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A retrospective comparison of organ dose and effective dose in percutaneous vertebroplasty performed under CT guidance or using a fixed C-arm with a flat-panel detector.

Phys Med 2021 Jul 23;88:235-241. Epub 2021 Jul 23.

Department of Medical Imaging, Nimes University Hospital, Univ Montpellier, Medical Imaging Group Nimes, EA 2992, France.

Purpose: To compare the organ-dose and effective-dose (E) delivered to the patient during percutaneous vertebroplasty (PVP) of one thoracic or lumbar vertebra performed under CT guidance or using a fixed C-arm.

Methods: Consecutive adult patients undergoing PVP of one vertebra under CT-guidance, with optimized protocol and training of physicians, or using a fixed C-arm were retrospectively included from January 2016 to June 2017. Organ-doses were computed on 16 organs using CT Expo 2. Read More

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A mixture of persistent organic pollutants detected in human follicular fluid increases progesterone secretion and mitochondrial activity in human granulosa HGrC1 cells.

Reprod Toxicol 2021 Jul 23. Epub 2021 Jul 23.

Laboratory of Physiology and Toxicology of Reproduction, Jagiellonian University, Gronostajowa 9, 30-387 Krakow, Poland. Electronic address:

Disruption of granulosa cells (GCs), the main functional cells in the ovary, is associated with impaired female fertility. Epidemiological studies demonstrated that women have detectable levels of organic pollutants (e.g. Read More

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The Photocatalysis-Enhanced [email protected] Membrane with High TiO Surface Content for Highly Effective Removal of Cationic Dyes.

Langmuir 2021 Jul 26. Epub 2021 Jul 26.

State Key Laboratory of Separation Membranes and Membrane Processes, School of Materials Science and Engineering, Tiangong University, Tianjin 300387, China.

The elimination of dye pollutants from wastewater is a significant concern that has prompted extensive research into the development of highly efficient photocatalytic membranes. A novel method was proposed to prepare photocatalysis-enhanced poly(acrylonitrile-methyl acrylate) (PAN-based) membranes in this study. In detail, the blended membrane containing [email protected] nanoparticles with a shell-core structure was first prepared via thermal-induced phase separation. Read More

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Stimulating Fungi with Hydrocortisone.

ACS Biomater Sci Eng 2021 Jul 26. Epub 2021 Jul 26.

Unconventional Computing Laboratory, UWE, Bristol, U.K.

Fungi cells can sense extracellular signals via reception, transduction, and response mechanisms, allowing them to communicate with their host and adapt to their environment. They feature effective regulatory protein expressions that enhance and regulate their response and adaptation to various triggers such as stress, hormones, physical stimuli such as light, and host factors. In our recent studies, we have shown that oyster fungi generate electrical potential impulses in the form of spike events in response to their exposure to environmental, mechanical, and chemical triggers, suggesting that the nature of stimuli may be deduced from the fungal electrical responses. Read More

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Psychosocial experiences of frontline nurses working in hospital-based settings during the COVID-19 pandemic - A qualitative systematic review.

Int J Nurs Stud Adv 2021 Jul 17:100037. Epub 2021 Jul 17.

Integrative Health Research, Department of Health Sciences, Faculty of Medicine, Lund University, Margaretavägen 1 B, S- 222 41 Lund, Sweden.

Background: Frontline nurses have been directly exposed to the SARS-CoV-2 virus and come in close contact with patients during the COVID-19 pandemic. Nurses endorse tasks related to disease control and face multiple psychosocial challenges in their frontline work, potentially affecting their mental well-being and ability to satisfyingly perform their tasks.

Objectives: To explore the psychosocial experiences of frontline nurses working in hospital-based settings during the COVID-19 pandemic. Read More

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Using the Arcuate Eminence-Trigeminal Notch Line to Localize the Anterior Wall of the Internal Auditory Canal in a Subtemporal Approach: An Anatomical Study.

J Neurol Surg B Skull Base 2021 Jul 28;82(Suppl 3):e196-e202. Epub 2020 Feb 28.

Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

 This article aims to describe the regional anatomy of the anterior end of the arcuate eminence, the lateral end of the trigeminal notch, and the line connecting the two (i.e., the arcuate eminence-trigeminal notch line [ATL]) and to determine whether the ATL could be used as a landmark for localizing the internal auditory canal (IAC). Read More

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Rapid Antibiotic Susceptibility Testing of Tier-1 Agents , , and Directly From Whole Blood Samples.

Front Microbiol 2021 9;12:664041. Epub 2021 Jul 9.

Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona, Israel.

Rapid antibiotic susceptibility tests, performed directly on whole blood samples, will offer great clinical advantages. This issue is of considerable importance when it comes to bioterror pathogens where prompt antibiotic treatment should be offered to infected patients as well as prophylaxis to suspected exposed individuals. Herein, we describe a novel and rapid method, named MAPt, that is based on the direct application of a blood sample onto solid agar that has been embedded with different concentrations of the tested antibiotic. Read More

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Exposure to Perfluoroalkyl Chemicals and Cardiovascular Disease: Experimental and Epidemiological Evidence.

Front Endocrinol (Lausanne) 2021 9;12:706352. Epub 2021 Jul 9.

Department of Medicine, University of Verona, Verona, Italy.

Polyfluoro- and perfluoro-alkyl substances (PFAS) are organic chemicals extensively used worldwide for industry and consumer products. Due to their chemical stability, PFAS represent a major cause of environmental pollution. PFAS accumulate in animal and human blood and tissues exerting their toxicity. Read More

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[Clinical application effect of latissimus dorsi muscle flap in reconstruction of muscle strength around shoulder after electric burns].

Zhonghua Shao Shang Za Zhi 2021 Jul;37(7):622-628

Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China.

To investigate the clinical application effect of latissimus dorsi muscle flap in reconstruction of muscle strength around shoulder after electric burns. From March 2014 to September 2020, 13 patients with electric burns and severe injury around shoulder were admitted to the First Affiliated Hospital of Air Force Medical University, including 11 males and 2 females, aged 19-55 years. A retrospective observational study was conducted. Read More

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Imidacloprid induces locomotion impairment of the freshwater crayfish, Procambarus clarkii via neurotoxicity and oxidative stress in digestive system.

Aquat Toxicol 2021 Jul 16;238:105913. Epub 2021 Jul 16.

Key Laboratory of Application of Ecology and Environmental Protection in Plateau Wetland of Sichuan, Xichang University, Xichang 415000, Sichuan Province, China.

Imidacloprid (IMI) is used in integrated farming like the rice-crayfish co-culture system to prevent water weevil. However, the toxic effect of IMI on the freshwater crayfish Procambarus clarkii is unknown. In the current study, the effects of IMI on the locomotion, antioxidative status, digestion and intestinal microbiota of P. Read More

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Impact of Humidity and Temperature on the Stability of the Optical Properties and Structure of MAPbI, MAFAPbI and (FAPbI)(MAPbBr) Perovskite Thin Films.

Materials (Basel) 2021 Jul 20;14(14). Epub 2021 Jul 20.

Department of Physics & Astronomy and The Wright Center for Photovoltaics Innovation & Commercialization, University of Toledo, Toledo, OH 43606, USA.

In situ real-time spectroscopic ellipsometry (RTSE) measurements have been conducted on MAPbI, MAFAPbI, and (FAPbI)(MAPbBr) perovskite thin films when exposed to different levels of relative humidity at given temperatures over time. Analysis of RTSE measurements track changes in the complex dielectric function spectra and structure, which indicate variations in stability influenced by the underlying material, preparation method, and perovskite composition. MAPbI and MAFAPbI films deposited on commercial fluorine-doped tin oxide coated glass are more stable than corresponding films deposited on soda lime glass directly. Read More

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The Causes of Occupational Accidents and Injuries in Romanian Firms: An Application of the Johansen Cointegration and Granger Causality Test.

Int J Environ Res Public Health 2021 Jul 18;18(14). Epub 2021 Jul 18.

Faculty of Economics and Administrative Sciences, Cag University, Mersin 33800, Turkey.

Organizational risks are present in any activity, so it is important to manage them properly. The jobs are dynamic and involve a series of processes and activities. The entire human resource is exposed to several risks. Read More

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Stress and Associated Factors among Frontline Healthcare Workers in the COVID-19 Epicenter of Da Nang City, Vietnam.

Int J Environ Res Public Health 2021 Jul 10;18(14). Epub 2021 Jul 10.

Institute for Community Health Research, University of Medicine and Pharmacy, Hue University, Hue 530000, Vietnam.

Frontline healthcare workers (HCWs) involved in the COVID-19 response have a higher risk of experiencing psychosocial distress amidst the pandemic. Between July and September 2020, a second wave of the COVID-19 pandemic appeared in Vietnam with Da Nang city being the epicenter. During the outbreak, HCWs were quarantined within the health facilities in a bid to limit the spread of COVID-19 to their respective communities. Read More

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Perinatal High-Fat Diet Influences Ozone-Induced Responses on Pulmonary Oxidant Status and the Molecular Control of Mitophagy in Female Rat Offspring.

Int J Mol Sci 2021 Jul 14;22(14). Epub 2021 Jul 14.

Department of Pharmacology and Toxicology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 Maastricht, The Netherlands.

Previous research has shown that a perinatal obesogenic, high-fat diet (HFD) is able to exacerbate ozone-induced adverse effects on lung function, injury, and inflammation in offspring, and it has been suggested that mitochondrial dysfunction is implicated herein. The aim of this study was to investigate whether a perinatal obesogenic HFD affects ozone-induced changes in offspring pulmonary oxidant status and the molecular control of mitochondrial function. For this purpose, female Long-Evans rats were fed a control diet or HFD before and during gestation, and during lactation, after which the offspring were acutely exposed to filtered air or ozone at a young-adult age (forty days). Read More

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Genotoxicity and oxidative stress induction by polystyrene nanoparticles in the colorectal cancer cell line HCT116.

PLoS One 2021 23;16(7):e0255120. Epub 2021 Jul 23.

Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.

The potential risks of environmental nanoparticles (NPs), in particular Polystyrene Nanoparticles (PNPs), is an emerging problem; specifically, the interaction of PNPs with intestinal cells has not been characterized so far. The mechanism by which polystyrene particles are transferred to humans has not yet been clarified, whether directly through ingestion from contaminated food. We evaluated the interaction between PNPs and colorectal adenocarcinoma cells (HCT116). Read More

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Natural CO seeps reveal adaptive potential to ocean acidification in fish.

Evol Appl 2021 Jul 5;14(7):1794-1806. Epub 2021 May 5.

Swire Institute of Marine Science School of Biological Sciences The University of Hong Kong Hong Kong Hong Kong SAR.

Volcanic CO seeps are natural laboratories that can provide insights into the adaptation of species to ocean acidification. While many species are challenged by reduced-pH levels, some species benefit from the altered environment and thrive. Here, we explore the molecular mechanisms of adaptation to ocean acidification in a population of a temperate fish species that experiences increased population sizes under elevated CO. Read More

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Perceived Vulnerability and Severity Predict Adherence to COVID-19 Protection Measures: The Mediating Role of Instrumental Coping.

Front Psychol 2021 6;12:674032. Epub 2021 Jul 6.

Social Psychology Department, University of the Basque Country, Gipuzkoa, Spain.

The COVID-19 disease has caused thousands of deaths worldwide and required the rapid and drastic adoption of various protective measures as main resources in the fight to reduce the spread of the disease. In the present study we aimed to identify socio cognitive factors that may influence adherence to protective measures toward COVID-19 in a Spanish sample. This longitudinal study analyzes the predictive value of perceived severity and vulnerability of infection, self-efficacy, direct exposure to the virus, and instrumental focused coping style for adhering to infection protection behaviors during the first months of the COVID-19 pandemic. Read More

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Timing, duration, and differential susceptibility to early life adversities and cardiovascular disease risk across the lifespan: Implications for future research.

Prev Med 2021 Jul 19:106736. Epub 2021 Jul 19.

Department of Psychology, University of Denver, Denver, CO, United States of America.

Early life adversities (ELA), include experiences such as child maltreatment, household dysfunction, bullying, exposure to crime, discrimination, bias, and victimization, and are recognized as social determinants of cardiovascular disease (CVD). Strong evidence shows exposure to ELA directly impacts cardiometabolic risk in adulthood and emerging evidence suggests there may be continuity in ELA's prediction of cardiometabolic risk over the life course. Extant research has primarily relied on a cumulative risk framework to evaluate the relationship between ELA and CVD. Read More

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Gamma Radiation Induce Inflammasome Signaling and Pyroptosis in Microvascular Endothelial Cells.

J Inflamm Res 2021 15;14:3277-3288. Epub 2021 Jul 15.

Department of Blood Diseases Institute, Xuzhou Medical University, Xuzhou City, 221002, Jiangsu Province, People's Republic of China.

Introduction: The extend to the clinical benefit of radiation therapy is the inability to eliminate only cancer cells and destroy normal cells such as microvascular endothelial in the vascular niche and turn induced-inflammasome signaling and cell death. These unfortunate injuries generated by ionizing radiation alter the therapeutic window and result in the re-occurrence of the malignancy. Therefore, we engaged in vitro studies by demonstrating radiation-induced inflammasome and cell death in endothelial cells. Read More

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The Effects of Exergaming on Sensory Reweighting and Mediolateral Stability of Women Aged Over 60: Usability Study.

JMIR Serious Games 2021 Jul 21;9(3):e27884. Epub 2021 Jul 21.

Doctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary.

Background: Older adults tend to experience difficulties in switching quickly between various reliable sensory inputs, which ultimately may contribute to an increased risk of falls and injuries. Sideward falls are the most frequent cause of hip fractures among older adults. Recently, exergame programs have been confirmed as beneficial tools for enhancing postural control, which can reduce the risk of falls. Read More

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A multimodal, implantable sensor array and measurement system to investigate the suppression of focal epileptic seizure using hypothermia.

J Neural Eng 2021 Jul 19. Epub 2021 Jul 19.

Peter Pazmany Catholic University Faculty of Information Technology and Bionics, Prater utca 50/A, Budapest, 1083, HUNGARY.

Objective: Local cooling of the brain as a therapeutic intervention is a promising alternative for patients with epilepsy who do not respond to medication. In vitro and in vivo studies have demonstrated the seizure-suppressing effect of local cooling in various animal models. In our work, focal brain cooling in a bicuculline induced epilepsy model in rats is demonstrated and evaluated using a multimodal micro-electrocorticography (microECoG) device. Read More

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Claudin-1/4 as directly target gene of HIF-1α can feedback regulating HIF-1α by PI3K-AKT-mTOR and impact the proliferation of esophageal squamous cell though Rho GTPase and p-JNK pathway.

Cancer Gene Ther 2021 Jul 19. Epub 2021 Jul 19.

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250022, P.R. China.

Immunohistochemical microarray comprising 80 patients with esophageal squamous cell carcinoma (ESCC) and discovered that the expression of CLDN1 and CLDN4 were significantly higher in cancer tissues compared to para-cancerous tissues. Furthermore, CLDN4 significantly affected the overall survival of cancer patients. When two ESCC cell lines (TE1, KYSE410) were exposed to hypoxia (0. Read More

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Host Gasdermin D restrains systemic endotoxemia by capturing Proteobacteria in the colon of high-fat diet-feeding mice.

Gut Microbes 2021 Jan-Dec;13(1):1946369

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.

Gasdermin D (GSDMD) functions as a key pyroptotic executor through its secreted N-terminal domain (GSDMD-N). However, the functional relevance and mechanistic basis of the precise roles of host colonic GSDMD in high-fat diet (HFD)-induced gut dysbiosis and systemic endotoxemia remain elusive. In this study, we demonstrate that HFD feeding triggers GSDMD-N secretion of both T-lymphocytes and enterocytes in mouse colons. Read More

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The changes of essential trace elements in residents from an e-waste site and the relationships between elements and hormones of the hypothalamic-pituitary-thyroid (HPT) axis.

Ecotoxicol Environ Saf 2021 Jul 15;222:112513. Epub 2021 Jul 15.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. Electronic address:

The heavy metals pollution and related health issues were widely reported in e-waste sites, while the impacts of e-waste exposure on the essential trace elements have been neglected. The aim of this study was focused on the internal Cu, Fe, Mn and Zn levels in the residents from an e-waste site and the potential endocrine disrupting effects of these essential trace elements on the hypothalamic-pituitary-thyroid (HPT) axis. This was a cross-sectional study that 87 subjects were recruited from the e-waste site and 81 from the reference site. Read More

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Tumor rejection in mice depends on IL-9 and Th9 cells.

J Immunother Cancer 2021 Jul;9(7)

Oncology, Hematology, Immunoncology and Rheumatology, University Hospital Bonn, Bonn, Germany

Background: Casitas B lymphoma-b (Cbl-b) is a central negative regulator of cytotoxic T and natural killer (NK) cells and functions as an intracellular checkpoint in cancer. In particular, Th9 cells support mast cell activation, promote dendritic cell recruitment, enhance the cytolytic function of cytotoxic T lymphocytes and NK cells, and directly kill tumor cells, thereby contributing to tumor immunity. However, the role of Cbl-b in the differentiation and antitumor function of Th9 cells is not sufficiently resolved. Read More

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Reproductive fitness of honey bee queens exposed to thiamethoxam during development.

Vet Pathol 2021 Jul 16:3009858211031845. Epub 2021 Jul 16.

University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

The productivity and survival of honey bee () colonies depend on queen bee health. Colony-level neonicotinoid exposure has negative effects on reproductive fitness of honey bee queens. However, it is unclear if the observed effects are a direct outcome of neonicotinoid toxicity or result from suboptimal care of developing queens by exposed workers. Read More

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Effects of anagliptin on the stress induced accelerated senescence of human umbilical vein endothelial cells.

Ann Transl Med 2021 May;9(9):750

Department of Internal Medicine, Busan Paik Hospital, College of Medicine, Inje University, Busan, South Korea.

Background: Dipeptidyl peptidase 4 (DPP-4) inhibitors have been used to treat type 2 diabetes mellitus (T2DM) via inhibition of the enzymatic activity of DPP-4 in degrading active circulating glucagon-like peptide-1. In addition to their glucose-lowering effect, DPP-4 inhibitors have pleiotropic effects. Cellular senescence regarded as important pathophysiological mechanism underlying many degenerative diseases, including atherosclerosis. Read More

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Validation of the Japanese version of Stress and Anxiety to Viral Epidemics-9 (SAVE-9) and relationship among stress, insomnia, anxiety, and depression in healthcare workers exposed to coronavirus disease 2019.

Sleep Med 2021 Jun 29;84:397-402. Epub 2021 Jun 29.

Department of Psychology, Sungshin Women's University, Seoul, South Korea.

Objective: This study aimed to validate the Japanese version of the 9-item Stress and Anxiety to Viral Epidemics scale (SAVE-9) and the relationships among the stress related to viral epidemics, insomnia, anxiety, and depression.

Patients/methods: A cross-sectional questionnaire-based study was conducted online. In total, 1000 healthcare workers (579 men, 421 women; mean age: 43. Read More

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A stochastic oscillator model simulates the entrainment of vertebrate cellular clocks by light.

Sci Rep 2021 Jul 14;11(1):14497. Epub 2021 Jul 14.

Institute of Biological and Chemical Systems-Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.

The circadian clock is a cellular mechanism that synchronizes various biological processes with respect to the time of the day. While much progress has been made characterizing the molecular mechanisms underlying this clock, it is less clear how external light cues influence the dynamics of the core clock mechanism and thereby entrain it with the light-dark cycle. Zebrafish-derived cell cultures possess clocks that are directly light-entrainable, thus providing an attractive laboratory model for circadian entrainment. Read More

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The Axial Impact Response and Plantar Load Distribution of the Hybrid III and MIL-Lx Under Altered Ankle Postures.

J Biomech Eng 2021 Jul 14. Epub 2021 Jul 14.

Department of Mechanical Engineering, McMaster University, School of Biomedical Engineering, McMaster University, 1280 Main St. W., Hamilton, Ontario, Canada, L8S 4L8.

Foot injuries as a result of automotive collisions are frequent and impactful. Anthropomorphic Test Devices (ATDs), used to assess injury risk during impact scenarios such as motor vehicle collisions, typically assess risk of foot/ankle injuries by analyzing data in tibia load cells. The peak axial force (Fz) and the Tibia Index (TI) are metrics commonly used to evaluate risk of injury to the lower extremity but do not directly account for injury risk to the foot, or the risk of injury associated with out-of-position loading. Read More

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