107 results match your criteria diopters thinning

Clinical and morphologic features of posterior staphyloma edges by ultra-widefield imaging in pathologic myopia.

Retina 2021 Jun 8. Epub 2021 Jun 8.

Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan Faculty of Medicine, Imperial College London, London, United Kingdom Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Purpose: To investigate morphologic features along posterior staphyloma edges in eyes with pathologic myopia using ultra-widefield optical coherence tomography (UWF-OCT) imaging.

Methods: Highly myopic patients (refractive error < 8.0 diopters or axial length ≥ 26. Read More

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Reduced macular thickness and macular vessel density in early-treated adult patients with PKU.

Mol Genet Metab Rep 2021 Jun 5;27:100767. Epub 2021 May 5.

Department of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, Koranyi Sandor street 2/a, 1083 Budapest, Hungary.

Purpose: Macular structure is poorly evaluated in early-treated phenylketonuria (ETPKU). To evaluate potential changes, we aimed to examine retinas of PKU patients using optical coherence tomography (OCT) with additional OCT angiography (OCTA) and compare the results to healthy controls.

Methods: A total of 100 adults were recruited in this monocentric, case-control study: 50 patients with ETPKU (mean age: 30. Read More

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The effect of Wnt/β-catenin pathway on the scleral remolding in the mouse during form deprivation.

Int Ophthalmol 2021 May 13. Epub 2021 May 13.

Department of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.

Background: Many reports have shown that Wnt/β-Catenin pathway is associated with a variety of diseases, but its role in the pathogenesis of myopia is still unknown. In order to clarify the role of Wnt/β-catenin pathway in the development of form deprivation myopia (FDM), this study investigated the expression of scleral Wls, β-catenin and TCF4 in mice model of form deprivation (FD) myopia.

Methods: Three parallel experimental groups, including FD, monocular exposure (SC) and binocular exposure (NC) group, were designed to investigate the effects of Wnt/β-Catenin pathway on scleral remodeling mouse during form deprivation in three-week-old C57BL/6 mice. Read More

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Two-step keratoplasty for deep vascularized corneal opacity with severe peripheral thinning following Acanthamoeba keratitis.

Graefes Arch Clin Exp Ophthalmol 2021 Apr 27. Epub 2021 Apr 27.

Cornea and Ocular Surface Unit, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.

Purpose: In cases of corneal opacity with vascularization and peripheral thinning, traditional keratoplasty techniques have several risks and drawbacks. We report the results of a two-step surgical strategy consisting in performing a large diameter tectonic lamellar keratoplasty (TLK) to restore appropriate corneal thickness and an avascular recipient bed, followed by central optical PK within the lamellar graft at a later date.

Methods: This single-institution study analyzes the results of 7 eyes of 7 patients who received PK after large diameter TLK. Read More

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Transepithelial versus epithelium-off corneal crosslinking for progressive keratoconus.

Cochrane Database Syst Rev 2021 03 23;3:CD013512. Epub 2021 Mar 23.

Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Background: Keratoconus is the most common corneal dystrophy. It can cause loss of uncorrected and best-corrected visual acuity through ectasia (thinning) of the central or paracentral cornea, irregular corneal scarring, or corneal perforation. Disease onset usually occurs in the second to fourth decade of life, periods of peak educational attainment or career development. Read More

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Partial corneal recovery following selective trabeculoplasty-induced keratopathy: Longitudinal analysis through scheimpflug imaging.

Am J Ophthalmol Case Rep 2021 Jun 26;22:101062. Epub 2021 Feb 26.

Glaucoma Unit, Hospital Medicina dos Olhos, 207, Salem Bechara Street, Osasco, São Paulo, 06018-180, Brazil.

Purpose: To report an uncommon case of hyperopic shift and corneal haze, flattening and thinning following a single session of selective laser trabeculoplasty (SLT), and provide longitudinal clinical data and serial analyses of corneal profile through Scheimpflug imaging. Furthermore, a careful literature review was undertaken to determine possible risk factors for this complication.

Observations: A 47-year-old woman presented with blurred vision and mild corneal edema and haze three days following routine SLT. Read More

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Optic Atrophy and Inner Retinal Thinning in -related Congenital Stationary Night Blindness.

Genes (Basel) 2021 Feb 25;12(3). Epub 2021 Feb 25.

Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.

Hemizygous pathogenic variants in lead to defective signal transmission from retinal photoreceptors to bipolar cells and cause incomplete congenital stationary night blindness in humans. Although the primary defect is at the terminal end of first-order neurons (photoreceptors), there is limited knowledge of higher-order neuronal changes (inner retinal) in this disorder. This study aimed to investigate inner retinal changes in -retinopathy by analyzing macular ganglion cell layer-inner plexiform layer (GCL-IPL) thickness and optic disc pallor in 22 subjects with molecularly confirmed -retinopathy. Read More

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February 2021

Detection of refractive photokeratectomy traces during eye banking: impossible with organ culture but possible with an active storage machine: case report.

Cell Tissue Bank 2021 Jan 4. Epub 2021 Jan 4.

Laboratory for Corneal Graft Biology, engineering and imaging (BiiGC, EA2521), Faculty of Medicine, University Jean Monnet, Health Innovation Campus, 10 rue de la marandière, F-42055, Saint-Etienne, France.

The detection of corneas operated on for refractive surgery [LASIK or photorefractive keratectomy (PRK)] will become a major concern for eye banks in the coming years because this surgery is often forgotten during the interview with the deceased's relatives. We present here 2 corneas operated on with PKR and stored successively in organ culture (OC) and in the active storage machine (ASM) that restores intraocular pressure, restores the cornea to its original shape, respects transparency and incorporates non-invasive controls. The 2 corneas of a 49-year-old donor operated 17 years earlier by PRK for -2 and -3 diopters myopia were stored in OC for 14 days and then placed in ASM for 48 h. Read More

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January 2021

Assessment of Choroidal Vascularity and Choriocapillaris Blood Perfusion in Anisomyopic Adults by SS-OCT/OCTA.

Invest Ophthalmol Vis Sci 2021 01;62(1)

Eye Hospital and School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Purpose: To explore the association of choroidal vascularity and choriocapillaris blood perfusion with myopic severity in anisomyopes.

Methods: Refractive error, axial length (AL), and other biometric parameters were measured in 34 anisomyopic young adults. Macular choroidal thickness (ChT) and choroidal vascularity, including total choroidal area (TCA), luminal area (LA), stromal area (SA), and choroidal vascularity index (CVI), were determined from swept-source optical coherence tomography (SS-OCT) vertical and horizontal B-scans. Read More

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January 2021

Prognostic Factors for Axial Length Elongation and Posterior Staphyloma in Adults With High Myopia: A Japanese Observational Study.

Am J Ophthalmol 2021 May 9;225:76-85. Epub 2020 Dec 9.

Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.

Purpose: To identify prognostic factors for axial length (AL) elongation and incidence of posterior staphyloma (PS) in adult Japanese patients with high myopia.

Design: Retrospective, observational cohort study.

Methods: Six-year follow-up data for 345 patients (620 eyes with AL ≥ 26. Read More

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Diagnostic Criteria for Terrien Marginal Degeneration: Nordic Terrien Degeneration Study.

Cornea 2021 Feb;40(2):133-141

Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Purpose: To refine the diagnostic criteria for Terrien marginal degeneration (TMD) based on experience in 3 Nordic countries.

Methods: This is a retrospective, multicenter, hospital-based cross-sectional study of 49 eyes of 29 white patients in tertiary referral centers in Finland, Sweden, and Denmark from 1998 to January 2018. The median follow-up was 3 years. Read More

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February 2021

Intracorneal Stromal Ring Can Affect the Biomechanics of Ectatic Cornea.

J Ophthalmol 2020 7;2020:4274037. Epub 2020 Oct 7.

Poostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: The biomechanical properties of ecstatic cornea undergo changes. This study evaluates the biomechanical changes of ecstatic cornea after implantation of two types of intracorneal stromal ring (ICR).

Methods: For doing this prospective cross-sectional study, 32 patients with keratoconus (KCN) were randomly divided into two 16-member groups (group I: MyoRing, group II: KeraRing). Read More

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October 2020

Longitudinal Macular Ganglion Cell-Inner Plexiform Layer Measurements to Detect Glaucoma Progression in High Myopia.

Am J Ophthalmol 2021 03 29;223:9-20. Epub 2020 Sep 29.

Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea. Electronic address:

Purpose: To investigate whether progressive macular ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (RNFL) thinning are predictive for detecting visual field (VF) progression in eyes with high myopia.

Design: Cohort study.

Methods: A total of 104 primary open-angle glaucoma (POAG) eyes with high myopia and 104 age- and VF severity-matched POAG eyes without high myopia (mean follow-up, 5. Read More

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Inflammatory-induced astigmatism: acute changes in corneal curvature secondary to marginal keratitis and previous mitomycin-C treatment.

J Cataract Refract Surg 2020 12;46(12):e54-e56

From the Department of Ophthalmology, University of Auckland, Auckland, and the Department of Ophthalmology, Waikato Hospital, Hamilton, New Zealand.

A 52-year-old man presented with left eye redness, blurred vision, and photophobia. A history included marginal keratitis and conjunctival squamous cell carcinoma treated with excision and topical mitomycin-C. Examination revealed current marginal keratitis, managed with topical antibiotic and corticosteroid. Read More

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December 2020

High Myopia and Glaucoma-Like Optic Neuropathy.

Asia Pac J Ophthalmol (Phila) 2020 May-Jun;9(3):234-238

Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karis-University, Mannheim, Germany.

Purpose: Previous population-based and hospital-based studies have shown an association between high myopia and higher prevalence of glaucomatous or glaucoma-like optic neuropathy (GON). Here we discuss potential factors associated with such a correlation.

Design: Review. Read More

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Anterior Sclera Undergoes Thinning with Increasing Degree of Myopia.

Invest Ophthalmol Vis Sci 2020 04;61(4)


Purpose: Considering that ocular expansion is associated with scleral thinning, this study investigated variation in scleral thickness (anterior scleral thickness [AST] and posterior scleral thickness [PST]) in different meridians across emmetropes and a wide range of myopes.

Methods: A total of 95 participants (mean age, 24 ± 4 years) including emmetropes (spherical equivalent refractive error, ±0.75 diopters [D]; n = 20) and myopes (-1. Read More

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Advanced keratoconus in a child with juvenile scleroderma.

Indian J Ophthalmol 2020 04;68(4):658-659

Refractive Surgery Services; Cornea and Anterior Segment Services, LV Prasad Eye Institute, Hyderabad, Telangana, India.

An 18-year-old male presented with complaints of gradually decreasing vision in both eyes for 6 years. He was a diagnosed with juvenile scleroderma at the age of 11 years by a pediatric rheumatologist. Clinical slit lamp examination showed features of ectasia, thinning, Vogt's striae, and apical scarring in both eyes. Read More

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Accelerated Corneal Cross-Linking: Efficacy, Risk of Progression, and Characteristics Affecting Outcomes. A Large, Single-Center Prospective Study.

Am J Ophthalmol 2020 05 13;213:76-87. Epub 2020 Jan 13.

Kensington Eye Institute, Toronto, Ontario, Canada; Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.

Purpose: We examined the efficacy and preoperative characteristics that affect outcomes of accelerated (9 mW/cm for 10 minutes) corneal cross-linking (CXL).

Design: Prospective single-center observational cohort study.

Methods: We enrolled 612 eyes of 391 subjects with progressive keratoconus (n = 589), pellucid marginal degeneration (n = 11), and laser in situ keratomileusis-induced ectasia (n = 12). Read More

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Emmetropia Is Maintained Despite Continued Eye Growth From 16 to 18 Years of Age.

Invest Ophthalmol Vis Sci 2019 10;60(13):4178-4186

National Centre for Optics, Vision and Eye Care, Faculty of Health and Social Sciences, University of South-Eastern Norway, Kongsberg, Norway.

Purpose: To examine, in Norwegian adolescents, to what degree emmetropia and low hyperopia were maintained from 16 to 18 years of age, and if this was the case, whether it was associated with continued coordinated ocular growth.

Methods: Cycloplegic autorefraction and ocular biometry, including crystalline lens thickness, were measured in 93 Norwegian adolescents (mean age: 16.7 ± 0. Read More

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October 2019

Analysis of Compensatory Corneal Epithelial Thickness Changes in Keratoconus Using Corneal Tomography.

Cornea 2020 Mar;39(3):298-302

Department of Ophthalmology, Jamaica Hospital Medical Center, Richmond Hill, NY.

Purpose: To determine patterns of epithelial remodeling in keratoconus and to assess changes in these patterns as the disease progresses.

Methods: This is a prospective case series. Patients with keratoconus undergoing corneal collagen crosslinking underwent Scheimpflug imaging before and after epithelial debridement. Read More

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Simultaneous Implantation of Refractive Lenticule and Intracorneal Ring Segment in the Management of Pellucid Marginal Degeneration.

J Refract Surg 2019 Sep;35(9):606-609

Purpose: To describe a patient with pellucid macular degeneration suffering from visual deterioration due to high irregular astigmatism and intolerant to contact lenses, who underwent a new surgical procedure that combined intrastromal lamellar keratoplasty and a 359° intracorneal ring segment implantation, enabling both ametropia and corneal thinning correction.

Methods: Case report.

Results: Refractive lenticule obtained during a myopic small incision lenticule extraction procedure was used as the donor lamellar graft. Read More

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September 2019

Choroidal thickness in keratoconus.

Int Ophthalmol 2020 Jan 20;40(1):135-140. Epub 2019 Aug 20.

Department of Ophthalmology, Adıyaman University, Adıyaman, Turkey.

Purpose: Keratoconus is an ectatic eye disease characterized by progressive thinning and steepening of the cornea which leads to irregular astigmatism and visual function loss. Determination of choroidal thickness in keratoconus patients may help us to better understand and manage the keratoconus disease. Choroidal thickness may be a potential marker for disease activity in keratoconus patients. Read More

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January 2020

Long-term Results of Mini Asymmetric Radial Keratotomy and Corneal Cross-linking for the Treatment of Keratoconus.

Korean J Ophthalmol 2019 Apr;33(2):189-195

Graduate School of Public Health, St. Luke's International University, Tokyo, Japan.

Purpose: To investigate the long-term results (at least 5 years of follow-up) of the mini asymmetric radial keratotomy (MARK) and corneal cross-linking (CXL) combined intervention, also known as the 'Rome protocol,' for patients with progressive stage I and II keratoconus and contact lens intolerance.

Methods: This was a retrospective observational case series. Fifteen eyes of 12 patients were evaluated, with a mean follow-up of 6. Read More

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Effect of Optical Defocus on Choroidal Thickness in Healthy Adults With Presbyopia.

Invest Ophthalmol Vis Sci 2018 10;59(12):5188-5193

Department of Optometry, Asia University, Taichung, Taiwan.

Purpose: To investigate changes in subfoveal choroidal thickness (SFCT) induced by retinal defocus in presbyopic adults.

Methods: Thirty-seven healthy presbyopic subjects (age 57.74 ± 4. Read More

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October 2018

Retinal nerve fiber layer (RNFL) integrity and its relations to retinal microvasculature and microcirculation in myopic eyes.

Eye Vis (Lond) 2018 10;5:25. Epub 2018 Oct 10.

1Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL USA.

Background: The aim was to determine retinal nerve fiber layer function and its relations to retinal microvasculature and microcirculation in patients with myopia.

Method: Polarization-sensitive optical coherence tomography (PS-OCT) was used to measure phase retardation per unit depth (PR/UD, proportional to the birefringence) of the retinal nerve fiber layer (RNFL). Optical coherence tomography angiography (OCTA) was used to measure macular vessel density analyzed using fractal analysis. Read More

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October 2018

Crescentic Tuck in Lamellar Keratoplasty-A Novel Technique in a Case of Advanced Pellucid Marginal Corneal Degeneration.

Eye Contact Lens 2018 Sep;44 Suppl 1:S345-S347

Department of Ophthalmology, Guru Nanak Eye Centre (R.A., J.L.G.), Affiliated to Maulana Azad Medical College, New Delhi, India; Tirupati Eye Centre (A.M.), Noida, Uttar Pradesh, India; and I CARE Hospital and Post Graduate Research Institute (P.J.), Noida, Uttar Pradesh, India.

Purpose: To describe a new surgical technique "crescentic tuck in lamellar keratoplasty" for the management of advanced pellucid marginal corneal degeneration (PMCD).

Methods: A 45-year-old man with advanced PMCD and maximal thinning in the inferior juxtalimbal periphery underwent a crescentic lamellar keratoplasty in the right eye. Best-corrected visual acuity was 6/60 with no further improvement because of severe irregular astigmatism. Read More

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September 2018

Spectral-domain optical coherence tomography of peripheral lattice degeneration of myopic eyes before and after laser photocoagulation.

J Formos Med Assoc 2019 Mar 24;118(3):679-685. Epub 2018 Aug 24.

Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taiwan. Electronic address:

Purpose: To investigate the microstructural characteristics of lattice degenerations before and after laser photocoagulation in myopic eyes by spectral-domain optical coherence tomography (SD-OCT).

Methods: Twenty-five eyes of 25 consecutive patients at the High Myopia Clinic of the National Taiwan University Hospital were retrospectively reviewed. Myopic eyes with peripheral lattice degeneration were enrolled in the study. Read More

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Retinal nerve fiber layer thickness after laser-assisted subepithelial keratomileusis and femtosecond LASIK: a prospective observational cohort study.

Clin Ophthalmol 2018 4;12:1213-1218. Epub 2018 Jul 4.

Clínica Novovisión, Madrid, Spain,

Purpose: Based on the assumption that high levels of intraocular pressure (IOP) during femtosecond laser-assisted in situ keratomileusis (FS-LASIK) may compromise the retinal nerve fiber layer (RNFL), newer femtosecond platforms that operate without causing significant IOP elevation have been developed in recent years. However, this assumption has not been adequately tested. The aim of the current study was to evaluate possible changes in RFNL thickness in nonglaucomatous myopic patients undergoing FS-LASIK using the 60 KHz IntraLase device that significantly elevates the IOP for an appreciable period of time vs an advanced surface ablation technique (laser-assisted subepithelial keratomileusis, LASEK) that does not induce any IOP elevation. Read More

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Long-term Results of Corneal Cross-linking for Terrien's Marginal Degeneration.

J Refract Surg 2018 Jun;34(6):424-429

Purpose: To report the long-term clinical outcomes of a patient with Terrien's marginal degeneration who underwent successful peripheral corneal cross-linking (CXL) to arrest progression.

Methods: Clinical assessment included uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), corneal topography, anterior segment optical coherence tomography, ultrasonic pachymetry, corneal hysteresis, and corneal resistance factor. Eccentric epithelium-off CXL was performed in both eyes after limbal conjunctival resection. Read More

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Influence of the beam profile crosslinking setting on changes in corneal topography and tomography in progressive keratoconus: Preliminary results.

J Cataract Refract Surg 2018 Jun 31;44(6):718-724. Epub 2018 May 31.

From the Department of Ophthalmology (Herber, Spoerl, Pillunat, Raiskup), University Hospital Carl Gustav Carus, Dresden, and the Ernst-Abbe-University of Applied Sciences (Kunert), Jena, Germany; Department of Ophthalmology (Veliká, Raiskup), University Hospital Hradec Králové, Charles University, Prague, Czech Republic.

Purpose: To evaluate the effect of accelerated corneal crosslinking (CXL) with a "higher peripheral intensity" profile setting compared with a standard "top hat" profile setting performed using different CXL systems.

Setting: Department of Ophthalmology, University Hospital Carl Gustav Carus, Dresden, Germany.

Design: Retrospective case series. Read More

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