of the Dubai Household Health Survey 2019 data was conducted. Demographic and physical parameters, as well as blood glucose levels, were included in the data. Read More

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September 2021

Development and validation of a risk prediction nomogram for in-stent restenosis in patients undergoing percutaneous coronary intervention.

BMC Cardiovasc Disord 2021 Sep 14;21(1):435. Epub 2021 Sep 14.

Department of Cardiology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang, Wuhan, 430060, People's Republic of China.

Background: This study aimed to develop and validate a nomogram to predict probability of in-stent restenosis (ISR) in patients undergoing percutaneous coronary intervention (PCI).

Methods: Patients undergoing PCI with drug-eluting stents between July 2009 and August 2011 were retrieved from a cohort study in a high-volume PCI center, and further randomly assigned to training and validation sets. The least absolute shrinkage and selection operator (LASSO) regression model was used to screen out significant features for construction of nomogram. Read More

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September 2021