1,377 results match your criteria digestive track

CARMN-NOTCH2 fusion transcript drives high NOTCH2 expression in glomus tumors of the upper digestive tract.

Genes Chromosomes Cancer 2021 Jul 10. Epub 2021 Jul 10.

EA4340 Research Unit, University of Versailles SQY, Boulogne, France.

Glomus tumors (GTs) are perivascular tumors mostly occurring in the distal extremities. Rare cases arise in the digestive tract and may be misdiagnosed with neuroendocrine or gastrointestinal stromal tumors. We aimed to specify the features of GT of the upper digestive tract. Read More

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Unusual presentation of a first branchial arch fistula with maxillofacial infection: a case report.

BMC Surg 2021 Jul 3;21(1):306. Epub 2021 Jul 3.

Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China.

Background: First branchial cleft anomaly (FBCA) is a rare congenital defect that arises due to incomplete closure of the ventral portion of the first and second branchial arches. There are variable complex clinical manifestations for patients with FBCA, which are prone to misdiagnosis and inadequate treatment. FBCAs usually involve the facial nerve with a consequent increased risk of facial nerve damage. Read More

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Keeping Track of (Bacillariophyta) Culture Contamination by Potentiometric E-Tongue.

Sensors (Basel) 2021 Jun 12;21(12). Epub 2021 Jun 12.

Department of Biology, University of Rome "Tor Vergata", 00133 Rome, Italy.

The large-scale cultivation of microalgae provides a wide spectrum of marketable bioproducts, profitably used in many fields, from the preparation of functional health products and feed supplement in aquaculture and animal husbandry to biofuels and green chemistry agents. The commercially successful algal biomass production requires effective strategies to maintain the process at desired productivity and stability levels. Hence, the development of effective early warning methods to timely indicate remedial actions and to undertake countermeasures is extremely important to avoid culture collapse and consequent economic losses. Read More

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Analysis of a mathematical model of immune response to fungal infection.

J Math Biol 2021 Jun 29;83(1). Epub 2021 Jun 29.

Department of Mathematics, The Ohio State University, Columbus, OH 43210, USA.

Fungi are cells found as commensal residents, on the skin, and on mucosal surfaces of the human body, including the digestive track and urogenital track, but some species are pathogenic. Fungal infection may spread into deep-seated organs causing life-threatening infection, especially in immune-compromised individuals. Effective defense against fungal infection requires a coordinated response by the innate and adaptive immune systems. Read More

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[Perioperative Medicine in Visceral Surgery in the Elderly Patient from an Anaesthesiological Perspective].

Zentralbl Chir 2021 Jun 21;146(3):296-305. Epub 2021 Jun 21.

Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Bonn, Deutschland.

Demographic change is leading to an increasing number of old patients both in our society and in hospitals. With increasing age, not only the number of pre-existing conditions increases, but also the postoperative complication rate and mortality. Ultimately, however, it is not age that is decisive, but the condition of the patient and his or her capacity to face the physical and mental challenges of a surgical procedure. Read More

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Effects of sonication and ultrasound on properties and bioactivities of liposomes loaded with hydrolyzed collagen from defatted sea bass skin conjugated with epigallocatechin gallate.

J Food Biochem 2021 Jun 18:e13809. Epub 2021 Jun 18.

International Center of Excellence in Seafood Science and Innovation, Faculty of Agro-Industry, Prince of Songkla University, Songkhla, Thailand.

Hydrolyzed collagen (HC) from defatted sea bass skin conjugated with 3% epigallocatechin gallate (EGCG) was prepared and the resulting HC-EGCG conjugate at various levels (0.25%-2%, w/v) was loaded into liposome. The obtained liposomes were subjected to sonication (S). Read More

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Iodine intake among pregnant mothers residing in hilly terrains of two districts of Himachal Pradesh, India.

Indian J Public Health 2021 Apr-Jun;65(2):185-189

Lecturer (Statistics), Department of Community Medicine, Dr. Rajendra Prasad Government Medical College, Kangra, Himachal Pradesh, India.

Background: Under programmatic settings, routine monitoring and evaluation of household consumption of iodized salt are recommended to track the reach of universal salt iodization strategy. The program needs evaluation in different settings and locations.

Objective: The objective of this study was to assess urine-based estimation for recent iodine intake among pregnant women living in hilly terrains of two districts of northern state of India. Read More

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Hyaluronic Acid-Based Nanocapsules as Efficient Delivery Systems of Garlic Oil Active Components with Anticancer Activity.

Nanomaterials (Basel) 2021 May 20;11(5). Epub 2021 May 20.

Jagiellonian University, Faculty of Chemistry, Gronostajowa 2, 30-387 Krakow, Poland.

Diallyl disulfide (DADS) and diallyl trisulfide (DATS) are garlic oil compounds exhibiting beneficial healthy properties including anticancer action. However, these compounds are sparingly water-soluble with a limited stability that may imply damage to blood vessels or cells after administration. Thus, their encapsulation in the oil-core nanocapsules based on a derivative of hyaluronic acid was investigated here as a way of protecting against oxidation and undesired interactions with blood and digestive track components. Read More

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Enhancing recovery after minimally invasive surgery in children: A systematic review of the literature and meta-analysis.

J Pediatr Surg 2021 Apr 20. Epub 2021 Apr 20.

Department of Pediatric Surgery and Urology, Robert-Debré University Hospital, APHP, 48 boulevard Sérurier, 75019Paris, France; Paris University, Paris, France; UFR de Médecine, Université Paris Diderot-Sorbonne Paris Cité, Paris, France.

Objective: Enhanced recovery after surgery (ERAS) has been widely implemented after minimally invasive surgeries (MIS) in adults. The aim of this study was to evaluate the current evidence available on ERAS after MIS in children.

Methods: Using a defined search strategy (PubMed, Cochrane, Scopus), we performed a systematic review of the literature, searching for studies reporting on ERAS after MIS (thoracoscopy, laparoscopy, retroperitoneoscopy) in children (1975-2019). Read More

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Ten-year assessment of a cancer fast-track programme to connect primary care with oncology: reducing time from initial symptoms to diagnosis and treatment initiation.

ESMO Open 2021 Jun 11;6(3):100148. Epub 2021 May 11.

Department of Medical Oncology, Biomedical Research Institute INCLIVA, University of Valencia, Valencia, Spain. Electronic address:

Background: Cancer is the second leading cause of mortality worldwide. Integrating different levels of care by implementing screening programmes, extending diagnostic tools and applying therapeutic advances may increase survival. We implemented a cancer fast-track programme (CFP) to shorten the time between suspected cancer symptoms, diagnosis and therapy initiation. Read More

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Rapid Assessment of Pepsin Column Activity for Reliable HDX-MS Studies.

J Am Soc Mass Spectrom 2021 May 13. Epub 2021 May 13.

Department of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, United States.

Hydrogen/deuterium exchange with mass spectrometry (HDX-MS) is a widely used technique to probe protein structural dynamics, track conformational changes, and map protein-protein interactions. Most HDX-MS studies employ a bottom-up approach utilizing the acid active protease pepsin to digest the protein of interest, often utilizing immobilized protease in a column format. The extent of proteolytic cleavage will greatly influence data quality and presents a major source of variation in HDX-MS studies. Read More

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Achieving realistic gastric emptying curve in an advanced dynamic human digestion system: experiences with cheese-a difficult to empty material.

Food Funct 2021 May;12(9):3965-3977

Department of Chemical Engineering and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China and School of Chemical and Environmental Engineering, College of Chemistry, Chemical Engineering and Material Science, Soochow University, Suzhou 215123, Jiangsu Province, China.

Nowadays, in vitro digestion models have received growing interest in recent years to track the digestive fate of foods in the gastrointestinal tract. A major challenge in the development of more physiologically relevant in vitro gastric models is to simulate realistic gastric emptying. In this study, an advanced dynamic in vitro human gastric system was investigated for its potential in achieving the above. Read More

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Actinomycosis of the parotid gland: case series.

Ann Palliat Med 2021 Jun 7;10(6):6062-6066. Epub 2021 May 7.

Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School & Hwasun Hospital, Hwasun, South Korea.

Background: Actinomycosis of the parotid gland is very rare. We sought to examine the clinical features, treatment methods, and treatment results of actinomycosis of the parotid gland in our hospital.

Methods: We retrospectively enrolled 5 patients with histopathologically identified actinomycosis of the parotid gland from January 2010 to May 2020. Read More

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Environmental conditions, diel period, and fish size influence the horizontal and vertical movements of red snapper.

Sci Rep 2021 May 5;11(1):9580. Epub 2021 May 5.

Department of Applied Ecology, Center for Marine Sciences and Technology, North Carolina State University, Morehead City, NC, 28557, USA.

Most demersal fishes are difficult to observe and track due to methodological and analytical constraints. We used an acoustic positioning system to elucidate the horizontal and vertical movements of 44 red snapper (Lutjanus campechanus) off North Carolina, USA, in 2019. Mean movement rate and distance off bottom varied by individual, with larger red snapper generally moving faster and spending more time farther off the bottom than smaller individuals. Read More

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The Landscape of Cell-Free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients.

Clin Cancer Res 2021 Jul 4;27(13):3772-3783. Epub 2021 May 4.

Berry Oncology Corporation. Beijing, PR China.

Purpose: Intratumoral hepatitis B virus (HBV) integrations and mutations are related to hepatocellular carcinoma (HCC) progression. Circulating cell-free DNA (cfDNA) has shown itself as a powerful noninvasive biomarker for cancer. However, the HBV integration and mutation landscape on cfDNA remains unclear. Read More

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Cell-free DNA beyond a biomarker for rejection: Biological trigger of tissue injury and potential therapeutics.

J Heart Lung Transplant 2021 Jun 24;40(6):405-413. Epub 2021 Mar 24.

Lasker Clinical Research Tenure Track Investigator and Laboratory Chief, Laboratory of Applied Precision Omics, National Heart, Lung, and Blood Institute, Bethesda, Maryland; Lung Transplantation Program, Johns Hopkins School of Medicine, Baltimore, M. Electronic address:

Cell-free DNA, measured as donor-derived cell-free DNA is developed as a non-specific biomarker for allograft injury and transplant rejection. However, cell-free DNA characteristics are more specific, its fragment length, nucleotide content, and composition, as well as the tissue source of origin, are intrinsically linked to the underlying disease pathogenesis, showing distinct features in acute cellular rejection and antibody-mediated rejection for example. Further, cell-free DNA and cell-free mitochondrial DNA can directly trigger tissue injury as damage-associated molecular patterns through three major intracellular receptors, toll-like receptor 9 , cyclic guanosine monophosphate-adenosine monophosphate synthase, and inflammasomes (i. Read More

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Fistula Laser Closure (FiLaC™) for fistula-in-ano-yet another technique with 50% healing rates?

Int J Colorectal Dis 2021 Apr 21. Epub 2021 Apr 21.

Digestive Disease Center, Bispebjerg University Hospital, Bispebjerg Bakke 23, 2400, Copenhagen, NV, Denmark.

Purpose: Treatment of ano-cutaneous fistulas remains a therapeutic challenge. Fistula Laser Closure (FiLaC™) is a relatively new technique for the treatment of ano-cutaneous fistulas. This study aimed to determine the success rate of fistula closure using FiLaC™. Read More

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[Evaluation of the Effectiveness of a Standard Operating Procedure (SOP) for the Perioperative Management of Colorectal Surgery].

Zentralbl Chir 2021 Jun 13;146(3):269-276. Epub 2021 Apr 13.

Klinik- und Poliklinik für Allgemein-, Viszeral-, Thorax- und Gefäßchirurgie, Universitätsklinikum Bonn, Deutschland.

Introduction: In recent years, perioperative care of patients after colorectal surgery has been increasingly standardised according to the fast-track concept and is accepted as a structured method of care to reduce perioperative complications. Indeed, initial studies have indicated that there is a long-term favourable effect on the oncological outcome, if the adherence to the individual measures is at least 70%. Even though there is unambiguous evidence for the efficacy of the modern perioperative treatment concept, it is often difficult to comply with the protocol during normal clinical work, particularly in Germany. Read More

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The first record of exceptionally-preserved spiral coprolites from the Tsagan-Tsab formation (lower cretaceous), Tatal, western Mongolia.

Sci Rep 2021 Apr 12;11(1):7891. Epub 2021 Apr 12.

Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, 100044, China.

In this paper, seven coprolites from the Lower Cretaceous of Tsagan-Tsab formation have been described. Thus, producing a significant contribution to what we perceived as the first detailed study of coprolites from the Mesozoic deposits in Mongolia. The collected coprolites encompass a total of six spiral amphipolar and one scroll coprolites. Read More

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Where there is pancreatic juice, there is a way: Spontaneous fistulization of severe acute pancreatitis-associated collection into urinary bladder.

Indian J Radiol Imaging 2020 Oct-Dec;30(4):529-532. Epub 2021 Jan 13.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Pancreatic fluid collections (PFC) are notorious for their extension beyond the normal confines of the pancreatic bed. This distribution is explained by dissection along the fascial planes in retroperitoneum due to the digestive enzymes within the PFC. In genitourinary track, PFCs have been described to involve the kidneys and the ureters. Read More

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January 2021

Toward net-zero sustainable aviation fuel with wet waste-derived volatile fatty acids.

Proc Natl Acad Sci U S A 2021 Mar;118(13)

Catalytic Carbon Transformation Center, National Renewable Energy Laboratory, Golden, CO 80401;

With the increasing demand for net-zero sustainable aviation fuels (SAF), new conversion technologies are needed to process waste feedstocks and meet carbon reduction and cost targets. Wet waste is a low-cost, prevalent feedstock with the energy potential to displace over 20% of US jet fuel consumption; however, its complexity and high moisture typically relegates its use to methane production from anaerobic digestion. To overcome this, methanogenesis can be arrested during fermentation to instead produce C to C volatile fatty acids (VFA) for catalytic upgrading to SAF. Read More

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Digital tools for ambulatory surgery patient surveillance and beyond….

O Raspado

J Visc Surg 2021 Jun 9;158(3S):S32-S36. Epub 2021 Mar 9.

Department of visceral, digestive and robotic surgery, protestant infirmary, 1-3, chemin du Penthod, 69300 Caluire et Cuire, France. Electronic address:

Management of patients in ambulatory (or short stay) surgery relies on optimal organisation of the health care pathways and specific anesthesiology and surgical protocols. Postoperative medico-surgical complications can occur undetected by traditional hospital surveillance. This article identifies modern digital means that can be adapted to surveillance of patients at home: telephone calls or teleconferences, automatic messaging, mobile phone applications, Web platforms and other e-connected devices. Read More

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Fast-Track Liver Transplantation: Six-year Prospective Cohort Study with an Enhanced Recovery After Surgery (ERAS) Protocol.

World J Surg 2021 05 23;45(5):1262-1271. Epub 2021 Feb 23.

Hepatobiliary Surgery and Liver Transplantation, Hospital General Universitario de Alicante, Alicante, Spain.

Introduction: Enhanced recovery after surgery (ERAS) has been shown to facilitate discharge, decrease length of stay, improve outcomes and reduce costs. We used this concept to design a comprehensive fast-track pathway (OR-to-discharge) before starting our liver transplant activity and then applied this protocol prospectively to every patient undergoing liver transplantation at our institution, monitoring the results periodically. We now report our first six years results. Read More

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Performing Colonoscopic-Guided Pinch Biopsies in Mice and Evaluating Subsequent Tissue Changes.

J Vis Exp 2021 02 5(168). Epub 2021 Feb 5.

Department of Medicine, Weill Cornell Medicine, New York, NY.

Understanding the tissue and cellular changes that occur in the acute injury response as well as during the wound healing process is of paramount importance when studying diseases of the gastrointestinal (GI) tract. The murine colonic pinch biopsy model is a useful tool to define these processes. Additionally, the interplay between gut luminal content (e. Read More

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February 2021

An epidermal patch for the simultaneous monitoring of haemodynamic and metabolic biomarkers.

Nat Biomed Eng 2021 Jul 15;5(7):737-748. Epub 2021 Feb 15.

Department of Nanoengineering, University of California, San Diego, La Jolla, CA, USA.

Monitoring the effects of daily activities on the physiological responses of the body calls for wearable devices that can simultaneously track metabolic and haemodynamic parameters. Here we describe a non-invasive skin-worn device for the simultaneous monitoring of blood pressure and heart rate via ultrasonic transducers and of multiple biomarkers via electrochemical sensors. We optimized the integrated device so that it provides mechanical resiliency and flexibility while conforming to curved skin surfaces, and to ensure reliable sensing of glucose in interstitial fluid and of lactate, caffeine and alcohol in sweat, without crosstalk between the individual sensors. Read More

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Mixing and emptying of gastric contents in human-stomach: A numerical study.

J Biomech 2021 03 4;118:110293. Epub 2021 Feb 4.

Center of Applied Space Technology and Microgravity (ZARM), University of Bremen, Am Fallturm 2, 28359 Bremen, Germany. Electronic address:

Stomach is one of the most important organs in human gastro-track. To better understand the operation of human-stomach, the process of mixing and emptying of gastric contents is simulated using a numerical method. The numerical results confirm that a fast pathway is located close to the lesser curvature of the stomach when water is emptied. Read More

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Stage-, sex- and tissue-related changes in HO, glutathione concentration, and glutathione-dependent enzymes activity in Aiolopus thalassinus (Orthoptera: Acrididae) from heavy metal polluted areas.

Ecotoxicology 2021 Apr 13;30(3):478-491. Epub 2021 Feb 13.

Entomology Department, Faculty of Science, Cairo University, Giza, Egypt.

This study is part of a large project carried out at the Cairo University, Egypt, and focused on assessing physiological and biochemical changes in Aiolopus thalassinus under the influence of environmental pollution with heavy metals (Pb, Cd, Cu, and Zn). The study aimed to investigate parameters related to maintaining redox balance, with particular emphasis on stage-, sex- and tissue-dependent differences in HO and glutathione (GSH) levels and activity of selected enzymes involved in GSH metabolism. A noticeable increase in the concentration of HO was found, especially in the gut of 5th instar nymphs and females from the highly polluted site. Read More

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Re-evaluating Blood Markers as Predictors of Outcome in Multivisceral and Intestinal Transplantation.

Transplant Proc 2021 Mar 6;53(2):696-704. Epub 2021 Feb 6.

Department of Pediatrics, Division of Pediatric Infectious Disease and Immunology, University of Miami, Miami, Florida.

Background: Multivisceral transplant (MVTx) and isolated intestinal transplant (ITx) are complex surgical procedures. The subsequent proinflammatory state in the immediate postoperative period makes interpretation of blood markers difficult.

Method: We aimed to establish the course of various blood markers after MVTx/ITx, and to evaluate their use as diagnostic markers of complications. Read More

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Objective measures of lingual and jaw function in healthy adults and persons with Parkinson's disease: Implications for swallowing.

Physiol Behav 2021 04 3;232:113349. Epub 2021 Feb 3.

Metro Health, Univ of Michigan, 5900 Byron Center Ave, Wyoming, MI 49519, United States.

The study examines the effects of age and Parkinson's disease on lingual and jaw function in neurotypical adults, as well as persons with Parkinson's Disease. Preliminary results provide reference measures in these populations and support the systematic collection of objective data regarding lingual strength, lingual range of motion, and jaw range of motion in clinical populations. The application of this clinically meaningful protocol also provides a means to track physiological changes over time in order to maximize the results of rehabilitative efforts to restore swallow function. Read More

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