27,642 results match your criteria direct damage


A novel swine model of the acute respiratory distress syndrome using clinically relevant injury exposures.

Physiol Rep 2021 May;9(9):e14871

Michigan Center for Integrative Research in Critical Care, University of Michigan, Ann Arbor, MI, USA.

To date, existing animal models of the acute respiratory distress syndrome (ARDS) have failed to translate preclinical discoveries into effective pharmacotherapy or diagnostic biomarkers. To address this translational gap, we developed a high-fidelity swine model of ARDS utilizing clinically relevant lung injury exposures. Fourteen male swine were anesthetized, mechanically ventilated, and surgically instrumented for hemodynamic monitoring, blood, and tissue sampling. Read More

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First Report of SARS-CoV-2 Detection in Cerebrospinal Fluid in a Child With Guillain-Barré Syndrome.

Pediatr Infect Dis J 2021 May 7. Epub 2021 May 7.

From the Medical Residence Program, Fundação de Beneficência Hospital de Cirurgia Neuroimmunology Clinic, Federal University of Sergipe Department of Medicine, Tiradentes University, Aracaju Health Foundation Parreiras Horta, Central Laboratory of Public Health (LACEN/SE), Sergipe State Health Secretariat Health Sciences Graduate Program, Federal University of Sergipe Investigative Pathology Laboratory, Federal University of Sergipe, Aracaju, Sergipe, Brazil.

Underlying mechanisms on the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and neurological complications are still poorly understood. Cases of Guillain-Barré Syndrome (GBS) have been linked to the SARS-CoV-2 infection as the result of dysregulated immune response with damage in neuronal tissues. In the current report, we present the first pediatric case of GBS with detection of SARS-CoV-2 in the cerebrospinal fluid (CFS). Read More

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Acute kidney injury in COVID-19: are kidneys the target or just collateral damage? A comprehensive assessment of viral RNA and AKI rate in patients with COVID-19.

Curr Opin Urol 2021 May 14. Epub 2021 May 14.

Institute for Urology and Reproductive Health, Sechenov University Sechenov University DNA Technologies Ltd. Tareev Clinic of Internal Diseases, Sechenov University, Moscow, Russia S.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China Department of Urology, Spital Thurgau AG, Frauenfeld, Switzerland Department of Urology, Hannover Medical School, Hannover, Germany Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria Department of Urology, Weill Cornell Medical College, New York, New York Department of Urology, University of Texas Southwestern, Dallas, Texas, USA.

Purpose Of Review: To investigate the possible effects of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) on kidney function and assess the rate of viral ribonucleic acid (RNA) shedding/detection in urine.

Recent Findings: Most of the research on the topic suggests that for the moment our ability to estimate whether SARS-CoV-2 is a direct causative agent in acute kidney injury (AKI) or whether it has a cytokine storm effect is limited. During our prospective assessment of 333 patients with COronaVIrus Disease 2019 (COVID-19) it was found that frequency of AKI of 9. Read More

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Human Gut Microbiota-associated Gastrointestinal Malignancies: A Comprehensive Review.

Radiographics 2021 May 14:200168. Epub 2021 May 14.

From the Department of Radiology, University of Texas Health at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 (A.B., S.D., J.K., V.S.K.); University of Texas at Austin, Austin, Tex (S.K.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (V.M.); and Department of Radiology, Mayo Clinic, Scottsdale, Ariz (C.O.M.).

The human gastrointestinal tract houses trillions of microbes. The gut and various types of microorganisms, including bacteria, viruses, fungi, and archaea, form a complex ecosystem known as the gut microbiota, and the whole genome of the gut microbiota is referred to as the gut microbiome. The gut microbiota is essential for homeostasis and the overall well-being of a person and is increasingly considered an adjunct "virtual organ," with a complexity level comparable to that of the other organ systems. Read More

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Assessment of causality between climate variables and production for whole crop maize using structural equation modeling.

J Anim Sci Technol 2021 Mar 31;63(2):339-353. Epub 2021 Mar 31.

Department of Animal Industry Convergence, Kangwon National University, Chuncheon 24341, Korea.

This study aimed to assess the causality of different climate variables on the production of whole crop maize ( L.; WCM) in the central inland region of the Korea. Furthermore, the effect of these climate variables was also determined by looking at direct and indirect pathways during the stages before and after silking. Read More

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extract causes precocious acrosome reaction and viability loss but low rate of membrane damage in mouse spermatozoa.

J Anim Sci Technol 2021 Jan 31;63(1):58-68. Epub 2021 Jan 31.

Central Department of Biotechnology, Tribhuvan University, Kirtipur, Kathmandu 44618, Nepal.

Several herbs including are known to possess conceptive property. In the present study, mouse spermatozoa were incubated with ethanol extract of leaves. The effect of extract on acrosome exocytosis was studied by labeling spermatozoa with fluorescein isothiocyanate (FITC) peanut agglutinin and by staining with Coomassie blue. Read More

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January 2021

miR-194-5p protects against myocardial ischemia/reperfusion injury via MAPK1/PTEN/AKT pathway.

Ann Transl Med 2021 Apr;9(8):654

Department of Cardiovascular Medicine, Xiaoshan Hospital, Xiaoshan, China.

Background: MicroRNA (miRNA), which participates in various physiological and pathological processes, is a highly conserved small RNA sequence. This study aimed to investigate the role of miR-194-5p in hypoxia/reoxygenation (H/R)-induced cardiomyocyte apoptosis and myocardial ischemia/reperfusion (I/R) injury.

Methods: We set up an H/R H9c2 cell model and an I/R mouse model . Read More

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Effects of Cardiotoxins on Cardiac Stem and Progenitor Cell Populations.

Authors:
Andrew J Smith

Front Cardiovasc Med 2021 27;8:624028. Epub 2021 Apr 27.

Faculty of Biological Sciences, School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom.

As research and understanding of the cardiotoxic side-effects of anticancer therapy expands further and the affected patient population grows, notably the long-term survivors of childhood cancers, it is important to consider the full range of myocardial cell types affected. While the direct impacts of these toxins on cardiac myocytes constitute the most immediate damage, over the longer term, the myocardial ability to repair, or adapt to this damage becomes an ever greater component of the disease phenotype. One aspect is the potential for endogenous myocardial repair and renewal and how this may be limited by cardiotoxins depleting the cells that contribute to these processes. Read More

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Downregulation of both mismatch repair and non-homologous end-joining pathways in hypoxic brain tumour cell lines.

PeerJ 2021 30;9:e11275. Epub 2021 Apr 30.

Institute of Systems, Molecular and Integrative Biology, Department of Molecular Physiology and Cell Signalling, University of Liverpool, Liverpool, Merseyside, United Kingdom.

Glioblastoma, a grade IV astrocytoma, has a poor survival rate in part due to ineffective treatment options available. These tumours are heterogeneous with areas of low oxygen levels, termed hypoxic regions. Many intra-cellular signalling pathways, including DNA repair, can be altered by hypoxia. Read More

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CT Imaging Characteristics and Influence Factors of Renal Dialysis-Associated Peritoneal Injury.

Authors:
Jin Tong Wangda Xu

J Healthc Eng 2021 20;2021:5591124. Epub 2021 Apr 20.

Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.

Peritoneal dialysis (PD), as one of the main renal replacement modalities for end-stage renal disease, gets the advantages of better protection of residual renal function and better quality of survival. However, ultrafiltration failure after peritoneal injury is an important reason for patients to withdraw from PD treatment. Peritonitis is a major complication of peritoneal dialysis, which results in an accelerated process of peritoneal injury due to direct damage from acute inflammation and local release of cytokine TGF-. Read More

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Cost-Effectiveness of Repository Corticotropin Injection versus Standard of Care for the Treatment of Active Rheumatoid Arthritis.

Clinicoecon Outcomes Res 2021 6;13:349-358. Epub 2021 May 6.

Mallinckrodt Pharmaceuticals, Hampton, NJ, USA.

Introduction: Patients with active rheumatoid arthritis (RA) often have inadequately controlled symptoms and are unable to achieve remission or low disease activity despite aggressive treatment. This results in irreversible joint damage, adversely affecting patients' physical and social functioning. The objective was to estimate the cost-effectiveness of repository corticotropin injection (RCI) versus standard of care (SoC) in patients with active RA from the United States (US) payer and societal perspectives over two to three years. Read More

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Removal of antibiotic-resistant genes during drinking water treatment: A review.

J Environ Sci (China) 2021 Jun 30;104:415-429. Epub 2020 Dec 30.

Zhejiang Key Laboratory of Drinking Water Safety and Distribution Technology, Zhejiang University, Hangzhou 310058, China; Ocean College, Zhejiang University, Hangzhou 310058, China. Electronic address:

Once contaminate the drinking water source, antibiotic resistance genes (ARGs) will propagate in drinking water systems and pose a serious risk to human health. Therefore, the drinking water treatment processes (DWTPs) are critical to manage the risks posed by ARGs. This study summarizes the prevalence of ARGs in raw water sources and treated drinking water worldwide. Read More

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Genetic damage in coal and uranium miners.

Mutat Res 2021 Jun 16;866:503348. Epub 2021 Mar 16.

Programa de Pós-graduação em Ciências da Saúde, Faculdade de Medicina, Universidade Federal do Rio Grande, FURG, Rio Grande, Brazil; Laboratório de Ensaios Farmacológicos e Toxicológicos, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, FURG, Brazil.

Mining has a direct impact on the environment and on the health of miners and is considered one of the most hazardous occupations worldwide. Miners are exposed to several occupational health risks, including genotoxic substances, which may cause adverse health effects, such as cancer. This review summarizes the relation between DNA damage and mining activities, focusing on coal and uranium miners. Read More

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Potential of HBx Gene for Hepatocarcinogenesis in Noncirrhotic Liver.

Semin Liver Dis 2021 May 6. Epub 2021 May 6.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Current treatments for hepatitis B virus (HBV) using nucleos(t)ide analogs cannot eliminate the risk of hepatocellular carcinoma (HCC) development. As HBV-associated HCC can develop even in the absence of liver cirrhosis, HBV is regarded to possess direct oncogenic potential. HBV regulatory protein X (HBx) has been identified as a primary mediator of HBV-mediated hepatocarcinogenesis. Read More

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Interventions to Reduce Meat Consumption by Appealing to Animal Welfare: Meta-Analysis and Evidence-Based Recommendations.

Appetite 2021 May 10:105277. Epub 2021 May 10.

Stanford Solutions Science Lab, Department of Pediatrics, Stanford University. Electronic address:

Reducing meat consumption may improve human health, curb environmental damage, and limit the large-scale suffering of animals reared in factory farms. Most attention to reducing consumption has focused on restructuring environments where foods are chosen or on making health or environmental appeals. However, psychological theory suggests that interventions appealing to animal welfare concerns might operate on distinct, potent pathways. Read More

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Kirenol Inhibits B[a]P-Induced Oxidative Stress and Apoptosis in Endothelial Cells via Modulation of the Nrf2 Signaling Pathway.

Oxid Med Cell Longev 2021 23;2021:5585303. Epub 2021 Apr 23.

Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600 077, India.

Atherosclerosis is a persistent inflammatory disorder specified by the dysfunction of the arteries, the world's leading cause of cardiovascular diseases. We sought to determine the effectiveness of KRL in B[a]P-induced oxidative stress and programmed cell death in endothelial cells. Western blotting, real-time PCR, DCFH2-DA, and TUNEL staining were performed to detect pPI3K, pAKT, Nrf2, HO-1, NQO-1, Bcl2, Bax, and caspase-3 on the HUVECs. Read More

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Intentional and unintentional selection during plant domestication: herbivore damage, plant defensive traits and nutritional quality of fruit and seed crops.

New Phytol 2021 May 11. Epub 2021 May 11.

Laboratorio Ecotono, INIBIOMA, Universidad Nacional del Comahue, CONICET, Quintral, 1250, Bariloche, 8400, Argentina.

●Greater susceptibility to herbivory can arise as an effect of crop domestication. One proposed explanation is that defenses decreased intentionally or unintentionally during the domestication process, but evidence remains elusive. An alternative but non-excluding explanation is presumed selection for higher nutritional quality. Read More

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Biomonitoring of children and adolescents using orthodontic appliances made of acrylic resins through micronucleus testing of exfoliated buccal and palatal mucosa cells.

Am J Orthod Dentofacial Orthop 2021 May 8. Epub 2021 May 8.

Department of Biological Science, State University of Feira de Santana Feira de Santana, Bahia, Brazil.

Introduction: The present study aimed to investigate the occurrence of micronuclei and the degenerative nuclear alterations indicative of apoptosis and necrosis in the exfoliated buccal and palatal mucosa cells of children and adolescents using orthodontic appliances made of self-curing acrylic resins.

Methods: The micronuclei and nuclear alterations were evaluated in a minimum of 2000 cells collected from the cheeks and palates of 30 patients of both sexes, aged between 6 and 12 years. The cell evaluations were performed before appliance installation and 15 to 21 days after installation. Read More

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Prodromal sensory neuropathy in Pink1 SNCA double mutant Parkinson mice.

Neuropathol Appl Neurobiol 2021 May 11. Epub 2021 May 11.

Institute for Clinical Pharmacology, Faculty of Medicine, Goethe-University, Frankfurt, Germany.

Aims: Parkinson's Disease (PD) is frequently associated with a prodromal sensory neuropathy manifesting with sensory loss and chronic pain. We have recently shown that PD-associated sensory neuropathy in patients is associated with high levels of glucosylceramides. Here, we assessed the underlying pathology and mechanisms in Pink1 SNCA double mutant mice. Read More

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