10,284 results match your criteria differences geriatric


Cognitive Performance Trajectories Before and After Sleep Treatment Initiation in Middle-Aged and Older Adults: Results from the Health and Retirement Study.

J Gerontol A Biol Sci Med Sci 2021 Jun 11. Epub 2021 Jun 11.

Division of Pulmonary Medicine, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, CA.

Background: Sleep disturbances are associated with risk of cognitive decline but it is not clear if treating disturbed sleep mitigates decline. We examined differences in cognitive trajectories before and after sleep treatment initiation.

Methods: Data came from the 2006-2014 Health and Retirement Study. Read More

View Article and Full-Text PDF

Clinical and prognostic role of sarcopenia in elderly patients with classical Hodgkin lymphoma: a multicentre experience.

J Cachexia Sarcopenia Muscle 2021 Jun 11. Epub 2021 Jun 11.

Division of Hematology, ASST Spedali Civili, Brescia, Italy.

Background: Elderly classical Hodgkin lymphoma (cHL) (ecHL) is a rare disease with dismal prognosis and no standard treatment. Fitness-based approaches may help design appropriate treatments. Sarcopenia has been associated with an increased risk of treatment-related toxicities and worse survival in various solid tumours, but its impact in ecHL is unknown. Read More

View Article and Full-Text PDF

Long term fMRI adaptation depends on adapter response in face-selective cortex.

Commun Biol 2021 Jun 10;4(1):712. Epub 2021 Jun 10.

Neuropsychiatry, Leuven Brain Institute, KU Leuven, Leuven, Belgium.

Repetition suppression (RS) reflects a neural attenuation during repeated stimulation. We used fMRI and the subsequent memory paradigm to test the predictive coding hypothesis for RS during visual memory processing by investigating the interaction between RS and differences due to memory in category-selective cortex (FFA, pSTS, PPA, and RSC). Fifty-six participants encoded face and house stimuli twice, followed by an immediate and delayed (48 h) recognition memory assessment. Read More

View Article and Full-Text PDF

Comparison of complication profiles for femoral neck, intertrochanteric, and subtrochanteric geriatric hip fractures.

Arch Orthop Trauma Surg 2021 Jun 10. Epub 2021 Jun 10.

Department of Orthopaedic Surgery, David Geffen School of Medicine At UCLA, 10833 Le Conte Avenue, 76-143 CHS, Los Angeles, CA, 90095-6902, USA.

Introduction: Most geriatric hip fractures occur in the femoral neck (FN) and intertrochanteric (IT) regions of the femur, while a minority occur in the subtrochanteric (ST) region. Relative outcomes based on the anatomical subtype of fracture are not well studied. This study characterizes postoperative complications and outcomes of hip fractures distinguished by anatomic region. Read More

View Article and Full-Text PDF

Nursing Students' Perception Regarding Community Health Nursing Practical Modules Experience, at the Faculty of Nursing, [Institution MASKED], Egypt.

J Dr Nurs Pract 2021 Jun 9. Epub 2021 Jun 9.

Modern University for Technology and Information, Giza, ELharam, Egypt

Background: Learning depends not only upon how teachers have designed and structured their subjects and courses but also upon how their students perceive and understand this design and structure. Understanding student's level of perception with their clinical education forms a basis of determining the quality of nursing education.

Objective: Assess nursing students' perception of their learning experience with community health nursing practical modules. Read More

View Article and Full-Text PDF

Levels and clinical significance of serum homocysteine (Hcy), high-density lipoprotein cholesterol (HDL-C), vaspin, and visfatin in elderly patients with different types of coronary heart disease.

Ann Palliat Med 2021 May;10(5):5679-5686

Department of Geriatric ICU, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Chinese Academy of Sciences, Sichuan Translational Medicine Research Hospital, Chengdu, China.

Background: To investigate the levels and clinical significance of serum homocysteine (Hcy), high-density lipoprotein cholesterol (HDL-C), visceral adipose tissue-derived serine protease inhibitor (vaspin), and visceral fat-specific adipokine (visfatin) in elderly patients with different types of coronary heart disease (CHD).

Methods: A total of 208 elderly patients with CHD admitted to our hospital were selected as the observation group, and 57 healthy volunteers who received physical examinations during the same period were selected as the healthy control group. The patients in the observation group were divided into a stable angina pectoris (SAP) group, an unstable angina pectoris (UAP) group, and an acute myocardial infarction (AMI) group according to their clinical diagnosis. Read More

View Article and Full-Text PDF

Evaluation of F-AlF-NOTA-octreotide for imaging neuroendocrine neoplasms: comparison with Ga-DOTATATE PET/CT.

EJNMMI Res 2021 Jun 9;11(1):55. Epub 2021 Jun 9.

Department of Nuclear Medicine, XiangYa Hospital, Central South University, No. 87 XiangYa Road, ChangSha, Hunan Province, People's Republic of China.

Objective: To evaluate the diagnostic efficacy of F-AlF-NOTA-octreotide (F-OC) PET/CT compared with that of Ga-DOTATATE PET/CT.

Materials And Methods: Twenty patients (mean age: 52.65 years, range: 24-70 years) with biopsy-proven neuroendocrine neoplasms (NENs) were enrolled in this prospective study. Read More

View Article and Full-Text PDF

Obesity Measures and Definitions of Sarcopenic Obesity in Singaporean Adults - the Yishun Study.

J Frailty Aging 2021 ;10(3):202-210

Shiou-Liang Wee, Geriatric Education and Research Institute (GERI), 2 Yishun Central 2, Tower E Level 4 GERI Admin, 768024, Singapore, Phone: +65 6807 8011, Benedict Wei Jun Pang, Geriatric Education and Research Institute (GERI), 2 Yishun Central 2, Tower E Level 4 GERI Admin, 768024, Singapore, Phone: +65 6807 8030, (B.W.J. Pang) partment, World Health Organization, Geneva, Switzerland, E-mail:

Objectives: Due to the lack of a uniform obesity definition, there is marked variability in reported sarcopenic obesity (SO) prevalence and associated health outcomes. We compare the association of SO with physical function using current Asian Working Group for Sarcopenia (AWGS) guidelines and different obesity measures to propose the most optimal SO diagnostic formulation according to functional impairment, and describe SO prevalence among community-dwelling young and old adults.

Design: Obesity was defined according to waist circumference (WC), percentage body fat (PBF), fat mass index (FMI), fat mass/fat-free mass ratio (FM/FFM), or body mass index (BMI). Read More

View Article and Full-Text PDF

Tuberculous meningitis in the elderly.

QJM 2021 Jun 8. Epub 2021 Jun 8.

Professor, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Nehru Hospital, Sector 12, Chandigarh (India).

Objective: Although the elderly population remains at high risk for tuberculosis, studies addressing tuberculous meningitis (TBM) in this age group are scarce. The present study aimed to evaluate the spectrum and outcome of geriatric TBM and document differences between older and young patients.

Methods: A prospective cohort study was conducted in the adult TBM patients admitted at PGIMER, Chandigarh (India). Read More

View Article and Full-Text PDF

Cohort study of ageing from Bagé (SIGa-Bagé), Brazil: profile and methodology.

BMC Public Health 2021 Jun 7;21(1):1089. Epub 2021 Jun 7.

Post-Graduate Programme in Nursing, Federal University of Pelotas, Pelotas, Brazil.

Background: The Bagé Cohort Study of Ageing is a population-based cohort study that has recently completed the first follow-up of a representative sample of older adults from Bagé, a city with more than 100,000 inhabitants located in the state of Rio Grande do Sul, Brazil. This is one of the first longitudinal studies to assess the impact of primary health care coverage on health conditions and inequalities. Our aim is to investigate the prevalence, incidence and trends of risk factors, health behaviours, social relationships, non-communicable diseases, geriatric diseases and disorders, hospitalisation, self-perceived health, and all-cause and specific-cause mortality. Read More

View Article and Full-Text PDF

White matter tracts in Bipolar Disorder patients: A comparative study based on diffusion kurtosis and tensor imaging.

J Affect Disord 2021 May 27;292:45-55. Epub 2021 May 27.

Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.. Electronic address:

Background: Diffusion kurtosis imaging (DKI), an extension of diffusion tensor imaging (DTI), is a powerful tool for studying human brain.The purpose is to investigate differences between DKI and DTI by comparing parameters in same analysis methods with bipolar disorder (BD) patients.

Methods: In this study, we attained in 47 BD patients and 49 age-, sex-, and education-matched healthy controls, complimented DTI and DKI scanning and got Fractional Anisotropy (FA), Mean Diffusion (MD) and Mean Kurtosis (MK). Read More

View Article and Full-Text PDF

Frailty-a risk factor of global and domain-specific cognitive decline among a nationally representative sample of community-dwelling older adult U.S. Medicare beneficiaries.

Age Ageing 2021 Jun 7. Epub 2021 Jun 7.

Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, USA.

Objectives: frail older adults may be more vulnerable to stressors, resulting in steeper declines in cognitive function. Whether the frailty-cognition link differs by cognitive domain remains unclear; however, it could lend insight into underlying mechanisms.

Methods: we tested whether domain-specific cognitive trajectories (clock-drawing test, (CDT), immediate and delayed recall, orientation to date, time, president and vice-president naming) measured annually (2011-2016) differ by baseline frailty (physical frailty phenotype) in the National Health and Aging Trends Study (n = 7,439), a nationally representative sample of older adult U. Read More

View Article and Full-Text PDF

Differences in Health-Related Quality of Life Among Adults with a Potential Dihydropyridine Calcium Channel Blocker-Loop Diuretic Prescribing Cascade.

Drugs Aging 2021 Jun 7. Epub 2021 Jun 7.

Department of Pharmaceutical Outcomes and Policy, University of Florida College of Pharmacy, 1225 Center Dr, Gainesville, FL, 32610, USA.

Background: Dihydropyridine calcium channel blockers (DH CCBs) are commonly used for hypertension in older adults. However, loop diuretics can be inappropriately added to treat DH CCB-induced edema, putting individuals at increased risk for adverse events and potential decreases in quality of life.

Methods: We conducted a cross-sectional analysis using United States Medical Expenditure Panel Survey (MEPS) data from 2003 to 2015. Read More

View Article and Full-Text PDF

Differences in performance on English and Hebrew versions of the MoCA in Parkinson's patients.

Clin Park Relat Disord 2020 11;3. Epub 2020 Feb 11.

Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, NY, United States of America.

Introduction: The Montreal Cognitive Assessment (MoCA), an instrument widely used for cognitive screening in Parkinson's disease (PD), is validated in Hebrew and English. However, it remains unknown whether the scores are comparable.

Methods: The MoCA was analyzed in 483 Ashkenazi Jewish PD patients in Tel-Aviv and New York who had MoCA ≥21. Read More

View Article and Full-Text PDF
February 2020

Amyloid beta associations with connected speech in cognitively unimpaired adults.

Alzheimers Dement (Amst) 2021 27;13(1):e12203. Epub 2021 May 27.

Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA.

Introduction: Connected speech and language (CSL) decline has been associated with early cognitive decline, but associations between CSL and Alzheimer's disease (AD) biomarkers remain a gap in the literature. Our goal was to examine associations with amyloid beta (Aβ) and longitudinal CSL trajectories in cognitively unimpaired adults at increased AD risk.

Methods: Using data from the Wisconsin Registry for Alzheimer's Prevention, CSL measures were automatically extracted from digitally recorded picture descriptions. Read More

View Article and Full-Text PDF

DCBLD2 Affects the Development of Colorectal Cancer via EMT and Angiogenesis and Modulates 5-FU Drug Resistance.

Front Cell Dev Biol 2021 19;9:669285. Epub 2021 May 19.

Hunan Key Laboratory of Pharmacogenetics, Department of Clinical Pharmacology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.

DCBLD2 is highly expressed in various cancers, including colorectal cancer. DCBLD2 overexpression promotes tumor occurrence, development, and metastasis. However, DCBLD2 sensitivity to chemotherapy drugs and its mechanism on tumor development are unknown. Read More

View Article and Full-Text PDF

Effects of Antihypertensive Drugs on Cognitive Function in Elderly Patients with Hypertension: A Review.

Aging Dis 2021 Jun 1;12(3):841-851. Epub 2021 Jun 1.

Department of Geriatric Medicine, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China.

Hypertension is a common comorbidity that contributes to the development of various cardiovascular disorders in elderly patients. Moreover, hypertension has been associated with cognitive decline and dementia. Cognitive impairment leads to increased morbidity and mortality in elderly patients with hypertension. Read More

View Article and Full-Text PDF

Family Dynamics and Grandparents' Anxiety and Depression in Intergenerational Rearing Families: A Correlational Study.

Front Psychiatry 2021 20;12:633773. Epub 2021 May 20.

Geriatric Psychiatry Department, Shanghai Mental Health Center, Shanghai, China.

In China, intergenerational rearing is a ubiquitous phenomenon based on unique national conditions. This study aimed to explore family dynamics in intergenerational rearing families as well as their correlation with older household members' anxiety and depression. The elderly from intergenerational ( = 141) and non-intergenerational rearing families ( = 266) were investigated using the following scales: the general information questionnaire, Self-Rating Scale of Systemic Family Dynamics, Geriatric Depression Scale, and Self-Rating Anxiety Scale. Read More

View Article and Full-Text PDF

Using Time-Lagged Panel Data Analysis to Study Mechanisms of Change in Psychotherapy Research: Methodological Recommendations.

Couns Psychother Res 2020 Sep 26;20(3):435-441. Epub 2020 Jan 26.

Department of Psychology, Justus Liebig University Giessen, Giessen, Germany.

The introduction of novel methodologies in the past decade has advanced research on mechanisms of change in observational studies. Time-lagged panel models allow to track session-by-session changes and focus on within-patient associations between predictors and outcomes. This shift is crucial, as change in mechanisms inherently takes place at a within-patient level. Read More

View Article and Full-Text PDF
September 2020

Sex differences in off-target binding using tau positron emission tomography.

Neuroimage Clin 2021 May 29;31:102708. Epub 2021 May 29.

Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Sweden; Memory Clinic, Skåne University Hospital, Malmö, Sweden.

Purpose: Off-target binding in the skull and meninges is observed in some subjects undergoing tau positron emission tomography (PET) and could potentially differ between men and women. In this study we elucidate sex differences in tau off-target binding using three different tau PET tracers.

Methods: 541 cognitively unimpaired amyloid-β negative participants underwent tau PET using [F]flortaucipir (n = 165), [F]RO948 (n = 189) and [F]MK6240 (n = 187). Read More

View Article and Full-Text PDF

Gender- and age-related differences in the width of attached gingiva and clinical crown length in anterior teeth.

BMC Oral Health 2021 Jun 4;21(1):287. Epub 2021 Jun 4.

Department of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität Zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

Background: The anatomical features of the gingiva and the clinical crowns and their interrelation, especially in aesthetically and functionally demanding areas, are important in complex dental or implant-retained prosthetic rehabilitations. This observational cross-sectional study was designed to evaluate gender- and age-related differences in the width of attached gingiva (WAG), the clinical crown length (CCL), and their interrelation in the anterior teeth to determine the relationship between the pink and white aesthetics.

Methods: Eighty (54 females, 26 males) fully dentate Caucasian participants between the ages of 20 and 25 years and 36 probands (23 females, 13 males) between the ages of 45 and 55 years were included in the present study. Read More

View Article and Full-Text PDF

Improvements in physical functionality in elderly patients with spinal deformity after corrective fusion surgery: a gait analysis.

J Neurosurg Spine 2021 Jun 4:1-8. Epub 2021 Jun 4.

1Department of Orthopaedic Surgery and.

Objective: Extensive corrective fusion surgery was performed on elderly patients with adult spinal deformity (ASD) to improve abnormal posture. Varying improvements in postoperative walking function were expected owing to differences in muscular strength and bone quality between patients in their 40s and those over 75 years of age. The purpose of this study was to compare preoperative and postoperative gait posture and physical functionality in elderly patients with ASD who underwent extensive corrective fusion to the thoracic spine. Read More

View Article and Full-Text PDF

Abnormally reduced frontal cortex activity during Trail-Making-Test in prodromal parkinson's disease-a fNIRS study.

Neurobiol Aging 2021 Apr 28;105:148-158. Epub 2021 Apr 28.

Department of Psychiatry and Psychotherapy, University Hospital of Tübingen, Tübingen, Germany; Geriatric Center, University Hospital of Tübingen, Tübingen, Germany; Vitos Hospital for Psychiatry and Psychotherapy Haina, Haina, Germany.

Parkinson's Disease (PD) is a neurodegenerative disorder leading to typical motor as well as a range of non-motor symptoms, including cognitive decline mainly characterized by executive deficits. The latter are known to appear years before the typical motor signs, thus representing the prodromal phase of PD. However, appropriate methods for measuring executive dysfunction in this context are not well established yet. Read More

View Article and Full-Text PDF

The association between severe or death COVID-19 and solid organ transplantation: A systematic review and meta-analysis.

Transplant Rev (Orlando) 2021 May 21;35(3):100628. Epub 2021 May 21.

Department of Geriatric Cardiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, Sichuan, China. Electronic address:

Background: The effect of solid organ transplantation (SOT) on the severity and mortality of coronavirus disease 2019 (COVID-19) remained controversial. There is still no consensus on whether solid organ transplantation (SOT) recipients with COVID-19 are at greater risk of developing severe or fatal COVID-19. Therefore, we conducted a systematic review and meta-analysis to investigate the association between SOT, severe COVID-19 illness, and mortality. Read More

View Article and Full-Text PDF

Measurement batch differences and between-batch conversion of Alzheimer's disease cerebrospinal fluid biomarker values.

Alzheimers Dement (Amst) 2021 25;13(1):e12194. Epub 2021 May 25.

Division of Geriatrics and Gerontology Department of Medicine University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA.

Introduction: Batch differences in cerebrospinal fluid (CSF) biomarker measurement can introduce bias into analyses for Alzheimer's disease studies. We evaluated and adjusted for batch differences using statistical methods.

Methods: A total of 792 CSF samples from 528 participants were assayed in three batches for 12 biomarkers and 3 biomarker ratios. Read More

View Article and Full-Text PDF

Improvement in the long-term care burden after surgical treatment of patients with idiopathic normal pressure hydrocephalus: a supplementary study.

Sci Rep 2021 Jun 3;11(1):11732. Epub 2021 Jun 3.

Department of Behavioral Neurology and Neuropsychiatry, Osaka University United Graduate School of Child Development, Toyonaka, Osaka, Japan.

Idiopathic normal pressure hydrocephalus (iNPH) is a surgically treatable syndrome commonly observed in older adults. However, it is unclear whether clinical improvements after surgery can effectively reduce the long-term care burden (LTCB). In this study, we determined whether shunt surgery was effective in decreasing LTCB. Read More

View Article and Full-Text PDF

Is laparoscopic adrenalectomy for pheochromocytoma safe and effective in geriatric patients?

Int J Clin Pract 2021 Jun 3:e14427. Epub 2021 Jun 3.

Department of Urology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.

Objectives: The study aimed to assess the haemodynamic changes of laparoscopic adrenalectomy (LA) in geriatric patients with pheochromocytoma (PHEO). To the best of our knowledge, this is the first study to evaluate the haemodynamic outcomes of LA in this patient population.

Methods: Data of 350 patients who underwent single-side transperitoneal LA between 2000 and 2020 were reviewed retrospectively. Read More

View Article and Full-Text PDF

Convergence Insufficiency in the Geriatric Population.

Optom Vis Sci 2021 Jun 2. Epub 2021 Jun 2.

Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran Rehabilitation Research Center, Department of Optometry, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran Department of Optometry, Mashhad University of Medical Sciences, Mashhad, Iran Eye Research Center, Tehran University of Medical Sciences, Tehran, Iran Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran Refractive Errors Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Department of Ophthalmology, Feiz Hospital, Isfahan University of Medical Sciences, Isfahan, Iran Department of Medical Surgical Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Significance: The present study is the first population-based study to examine the prevalence of convergence insufficiency and its associations specifically in the geriatric population. Knowledge of the population-based determination of prevalence of this disorder in the elderly is necessary to support proper clinical diagnosis and management.

Purpose: This study aimed to determine the prevalence of convergence insufficiency and its associated factors in a geriatric population. Read More

View Article and Full-Text PDF

Resting-State Network Alterations Differ between Alzheimer's Disease Atrophy Subtypes.

Cereb Cortex 2021 Jun 3. Epub 2021 Jun 3.

Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Goettingen 37075, Germany.

Several Alzheimer's disease (AD) atrophy subtypes were identified, but their brain network properties are unclear. We analyzed data from two independent datasets, including 166 participants (103 AD/63 controls) from the DZNE-longitudinal cognitive impairment and dementia study and 151 participants (121 AD/30 controls) from the AD neuroimaging initiative cohorts, aiming to identify differences between AD atrophy subtypes in resting-state functional magnetic resonance imaging intra-network connectivity (INC) and global and nodal network properties. Using a data-driven clustering approach, we identified four AD atrophy subtypes with differences in functional connectivity, accompanied by clinical and biomarker alterations, including a medio-temporal-predominant (S-MT), a limbic-predominant (S-L), a diffuse (S-D), and a mild-atrophy (S-MA) subtype. Read More

View Article and Full-Text PDF

Thiol-disulfide homeostasis and ischemia-modified albumin as a marker of oxidative stress in patients with sarcopenia.

Geriatr Gerontol Int 2021 Jun 2. Epub 2021 Jun 2.

Division of Geriatric Medicine, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Aim: Sarcopenia is characterized by progressive and generalized loss of skeletal muscle mass and strength. Chronic inflammatory conditions and increased oxidative stress are in the pathogenesis of sarcopenia. Our aim was to evaluate the relationship between sarcopenia and thiol-disulfide homeostasis and ischemia-modified albumin levels as an oxidative stress marker. Read More

View Article and Full-Text PDF