Neurosci Lett 2021 04 13;751:135776. Epub 2021 Mar 13.
Graduate Program in Biochemistry, Institute of Basic Health Sciences, UFRGS, Porto Alegre, Brazil; Graduate Program in Neuroscience, Institute of Basic Health Sciences, UFRGS, Porto Alegre, Brazil.
Astrocytes respond to injury by modifying the expression profile of several proteins, including the S100 calcium-binding protein B (S100B), assumed to be a marker as well as a mediator of brain injury. AA is an inhibitor of S100B synthesis and plays a protective role in different models of brain injury, as decreases in S100B expression cause decreases in extracellular S100B. However, S100B mRNA expression, S100B protein content and S100B secretion do not always occur in association; as such, we herein investigated the effect of AA on S100B secretion, using different approaches with three stimulating conditions for S100B secretion, namely, low potassium medium, TNF-α (in hippocampal slices) and LPS exposure (in astrocyte cultures). Read More