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Testicular shear wave elastography in oligo-astheno-teratozoospermic individuals: a prospective case-control study.

Int Urol Nephrol 2021 Jun 10. Epub 2021 Jun 10.

Andrology and Urogynecology Clinic, Santa Maria Terni Hospital, University of Perugia, Viale Tristano di Jannuccio 1 Terni, Perugia, Italy.

Purpose: The primary objective of this study was to evaluate the testicular stiffness by ultrasound shear wave elastography (SWE) both in men with oligo-astheno-teratozospermia (OAT) and in control group. The secondary objective was to identify a possible correlation between semen quality with testicular stiffness.

Methods: This was a prospective case-control study. Read More

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Cardiac time intervals and myocardial performance index for prediction of twin-twin transfusion syndrome.

Prenat Diagn 2021 Jun 9. Epub 2021 Jun 9.

Division of Fetal Medicine, Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands.

Objectives: To explore whether intertwin discordance in myocardial performance index (MPI) or cardiac time intervals enables the prediction of twin-twin transfusion syndrome (TTTS) in monochorionic diamniotic (MCDA) pregnancies with amniotic fluid discordance.

Methods: Prospective cohort study of MCDA pregnancies with amniotic fluid discordance ≥4 cm. Serial ultrasound examinations consisted of evaluation of amniotic fluid, fetal Dopplers and fetal cardiac function. Read More

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Multimodality cardiac imaging for management of a cardiac mass in the era of COVID-19: a case report.

Eur Heart J Case Rep 2021 Mar 4;5(3):ytab062. Epub 2021 Mar 4.

Icahn School of Medicine at Mount Sinai, New York, USA.

Background : Atrial myxomas are the most common benign cardiac tumours. This case highlights an unusual presentation and complex management of a patient who was incidentally found to have a left atrial tumour concerning for a myxoma.

Case Summary : A 54-year-old-woman presented with symptoms of nausea and vomiting and was found to have a left atrial mass incidentally in addition to a renal infarct. Read More

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Treatable cardiac disease in hospitalised COPD exacerbations.

ERJ Open Res 2021 Jan 8;7(1). Epub 2021 Feb 8.

Monash Lung and Sleep, Monash Health, Clayton, Victoria, Australia.

Introduction: Acute exacerbations of COPD (AECOPD) are accompanied by escalations in cardiac risk superimposed upon elevated baseline risk. Appropriate treatment for coronary artery disease (CAD) and heart failure with reduced ejection fraction (HFrEF) could improve outcomes. However, securing these diagnoses during AECOPD is difficult, so their true prevalence remains unknown, as does the magnitude of this treatment opportunity. Read More

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January 2021

Evaluation of the performance of instruments to diagnose grief disorders: A diagnostic meta-analysis.

Int J Nurs Stud 2021 May 7;120:103972. Epub 2021 May 7.

School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan; Center for Nursing and Healthcare Research in Clinical Practice Application, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Nursing, Taipei Medical University-Shuang Ho Hospital, New Taipei, Taiwan; Psychiatric Research Center, Taipei Medical University Hospital, Taipei, Taiwan. Electronic address:

Background: Prolonged or complicated grief disorder occurs in 9.8% of bereaved adults and can progress into adverse health effects if left unresolved. Evidence on the appropriate and specific diagnostic instrument for the assessment of prolonged or complicated grief disorders is lacking. Read More

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Time-Frequency Characterization of Resting Brain in Bipolar Disorder during Euthymia-A Preliminary Study.

Brain Sci 2021 May 7;11(5). Epub 2021 May 7.

Department of Affective Disorders, Jagiellonian University Medical College, Kopernika st. 21a, 31-501 Kraków, Poland.

The goal of this paper is to investigate the baseline brain activity in euthymic bipolar disorder (BD) patients by comparing it to healthy controls (HC) with the use of a variety of resting state functional magnetic resonance imaging (rs-fMRI) analyses, such as amplitude of low frequency fluctuations (ALFF), fractional ALFF (f/ALFF), ALFF-based functional connectivity (FC), and r egional homogeneity (ReHo). We hypothesize that above-mentioned techniques will differentiate BD from HC indicating dissimilarities between the groups within different brain structures. Forty-two participants divided into two groups of euthymic BD patients (n = 21) and HC (n = 21) underwent rs-fMRI evaluation. Read More

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A designathon to co-create community-driven HIV self-testing services for Nigerian youth: findings from a participatory event.

BMC Infect Dis 2021 May 31;21(1):505. Epub 2021 May 31.

Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.

Background: Youth are at high risk for HIV, but are often left out of designing interventions, including those focused on adolescents. We organized a designathon for Nigerian youth to develop HIV self-testing (HIVST) strategies for potential implementation in their local communities. A designathon is a problem-focused event where participants work together over a short period to create and present solutions to a judging panel. Read More

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Hypertrophic cardiomyopathies requiring more monitoring for less atrial fibrillation-related complications: a clustering analysis based on the French registry on hypertrophic cardiomyopathy (REMY).

Clin Res Cardiol 2021 May 27. Epub 2021 May 27.

Service de Cardiologie-Hôpital Pontchaillou, Univ Rennes, CHU Rennes, Inserm, LTSI-UMR 1099, F-35000, Rennes, France.

Aims: Defining the risk of atrial fibrillation (AF) in hypertrophic cardiomyopathy (HCM) patients is an important clinical and prognostic challenge. The aim of this study is to determine HCM phenogroups with different risk of AF occurrence at 5 years.

Methods And Results: We applied retrospectively the Bayesian method, which can analyze a large number of variables, to differentiate phenogroups of patients with different risks of AF and prognoses across a French prospective on-going hospital-based registry of adult HCM patients (REMY). Read More

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Restricted left atrial dilatation can visually differentiate cardiac amyloidosis from hypertrophic cardiomyopathy.

ESC Heart Fail 2021 May 27. Epub 2021 May 27.

Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine, Toon, Japan.

Aims: Cardiac amyloidosis (CA) is an infiltrative myocardial disease that occasionally mimics hypertrophic cardiomyopathy (HCM). The aim of this study is to investigate the discriminatory ability of visual assessment of left atrial (LA) function between CA and HCM on echocardiography.

Methods And Results: In total, 93 patients with cardiac magnetic resonance imaging (CMR)-confirmed HCM and 34 with cardiac biopsy-confirmed CA were retrospectively assessed. Read More

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Altered Functional Connectivity of the Primary Visual Cortex in Patients With Iridocyclitis and Assessment of Its Predictive Value Using Machine Learning.

Front Immunol 2021 7;12:660554. Epub 2021 May 7.

Eye Center, Renmin Hospital of Wuhan University, Wuhan, China.

Purpose: To explore the intrinsic functional connectivity (FC) alteration of the primary visual cortex (V1) between individuals with iridocyclitis and healthy controls (HCs) by the resting-state functional magnetic resonance imaging (fMRI) technique, and to investigate whether FC findings be used to differentiate patients with iridocyclitis from HCs.

Methods: Twenty-six patients with iridocyclitis and twenty-eight well-matched HCs were recruited in our study and underwent resting-state fMRI examinations. The fMRI data were analyzed by Statistical Parametric Mapping (SPM12), Data Processing and Analysis for Brain Imaging (DPABI), and Resting State fMRI Data Analysis Toolkit (REST) software. Read More

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Cardiac MRI findings to differentiate athlete's heart from hypertrophic (HCM), arrhythmogenic right ventricular (ARVC) and dilated (DCM) cardiomyopathy.

Int J Cardiovasc Imaging 2021 May 21. Epub 2021 May 21.

Department of Radiology, Diagnostic and Interventional Radiology, University of Tübingen, Tübingen, Germany.

To provide clinically relevant criteria for differentiation between the athlete's heart and similar appearing hypertrophic (HCM), dilated (DCM), and arrhythmogenic right-ventricular cardiomyopathy (ARVC) in MRI. 40 top-level athletes were prospectively examined with cardiac MR (CMR) in two university centres and compared to retrospectively recruited patients diagnosed with HCM (n = 14), ARVC (n = 18), and DCM (n = 48). Analysed MR imaging parameters in the whole study cohort included morphology, functional parameters and late gadolinium enhancement (LGE). Read More

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Cardiac myxosarcoma: A case report.

Caspian J Intern Med 2021 Mar;12(2):228-231

Department of Obstetrics and Gynecology, Tehran University of Medical Sciences, Tehran, Iran.

Background: It is a rare cardiac malignant primary tumor that seems to derive from the same cellular line as myxomas, but the prognosis is very different. It is a rare cardiac malignant primary tumor that seems to derive from the same cellular line as myxomas, but the prognosis is very different. It is a rare cardiac malignant primary tumor that seems to derive from the same cellular line as myxomas, but the prognosis is very different. Read More

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Comparing cardiovascular magnetic resonance strain software packages by their abilities to discriminate outcomes in patients with heart failure with preserved ejection fraction.

J Cardiovasc Magn Reson 2021 May 20;23(1):55. Epub 2021 May 20.

Cardiovascular Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA, 19104, USA.

Background: Cardiovascular magnetic resonance (CMR) myocardial strain analysis using feature tracking (FT) is an increasingly popular method to assess cardiac function. However, different software packages produce different strain values from the same images and there is little guidance regarding which software package would be the best to use. We explored a framework under which different software packages could be compared and used based on their abilities to differentiate disease from health and differentiate disease severity based on outcome. Read More

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Quantitative analysis of piano performance proficiency focusing on difference between hands.

PLoS One 2021 19;16(5):e0250299. Epub 2021 May 19.

Music and Audio Research Group, Department of Intelligence and Information, Seoul National University, Seoul, South Korea.

Quantitative evaluation of piano performance is of interests in many fields, including music education and computational performance rendering. Previous studies utilized features extracted from audio or musical instrument digital interface (MIDI) files but did not address the difference between hands (DBH), which might be an important aspect of high-quality performance. Therefore, we investigated DBH as an important factor determining performance proficiency. Read More

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Intracranial solitary fibrous tumor/hemangiopericytoma mimicking cystic meningioma: A case report and literature review.

Radiol Case Rep 2021 Jul 30;16(7):1637-1642. Epub 2021 Apr 30.

Department of Radiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.

Intracranial solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is a relatively rare type of tumor that originates from meningeal mesenchyme. A 30-year-old man presented leaning his body to the left and with weakness of his left lower limb. Computed tomography revealed a heterogeneous mass with multiple cystic components and hyperostosis of the right cranial convexity. Read More

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Primary intestinal lymphangiectasia presenting as limb hemihyperplasia: a case report and literature review.

Ammar A Khayat

BMC Gastroenterol 2021 May 18;21(1):225. Epub 2021 May 18.

Department of Pediatrics, Gastroenterology Unit, Department of Pediatrics, Faculty of Medicine, Umm AL Qura University, King Abdulaziz University, 24381, Al-Abdiyyah, Makkah, Saudi Arabia.

Background: Primary intestinal lymphangiectasia is an exceedingly rare disorder. Epidemiology is unknown. It usually presents with lower extremity swelling, diarrhea, ascites, and protein-losing enteropathy. Read More

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Bilateral calcification of the optic nerve sheath: A diagnostic dilemma.

Am J Ophthalmol Case Rep 2021 Jun 22;22:101106. Epub 2021 Apr 22.

Department of Ophthalmology, Oslo University Hospital, Norway.

Purpose: To present a case of symptomatic optic nerve sheath calcification and highlight clues and pitfalls for the final diagnosis: bilateral optic nerve sheath meningioma.

Observations: A 48-year-old man presented with painless vision loss in his left eye and findings consistent with left optic nerve atrophy. Magnetic resonance imaging (MRI) displayed thinning of the left optic nerve without contrast-enhancement or evidence of compressive lesions. Read More

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Electrocardiogram Changes in the Spectrum of TTNtv Dilated Cardiomyopathy: Accuracy and Predictive Value of a New Index for LV-Changes Identification.

Heart Lung Circ 2021 May 13. Epub 2021 May 13.

Cardiology Department, 12 de Octubre University Hospital, Madrid, Spain; Research Institute i+12, 12 de Octubre University Hospital, Madrid, Spain; CIBER-CV (Biomedical Research Networking Centres, Cardiovascular Diseases), Institute of Health Carlos III, Madrid, Spain; Faculty of Medicine, Complutense University of Madrid, Spain.

Background: Truncating TTN variants (TTNtv) are the main cause of dilated cardiomyopathy (DCM). The dynamic nature of this entity has previously been described. Based on own empirical observations and previous evidences, this study assessed repolarisation patterns and the possible association with morphological and functional status of TTNtv-DCM patients. Read More

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Neurocircuitry of Contingency Awareness in Pavlovian Fear Conditioning.

Cogn Affect Behav Neurosci 2021 May 15. Epub 2021 May 15.

Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Dr., Tolan Park Suite 2C Room 273, Detroit, MI, 48201, USA.

In Pavlovian fear conditioning, contingency awareness provides an indicator of explicit fear learning. A less studied aspect of fear-based psychopathologies and their treatment, awareness of learned fear is a common cause of distress in persons with such conditions and is a focus of their treatment. The present work is a substudy of a broader fear-conditioning fMRI study. Read More

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Application of Genome-Wide DNA Methylation Analysis to Differentiate a Case of Radiation-Induced Glioblastoma From Late-Relapsed Medulloblastoma.

J Neuropathol Exp Neurol 2021 Jun;80(6):552-557

From Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.

Recurrent medulloblastoma can be difficult to diagnose with conventional diagnostic methods because other lesions mimic tumor relapse, particularly at later stages. We report 2 cases of medulloblastoma, both of which seemed to develop late recurrences. Case 1 was a 6-year-old girl who had a medulloblastoma with focal desmoplasia. Read More

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Primary Duodenal Periampullary Adenocarcinoma: An Uncommon Presentation.

Cureus 2021 Apr 6;13(4):e14323. Epub 2021 Apr 6.

Internal Medicine, University of California, Riverside School of Medicine, Riverside, USA.

Periampullary carcinoma is a broad term used to define the group of carcinomas arising from the head of the pancreas, the distal common bile duct, and the duodenum. It is clinically important to differentiate ampullary from periampullary carcinoma as this can affect resectability and prognosis. Atypical left-sided chest pain is an atypical presentation of periampullary duodenal adenocarcinoma. Read More

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Takotsubo Cardiomyopathy: An ST-Elevation Myocardial Infarction Mimic.

Kristina A Davis

Adv Emerg Nurs J 2021 Jan-Mar 01;43(1):48-52

College of Nursing, Rocky Mountain University of Health Professions, Provo, Utah.

Takotsubo cardiomyopathy (TC), a rare syndrome often preceded by an emotional or physical trigger, which earned the nickname broken heart syndrome, was first diagnosed in 1990. Takotsubo cardiomyopathy can mimic an ST-elevation myocardial infarction (STEMI). Originally, TC was thought to be self-limiting and benign. Read More

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Temporal variability of regional intrinsic neural activity in drug-naïve patients with obsessive-compulsive disorder.

Hum Brain Mapp 2021 May 5. Epub 2021 May 5.

Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.

Obsessive-compulsive disorder (OCD) displays alterations in regional brain activity represented by the amplitude of low-frequency fluctuation (ALFF), but the time-varying characteristics of this local neural activity remain to be clarified. We aimed to investigate the dynamic changes of intrinsic brain activity in a relatively large sample of drug-naïve OCD patients using univariate and multivariate analyses. We applied a sliding-window approach to calculate the dynamic ALFF (dALFF) and compared the difference between 73 OCD patients and age- and sex-matched healthy controls (HCs). Read More

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Increased early motivational response to food in adolescent anorexia nervosa revealed by magnetoencephalography.

Psychol Med 2021 May 5:1-9. Epub 2021 May 5.

Department of Child and Adolescent Psychiatry, University Hospital Muenster, Muenster, Germany.

Background: It remains unclear to what extent reduced nutritional intake in anorexia nervosa (AN) is a consequence of a reduced motivational response to food. Although self-reports typically suggest AN patients have a reduced appetitive response, behavioral and neurophysiological measures have revealed evidence for both increased and reduced attentional biases towards food stimuli. The mechanisms influencing food perception in AN, might be clarified using time-sensitive magnetoencephalography (MEG) to differentiate the early (more automatic processing) stages from the late (more controlled) stages. Read More

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The Role of Left-Atrial Mechanics Assessed by Two-Dimensional Speckle-Tracking Echocardiography to Differentiate Hypertrophic Cardiomyopathy from Hypertensive Left-Ventricular Hypertrophy.

Diagnostics (Basel) 2021 Apr 30;11(5). Epub 2021 Apr 30.

Cardio-thoracic Department, University of Medicine and Pharmacy Carol Davila, Eroii Sanitari Bvd. 8, 050474 Bucharest, Romania.

Hypertrophic cardiomyopathy (HCM) and arterial hypertension (HTN) are conditions with different pathophysiology, but both can result in left-ventricular hypertrophy (LVH). The role of left-atrial (LA) functional changes detected by two-dimensional speckle-tracking echocardiography (STE) in indicating LVH etiology is unknown.

Methods: We aimed to characterize LA mechanics using STE in LVH patients with HCM and HTN. Read More

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Electrocardiographic Criteria for Differentiating Left from Right Idiopathic Outflow Tract Ventricular Arrhythmias.

Arrhythm Electrophysiol Rev 2021 Apr;10(1):10-16

Department of Cardiovascular, Respiratory, Nephrology, Anaesthesiology and Geriatric Sciences, Sapienza University of Rome, Italy.

Idiopathic ventricular arrhythmias are ventricular tachycardias or premature ventricular contractions presumably not related to myocardial scar or disorders of ion channels. Of the ventricular arrhythmias (VAs) without underlying structural heart disease, those arising from the ventricular outflow tracts (OTs) are the most common. The right ventricular outflow tract (RVOT) is the most common site of origin for OT-VAs, but these arrhythmias can, less frequently, originate from the left ventricular outflow tract (LVOT). Read More

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A highly accurate method for quantifying LVNC cardiomyophaty.

AMIA Annu Symp Proc 2020 25;2020:223-232. Epub 2021 Jan 25.

Computer Engineering, University of Murcia, Spain.

Left ventricular non-compaction (LVNC) is defined by an increase of trabeculations in left ventricular endo-myocardium. Although LVNC can be in isolation, an increase in hypertrabeculation often accompanies genetic cardiomyopthies. Several enhancements are proposed and implemented to improve a software tool for the automatic quantification of the exact hyper-trabeculation degree in the left ventricular myocardium for a population of patients with LVNC cardiomyopathy (QLVTHC-NC). Read More

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In Situ and Intraoperative Detection of the Ureter Injury Using a Highly Sensitive Piezoresistive Sensor with a Tunable Porous Structure.

ACS Appl Mater Interfaces 2021 May 30;13(18):21669-21679. Epub 2021 Apr 30.

Schlegel Research Institute for Aging, University of Waterloo, Waterloo N2L 3G1, Canada.

Iatrogenic ureteral injury, as a commonly encountered problem in gynecologic, colorectal, and pelvic surgeries, is known to be difficult to detect in situ and in real-time. Consequently, this injury may be left untreated, thereby leading to serious complications such as infections, renal failure, or even death. Here, high-performance tubular porous pressure sensors were proposed to identify the ureter in situ intraoperatively. Read More

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Quantitative Analysis of Synthetic Magnetic Resonance Imaging in Alzheimer's Disease.

Front Aging Neurosci 2021 12;13:638731. Epub 2021 Apr 12.

Department of Radiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.

The purpose of this study was to evaluate the feasibility and whether synthetic MRI can benefit diagnosis of Alzheimer's disease (AD). Eighteen patients and eighteen age-matched normal controls (NCs) underwent MR examination. The mini-mental state examination (MMSE) scores were obtained from all patients. Read More

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