18,464 results match your criteria dilation compared

Hydralazine augmented ultrasound hyperthermia for the treatment of hepatocellular carcinoma.

Sci Rep 2021 Jul 30;11(1):15553. Epub 2021 Jul 30.

Ultrasound Research Laboratory, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA, 19104, USA.

This study investigates the use of hydralazine to enhance ultrasound hyperthermia for the treatment of hepatocellular carcinoma (HCC) by minimizing flow-mediated heat loss from the tumor. Murine HCC tumors were treated with a continuous mode ultrasound with or without an intravenous administration of hydralazine (5 mg/kg). Tumor blood flow and blood vessels were evaluated by contrast-enhanced ultrasound (CEUS) imaging and histology, respectively. Read More

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Efficacy of endoscopic large balloon dilation extended for 2 minutes in bile duct stone removal: A multicenter retrospective study.

J Hepatobiliary Pancreat Sci 2021 Jul 30. Epub 2021 Jul 30.

Department of Gastroenterology and Hepatology, St. Marianna University, School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki, 216-8511, Japan.

Background/purpose: There is no evidence regarding the optimal balloon dilation time during endoscopic papillary large balloon dilation (EPLBD). The study aim was to evaluate the efficacy of 2-min extended balloon dilation for EPLBD.

Methods: 205 patients who underwent EPLBD during endoscopic retrograde cholangiopancreatography (ERCP) for bile duct stones at three tertiary centers were included in the analysis. Read More

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Ultrasound and Influenza: The Spectrum of Lung and Cardiac Ultrasound Findings in Patients with Suspected Influenza A and B.

Ultrasound Med Biol 2021 Jul 26. Epub 2021 Jul 26.

Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

In patients with influenza, cardiac and lung ultrasound may help determine the severity of illness and predict clinical outcomes. To determine the ultrasound characteristics of influenza and define the spectrum of lung and cardiac findings in patients with suspected influenza A or B, we conducted a prospective observational study in patients presenting to the emergency department at a tertiary care academic institution. An ultrasound protocol consisting of cardiac, lung and inferior vena cava scans was performed within 6 h of admission. Read More

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Effect of upper airway fat on tongue dilation during inspiration in awake people with obstructive sleep apnea.

Sleep 2021 Jul 29. Epub 2021 Jul 29.

Neuroscience Research Australia, Sydney, New South Wales, Australia.

Study Objectives: To investigate the effect of upper airway fat composition on tongue inspiratory movement and obstructive sleep apnea (OSA).

Methods: Participants without or with untreated OSA underwent a 3T magnetic resonance imaging (MRI) scan. Anatomical measurements were obtained from T2-weighted images. Read More

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One step further: randomised single-centre trial comparing the direct and afterload techniques of embryo transfer.

Hum Reprod 2021 Jul 29. Epub 2021 Jul 29.

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT, USA.

Study Question: What are the differences in ease of use between two different embryo transfer (ET) techniques: the preload direct approach and the afterload approach.

Summary Answer: The afterload technique seems to reduce the rate of difficult ETs.

What Is Known Already: Numerous published trials now document that the ET procedure has an impact on pregnancy and delivery rates after IVF. Read More

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Mesenchymal stem cells from different sources show distinct therapeutic effects in hyperoxia-induced bronchopulmonary dysplasia in rats.

J Cell Mol Med 2021 Jul 29. Epub 2021 Jul 29.

Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Mesenchymal stem cells (MSCs) have been shown as an effective medicinal means to treat bronchopulmonary dysplasia (BPD). The widely used MSCs were from Wharton's jelly of umbilical cord (UC-MSCs) and bone marrow (BM-MSCs). Amniotic fluid MSCs (AF-MSCs) may be produced before an individual is born to treat foetal diseases by autoplastic transplantation. Read More

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Defective Allele of the Neuronal Nitric Oxide Synthase Gene Increases Insulin Resistance During Acute Phase of Myocardial Infarction.

Int J Gen Med 2021 20;14:3669-3676. Epub 2021 Jul 20.

Programa de Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade de Brasília (UnB), Brasília, DF, Brazil.

Background: Glycemic disorders are strong predictors of mortality in ST-elevation myocardial infarction (STEMI) patients, and disruption in nitric oxide (NO) production is associated with insulin-resistant states. We evaluated whether a defective allele of the neuronal nitric oxide synthase (nNOS) gene () might influence insulin response and blood-glucose balance during the acute phase of STEMI and if post-infarction total plasma-NO levels and vasodilation scores varied across nNOS genotypes.

Methods: Consecutive patients with STEMI (n=354) underwent clinical evaluations and genotyping for the promoter variation rs41279104. Read More

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Risk Factors for Intrapartum Cesarean Section Delivery in Low-risk Multiparous Women Following at Least a Prior Vaginal Birth (Robson Classification 3 and 4).

Rev Bras Ginecol Obstet 2021 Jun 27;43(6):436-441. Epub 2021 Jul 27.

Department of Obstetrics and Gynecology, University of Health Sciences, Zekai Tahir Burak Woman's Health, Education and Research Hospital, Ankara, Turkey.

Objective:  The aim of the present study was to evaluate the risk factors for cesarean section (C-section) in low-risk multiparous women with a history of vaginal birth.

Methods:  The present retrospective study included low-risk multiparous women with a history of vaginal birth who gave birth at between 37 and 42 gestational weeks. The subjects were divided into 2 groups according to the mode of delivery, as C-section Group and vaginal delivery Group. Read More

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Computed Tomography Findings in Intraabdominal Hypertension in Patients with Acute Pancreatitis.

Indian J Radiol Imaging 2021 Jan 23;31(1):150-156. Epub 2021 May 23.

Department of Gastroenterology, PGIMER, Chandigarh, India.

 Intraabdominal hypertension (IAH) in acute pancreatitis (AP) may reduce tissue perfusion and impair organ function and has been shown to portend poor prognosis. We investigated the computed tomography (CT) findings in patients with AP with IAH.  This retrospective study comprised of consecutive patients with AP from June 2016 to June 2018 in whom intraabdominal pressure (IAP) was measured. Read More

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January 2021

Transplantation of an obesity-associated human gut microbiota to mice induces vascular dysfunction and glucose intolerance.

Gut Microbes 2021 Jan-Dec;13(1):1940791

Department of Food Science & Human Nutrition, Colorado State University, Fort Collins, CO, USA.

Recent preclinical data suggest that alterations in the gut microbiota may be an important factor linking obesity to vascular dysfunction, an early sign of cardiovascular disease. The purpose of this study was to begin translation of these preclinical data by examining whether vascular phenotypes in humans are transmissible through the gut microbiota. We hypothesized that germ-free mice colonized with gut microbiota from obese individuals would display diminished vascular function compared to germ-free mice receiving microbiota from lean individuals. Read More

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Altered central and peripheral hemodynamics during rhythmic handgrip exercise in young adults with SARS-CoV-2.

Exp Physiol 2021 Jul 26. Epub 2021 Jul 26.

Department of Health & Exercise Science, Appalachian State University, Boone, NC.

New Findings: What is the central question of this study? This study sought to investigate whether central and peripheral hemodynamics during handgrip exercise were different in young adults 3-4 weeks following infection with of SARS-CoV-2 compared with young healthy adults. What is the main finding and its importance? The main findings are that exercising heart rate was higher while brachial artery blood flow and vascular conductance were lower in the SARS-CoV-2 compared with the control group. These findings provide evidence for peripheral impairments to exercise among adults with SARS-CoV-2, which may contribute to exercise limitations. Read More

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Cytomegalovirus colitis induced segmental colonic hypoganglionosis in an immunocompetent patient: A case report.

World J Clin Cases 2021 Jul;9(20):5631-5636

Department of Gastroenterology, Chonnam National University Hospital, Gwangju 501-757, South Korea.

Background: Cytomegalovirus (CMV) colitis is usually seen in immunocompromised patients with risk factors such as human immunodeficiency virus infection, solid organ transplant, inflammatory bowel disease, or malignancy. Therefore, many clinicians usually do not consider the possibility of CMV colitis in immunocompetent patients. We reported a rare case of segmental colonic hypoganglionosis associated with CMV colitis in an immunocompetent patient. Read More

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Do Blood-Borne Viruses Affect the Progression of Labor: A Hospital-Based Pilot Study.

Cureus 2021 Jun 14;13(6):e15631. Epub 2021 Jun 14.

Obstetrics and Gynecology, All India Institute of Medical Sciences, Rishikesh, IND.

Background Blood-borne viruses form the basis of enormous research on universal precautions. A paucity of research is noted regarding labor progression in seropositive women. Women testing positive for human immunodeficiency virus (HIV)/hepatitis B surface antigen (HBsAg)/hepatitis C virus (HCV) are often denied obstetric care and referred. Read More

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[Observation on the efficacy of Eustachian tube dilation hormone under the guidance of endoscope in the treatment of sudden deafness].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 May;35(5):424-427

Department of Otorhinolaryngology Head and Neck Surgery,Shaanxi Provincial People's Hospital,Xi'an,710068,China.

To evaluate the efficacy of Eustachian tube dilation hormone under the guidance of otoscope in the treatment of patients with sudden deafness. One hundred and seventy-six patients(185 ears) with sudden deafness treated by otorhinolaryngology head and neck surgery in Shaanxi Provincial People's Hospital from January 2020 to December 2020 were selected. According to the inclusion and exclusion criteria, 176 patients(185 ears) were randomly divided into control group(=86, 90 ears) and study group(=90, 95 ears). Read More

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Sexual Orientation, Sexual Arousal, and Finger Length Ratios in Women.

Arch Sex Behav 2021 Jul 23. Epub 2021 Jul 23.

Department of Psychology, University of Essex, Colchester, CO4 3SQ, UK.

In general, women show physiological sexual arousal to both sexes. However, compared with heterosexual women, homosexual women are more aroused to their preferred sex, a pattern typically found in men. We hypothesized that homosexual women's male-typical arousal is due to their sex-atypical masculinization during prenatal development. Read More

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Blunted peripheral but not cerebral vasodilator function in young otherwise healthy adults with persistent symptoms following COVID-19.

Am J Physiol Heart Circ Physiol 2021 07 23. Epub 2021 Jul 23.

Department of Kinesiology, University of Texas at Arlington, Arlington, Texas, Arlington, Texas, United States.

Recent findings suggest that COVID-19 causes vascular dysfunction during the acute phase of the illness in otherwise healthy young adults. To date, no studies have investigated the longer-term effects of COVID-19 on vascular function. Herein, we hypothesized that young, otherwise healthy adults who are past the acute phase of COVID-19 would exhibit blunted peripheral (brachial artery flow-mediated dilation (FMD) and reactive hyperemia) and cerebral vasodilator function (cerebral vasomotor reactivity to hypercapnia; CVMR) and increased central arterial stiffness. Read More

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[Experimental study on liver injury induced by intraperitoneal hypertension under mechanical ventilation].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Jun;33(6):740-743

Department of Tumor Surgery, the Affiliated Hospital of Shanxi Datong University, Datong 037005, Shanxi, China. Corresponding author: Wang Hongye, Email:

Objective: To investigate the effects of mechanical ventilation on liver cytological and enzymatic indexes in abdominal compartment syndrome (ACS) by establishing a porcine model of abdominal hypertension.

Methods: Six healthy adult pigs were selected. After general anesthesia, they were intubated and given ventilator assisted breathing. Read More

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In-depth bioinformatic study of the cadherin 5 interactome in patients with thoracic aortic aneurysm unveils 8 novel biomarkers.

Eur J Cardiothorac Surg 2021 Jul 19. Epub 2021 Jul 19.

Department of Surgery and Cancer, Imperial College London, St Mary's Hospital, London, UK.

Objectives: Thoracic aortic aneurysm (TAA) is characterized by the dilation of the aorta and is associated with poor prognosis if not diagnosed and treated early. In this context, the identification of biomarkers regarding the TAA diagnosis, monitoring and prognosis is crucial. The purpose of the current study was to investigate the differential gene expression profile of the cadherin 5 (CDH5 or VE-Cadherin) gene network in patients with TAA, to propose novel biomarkers. Read More

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Impact of Surgical Wait Time on Survival in Patients With Upper Urinary Tract Urothelial Carcinoma With Hydronephrosis.

Front Oncol 2021 5;11:698594. Epub 2021 Jul 5.

Department of Urology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Background And Objectives: Due to the inevitability of waiting time for surgery, this problem seems to have become more pronounced since the outbreak of COVID-19, and due to the high incidence of preoperative hydronephrosis in upper urinary tract urothelial carcinoma (UTUC) patients, it is particularly important to explore the impact of preoperative waiting time and hydronephrosis on upper urinary urothelial carcinoma.

Methods: 316 patients with UTUC who underwent radical surgery at a high-volume center in China between January 2008 and December 2019 were included in this study. We retrospectively collected the clinicopathologic data from the medical records, including age, sex, smoking history, ECOG performance status (ECOG PS), body mass index (BMI), tumor location and size, number of lesions, T stage, N stage, surgical approach and occurrence of hydronephrosis, lymph node invasion, lymph node dissection, surgical margin, tumor necrosis, infiltrative tumor architecture, lymphovascular invasion and concomitant bladder cancer. Read More

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The pupillary dynamics of patients with physiological anisocoria.

Eye (Lond) 2021 Jul 21. Epub 2021 Jul 21.

Ankara Kudret Eye Hospital, Ophthalmology Clinic, Ankara, Turkey.

Background: To evaluate static pupillometric measurements and making inter-ocular comparative analysis in healthy subjects for demonstrating the prevalance of physiological anisocoria in various lighting conditions and to compare the variations of the dynamic pupillometric measurements of the patients with physiological anisocoria.

Methods: Automatic quantitative pupillometry system was used to measure pupillary diameters in low mesopic (0.1 cd/m), high mesopic (1 cd/m), low photopic (10 cd/m) and high photopic (100 cd/m) conditions. Read More

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Structural changes, increased hypoxia, and oxidative DNA damage in placenta due to maternal smokeless tobacco use.

Birth Defects Res 2021 Jul 20. Epub 2021 Jul 20.

Environmental Toxicology and Electron Microscope Laboratory, ICMR-National Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India.

Background: Smokeless tobacco (SLT) consumption during pregnancy is a well-recognized health risk that causes placental damage including hypoxia and oxidative damage. Although consumption of SLT by women varies from region to region, majority of tea leave pluckers consume SLT for relieving stress and pain. Still, the effects of SLT consumption have not been evaluated in tea garden workers (TGW). Read More

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Evaluation of echocardiographic derived parameters for right ventricular size and function using cardiac magnetic resonance imaging.

Echocardiography 2021 Jul 19. Epub 2021 Jul 19.

Division of Cardiology, Department of Medicine, White River Junction VA Medical Center, White River Junction, Vermont, USA.

Background: Cardiac Magnetic Resonance Imaging (cMRI) is the gold standard for right ventricular (RV) assessment due to its high spatial resolution. The American Society of Echocardiography (ASE) recommends eight structural and six functional quantitative parameters for evaluation of the RV. This study sought to simplify echocardiographic RV assessment by examining the relative diagnostic value of the echo recommended parameters by applying them to cMRI imaging of the RV. Read More

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Abnormal hearing patterns are not associated with endothelium-dependent vasodilation and carotid intima-media thickness: The Framingham Heart Study.

Vasc Med 2021 Jul 21:1358863X211025087. Epub 2021 Jul 21.

Department of Medicine, Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.

Introduction: Prior data suggest associations between hearing loss, cardiovascular (CV) risk factors, and CV disease. Whether specific hearing loss patterns, including a strial pattern associated with inner ear vascular disease, are associated with systemic endothelial dysfunction and carotid intima-media thickness (IMT) remains unclear.

Methods: We evaluated participants without prevalent CVD in the Framingham Offspring Study who underwent formal audiogram testing and brachial and carotid artery ultrasounds. Read More

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COVID 19 disease independently predicted endothelial dysfunction measured by flow-mediated dilatation.

Int J Cardiovasc Imaging 2021 Jul 20. Epub 2021 Jul 20.

Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdogan University, 53020, Rize, Turkey.

The systemic effects of COVID-19 disease are still largely uncertain and needs to be scrutinized with further trials. Endothelial dysfunction (ED) is responsible for the majority of adverse cardiovascular events. Flow-mediated dilation (FMD) is easily obtainable method to assess ED accurately. Read More

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Time course of microvalve pathophysiology in high pressure low flow model of venous insufficiency and the role of micronized purified flavonoid fraction.

Int Angiol 2021 Jul 20. Epub 2021 Jul 20.

Laboratory for Clinical and Experimental Research on Vascular Biology (BioVasc), State University of Rio de Janeiro, Rio de Janeiro, Brazil.

Background: The aim of this study was to characterize, in an experimental model, the mechanisms involved in the initiation of venous insufficiency at the level of microvenous valve and whether they can be influenced by early treatment with micronized purified flavonoid fraction (MPFF).

Methods: The external right iliac vein of 78 male golden Syrian hamsters was ligated to induce chronic venous insufficiency. Internal venular diameter as well as leukocyteendothelium-interaction (leukocytes sticking after staining with rhodamine 6G), were assessed using an intravital microscope. Read More

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Hepatoprotective Impact of Ghrelin against Cyclophosphamide-Induced Toxicity in the Male Mice.

Drug Res (Stuttg) 2021 Jul 19. Epub 2021 Jul 19.

Department of Anatomical Sciences and Pathology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Background: Despite its vast spectrum of clinical usage, cyclophosphamide (CP) exerts many adverse impacts, including hepatotoxicity. Antioxidant properties of ghrelin might protect the liver from CP-induced toxicity. The current study aimed to assess the protective impacts of ghrelin on CP-induced liver toxicity. Read More

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Risk of Cesarean Delivery for Women with Obesity Using a Standardized Labor Induction Protocol.

Am J Perinatol 2021 Jul 19. Epub 2021 Jul 19.

Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

Objective:  We aimed to determine the risk of cesarean among women with obesity undergoing labor induction within a prospective trial that utilized a standardized labor protocol.

Study Design:  This was a secondary analysis of a randomized trial of induction methods. Term (≥37 weeks) women with intact membranes undergoing induction with an unfavorable cervix (Bishop's score ≤6 and dilation ≤2 cm) were included. Read More

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Remembering nothing: Encoding and memory processes involved in representing empty locations.

Mem Cognit 2021 Jul 19. Epub 2021 Jul 19.

Department of Psychological Sciences, Birkbeck University of London, Malet St, Bloomsbury, London, WC1E 7HX, UK.

Previous research has provided rich evidence that a set of visual objects can be encoded in isolation along with their exact coordinate positions as well as a global configuration that provides a network of interrelated spatial information. However, much less data is available on how unoccupied locations are encoded and maintained in memory. We tested this ability in adults using a novel paradigm that involved both empty and filled locations and required participants to monitor the addition or deletion of an item, which occurred 50% of the time. Read More

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Hepato-protective effects of thymoquinone and beta-aminoisobutyric acid in streptozocin induced diabetic rats.

Biotech Histochem 2021 Jul 19:1-10. Epub 2021 Jul 19.

Department of Histology and Embryology, Faculty of Medicine, Niğde Ömer Halisdemir University, Niğde, Turkey.

We investigated the hepato-protective effects of thymoquinone (TQ) and beta-aminoisobutyric acid (BAIBA). We used five groups of 8-week-old male rats: untreated control group, streptozotocin (STZ) diabetic group, STZ + TQ group, STZ + BAIBA group, and STZ + TQ + BAIBA group. After experimental diabetes mellitus (DM) was established using STZ, TQ was given to the STZ + TQ group, BAIBA to the STZ + BAIBA group, and TQ and BAIBA to the STZ + TQ + BAIBA group. Read More

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Post-stenting fractional flow reserve vs coronary angiography for optimisation of percutaneous coronary intervention: TARGET-FFR trial.

Eur Heart J 2021 Jul 19. Epub 2021 Jul 19.

West of Scotland Regional Heart & Lung Centre, Golden Jubilee National Hospital, Agamemnon Street, Clydebank, G81 4DY, UK.

Aims : A fractional flow reserve (FFR) value ≥0.90 after percutaneous coronary intervention (PCI) is associated with a reduced risk of adverse cardiovascular events. TARGET-FFR is an investigator-initiated, single-centre, randomized controlled trial to determine the feasibility and efficacy of a post-PCI FFR-guided optimization strategy vs. Read More

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