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Iatrogenic pseudoaneurysm of the superficial temporal artery following craniectomy from a scalp hook retractor penetrating injury: Case report and literature review.

Int J Surg Case Rep 2021 Jun 17;84:106076. Epub 2021 Jun 17.

Department of Neurosurgery, Chi-Mei Medical Center, Tainan, Taiwan; Department of Recreation and Healthcare Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan. Electronic address:

Background: Iatrogenic pseudoaneurysms in scalp vessels are an uncommon complication after cranial surgery. This paper reports a case of scalp pseudoaneurysm in the superficial temporal artery (STA) after forceful hook retraction in craniectomy and reviews the relevant literature.

Case Description: A 36-year-old man with history of hypertension and depression presented to the emergency department with head injury after using sedation medication. Read More

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Current knowledge on the immune microenvironment and emerging immunotherapies in diffuse midline glioma.

EBioMedicine 2021 Jun 19;69:103453. Epub 2021 Jun 19.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai,10 Union Square East, 5th Floor, Suite 5E, New York, NY 10003, USA; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

Diffuse midline glioma (DMG) is an incurable malignancy with the highest mortality rate among pediatric brain tumors. While radiotherapy and chemotherapy are the most common treatments, these modalities have limited promise. Due to their diffuse nature in critical areas of the brain, the prognosis of DMG remains dismal. Read More

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Phenotypical and genotypical differences among Leishmania (Leishmania) amazonensis isolates that caused different clinical frames in humans and dogs: a systematic review.

Acta Trop 2021 Jun 19:106018. Epub 2021 Jun 19.

Departamento de Medicina Veterinária Preventiva, Centro de Ciências Agrárias, Universidade Estadual de Londrina, Londrina, Brazil.

Leishmania (Leishmania) amazonensis is an important etiological agent of American cutaneous leishmaniasis (ACL) in Brazil. The species causes a large spectrum of clinical manifestations in humans and dogs, ranging from cutaneous, cutaneous diffuse, mucocutaneous, and visceral involvement, however, the factors that drive the development of different disease forms by the same species are not yet fully known. In the present work, it was systematically reviewed the studies addressing phenotypic and genotypic characteristics of Leishmania (L. Read More

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Determining subpopulation methylation profiles from bisulfite sequencing data of heterogeneous samples using DXM.

Nucleic Acids Res 2021 Jun 22. Epub 2021 Jun 22.

Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

Epigenetic changes, such as aberrant DNA methylation, contribute to cancer clonal expansion and disease progression. However, identifying subpopulation-level changes in a heterogeneous sample remains challenging. Thus, we have developed a computational approach, DXM, to deconvolve the methylation profiles of major allelic subpopulations from the bisulfite sequencing data of a heterogeneous sample. Read More

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Gross morphology, histology, and ultrastructure of the olfactory rosette of a critically endangered indicator species, the Delta Smelt, Hypomesus transpacificus.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol 2021 Jun 22. Epub 2021 Jun 22.

Integrative Pathobiology Graduate Group and Aquatic Health Program, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, VM3B, 3203, 1089 Veterinary Medicine Dr, Davis, CA, 95616, USA.

The Delta Smelt (Hypomesus transpacificus) is a small, semi-anadromous fish native to the San Francisco Bay-Delta Estuary and has been declared as critically endangered. Their olfactory biology, in particular, is poorly understood and a basic description of their sensory anatomy is needed to advance our understanding of the sensory ecology of species to inform conservation efforts to manage and protect them. We provide a description of the gross morphology, histological, immunohistochemical, and ultrastructural features of the olfactory rosette in this fish and discuss some of the functional implications in relation to olfactory ability. Read More

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[Dynamic11C-methionine PET/CT in differential diagnosis of brain gliomas].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(3):5-13

Burdenko Center of Neurosurgery, Moscow, Russia.

Objective: To evaluate the possibilities of dynamic preoperative C-methionine (MET) PET/CT in differential diagnosis of various types of brain gliomas in adults.

Material And Methods: The study included 74 patients aged 48±14 years with supratentorial gliomas: Grade IV - glioblastoma (GB, =33), Grade III - anaplastic oligodendroglioma (AOD, =10) and anaplastic astrocytoma (AA, =12), Grade II - diffuse astrocytoma (DA, =13) and oligodendroglioma (OD, =6). All patients underwent standard MRI and dynamic MET PET/CT within 20 minutes after intravenous injection of radiopharmaceutical. Read More

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January 2021

Mice born to mothers with gravida traumatic brain injury have distorted brain circuitry and altered immune responses.

J Neurotrauma 2021 Jun 22. Epub 2021 Jun 22.

Barrow Neurological Institute, 115467, Translational Neurotrauma Research Program, Phoenix, Arizona, United States.

Intimate partner violence (IPV) increases risk of traumatic brain injury (TBI). Physical assaults increase in frequency and intensity during pregnancy. The consequences of TBI during pregnancy (gravida TBI; gTBI) on offspring development is unknown, for which stress and inflammation during pregnancy worsen fetal developmental outcomes. Read More

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Variable selection for censored data using Modified Correlation Adjusted coRrelation (MCAR) scores.

Stat Med 2021 Jun 22. Epub 2021 Jun 22.

Applied Statistics, Institute of Statistical Research and Training, University of Dhaka, Dhaka, Bangladesh.

Dealing with high-dimensional censored data is very challenging because of the complexities in data structure. This article focuses on developing a variable selection procedure for censored high-dimensional data with the AFT models using the Modified Correlation Adjusted coRrelation (MCAR) scores method. The latter is developed based on CAR scores method that provides a canonical ordering that encourages grouping of correlated predictors and down-weights antagonistic variables. Read More

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SARS-CoV-2 Myocarditis Due to Severe Obesity.

Cureus 2021 May 17;13(5):e15074. Epub 2021 May 17.

Internal Medicine, Chicago Medical School Internal Medicine Residency Program at Northwestern Medicine McHenry Hospital, McHenry, USA.

Myocarditis is defined as a myocardial injury concomitant with myocardial dysfunction. Several causes are associated with it, including infectious versus inflammatory and inherited cardiomyopathies. It can be acute, subacute, or chronic, and it can present as focal versus diffuse myocardial dysfunction. Read More

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Status Triphasicus Versus Status Epilepticus?

J Clin Neurophysiol 2021 Jun 18. Epub 2021 Jun 18.

Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, U.S.A.; and Neurology Services, University of Miami Hospital and Clinics and Jackson Memorial Hospital, Miami, Florida, U.S.A.

Summary: Generalized periodic patterns with triphasic wave morphology, long referred to as triphasic waves [TWs], had been associated with metabolic encephalopathies, although other neurologic and systemic causes have since been identified. In a recent classification of periodic patterns, TWs were formally grouped with the generalized periodic discharges, which are often associated with ictal activity. The interpretation of generalized periodic patterns with TWs as nonictal can have significant implications in the management of comatose patients in nonconvulsive status epilepticus. Read More

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Fulminant granulomatosis with polyangiitis presenting with diffuse alveolar haemorrhage following COVID-19.

BMJ Case Rep 2021 Jun 21;14(6). Epub 2021 Jun 21.

Mercy Health St. Mary's Division of Infectious Disease and Michigan State University College of Human Medicine Department of Medicine, Michigan State University College of Human Medicine, Grand Rapids, Michigan, USA.

A 40-year-old man developed granulomatosis with polyangiitis (GPA) following a mild case of COVID-19. Initially, he experienced mild migrating joint pain for 2 months prior to testing positive for SARS-CoV-2 but dramatically worsened following resolution of his infection. The pain continued to progress until he suddenly develope haemoptysis, prompting him to present to a local hospital. Read More

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Droplet digital PCR allows vector copy number assessment and monitoring of experimental CAR T cells in murine xenograft models or approved CD19 CAR T cell-treated patients.

J Transl Med 2021 Jun 21;19(1):265. Epub 2021 Jun 21.

INSERM UMR1098, Right, EFSBFC, UFC, Laboratoire de Thérapeutique Immuno-Moléculaire Et Cellulaire Des Cancers, 8 rue du Dr Jean François Xavier Girod, 25020, Besançon, France.

Background: Genetically engineered chimeric antigen receptor (CAR) T lymphocytes are promising therapeutic tools for cancer. Four CAR T cell drugs, including tisagenlecleucel (tisa-cel) and axicabtagene-ciloleucel (axi-cel), all targeting CD19, are currently approved for treating B cell malignancies. Flow cytometry (FC) remains the standard for monitoring CAR T cells using a recombinant biotinylated target protein. Read More

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A scoping review of Q-methodology in healthcare research.

BMC Med Res Methodol 2021 Jun 21;21(1):125. Epub 2021 Jun 21.

Centre for Healthcare Resilience and Implementation Science, Australian Institute of Health Innovation, Macquarie University, Level 6, 75 Talavera Rd, Sydney, NSW, 2109, Australia.

Background: Q-methodology is an approach to studying complex issues of human 'subjectivity'. Although this approach was developed in the early twentieth century, the value of Q-methodology in healthcare was not recognised until relatively recently. The aim of this review was to scope the empirical healthcare literature to examine the extent to which Q-methodology has been utilised in healthcare over time, including how it has been used and for what purposes. Read More

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Bridging the gap between measurement-based and simulation-based metamodels for deriving bulk optical properties from spatially-resolved reflectance profiles: effect of illumination and detection geometry.

Opt Express 2021 May;29(11):15882-15905

Non-invasive determination of the optical properties is essential for understanding the light propagation in biological tissues and developing optical techniques for quality detection. Simulation-based models provide flexibility in designing the search space, while measurement-based models can incorporate the unknown system responses. However, the interoperability between these two types of models is typically poor. Read More

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Diffuse optics for glaciology.

Opt Express 2021 Jun;29(12):18845-18864

Optical probing of glaciers has the potential for tremendous impact on environmental science. However, glacier ice is turbid, which prohibits the use of most established optical measurements for determining a glacier's interior structure. Here, we propose a method for determining the depth, scattering and absorption length based upon diffuse propagation of short optical pulses. Read More

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Modelling of the optical signature of oil slicks at sea for the analysis of multi- and hyperspectral VNIR-SWIR images.

Opt Express 2021 Jun;29(12):18224-18242

This work focuses on the contribution of modelling for the interpretation of multi- or hyperspectral optical images for the detection, characterisation and quantification of oil spills. Many parameters contribute to the spectral signature of an oil layer on the sea surface: the optical properties of the water column and of the oil, the film thickness, the surface roughness, the atmospheric radiance reaching the surface (direct and diffuse components), the geometry of observation and illumination. The number of these contributors and their combinations make the analysis of the spectral variability of oil signatures at the sea surface complex. Read More

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Magnetic Resonance Imaging Findings in Preterm Infants With Bilirubin Encephalopathy Beyond Three Years Corrected Age.

Pediatr Neurol 2021 May 28;121:56-58. Epub 2021 May 28.

Department of Pediatrics and Child Health, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.

Background: Magnetic resonance imaging (MRI) abnormalities in preterm infants with bilirubin encephalopathy (BE) become less clear as the infants age. We assessed MRI findings in children with preterm BE older than 36 months corrected age (CA).

Methods: In a previous questionnaire survey, hospitals were asked to provide head MRI data of patients older than 36 months CA. Read More

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Covid19, beyond just the lungs: A review of multisystemic involvement by Covid19.

Pathol Res Pract 2021 Feb 16;224:153384. Epub 2021 Feb 16.

Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India. Electronic address:

With the commencement of the COVID19 pandemic, following its 1st case reported in Wuhan in China, the knowledge about the virus as well as the symptoms produced by the disease have drastically increased to this day. The manifestations of COVID19 is now known to affect multiple organ systems of the body, which have shown to have acute as well as chronic complications. Histopathological analysis of the biopsies from the affected organs have implied a direct cytopathic effect of the virus but at the same time not ruling out other causes like hypoxia metabolic changes etc. Read More

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February 2021

The First Mixed Calcium Zinc Borate with Flexible [B8O17] Fundamental Building Block and Short UV Cutoff Edge.

Chemistry 2021 Jun 21. Epub 2021 Jun 21.

Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences, Xinjiang Key Laboratory of Electronic Information Materials and Devices, 40-1 South Beijing Road, 830011, Urumqi, CHINA.

The first mixed calcium zinc borate with a new fundamental building block (FBB) [B 8 O 17 ], Ca 1.13 Zn 0.87 B 8 O 14 has been successfully synthesized. Read More

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[CAR T-cell therapy for malignant B-cell lymphoma : A new treatment paradigm].

Internist (Berl) 2021 Jun 21;62(6):589-596. Epub 2021 Jun 21.

Uniklinik Köln, Medizinische Klinik 1, 50937, Köln, Deutschland.

Following the first demonstration of efficacy of anti-CD19-directed chimeric antigen receptor (CAR) T cells in a patient with relapsed chronic lymphocytic leukemia (CLL) in 2011, pivotal studies for this innovative therapy were initially conducted in multiple relapsed or refractory (r/r) childhood and young adult acute B‑cell leukemia and in aggressive adult B‑cell lymphoma. The studies demonstrated efficacy even in chemotherapy-refractory disease, resulting in the first approval of autologous and genetically engineered T cells for the treatment of r/r B‑cell acute lymphoblastic leukemia (B-ALL) in the US for the product tisagenlecleucel (Kymriah®, Novartis) back in 2018. Approval for the treatment of r/r aggressive B‑cell lymphoma followed shortly thereafter for tisagenlecleucel and axicabtagene ciloleucel (Yescarta, Kite/Gilead). Read More

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Inorganic pyrophosphate is reduced in patients with systemic sclerosis.

Rheumatology (Oxford) 2021 Jun 21. Epub 2021 Jun 21.

Department of Medicine, Divisions of Rheumatology and Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois, USA.

Objective: The pathogenesis of calcinosis cutis, a disabling complication of systemic sclerosis (SSc), is poorly understood and effective treatments are lacking. Inorganic pyrophosphate (PPi) is a key regulator of ectopic mineralization, and its deficiency has been implicated in ectopic mineralization disorders. We therefore sought to test the hypothesis that SSc may be associated with reduced circulating PPi, which might play a pathogenic role in calcinosis cutis. Read More

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Acute Myocardial Infarction With Diffuse ST-Segment Elevation: Where Is the Culprit?

JAMA Intern Med 2021 Jun 21. Epub 2021 Jun 21.

Department of Internal Medicine, Atrium Health Carolinas Medical Center, Charlotte, North Carolina.

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Mn(II) Complex of Lipophilic Group-Modified Ethylenediaminetetraacetic Acid (EDTA) as a New Hepatobiliary MRI Contrast Agent.

J Med Chem 2021 Jun 21. Epub 2021 Jun 21.

Department of Radiotherapy, Sichuan Cancer Hospital & Institute, Chengdu 610041, China.

Liver-specific contrast agents (CAs) can improve the Magnetic resonance imaging (MRI) detection of focal and diffuse liver lesions by increasing the lesion-to-liver contrast. A novel Mn(II) complex, Mn-BnO-TyrEDTA, with a lipophilic group-modified ethylenediaminetetraacetic acid (EDTA) structure as a ligand to regulate its behavior in vivo, is superior to Gd-EOB-DTPA in terms of a liver-specific MRI contrast agent. An MRI study on mice demonstrated that Mn-BnO-TyrEDTA can be rapidly taken up by hepatocytes with a combination of hepatobiliary and renal clearance pathways. Read More

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Polyneuropathy: A Rare and Challenging Presentation of Essential Mixed Cryoglobulinemia.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211026503

Indiana University, Indianapolis, IN, USA.

A 49-year-old male presented with acute chronic sensory motor bilateral lower extremity polyneuropathy. Electromyography showed bilateral acute sensory motor axonal polyneuropathy. Lumbar spine magnetic resonance imaging showed diffuse bone marrow replacement and bilateral ankylosing spondylitis. Read More

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A novel variant in the gene-presenting as unilateral myopia, pediatric cataract, and heterochromia in a patient with familial exudative vitreoretinopathy.

Eur J Ophthalmol 2021 Jun 20:11206721211027415. Epub 2021 Jun 20.

Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Purpose: To report a case of 16-month-old boy with a novel variant TSPAN12 gene-presenting as unilateral myopia, pediatric cataract, and heterochromia in a patient with familial exudative vitreoretinopathy.

Observation: A 16-month-old otherwise healthy boy was referred to Boston Children's Hospital for evaluation of strabismus. Ocular examination revealed intermittent esotropia, left hypotropia, and limited left eye elevation in both adduction and abduction. Read More

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Nimotuzumab therapy in the treatment of pediatric central nervous system tumors: single-center experience.

Naunyn Schmiedebergs Arch Pharmacol 2021 Jun 21. Epub 2021 Jun 21.

Department of Pediatric Oncology, Faculty of Medicine, Hacettepe University, 06100, Ankara, Turkey.

Relapsed or refractory central nervous system (CNS) tumors still have poor prognosis, and, therefore, new treatment options are required. We retrospectively researched treatment results of patients with CNS tumors treated with nimotuzumab from 2010 to 2015. The study included nine patients with the diffuse intrinsic pontine glioma; eight with medulloblastoma; three each with anaplastic ependymoma, glioblastoma multiforme, and central nervous system primitive neuroectodermal tumor (CNS PNET); two patients with gliomatosis cerebri; and one patient each with other tumor types, including atypical teratoid rhabdoid tumor, thalamic astrocytoma, low-grade glial tumor, high-grade glial tumor, and cribriform neuroepithelial tumor. Read More

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Relating the structure and dynamics of ionic liquids under shear by means of reverse non-equilibrium molecular dynamics simulations.

Phys Chem Chem Phys 2021 Jun 21. Epub 2021 Jun 21.

Laboratório de Espectroscopia Molecular, Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, 05508-000, Brazil.

The effect of the shear rate on the viscosity and the structure of 1-ethyl-3-methylimidazolium based ionic liquids with three different anions (tetrafluoroborate, dicyanamide, and bis(trifluoromethylsulfonyl)imide) was studied by means of reverse non-equilibrium molecular dynamics (RNEMD) simulations using a polarizable force field. The three liquids display a Newtonian plateau followed by a shear thinning regime at shear rates of the order of GHz. Even though the main features of the liquid structure remains under shear, systematic changes were noticed at the GHz rates, with coordination shells becoming more diffuse as noticed by the reduction in the difference between consecutive maxima and minima in the radial distribution function. Read More

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Cutaneous and Pulmonary Manifestations: COVID-19 Virus or Coccidioidomycosis?

Cureus 2021 May 16;13(5):e15060. Epub 2021 May 16.

Internal Medicine & Academic Affairs, HonorHealth, Scottsdale , USA.

COVID-19 viral pandemic continues to manifest itself in the form of various clinical symptoms. Due to concerns of COVID-19 in the setting of high rates of false-negative, there is increased likelihood of anchoring bias. We present a case of a 48-year-old white female who presented with two weeks of dry cough and diffuse pruritic nodular cutaneous rash. Read More

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Autoimmune Hepatitis With Concomitant Pernicious Anemia: A Rare Association.

Cureus 2021 May 15;13(5):e15045. Epub 2021 May 15.

Gastroenterology, Cleveland Clinic Florida, Weston, USA.

The co-occurrence of autoimmune hepatitis (AIH) and pernicious anemia (PA) is extremely rare. We present a case of a 70-year-old woman with AIH who presented for the evaluation of poor appetite and weight loss. Laboratory studies were significant for microcytic anemia, B12, and iron deficiency. Read More

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Aliphatic hydrocarbons in urban runoff sediments: a case study from the megacity of Tehran, Iran.

J Environ Health Sci Eng 2021 Jun 12;19(1):205-216. Epub 2021 Jan 12.

Environmental Sciences Research Institute, Shahid Beheshti University, Tehran, Iran.

Urban runoff is known as an important contributor to diffuse a wide range of pollutants to receiving environments. Hydrocarbons are common contaminants in runoff mainly transported coupled to suspended particles and sediments. The aim of the study was to investigate the distribution and sources of Aliphatics in the sediments of Tehran's runoff drainage network. Read More

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