41,278 results match your criteria diffuse large


Diffuse large B-cell lymphomas in adults with aberrant coexpression of CD10, BCL6, and MUM1 are enriched in IRF4 rearrangements.

Blood Adv 2021 Oct 15. Epub 2021 Oct 15.

University of Tuebingen, Tuebingen, Germany.

Diffuse large B-cell lymphoma (DLBCL) with aberrant co-expression of CD10+BCL6+MUM1+ (DLBCL-AE), classified as germinal center B cell (GCB)-type by the Hans algorithm (HA), were genetically characterized. To capture the complexity of these DLBCL-AE, we used an integrated approach including gene expression profiling (GEP), fluorescence in-situ hybridization (FISH), targeted gene sequencing, and copy number (CN) arrays. According to GEP, 32/54 (59%) cases were classified as GCB-DLBCL, 16/54 (30%) as activated B-cell (ABC)-DLBCL and 6/54 (11%) as unclassifiable. Read More

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October 2021

hsa‑miR‑429 targets CBX8 to promote cell apoptosis in diffuse large B‑cell lymphoma.

Mol Med Rep 2021 Dec 15;24(6). Epub 2021 Oct 15.

Department of Hematology, Jingzhou Central Hospital, Institute of Hematology, Yangtze University, Jingzhou, Hubei 434020, P.R. China.

Diffuse large B‑cell lymphoma (DLBCL) is the most common type of non‑Hodgkin lymphoma worldwide. Several studies have indicated that (hsa)‑microRNA (miR)‑429 exerts a tumor‑suppressive effect on a variety of malignant tumors. To the best of our knowledge, the molecular function and mechanism of action of hsa‑miR‑429 in DLBCL have not been evaluated to date. Read More

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December 2021

The prognostic value of end-of-treatment FDG-PET/CT in diffuse large B cell lymphoma: comparison of visual Deauville criteria and a lesion-to-liver SUV ratio-based evaluation system.

Eur J Nucl Med Mol Imaging 2021 Oct 15. Epub 2021 Oct 15.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China.

Purpose: The aim of this study was to determine a better criterion for end-of-treatment PET (EoT-PET) assessment and prognostic evaluation of patients with diffuse large B cell lymphoma (DLBCL).

Method: EoT-PET scans were assessed using the visual Deauville 5-point scale (5PS) and LLR, the maximum standard uptake value ratio between the lesion and the liver. The cutoff value of LLR was obtained by receiver operator characteristic curve analysis. Read More

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October 2021

A novel analytic approach for outcome prediction in diffuse large B-cell lymphoma by [F]FDG PET/CT.

Eur J Nucl Med Mol Imaging 2021 Oct 15. Epub 2021 Oct 15.

Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.

Purpose: This study aimed to develop a novel analytic approach based on 2-deoxy-2-[F]fluoro-D-glucose positron emission tomography/computed tomography ([F]FDG PET/CT) radiomic signature (RS) and International Prognostic Index (IPI) to predict the progression-free survival (PFS) and overall survival (OS) of patients with diffuse large B-cell lymphoma (DLBCL).

Methods: We retrospectively enrolled 152 DLBCL patients and divided them into a training cohort (n = 100) and a validation cohort (n = 52). A total of 1245 radiomic features were extracted from the total metabolic tumor volume (TMTV) and the metabolic bulk volume (MBV) of pre-treatment PET/CT images. Read More

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October 2021

Management and Outcomes of Diffuse Large B-cell Lymphoma Post-transplant Lymphoproliferative Disorder in the Era of PET and Rituximab: A Multicenter Study From the Australasian Lymphoma Alliance.

Hemasphere 2021 Nov 11;5(11):e648. Epub 2021 Oct 11.

Department of Haematology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

There are limited data on post-transplant lymphoproliferative disorder (PTLD) in the era of positron emission tomography (PET) and rituximab (R). Furthermore, there is limited data on the risk of graft rejection with modern practices in reduction in immunosuppression (RIS). We studied 91 patients with monomorphic diffuse large B-cell lymphoma PTLD at 11 Australian centers: median age 52 years, diagnosed between 2004 and 2017, median follow-up 4. Read More

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November 2021

Paradoxical and Retrograde Air Embolism from Pressurized Peripheral Bolus.

Case Rep Neurol Med 2021 5;2021:1063264. Epub 2021 Oct 5.

Cerebrovascular Center, Neurological Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

Introduction: Cerebral air embolism is a rare, yet serious neurological occurrence with unclear incidence and prevalence. Here, we present a case of fatal cerebral arterial and venous cerebral gas embolism in a patient with infective endocarditis and known large right-to-left shunt and severe tricuspid regurgitation following pressurized fluid bolus administration. . Read More

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October 2021

Worse outcome and distinct mutational pattern in follicular lymphoma with anti-HBc positivity.

Blood Adv 2021 Oct 14. Epub 2021 Oct 14.

Group of Applied Clinical Research in Hematology, Cancer Research Program-IMIM (Hospital del Mar Medical Research Institute) Barcelona, Spain.

Epidemiological studies have demonstrated the association between hepatitis B virus (HBV) infection and B-cell non-Hodgkin lymphomas (NHL), mainly for diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). We studied a cohort of 121 FL patients for HBV infection status, clinical features and gene mutational profile. Anti-HBc was detectable in sixteen patients (13. Read More

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October 2021

Transcriptome sequencing of archived lymphoma specimens is feasible and clinically relevant using exome capture technology.

Genes Chromosomes Cancer 2021 Oct 14. Epub 2021 Oct 14.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Formalin-fixed, paraffin-embedded (FFPE) specimens are an underutilized resource in medical research, particularly in the setting of transcriptome sequencing, as RNA from these samples is often degraded. We took advantage of an exome capture-based RNA-sequencing protocol to explore global gene expression in paired fresh-frozen and FFPE samples from 16 diffuse large B-cell lymphoma (DLBCL) patients. While FFPE samples generated fewer mapped reads compared to their fresh-frozen counterparts, these reads captured the same library complexity and had a similar number of genes expressed on average. Read More

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October 2021

Acute Water Intoxication With Resultant Hypo-Osmolar Hyponatremia Complicated by Hypotension Secondary to Diffuse Third-Spacing.

Cureus 2021 Sep 30;13(9):e18410. Epub 2021 Sep 30.

Emergency Medicine, San Antonio Military Medical Center, San Antonio, USA.

Hypotonic hyponatremia secondary to acute water intoxication is most commonly associated with primary polydipsia in the setting of psychiatric illness. However, in certain circumstances, otherwise healthy individuals can be compelled to consume large enough volumes of water to overwhelm the kidney's dilutional capacity of urine and cause a potentially life-threatening rapid decline in serum sodium. We present such a case of a 20-year-old basic military trainee with acute symptomatic hypotonic hyponatremia after drinking five to six liters of water prior to urine drug testing. Read More

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September 2021

Cosmic-Ray Propagation in Light of the Recent Observation of Geminga.

Astrophys J 2019 Jul;879(2)

W. W. Hansen Experimental Physics Laboratory and Kavli Institute for Particle Astrophysics and Cosmology, Stanford University, Stanford, CA 94305, USA.

The High Altitude Water Cherenkov (HAWC) telescope recently observed extended emission around the Geminga and PSR B0656+14 pulsar wind nebulae (PWNe). These observations have been used to estimate cosmic-ray (CR) diffusion coefficients near the PWNe that appear to be more than two orders of magnitude smaller than the diffusion coefficients typically derived for the interstellar medium from measured abundances of secondary species in CRs. Two-zone diffusion models have been proposed as a solution to this discrepancy, where the slower diffusion zone (SDZ) is confined to a small region around the PWN. Read More

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High-energy Gamma Rays from the Milky Way: Three-dimensional Spatial Models for the Cosmic-Ray and Radiation Field Densities in the Interstellar Medium.

Astrophys J 2017 Sep 31;846(1). Epub 2017 Aug 31.

W. W. Hansen Experimental Physics Laboratory and Kavli Institute for Particle Astrophysics and Cosmology, Stanford University, Stanford, CA 94305, USA.

High-energy -rays of interstellar origin are produced by the interaction of cosmic-ray (CR) particles with the diffuse gas and radiation fields in the Galaxy. The main features of this emission are well understood and are reproduced by existing CR propagation models employing 2D galactocentric cylindrically symmetrical geometry. However, the high-quality data from instruments like the Large Area Telescope reveal significant deviations from the model predictions on few to tens of degrees scales, indicating the need to include the details of the Galactic spiral structure and thus requiring 3D spatial modeling. Read More

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September 2017

NUCLEAR ENHANCEMENT OF THE PHOTON YIELD IN COSMIC RAY INTERACTIONS.

Astrophys J 2014 Jul 23;789(2). Epub 2014 Jun 23.

Hansen Experimental Physics Laboratory and Kavli Institute for Particle Astrophysics and Cosmology, Stanford University, Stanford, CA 94305, USA.

The concept of the nuclear enhancement factor has been used since the beginning of ray astronomy. It provides a simple and convenient way to account for the contribution of nuclei ( > 1) in cosmic rays (CRs) and in the interstellar medium (ISM) to the diffuse ray emission. An accurate treatment of the dominant emission process, such as hadronic interactions of CRs with the ISM, enables one to study CR acceleration processes and CR propagation in the ISM, and provides a reliable background model for searches of new phenomena. Read More

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infection disturbs the tumor immune microenvironment and is associated with a discrepant prognosis in gastric de novo diffuse large B-cell lymphoma.

J Immunother Cancer 2021 Oct;9(10)

Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People's Republic of China

Background: Gastric diffuse large B-cell lymphoma (gDLBCL) related to infection exhibits a wide spectrum of prognosis, and the tumor immune microenvironment (TIME) affects tumor progression. However, there are few studies on the correlation between prognosis and changes of TIME induced by infection in de novo gDLBCL.

Methods: A retrospective study was performed to determine the prognostic value of TIME related to infection in de novo gDLBCL. Read More

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October 2021

Besnoitiosis in a miniature donkey.

Vet Dermatol 1997 Jun;8(2):139-143

Animal Health Diagnostic Laboratory and Department of Pathology, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48848, USA.

A 1-year-old male miniature donkey (Equus asinus) from a herd of eight was presented with a 9-month history of pruritic dermatitis, lethargy and anorexia. Physical examination revealed diffuse lichenification and scales involving the skin of the face, head and dorsum from the neck to the pelvis. The main histological alteration within the superficial and deep dermis was the presence of multiple large, spherical, thick walled, protozoal Besnoitia cysts. Read More

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Feline urticaria pigmentosa in three related Sphinx cats.

Vet Dermatol 1996 Dec;7(4):227-233

†Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 95616, USA.

Abstract  A pruritic maculopapular eruption with clinical and histological features similar to urticaria pigmentosa of humans is reported in three related Sphinx cats. All cats shared the same grandsire, had a juvenile onset of disease, and demonstrated similar historical, clinical and histological findings. Physical examination revealed widespread bilaterally symmetrical, erythematous, partially coalescing, crusted macules and papules on the trunk, limbs, neck and head. Read More

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December 1996

Phase II Study of Single-Agent and Combination Everolimus and Panobinostat in Relapsed or Refractory Diffuse Large B-Cell Lymphoma.

Cancer Invest 2021 Nov 13;39(10):871-879. Epub 2021 Oct 13.

Division of Hematologic Malignancies and Cellular Therapy, Duke University Medical Center, Durham, North Carolina, USA.

Novel therapeutics are needed for patients with relapsed or refractory diffuse large B-cell lymphoma (R/R DLBCL). Everolimus is an mTOR pathway inhibitor with synergistic anti-tumor activity when combined with histone deacetylase inhibitors, such as panobinostat, in preclinical lymphoma models. In this Phase II study, we evaluated overall response rate to single and combination everolimus and panobinostat in R/R DLBCL. Read More

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November 2021

Rituximab, lenalidomide, and ibrutinib in relapsed/refractory primary cutaneous diffuse large B-cell lymphoma, leg type.

Br J Haematol 2021 Oct 12. Epub 2021 Oct 12.

Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.

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October 2021

Augmented Reality-Assisted Craniotomy for Parasagittal and Convexity En Plaque Meningiomas and Custom-Made Cranio-Plasty: A Preliminary Laboratory Report.

Int J Environ Res Public Health 2021 Sep 22;18(19). Epub 2021 Sep 22.

Department of Information Engineering, University of Pisa, 56100 Pisa, Italy.

Background: This report discusses the utility of a wearable augmented reality platform in neurosurgery for parasagittal and convexity en plaque meningiomas with bone flap removal and custom-made cranioplasty.

Methods: A real patient with en plaque cranial vault meningioma with diffuse and extensive dural involvement, extracranial extension into the calvarium, and homogeneous contrast enhancement on gadolinium-enhanced T1-weighted MRI, was selected for this case study. A patient-specific manikin was designed starting with the segmentation of the patient's preoperative MRI images to simulate a craniotomy procedure. Read More

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September 2021

RAS Mediates BET Inhibitor-Endued Repression of Lymphoma Migration and Prognosticates a Novel Proteomics-Based Subgroup of DLBCL through Its Negative Regulator IQGAP3.

Cancers (Basel) 2021 Oct 7;13(19). Epub 2021 Oct 7.

Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.

Phenotypic heterogeneity and molecular diversity make diffuse large B-cell lymphoma (DLBCL) a challenging disease. We recently illustrated that amoeboid movement plays an indispensable role in DLBCL dissemination and inadvertently identified that the inhibitor of bromodomain and extra-terminal (BET) proteins JQ1 could repress DLBCL migration. To explore further, we dissected the impacts of BET inhibition in DLBCL. Read More

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October 2021

Detection of Persistent Organic Pollutants in Omental Adipose Tissue from Patients with Diffuse-Gastric Cancer: A Pilot Study.

Cancers (Basel) 2021 Sep 29;13(19). Epub 2021 Sep 29.

Hepato-Biliary-Pancreatic Gastrointestinal Surgery and Liver Transplantation, Pitié-Salpêtrière Hospital, Assistance Publique/Hôpitaux de Paris, F-75013 Paris, France.

The greater omentum represents a specific adipose tissue resected with gastric surgery for cancer. Diffuse gastric adenocarcinoma (diffuse-GC) is of major relevance among gastric cancers due to its unknown origin, aggressiveness, and metastasis in the peritoneal cavity. We postulated that persistent organic pollutants (POPs) could be detected in the greater omentum. Read More

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September 2021

Zanubrutinib Monotherapy for Relapsed or Refractory Non-Germinal Center Diffuse Large B-Cell Lymphoma.

Blood Adv 2021 Oct 12. Epub 2021 Oct 12.

Department of Hematology, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospit.

The non-germinal center (non-GCB) subtype of diffuse large B-cell lymphoma (DLBCL) has poor clinical outcomes. Bruton's tyrosine kinase (BTK) inhibitors have established therapeutic activity in B-cell malignancies, with modest activity in DLBCL. Zanubrutinib, a potent and selective BTK inhibitor, was evaluated in patients with relapsed or refractory (R/R) non-GCB DLBCL. Read More

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October 2021

A Germinal Center-Associated Microenvironmental Signature Reflects Malignant Phenotype and Outcome of DLBCL.

Blood Adv 2021 Oct 12. Epub 2021 Oct 12.

Kyushu University Hospital, Japan.

Diffuse large B-cell lymphoma (DLBCL) is the most common B-cell malignancy with varying prognosis after the gold standard rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Several prognostic models have been established by focusing primarily on characteristics of lymphoma cells themselves, including cell-of-origin, genomic alterations, and gene/protein expressions. However, the prognostic impact of the lymphoma microenvironment and its association with characteristics of lymphoma cells are not fully understood. Read More

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October 2021

Critical role of the high mobility group A proteins in hematological malignancies.

Hematol Oncol 2021 Oct 12. Epub 2021 Oct 12.

Department of Molecular Medicine and Medical Biotechnology (DMMBM), National Research Council (CNR), Institute for Experimental Endocrinology and Oncology (IEOS) "G. Salvatore", University of Naples "Federico II", Naples, Italy.

The high mobility group A (HMGA) protein family is composed of three non-histone chromatin remodeling proteins that act as architectural transcriptional factors. Indeed, although HMGA proteins lack transcriptional activity per se, they bind the minor groove of DNA at AT-rich sequences, and, interacting with the transcription machinery, are able to modify chromatin modeling, thus regulating the expression of several genes. HMGA proteins have been deeply involved in embryogenesis process, and a large volume of studies has pointed out their key role in human cancer. Read More

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October 2021

EBV-positive high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements: a multi-institutional study.

Histopathology 2021 Oct 12. Epub 2021 Oct 12.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Aims: It is unknown whether Epstein-Barr virus (EBV) infection can occur in high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, also known as double-hit or triple-hit lymphoma (DHL/THL).

Methods And Results: Here we report 16 cases of EBV+ DHL/THL from screening 846 cases of DHL/THL and obtaining additional EBV+ cases through multi-institutional collaboration: 8 MYC/BCL2 DHL, 6 MYC/BCL6 DHL, and 2 THL. There were 8 men and 8 women with a median age of 65 years (range, 32-86). Read More

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October 2021

Deciphering genes associated with diffuse large B-cell lymphoma with lymphomatous effusions: A mutational accumulation scoring approach.

Biomark Res 2021 Oct 9;9(1):74. Epub 2021 Oct 9.

Department of Pathology, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, 138 Sheng-Li Road, 704, Tainan, Taiwan.

Introduction: Earlier studies have shown that lymphomatous effusions in patients with diffuse large B-cell lymphoma (DLBCL) are associated with a very poor prognosis, even worse than for non-effusion-associated patients with stage IV disease. We hypothesized that certain genetic abnormalities were associated with lymphomatous effusions, which would help to identify related pathways, oncogenic mechanisms, and therapeutic targets.

Methods: We compared whole-exome sequencing on DLBCL samples involving solid organs (n = 22) and involving effusions (n = 9). Read More

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October 2021

Diagnostic retinal biopsy in the management of secondary non-CNS vitreoretinal lymphoma masquerading as viral retinitis: a case report.

Int J Retina Vitreous 2021 Oct 11;7(1):58. Epub 2021 Oct 11.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, USA.

Background: Intraocular lymphoma accounts for fewer than 1% of intraocular tumors. When the posterior segment is involved, it can be further classified as vitreoretinal or choroidal lymphoma. Vitreoretinal lymphoma (VRL) can rarely masquerade as an infectious retinitis making diagnosis and management challenging. Read More

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October 2021

Venetoclax with dose-adjusted EPOCH-R as initial therapy for patients with aggressive B-cell lymphoma: a single-arm, multicentre, phase 1 study.

Lancet Haematol 2021 Oct 8. Epub 2021 Oct 8.

Weill Cornell Medicine, Meyer Cancer Center, New York, NY, USA.

Background: Dose-adjusted EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab) is a front-line treatment for patients with aggressive B-cell lymphomas. Bcl-2 is associated with chemoresistance due to BCL2 gene rearrangement or protein overexpression and is antagonised by venetoclax. We aimed to assess the safety of venetoclax with dose-adjusted EPOCH-R as initial therapy in aggressive B-cell lymphoma. Read More

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October 2021

Diffuse Pagetoid Squamous Cell Carcinoma in Situ of the Esophagus: A Rare Case Report and Review of Literature.

Int J Surg Pathol 2021 Oct 11:10668969211046814. Epub 2021 Oct 11.

6923University of Rochester Medical Center, Rochester, NY, USA.

Squamous cell carcinoma in situ (SCCIS) with diffuse pagetoid features has been well-described in skin and external genitalia. Diffuse pagetoid SCCIS of the esophagus is extremely rare with only two cases published in the English literature. In this article, we report a rare case of diffuse pagetoid SCCIS of the esophagus in an 89-year-old female with no significant past medical history who presented with dysphagia. Read More

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October 2021