171 results match your criteria diffuse pvns


Long-term functional outcomes of diffuse pigmented villonodular synovitis of knee: The role of adjuvant radiotherapy.

Medicine (Baltimore) 2021 Mar;100(12):e23794

Department of Orthopedics, Kaohsiung Veterans General Hospital, Kaohsiung.

Abstract: Diffuse pigmented villonodular synovitis (PVNS) of knee is a rare benign disease that has a destructive clinical course. Synovectomy and adjuvant radiotherapy (RT) have been reported as treatment options but literatures reporting functional outcomes were sparse. This study aimed to evaluate the long-term functional outcomes and disease control among treatment modalities through the 22 years of experience. Read More

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cIAP2 expression and clinical significance in pigmented villonodular synovitis.

J Mol Histol 2021 Apr 18;52(2):397-406. Epub 2021 Feb 18.

Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.

Pigmented villonodular synovitis (PVNS) is a rare hyperplasia disease of the synovium with a predilection for the knee in either a localized (LPVNS) or a diffuse form (DPVNS). But the exact cause is not clear. The aim of this study was to explore the relationship between the expression of cellular inhibitor of apoptosis 2 (cIAP2) and proliferation, apoptosis, invasive growth and postoperative recurrence in PVNS. Read More

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Spinal pigmented villonodular synovitis and tenosynovial giant cell tumor: A report of two cases and a comprehensive systematic review.

Clin Neurol Neurosurg 2021 Mar 12;202:106489. Epub 2021 Jan 12.

Department of Neurosurgery, Tulane Medical Center, New Orleans, LA, USA; Department of Neurosurgery, Ochsner Clinic Foundation, New Orleans, LA, USA. Electronic address:

Background And Objective: Pigmented villonodular synovitis (PVNS) is a lesion of uncertain etiology that involves the synovial membranes of joints or tendon sheaths, representing a diffuse and non-encapsulated form of the more common giant cell tumors of the synovium (GCTTS). PVNS was reclassified to denote a diffuse form of synovial giant cell tumor (TSGCT), while 'giant cell tumor of the tendon sheath (GCTTS)' was used for localized lesions. These pathologies rarely affect the axial skeleton. Read More

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Open synovectomy treatment for intra- and extraarticular localized pigmented villonodular synovitis of the knee: a case report.

BMC Musculoskelet Disord 2021 Jan 7;22(1):41. Epub 2021 Jan 7.

Department of Orthopaedic Surgery, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan Xi Road, 325027, Wenzhou, Zhejiang, China.

Background: Pigmented villonodular synovitis (PVNS) is a rare, benign, proliferative neoplastic process that commonly affects synovial-lined anatomic spaces. The diffuse type (DPVNS) is characterized by invasion of the entire joint synovium, while the localized type (LPVNS) is characterized by a relatively normal synovial appearance. This report describes a unique case of massive intraarticular LPVNS with an extraarticular extension through the lateral patellar retinaculum. Read More

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January 2021

Management of Pigmented Villonodular Synovitis (PVNS): an Orthopedic Surgeon's Perspective.

Curr Oncol Rep 2020 06 4;22(6):63. Epub 2020 Jun 4.

Department of Orthopaedic Surgery, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90055, USA.

Purpose Of Review: Pigmented villonodular synovitis (PVNS) or tenosynovial giant cell tumor (TGCT) encompasses a wide spectrum of disease and is divided into localized and diffuse variants. Surgical resection remains the principal treatment for nearly all localized type disease and most diffuse type. Recent mechanistic understanding of the disease led to drug discovery that has opened new avenues for patients with recalcitrant disease. Read More

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Pexidartinib for the treatment of adult patients with symptomatic tenosynovial giant cell tumor: safety and efficacy.

Expert Rev Anticancer Ther 2020 06 22;20(6):441-445. Epub 2020 Apr 22.

Orthopedic Oncology, IRCCS Istituto Ortopedico Rizzoli , Bologna, Italy.

Introduction: Tenosynovial giant cell tumor (TGCT) is a benign clonal neoplastic proliferation arising from the synovium often causing pain, swelling, joint stiffness, and reduced quality of life. The optimal treatment strategy in patients with diffuse-type TGCT (dt-TGCT) is evolving. Surgery is the main treatment, with a high recurrence rate and surgery-related morbidity. Read More

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Mid-Term Results of Arthroscopic Synovectomy for Pigmented Villonodular Synovitis of the Hip.

Arthroscopy 2020 06 13;36(6):1587-1598. Epub 2020 Feb 13.

Sports Medicine, Department of Orthopaedic Surgery, Massachusetts General Hospital, Partners Heath System, Boston, Massachusetts, U.S.A.

Purpose: To analyze mid-term outcomes after arthroscopic synovectomy of both diffuse and nodular hip pigmented villonodular synovitis (PVNS).

Methods: This is a retrospective case series of patients that underwent hip arthroscopy for hip PVNS with a single senior surgeon between 2007 and 2016. Inclusion criteria were magnetic resonance imaging evidence, arthroscopic visualization, and/or histologic confirmation of PVNS; and a minimum of 3 years of follow-up. Read More

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Pigmented villonodular synovitis after anterior cruciate ligament reconstruction using active bioprosthetic composite artificial ligament.

Rheumatol Int 2020 Apr 9;40(4):657-661. Epub 2019 Dec 9.

Department of Orthopedic Surgery, Myongji Hospital, Hanyang University College of Medicine, 55, Hwasu-ro 14beon-gil, Deogyang-gu, Goyang-si, Gyeonggi-do, 10475, South Korea.

Pigmented villonodular synovitis (PVNS) is a proliferative disease that develops in the synovium of joints, especially the knee joints. A 52-year-old man visited our hospital with left knee pain, swelling and symptoms of collapse. Twenty-one years earlier, he had undergone anterior cruciate ligament (ACL) reconstruction using an active bioprosthetic composite (ABC) as an artificial ligament. Read More

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The surgical outcome and recurrence rate of tenosynovial giant cell tumor in the elbow: a literature review.

J Shoulder Elbow Surg 2019 Sep;28(9):1835-1840

Division of Orthopaedic Surgery, McGill University, Montreal, QC, Canada.

Background: Tenosynovial giant cell tumor (TSGCT) is a rare proliferative disorder of the synovium. Because of its aggressive nature and recurrence potential, treatment of TSGCT involves surgical resection with or without synovectomy. There is currently a paucity of literature describing the surgical management of TSGCT at the elbow. Read More

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September 2019

Localized pigmented villonodular synovitis with hemorrhage arising from lateral meniscocapsular junction: A case report.

Eklem Hastalik Cerrahisi 2019 Aug;30(2):177-81

Department of Orthopedic Surgery, Nanoori Suwon Hospital, 16503 Gyeonggi-do, Republic of Korea.

Pigmented villonodular synovitis (PVNS) is a benign tumorous condition commonly found in tendon sheathes, bursa, or joint synovium. Unlike the diffuse type which invades the entire synovium of the affected joint, synovium of localized PVNS shows relatively normal appearance. It presents nonspecific symptoms and typically progresses for a long time but acute locking phenomenon or internal derangement of knee symptoms suddenly commence in early stage. Read More

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Histologically benign metastasizing tenosynovial giant cell tumor mimicking metastatic malignancy: A case report and review of literature.

Radiol Case Rep 2019 Aug 24;14(8):934-940. Epub 2019 May 24.

University of Illinois College of Medicine, 1740 W. Taylor St., MC 931, Chicago, IL, 60612, USA.

Diffuse-type tenosynovial giant cell tumor (D-TGCT), otherwise known as pigmented villonodular synovitis, is a locally aggressive tumor which can show multiple recurrences but is rarely associated with metastasis. A handful of studies have elucidated the imaging features and clinical course in metastatic D-TGCT with malignant transformation on histology. However, only 5 cases of metastatic D-TGCT with benign histological features have been reported in the literature, with the clinical course and prognosis reported in only 1 case. Read More

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Osteochondral Lesion in Diffuse Pigmented Villonodular Synovitis of the Knee.

Knee Surg Relat Res 2019 Mar;31(1):67-71

Department of Orthopaedic Surgery, The Orthopaedic Speciality Clinic, Pune.

Pigmented villonodular synovitis (PVNS) is a rare benign condition that is locally aggressive and may destructively invade the surrounding soft tissues and bone causing functional loss of the joint and the limb. The knee is the most affected joint (range, 28% to 70%) but involvement of the bone is not a common feature seen at this site. We present a rare case of diffuse PVNS of the knee associated with subchondral cyst of the lateral femoral condyle. Read More

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Modified Lemaire extra-articular stabilisation of the knee for the treatment of anterolateral instability combined with diffuse pigmented villonodular synovitis: a case report.

BMC Musculoskelet Disord 2018 Sep 11;19(1):330. Epub 2018 Sep 11.

Department of Orthopedic and Trauma Surgery, Medical Center - Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Freiburg im Breisgau, Germany.

Background: Diffuse pigmented villonodular synovitis (PVNS) of the knee is a rare proliferative joint disease associated with high recurrence rates following surgical treatment. Intra-articular joint instability in conjunction with PVNS implies complex reconstructive strategies due to the destructive nature of the disease.

Case Presentation: Here, we present the case of a young patient with refractory PVNS and a chronic ipsilateral anterior cruciate ligament (ACL) rupture. Read More

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September 2018

Diffuse Pigmented Villonodular Synovitis of the Subtalar Joint.

J Belg Soc Radiol 2018 Jan 31;102(1):11. Epub 2018 Jan 31.

Centre Hospitalier Universitaire, Liège, BE.

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January 2018

BILATERAL LOCALIZED PIGMENTED VILLONODULAR SYNOVITIS OF THE KNEE: CASE REPORT AND REVIEW.

Acta Ortop Bras 2018 May-Jun;26(3):183-186

. Institute of Orthopedics and Traumatology, Hospital das Clinicas (HCFMUSP), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Objectives: Several cases of bilateral diffuse pigmented villonodular synovitis (PVNS) or tenosynovial giant cell tumor have been described in the literature. Nevertheless, some presentations are rare and differential diagnoses are necessary.

Methods: The purpose of this study was to perform a systematic review of the literature related to PVNS and to report a rare supra-patellar bilateral and focal presentation. Read More

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Tenosynovial giant cell tumor: case report of a patient effectively treated with pexidartinib (PLX3397) and review of the literature.

Clin Sarcoma Res 2018 10;8:14. Epub 2018 Jul 10.

1Division of Hematology and Oncology, University of California Los Angeles (UCLA), 2825 Santa Monica Blvd. Suite 200, Santa Monica, CA 90404 USA.

Background: Tenosynovial giant cell tumors (TGCTs) or giant cell tumors of tendon sheath are neoplasms that arise in the synovium. They can be categorized as nodular (localized) or diffuse type (D-TGCT). Historically, surgery has been the mainstay of therapy, but diffuse type disease recurs at a high rate and treatment often requires increasingly morbid procedures. Read More

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Pigmented Villonodular Synovitis of the Knee: An Underappreciated Source of Pain in Children and Adolescents.

J Pediatr Orthop 2018 Sep;38(8):e482-e485

Children's Healthcare of Atlanta, Atlanta, GA.

Background: Pigmented villonodular synovitis (PVNS) is a benign proliferative synovial disorder most commonly described in adults. The purpose of this study is to describe the presentation and management of a large single-center series of pediatric patients with PVNS of the knee.

Methods: A retrospective review was performed of consecutive pediatric patients treated for PVNS at a single institution from 2001 to 2016. Read More

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September 2018

Computed Tomography Findings of Pigmented Villonodular Synovitis in a Dog.

Vet Comp Orthop Traumatol 2018 Jul 4;31(4):304-310. Epub 2018 Jun 4.

Institute of Veterinary Science, University of Liverpool plus Institute of Ageing and Chronic Disease, Liverpool, Cheshire, United Kingdom of Great Britain and Northern Ireland.

Pigmented villonodular synovitis (PVNS) is a rare benign and usually monoarticular neoplastic lesion arising from the synovium, bursae and tendon sheaths in humans, horses and dogs. Categorization for PVNS in humans includes localized and diffuse forms of PVNS and tenosynovial giant cell tumour (TGCT), although histologically they are the same. The localized form is characterized by discrete nodular lesions, the diffuse form is often intra-articular, infiltrative, affecting the entire synovium with more aggressive behaviour and TGCT occurs along tendon sheaths. Read More

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Arthroscopic Treatment of Diffuse Pigmented Villonodular Synovitis of the Knee: Complete Synovectomy and Septum Removal-Midterm Results.

J Knee Surg 2019 May 4;32(5):427-433. Epub 2018 May 4.

Department of Orthopaedics, Orthopaedic Research Center, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

The purpose of this study was to evaluate and describe the clinical results of complete arthroscopic synovectomy through the four arthroscopic portals in the knees affected by diffuse pigmented villonodular synovitis (DPVNS). Between 2009 and 2012, 21 patients (15 men and 6 women) with the diffuse form of PVNS of the knee were enrolled in the study after qualification. The clinical diagnosis was confirmed by magnetic resonance imaging and postsurgical pathologic examination. Read More

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[Unusual presentation of pigmented villonodular synovitis of the hip joint: case report and review of the literature].

Acta Ortop Mex 2017 Nov-Dec;31(6):308-311

Departamento de Piel y Partes Blandas del Instituto Nacional de Cancerología. Avenida San Fernando 22, Belisario Domínguez Secc 16, 14080. Ciudad de México. México.

Introduction: Pigmented villonodular synovitis (PVNS) is a rare clinical entity with higher incidence in women (3:1) and an age of presentation between 20 and 40 years. The hip is a rare site of appearance, being involved in only 15% of all cases.

Case Report: 47-year-old male with 10 years of evolution characterized by a limited range of motion, pain associated with an increase in volume and shortening of the pelvic limb. Read More

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Distinct extra-articular invasion patterns of diffuse pigmented villonodular synovitis/tenosynovial giant cell tumor in the knee joints.

Knee Surg Sports Traumatol Arthrosc 2018 Nov 10;26(11):3508-3514. Epub 2018 Apr 10.

Investigation Performed at the University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.

Purpose: Pigmented villonodular synovitis (PVNS)/tenosynovial giant cell tumor (TGCT) is a benign, proliferative lesion of the synovium, the bursa, and the tendon sheath. Little is known about the anatomical distribution pattern of diffuse extra-articular PVNS/TGCT around the knee joint. In this retrospective study, anatomical distribution of PVNS/TGCT using magnetic resonance imaging (MRI) and arthroscopy was analyzed. Read More

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November 2018

Diffuse Pigmented Villonodular Synovitis Around the Ankle.

J Am Podiatr Med Assoc 2018 Mar;108(2):140-144

Background: Pigmented villonodular synovitis (PVNS) is a rare disorder around the ankle joint. The optimal treatment for diffuse-type PVNS is still controversial because of the high incidence of recurrence. We present the clinical features of our patients and review the current diagnostic and treatment modalities. Read More

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Arthroscopic Management of Pigmented Villonodular Synovitis of the Hip in Children and Adolescents.

Orthop J Sports Med 2018 Mar 21;6(3):2325967118763118. Epub 2018 Mar 21.

Children's Healthcare of Atlanta, Atlanta, Georgia, USA.

Background: Pigmented villonodular synovitis (PVNS) is a benign proliferative synovial disorder most commonly described to affect the knee in adults. Literature describing PVNS in the pediatric population is limited to 2 small case series and a handful of single-patient case reports. Within these studies, only 2 patients with PVNS of the hip are described. Read More

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Necessity of adjuvant postoperative radiotherapy for diffuse pigmented villonodular synovitis of the knee: A case report and literature review.

Medicine (Baltimore) 2018 Jan;97(3):e9637

Dalian Medical University Department of Oncology Radiotherapy, the Second Hospital of Dalian Medical University, Dalian, Liaoning, China.

Rationale: Pigmented villonodular synovitis (PVNS) is an idiopathic, proliferative disorder lesion of synovial tissue, which is regarded as a benign disease, but has a local invasion. Up to now, these are no consensus about the etiology and pathogenesis of PVNS. Because of the lack of typical clinical features, misdiagnosis and delayed diagnosis are not uncommon, magnetic resonance imaging (MRI) can assist diagnosis and histopathological examination is recognized as the gold standard for the final diagnosis. Read More

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January 2018

The Patient Perspective on the Impact of Tenosynovial Giant Cell Tumors on Daily Living: Crowdsourcing Study on Physical Function and Quality of Life.

Interact J Med Res 2018 Feb 23;7(1):e4. Epub 2018 Feb 23.

Department of Orthopedics, Leiden University Medical Center, University of Leiden, Leiden, Netherlands.

Background: Tenosynovial giant cell tumor (TGCT) is a rare, benign lesion affecting the synovial lining of joints, bursae, and tendon sheaths. It is generally characterized as a locally aggressive and often recurring tumor. A distinction is made between localized- and diffuse-type. Read More

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February 2018

Systematic Arthroscopic Treatment of Diffuse Pigmented Villonodular Synovitis in the Knee.

Arthrosc Tech 2017 Oct 12;6(5):e1547-e1551. Epub 2017 Oct 12.

Division of Orthopaedic Surgery, Department of Surgery, Mount Sinai Hospital and Women's College Hospital, Toronto, Ontario, Canada.

Pigmented villonodular synovitis (PVNS) is a benign aggressive disease that presents in either a localized (LPVNS) or diffuse (DPVNS) form. Arthroscopic synovectomy is the standard operative treatment for LPVNS, and when used to treat DPVNS, it is usually combined with an open posterior procedure. The purpose of this Technical Note is to report the technique that we have refined to allow for arthroscopic synovectomy as the sole treatment for DPVNS. Read More

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October 2017

Long-Term Outcome of Hip Arthroplasty in the Setting of Pigmented Villonodular Synovitis.

J Arthroplasty 2018 05 29;33(5):1467-1471. Epub 2017 Dec 29.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN.

Background: Pigmented villonodular synovitis (PVNS) is a rare, benign, painful proliferation of the synovium previously treated successfully with total hip arthroplasty (THA). Published results come from small series; therefore, the purpose of this study is to investigate the outcomes of THA in the setting of PVNS.

Methods: We identified 25 patients with histologically confirmed, diffuse PVNS who underwent THA between 1971 and 2013. Read More

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Long-term outcome of pigmented villonodular synovitis of the hip after joint preserving therapy.

Arch Orthop Trauma Surg 2018 Apr 27;138(4):471-477. Epub 2017 Dec 27.

Centrum für Muskuloskeletale Chirurgie, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany.

Introduction: Pigmented villonodular synovitis (PVNS) is a rare, destructive synovial disease that affects the hip joint the second most common after the knee. However, in contrast, joint preserving surgery in the hip joint is considered to be significantly more difficult or even impossible due to earlier occurrence of osteochondral dissemination and surgical difficulties. Today, earlier diagnosis due to the generous use of MRI and modern surgical strategies raise hope for improved outcomes. Read More

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All-Arthroscopic Treatment of Intra- and Extra-Articular Localized Villonodular Synovitis of Knee.

Joints 2017 Sep 8;5(3):184-187. Epub 2017 Aug 8.

Department of Orthopaedic & Trauma Surgery, Messina University, Messina, Italy.

Pigmented villonodular synovitis (PVNS) is a rare, benign, proliferative neoplastic condition affecting synovial-lined anatomic spaces. PVNS is characterized by hypertrophy of a synovial membrane by villous, nodular, and villonodular proliferation, with pigmentation secondary to hemosiderin deposition. The two forms of PVNS that have been described are diffuse (DPVNS) and localized (LPVNS). Read More

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September 2017

[Villonodular synovitis of the knee: about 20 cases].

Pan Afr Med J 2017 27;28:86. Epub 2017 Sep 27.

Service de Traumatologie Orthopédie de l'Hôpital Militaire Avicenne, Marrakech, Maroc.

Pigmented villonodular synovitis (PVNS) is a rare benign proliferation of synovial joints, serous bursa, tendinous sheaths of unknown etiopathogeny. We here report 20 cases of PVNS of the knee recorded at the Avicenne Military Hospital, Marrakech over a period of 9 years, from January 2000 to December 2009. This study aimed to identify the specific features of this lesion and to examine its anatomoclinic and prognostic aspects. Read More

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December 2017