Neurology 2021 05 14;96(20):e2500-e2512. Epub 2021 Apr 14.
From the Wisconsin Alzheimer's Disease Research Center (J.F.V.H., N.M.V., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., O.O., S.C.J., S.A., B.B.B.), Department of Medicine, Geriatrics Division (W.R.B., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Health Services and Care Research Program (W.R.B., A.J.H.K.), and Department of Biostatistics & Medical Informatics (M.Y.), University of Wisconsin School of Medicine and Public Health; University of Wisconsin School of Nursing (M.Z.); and Geriatric Research Education and Clinical Center (GRECC) (L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), William S. Middleton Hospital, United States Department of Veterans Affairs, Madison, WI.
Objective: To test the hypothesis that neighborhood-level disadvantage is associated with longitudinal measures of neurodegeneration and cognitive decline in an unimpaired cohort.
Methods: Longitudinal MRI and cognitive testing data were collected from 601 cognitively unimpaired participants in the Wisconsin Registry for Alzheimer's Prevention Study and the Wisconsin Alzheimer's Disease Research Center clinical cohort. Area Deprivation Index was geospatially determined based on participant residence geocode and ranked relative to state of residence. Read More