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Metabolic Profiles of the 30-15 Intermittent Fitness Test and the Corresponding Continuous Version in Team-Sport Athletes-Elucidating the Role of Inter-Effort Recovery.

Int J Sports Physiol Perform 2021 Apr 12:1-6. Epub 2021 Apr 12.

Purpose: To elucidate the role of inter-effort recovery in shuttle running by comparing the metabolic profiles of the 30-15 Intermittent Fitness Test (30-15IFT) and the corresponding continuous version (30-15IFT-CONT).

Methods: Sixteen state-level handball players (age = 23 [3] y, height = 185 [7] cm, weight = 85 [14] kg) completed the 30-15IFT and 30-15IFT-CONT, and speed at the last completed stage (in kilometers per hour) and time to exhaustion (in seconds) were assessed. Furthermore, oxygen uptake (in milliliters per kilogram per minute) and blood lactate were obtained preexercise, during exercise, and until 15 minutes postexercise. Read More

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Impact of Weight on Anti-Xa Attainment in High-Risk Trauma Patients on Enoxaparin Chemoprophylaxis.

J Surg Res 2021 Apr 10;264:425-434. Epub 2021 Apr 10.

Department of Pharmacy Services, UC Health - University of Cincinnati Medical Center, Cincinnati, Ohio; University of Cincinnati James L. Winkle College of Pharmacy, Cincinnati, Ohio.

Background: Serum anti-factor Xa (anti-Xa) concentration may guide low molecular weight heparin chemoprophylaxis in trauma patients. Higher total body weight (TBW) is a risk factor for subprophylactic anti-Xa and venous thromboembolism (VTE). The purpose of this study was to evaluate TBW differences in patients with subprophylactic versus prophylactic trough anti-Xa. Read More

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Retrospective analysis of hibernation parameters and breeding success in captive Vancouver Island marmots (Marmota vancouverensis): 1997-2018.

Zoo Biol 2021 Apr 13. Epub 2021 Apr 13.

Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.

Vancouver Island marmots (Marmota vancouverensis) have been managed in a captive-breeding program since 1997, as in situ conservation efforts were insufficient in raising the numbers of this critically endangered species. The success of captive-breeding programs centers on sustainable reproduction and survival of individuals once released into the wild. Captive-born Vancouver Island marmots released to the wild have lower survival rates than their wild-born counterparts; this difference may arise from compromised hibernation patterns or behaviors. Read More

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Quercetin as a nephroprotector after warm ischemia: histomorphometric evaluation in a rodent model.

Int Braz J Urol 2021 Jul-Aug;47(4):796-802

Unidade de Pesquisa Urogenital, Universidade do Estado do Rio de Janeiro - UERJ, Rio de Janeiro, RJ, Brasil.

Purpose: To quantitatively evaluate the possible long-term protective effects of quercetin during renal warm ischemia.

Materials And Methods: Male rats were allocated into 4 groups: sham (S), sham quercetin (SQ), ischemia (I), and ischemia quercetin (IQ). Groups SQ and IQ received quercetin (50mg/kg) before and after surgery. Read More

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Feeding rice fermented beer waste improves growth performance, nutrient digestibility and nitrogen utilization in growing rabbits.

J Anim Physiol Anim Nutr (Berl) 2021 Apr 13. Epub 2021 Apr 13.

Department of Animal Nutrition, West Bengal University of Animal and Fishery Sciences, Kolkata, India.

This study was conducted to investigate the effects of dietary rice brewer waste (RBW) on growth performance, nutrient utilization and nitrogen balance in growing rabbits. Thirty growing rabbits (758 ± 25.7 g initial body weight) were randomly assigned to control and four treatment groups (containing RBW) in a completely randomized design with six rabbits per group. Read More

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Effect of acupuncture on essential hypertension: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(15):e25572

Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.

Background: Essential hypertension is a risk factor for early cardiovascular disease and is a major preventable risk factor for premature death and disability worldwide. However, some antihypertensive drugs cannot be used for treatment because of their cost-effectiveness or side effects. Non-drug treatments for hypertension include weight loss, salt restriction, smoking cessation, alcohol withdrawal, and exercise, although these methods are difficult to maintain and to achieve. Read More

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Quantitative Three-dimensional Assessment of Knee Joint Space Width from Weight-bearing CT.

Radiology 2021 Apr 13:203928. Epub 2021 Apr 13.

From the Department of Radiology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Colney Lane, Norwich NR4 7UY, England (T.D.T., J.W.M.); Norwich Medical School, University of East Anglia, Norwich, England (T.D.T., J.W.M.); Royal Liverpool University Hospital, Liverpool, England (S.B.L.); Department of Radiology, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, England (S.R.); Departments of Engineering (G.M.T., A.H.G.) and Medicine (K.E.S.P.), University of Cambridge, Cambridge, England; Department of Epidemiology and Biostatistics, University of California-San Francisco, San Francisco, Calif (J.A.L.); and Department of Physical Medicine and Rehabilitation, Kansas University Medical Center, Kansas City, Kan (N.A.S.).

Background Imaging of structural disease in osteoarthritis has traditionally relied on MRI and radiography. Joint space mapping (JSM) can be used to quantitatively map joint space width (JSW) in three dimensions from CT images. Purpose To demonstrate the reproducibility, repeatability, and feasibility of JSM of the knee using weight-bearing CT images. Read More

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Dietary Restraint Related to Body Weight Maintenance and Neural Processing in Value-Coding Areas in Adolescents.

J Nutr 2021 Apr 13. Epub 2021 Apr 13.

The Center for Integrative Science of Human Behavior (CiSHuB), The University of Tokyo, Tokyo, Japan.

Background: There is an alarming increase in the obesity prevalence among children in an environment of increasing availability of preprocessed high-calorie foods. However, some people maintain a healthy weight even in such obesogenic environments. This difference in body weight management could be attributed to individual differences in dietary restraint; however, its underlying neurocognitive mechanisms in adolescents remain unclear. Read More

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Association between body fat distribution assessed by different techniques and body image perception in HIV-infected children and adolescents.

J Pediatr Nurs 2021 Apr 9. Epub 2021 Apr 9.

Federal University of Santa Catarina, Research Center in Kinanthropometry and Human Performance, Sports Centre, Florianópolis, Santa Catarina, Brazil.

Purpose: verify whether there is difference in body fat values assessed by different methods according to the body image perception of HIV-infected children and adolescents.

Design And Methods: This is a cross-sectional study with 65 HIV-infected children and adolescents (aged 8-15 years). Total fat mass, trunk fat mass, arm fat mass and leg fat mass were obtained through dual-energy X-ray absorptiometry (DXA). Read More

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Comparison of Dosing Schemes for Thyroid Hormone Replacement Therapy After Thyroidectomy.

J Surg Res 2021 Apr 9;264:316-320. Epub 2021 Apr 9.

Department of Surgery, Weill Cornell Medicine, New York City, New York. Electronic address:

Background: Current thyroid hormone replacement therapy (THRT) is built on weight-based standard calculation of dose. A novel Poisson regression model, which accounts for seven clinical variables, was recently proposed to improve accuracy of THRT. We aimed to compare the accuracy of estimated THRT dose to reach euthyroid and the difference in predicted dose between the Poisson (scheme A) and the weight-based standard (scheme B) in patients following total thyroidectomy for benign disease. Read More

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Omega-3 Use for the Treatment of Hypertriglyceridemia, Low High-Density Lipoprotein Cholesterol Levels, and Nonalcoholic Fatty Liver Disease in Children with Obesity.

Child Obes 2021 Apr 12. Epub 2021 Apr 12.

Center for Better Health and Nutrition, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Omega-3 fatty acid supplementation has been investigated in treating elevated triglycerides (TGs), nonalcoholic fatty liver disease (NAFLD), and low high-density lipoprotein cholesterol (HDL) in adults, but has not been well studied in youth with obesity. This retrospective study examined the effectiveness of omega-3 as an adjunct therapy for these conditions in patients participating in a pediatric weight management program (PWMP). Patients with a BMI ≥85th percentile and abnormal alanine transaminase (ALT), TGs, or HDL, participating in our PWMP, were identified ( = 617). Read More

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Satiety does not affect neuroaffective electrophysiological responses to food-related or emotional visual cues.

Behav Neurosci 2021 Apr 12. Epub 2021 Apr 12.

Behavioral Science Department, The University of Texas MD Anderson Cancer Center.

Continuing to eat even when full leads to excessive calorie consumption and obesity. Thus, understanding brain responses to food cues when satiated has important implications for weight control interventions. We used the late positive potential (LPP, a component of the event-related potentials (ERP) indexing motivational relevance) to determine the extent to which satiety affects brain responses to images of highly palatable foods (high-fat, high-sugar), high and low motivationally relevant (pleasant, unpleasant) and neutral stimuli in a sample of obese (body mass index [BMI] ≥ 30 kg/m2) and lean (BMI < 25 kg/m2) individuals. Read More

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Is Increased Kicking Leg Iliopsoas Muscle Tightness a Predictive Factor for Developing Spondylolysis in Adolescent Male Soccer Players?

Clin J Sport Med 2021 Mar 12. Epub 2021 Mar 12.

*Orthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; †Faculty of Sport Sciences, Waseda University, Saitama, Japan; ‡Faculty of Education and Human Sciences, Department of School Education, Teikyo University of Science, Tokyo, Japan; §School of Human and Social Sciences, Tokyo International University, Saitama, Japan; and ¶Japan Institute of Sport Sciences, Tokyo, Japan.

Objective: To identify predictive risk factors of lumbar stress (LS) fracture developing from an asymptomatic stress reaction of the pedicle among adolescent male soccer players.

Design: Prospective cohort study.

Setting: Amateur Japanese adolescent male soccer team. Read More

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Predictors and potential advantages of PERT and advanced therapy use in acute pulmonary embolism.

Catheter Cardiovasc Interv 2021 Apr 12. Epub 2021 Apr 12.

Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.

Objectives: We sought to examine predictors of pulmonary embolism response team (PERT) utilization and identify those who could benefit from advanced therapy.

Background: PERT and advanced therapy use remain low. Current risk stratification tools heavily weight age and comorbidities, which may not always correlate with presentation's severity. Read More

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Use of low-molecular weight heparin, transfusion and mortality in COVID-19 patients not requiring ventilation.

J Thromb Thrombolysis 2021 Apr 12. Epub 2021 Apr 12.

Medical Genetics, University of Foggia, Foggia, Italy.

It is still debated whether prophylactic doses of low-molecular- weight heparin (LMWH) are always effective in preventing Venous Thromboembolism (VTE) and mortality in COVID-19. Furthermore, there is paucity of data for those patients not requiring ventilation. We explored mortality and the safety/efficacy profile of LMWH in a cohort of Italian patients with COVID-19 who did not undergo ventilation. Read More

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Are all ALK variants created equal? Clinicopathologic features and outcomes: a propensity-matched study.

Int J Clin Oncol 2021 Apr 12. Epub 2021 Apr 12.

Department of Laboratory Services, Molecular Diagnostics and Transfusion Medicine, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

Anaplastic lymphoma kinase (ALK) rearranged NSCLC comprises a molecularly distinct subgroup occurring in 10% cases. Various EML4-ALK and non EML4 variants are known to occur which can be detected only on NGS and show differential TKI responses. 113 ALK-IHC positive cases were subjected to a custom panel-based NGS for detection of ALK variants. Read More

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Sparse angle CT reconstruction with weighted dictionary learning algorithm based on adaptive group-sparsity regularization.

J Xray Sci Technol 2021 Apr 2. Epub 2021 Apr 2.

School of Artificial Intelligence and Big Data, Henan University of Technology, Zhengzhou, Henan, China.

Objective: In order to solve the blurred structural details and over-smoothing effects in sparse representation dictionary learning reconstruction algorithm, this study aims to test sparse angle CT reconstruction with weighted dictionary learning algorithm based on adaptive Group-Sparsity Regularization (AGSR-SART).

Methods: First, a new similarity measure is defined in which Covariance is introduced into Euclidean distance, Non-local image patches are adaptively divided into groups of different sizes as the basic unit of sparse representation. Second, the weight factor of the regular constraint terms is designed through the residuals represented by the dictionary, so that the algorithm takes different smoothing effects on different regions of the image during the iterative process. Read More

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A new approach to predicting shoulder dystocia: Fetal clavicle length.

Elif Terzi

Turk J Med Sci 2021 Apr 12. Epub 2021 Apr 12.

Objective: This study aimed to evaluate the relationship between second- and third-trimester clavicle length and birth weight and shoulder dystocia.

Methods: This prospective observational study included 181 patients who presented to the Private Etlik Lokman Hekim Hospital for routine pregnancy visits between March 2019 and March 2020. In addition to routine pregnancy examinations, the patients also underwent ultrasonography twice at weeks 20-23 and 33-36 to determine the length of the fetal clavicle. Read More

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Occurrence and bioaccumulation of sulfonamide antibiotics in different fish species from Hangbu-Fengle River, Southeast China.

Environ Sci Pollut Res Int 2021 Apr 12. Epub 2021 Apr 12.

School of Resources and Environmental Engineering, Anhui University, Hefei, 230601, Anhui, China.

As a class of synthetic sulfur drugs, sulfonamides (SAs) have been used to treat diseases and promote organism growth. Different concentrations of SAs have been detected in the water environment, which has threatened the ecological environment. In this study, the contamination of 9 SAs in water, sediments, and 8 fish species from the Hangbu-Fengle River, China, were analyzed using UPLC-MS/MS. Read More

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Objectively Measured Physical Activity Increases Only in Males During a Summer Camp for Obese Children.

Front Sports Act Living 2021 25;3:624449. Epub 2021 Mar 25.

Pediatrics Unit, Hospital of Atri, Atri, Italy.

Childhood obesity is a major public health challenge. Summer camps for children with obesity represent an alternative setting to improve eating and physical activity habits. Here we evaluated if the participation in the camp improves objectively measured physical activity and sedentary behavior and whether there are differences between male and female participants. Read More

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Early Life Microbiota Colonization at Six Months of Age: A Transitional Time Point.

Front Cell Infect Microbiol 2021 26;11:590202. Epub 2021 Mar 26.

Department of Public Health, Experimental and Forensic Medicine, Dietetics and Clinical Nutrition Laboratory, University of Pavia, Pavia, Italy.

Background: Early life gut microbiota is involved in several biological processes, particularly metabolism, immunity, and cognitive neurodevelopment. Perturbation in the infant's gut microbiota increases the risk for diseases in early and later life, highlighting the importance of understanding the connections between perinatal factors with early life microbial composition. The present research paper is aimed at exploring the prenatal and postnatal factors influencing the infant gut microbiota composition at six months of age. Read More

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The Single Leg Squat Test: A "Top-Down" or "Bottom-Up" Functional Performance Test?

Int J Sports Phys Ther 2021 Apr 1;16(2):360-370. Epub 2021 Apr 1.

Colorado Mesa University.

Background: Medial knee deviation (MKD) during the single leg squat test (SLST) is a common clinical finding that is often attributed to impairments of proximal muscular structures. Investigations into the relationship between MKD and the foot and ankle complex have provided conflicting results, which may impact clinicians' interpretation of the SLST.

Purpose: The purpose of this study was to compare ankle dorsiflexion range of motion (ROM) and foot posture in subjects that perform the SLST with MKD (fail) versus without MKD (pass). Read More

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Calcium and phosphate levels after kidney transplantation and long-term patient and allograft survival.

Clin Kidney J 2021 Apr 22;14(4):1106-1113. Epub 2020 May 22.

Department of Nephrology and Transplantation, Beaumont Hospital, Dublin, Ireland.

Background: Non-traditional cardiovascular risk factors, including calcium and phosphate derangement, may play a role in mortality in renal transplant. The data regarding this effect are conflicting. Our aim was to assess the impact of calcium and phosphate derangements in the first 90 days post-transplant on allograft and recipient outcomes. Read More

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Evaluation of dietary behaviors of preschool children in Seoul and Gyeonggi-do associated with the level of parents' health consciousness: using nutrition quotient for preschoolers (NQ-P).

Nutr Res Pract 2021 Apr 23;15(2):248-265. Epub 2020 Nov 23.

Department of Foodservice Industry, Hanyang Women's University, Seoul 04763, Korea.

Background/objectives: This study aimed to assess the dietary behaviors of preschool children using the nutrition quotient for preschoolers (NQ-P) and analyzed the difference in the scores of the children's dietary behaviors in regards to the parents' health consciousness.

Subjects/methods: The subjects were 257 children aged 3-5 years and their parents residing in Seoul and Gyeonggi-do, South Korea. The questionnaire is composed of demographic characteristics, the NQ-P questions, and health consciousness. Read More

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Cardiovascular Risk Is Increased in Miner's Chronic Intermittent Hypobaric Hypoxia Exposure From 0 to 2,500 m?

Front Physiol 2021 26;12:647976. Epub 2021 Mar 26.

Laboratorio de Fisiología, Hipoxia y Función Vascular, Departamento de Ciencias Biomédicas, Facultad de Medicina, Universidad Católica del Norte, Coquimbo, Chile.

Over the past 40 years, mining activities in Chile have relocated miners who normally live at sea level to work at high altitudes. This results in a form of chronic intermittent hypobaric hypoxia (CIHH) characterized by alternating periods of work at high altitude and rest periods at sea level. Previous studies performed in our laboratory showed that aerobic capacity is reduced at 3,800 m, even when oxygen content is maintained. Read More

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Holmium Versus Thulium Laser Enucleation of the Prostate: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Eur Urol Focus 2021 Apr 8. Epub 2021 Apr 8.

Department of Urology, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address:

Context: Holmium (HoLEP) and thulium laser enucleation of the prostate (ThuLEP) are the two methods most commonly applied for endoscopic enucleation of the prostate. It remains unclear which of the two is superior in terms of outcome and complications.

Objective: To compare perioperative and functional outcomes between HoLEP and ThuLEP. Read More

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A weight-loss Mediterranean diet/lifestyle intervention ameliorates inflammation and oxidative stress in patients with obstructive sleep apnea: results of the "MIMOSA" randomized clinical trial.

Eur J Nutr 2021 Apr 10. Epub 2021 Apr 10.

Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, 70 Eleftheriou Venizelou Str., 17671, Athens, Greece.

Purpose: Inflammation and oxidative stress are implicated in obstructive sleep apnea (OSA) pathophysiology. We aimed at exploring whether the combination of a weight-loss Mediterranean diet/lifestyle intervention with OSA standard care, i.e. Read More

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Examining weight suppression as a predictor and moderator of intervention outcomes in an eating disorder and obesity prevention trial: A replication and extension study.

Behav Res Ther 2021 Mar 29;141:103850. Epub 2021 Mar 29.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA, 94305-5101, USA. Electronic address:

Weight suppression (WS) predicts future weight gain and increases in eating disorder symptoms in community and clinical samples but has received minimal attention in obesity and eating disorder prevention programs. In a sample of emerging adults (N = 364) in a randomized controlled trial evaluating two obesity and eating disorder prevention interventions versus a control condition, this study aimed to replicate the findings that WS and its interaction with baseline BMI predict increases in weight and eating disorder symptoms and test a novel hypothesis that WS would moderate the effects of the interventions on change in weight and eating disorder symptoms. Participants completed assessments at baseline, post-intervention, 6-, 12-, and 24-months. Read More

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Lubiprostone for Pediatric Functional Constipation: Randomized, Controlled, Double-blind Study With Long-term Extension.

Clin Gastroenterol Hepatol 2021 Apr 7. Epub 2021 Apr 7.

Pediatric Gastroenterologist, Division of Pediatric Gastroenterology, Nationwide Children's Hospital, Columbus, OH, USA. Electronic address:

Background & Aims: Pediatric functional constipation (PFC) is a common problem in children that causes distress and presents treatment challenges to healthcare professionals. We conducted a randomized, placebo-controlled trial (Study 1) in patients with PFC (aged 6-17 years) to evaluate the efficacy and safety of lubiprostone, followed by an open-label extension for those who completed the placebo-controlled phase (Study 2).

Methods: Study 1 (NCT02042183) was a phase 3, multicenter, randomized, double-blind, placebo-controlled, 12-week study evaluating the efficacy and safety of lubiprostone 12 mcg twice-daily (BID) and 24 mcg BID. Read More

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Sensory, voluntary, and motor postural control in children and adolescents with mucopolysaccharidosis.

J Pediatr Endocrinol Metab 2021 Apr 12. Epub 2021 Apr 12.

Department of Pediatrics, Section of Metabolism, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Objectives: This study aimed to investigate automatic and voluntary motor control performances, which have an important function in maintaining balance, in children and adolescents with mucopolysaccharidosis (MPS).

Methods: The records of 70 patients were retrospectively analyzed. The results of Computerized Dynamic Posturography (CDP) performed according to the age and development of the individuals were examined. Read More

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