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Preoperative Alpha-Fetoprotein Has No Prognostic Role in Small Hepatocellular Carcinoma in Non-Cirrhotic Patients After Surgical Resection.

Turk J Gastroenterol 2021 Feb;32(2):133-140

Department of Hepatobiliary Surgery, Clinical Medical College, Yangzhou University, Yangzhou, China.

Background: Alpha-fetoprotein (AFP) has been widely used as a tumor marker in the treatment of hepatocellular carcinoma (HCC) in patients with cirrhosis. However, a large number of HCC patients are diagnosed without cirrhosis, and the prognostic capability of AFP was unclear in HCC patients without cirrhosis. Our purpose was to investigate the prognostic efficiency of AFP in patients with non-cirrhosis, single, and small HCC who were treated with surgical resection. Read More

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February 2021

Risk Factors Associated with Mortality in Intensive Care COVID-19 Patients: the importance of chest CT score and intubation timing as risk factors.

Turk J Med Sci 2021 May 7. Epub 2021 May 7.

Background/aim: Coronavirus disease 2019 (COVID-19) is a disease with a high rate of progression to critical illness. However, the predictors of mortality in critically ill patients admitted to the intensive care unit (ICU) are not yet well understood. In this study, we aimed to investigate the risk factors associated with ICU mortality in our hospital. Read More

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ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors.

Clin Chim Acta 2021 May 3. Epub 2021 May 3.

Czech Technical University, Faculty of Biomedical Engineering, Sítná 3105, Kladno, Czech Republic; Department of Preventive Cardiology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague, Czech Republic.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread from China in 2019/2020 to all continents. Significant geographical and ethnic differences were described, and host genetic background seems to be important for the resistance to and mortality of COVID-19. Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism (rs4646994) is one of the candidates with the potential to affect infection symptoms and mortality. Read More

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Methods of Ovarian Tissue Cryopreservation: Is Vitrification Superior to Slow Freezing?-Ovarian Tissue Freezing Methods.

Reprod Sci 2021 May 3. Epub 2021 May 3.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Florida, Gainesville, FL, USA.

After cancer treatment, female survivors often develop ovarian insufficiency or failure. Oocyte and embryo freezing are well-established fertility preservation options, but cannot be applied in pre-pubescent girls, in women with hormone-sensitive malignancies, or when gonadotoxic treatment cannot be delayed. Although ovarian tissue cryopreservation (OTC) has been used to restore fertility and endocrine function, the relative efficacy of its two major protocols, slow freezing and vitrification, remains controversial. Read More

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Rescue extracorporeal cardiopulmonary resuscitation in pediatric patients: a nine-year single-center experience in Zagreb, Croatia.

Croat Med J 2021 Apr;62(2):146-153

Matija Bakoš, Department of Pediatrics, University Hospital Center Zagreb, Kišpatićeva 12, 10 000 Zagreb, Croatia,

Aim: To investigate the risk factors and the outcomes of extracorporeal membrane oxygenation (ECMO) in pediatric patients treated at the University Hospital Center Zagreb, the largest center in Croatia providing pediatric ECMO.

Methods: This retrospective study enrolled all the pediatric patients who required E-CPR from 2011 to 2019. Demographic data, cardiac anatomy, ECMO indications, ECMO complications, and neurodevelopmental status at hospital discharge were analyzed. Read More

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Immune Profile in Patients With COVID-19: Lymphocytes Exhaustion Markers in Relationship to Clinical Outcome.

Front Cell Infect Microbiol 2021 15;11:646688. Epub 2021 Apr 15.

Centre for Primary Immunodeficiencies, Clinic of Pneumology and Phthisiology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin University Hospital, Martin, Slovakia.

The velocity of the COVID-19 pandemic spread and the variable severity of the disease course has forced scientists to search for potential predictors of the disease outcome. We examined various immune parameters including the markers of immune cells exhaustion and activation in 21 patients with COVID-19 disease hospitalised in our hospital during the first wave of the COVID-19 pandemic in Slovakia. The results showed significant progressive lymphopenia and depletion of lymphocyte subsets (CD3, CD4, CD8 and CD19) in correlation to the disease severity. Read More

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Comparative analysis of postoperative sexual dysfunction and quality of life in type a aortic dissection patients of different ages.

J Cardiothorac Surg 2021 May 1;16(1):117. Epub 2021 May 1.

Department of Cardiovascular Surgery and Cardiac Disease Center, Union Hospital, Fujian Medical University, Fuzhou, 350001, P. R. China.

Background: To compare postoperative sexual dysfunction (SD) and quality of life (QOL) in Type A Aortic Dissection (AAD) Patients of Different Ages.

Methods: From January 2018 to December 2019, 204 AAD postoperative survivors in Union Hospital of Fujian Medical University were selected and were divided into young group (less than 50 years old) and elderly group (more than 50 years old). We evaluated SD according to the male International Erectile Dysfunction Index (IIEF-5) and female sexual function index (FSFI). Read More

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A Prospective Single-Arm Study Evaluating the Effects of a Multimodal Physical Therapy Intervention on Psychosexual Outcomes in Women With Dyspareunia After Gynecologic Cancer.

J Sex Med 2021 Apr 27. Epub 2021 Apr 27.

School of Rehabilitation, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada; Research Center of the Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada. Electronic address:

Background: Dyspareunia affects most women after treatment for gynecologic malignancies. However, to date, evidence-based interventions remain limited and no study has examined the effects of multimodal physical therapy on psychosexual outcomes in these patients.

Aim: To assess the effects of multimodal physical therapy on psychosexual outcomes including sexual distress, body image concerns, pain anxiety, pain catastrophizing, pain self-efficacy and depressive symptoms in women with dyspareunia after treatment for gynecologic malignancies. Read More

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Impact of Rescue Collapse on mortality rate in severe accidental hypothermia: a matched-pair analysis.

Resuscitation 2021 Apr 27. Epub 2021 Apr 27.

Department of Anaesthesiology and Intensive Care, Medical University of Silesia, Katowice, Poland. Electronic address:

Aim: To assess the impact of the occurrence of cardiac arrest associated with initial management on the outcome of severely hypothermic patients who were rewarmed with Extracorporeal Life Support (ECLS).

Methods: We collected the individual data of patients in a state of severe accidental hypothermia who were found with spontaneous circulation and rewarmed with ECLS, from cardiac surgery departments. Patients were divided into two groups: those with a subsequent cardiac arrest (RC group); and those with the retained circulation (HT3 group), and compared by using a matched-pair analysis. Read More

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Investigation of how accurately individuals with hemiparetic stroke can mirror their forearm positions.

PLoS One 2021 30;16(4):e0250868. Epub 2021 Apr 30.

Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, Illinois, United States of America.

Current literature suggests that greater than 50% of survivors of a stroke cannot accurately perceive where their upper extremity is positioned. Our recent work demonstrates that the extent to which this perception is affected can depend on how the task is performed. For example, individuals with stroke who have a deficit in mirroring the position of their passively-placed paretic forearm during a between-arms task may accurately reproduce the position of their actively-controlled paretic forearm during a single-arm task. Read More

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Aerobic and Resistance Exercise Improve Patient-reported Sleep Quality and is Associated with Cardiometabolic Biomarkers in Hispanic and Non-Hispanic Breast Cancer Survivors who are Overweight or Obese: Results from a Secondary Analysis.

Sleep 2021 Apr 30. Epub 2021 Apr 30.

Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Study Objectives: Poor sleep quality affects nearly one third of breast cancer survivors and is associated with insulin resistance. The purpose of this secondary analysis was to examine the effects of a 16-week exercise intervention on patient-reported sleep quality among breast cancer survivors and assess whether changes in patient-reported sleep quality were associated with cardiometabolic biomarkers. We explored Hispanic ethnicity as a moderator of the effects of exercise on patient-reported sleep quality. Read More

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Effect of Traditional plus Virtual Reality Rehabilitation on Prognosis of Stroke Survivors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Am J Phys Med Rehabil 2021 Apr 28. Epub 2021 Apr 28.

Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, China College of Pharmacy, Fujian Medical University, Fuzhou, China.

Objective: Virtual reality (VR) technology has begun to be gradually applied to clinical stroke rehabilitation. The study aims to evaluate the effect of traditional plus VR rehabilitation on motor function recovery, balance, and activities of daily living in stroke patients.

Method: Studies published in English prior to October 2020 were retrieved from PubMed, EMBASE, Web of Science, and the Cochrane Library. Read More

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Health-Related Quality of Life in Pediatric Cardiac Patients After Extracorporeal Life Support.

Pediatr Cardiol 2021 Apr 30. Epub 2021 Apr 30.

Department of Cardiothoracic Surgery, Children's Health Ireland at Crumlin, Dublin, Ireland.

Extracorporeal Life Support (ECLS) is often considered successful if the child leaves intensive care alive. For the child and family, a major concern is quality of life. Aim of this study is to compare health-related quality of life scores of children following cardiac ECLS to a healthy control group. Read More

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Prevalence of erectile dysfunction in male survivors of cancer: a systematic review and meta-analysis of cross-sectional studies.

Br J Gen Pract 2021 May 29;71(706):e372-e380. Epub 2021 Apr 29.

Department of Social and Preventive Medicine, Centre for Public Health, Medical University of Vienna, Vienna, Austria.

Background: Prevalence of erectile dysfunction (ED) in male survivors of cancer across cancer types has not been systematically analysed.

Aim: To estimate the prevalence of ED in all types of cancer and identify characteristics associated with ED in survivors of cancer.

Design And Setting: Systematic review and meta-analysis (MA) of cross-sectional studies. Read More

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The Effectiveness of Massage Therapy for Improving Sequelae in Post-Stroke Survivors. A Systematic Review and Meta-Analysis.

Int J Environ Res Public Health 2021 Apr 21;18(9). Epub 2021 Apr 21.

Physiotherapy Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, 08195 Barcelona, Spain.

Objective: To assess the effect of therapeutic massage for improving sequelae in stroke survivors.

Methods: A systematic review of the nine medical databases from January 1961 to December 2020 was carried out. The bibliography was screened to identify randomized controlled clinical trials (RCTs). Read More

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Increased Levels of Adipocyte and Epidermal Fatty Acid-Binding Proteins in Acute Lymphoblastic Leukemia Survivors.

J Clin Med 2021 Apr 8;10(8). Epub 2021 Apr 8.

Department of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Bialystok, Poland.

Childhood cancer survivors are highly exposed to the development of side effects after many years of cessation of anticancer treatment, including altered lipid metabolism that may result in an increased risk of overweight and metabolic syndrome. Adipocyte (A-FABP) and epidermal (E-FABP) fatty acid-binding proteins are expressed in adipocytes and are assumed to play an important role in the development of lipid disturbances leading to the onset of metabolic syndrome. The aim of this study was to investigate the association between serum A-FABP and E-FABP levels, overweight, and components of the metabolic syndrome in acute lymphoblastic leukemia survivors. Read More

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Cognitive decline before and after a first-ever stroke in Africans.

Acta Neurol Scand 2021 Apr 29. Epub 2021 Apr 29.

Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Objectives: There is a knowledge gap on the impact of pre-existing cognitive decline on poststroke decline in indigenous Africans. We describe the trajectories of domain-specific cognitive and activities of daily life (ADL) functioning across the first year of stroke in Nigerians with pre-existing cognitive decline.

Materials And Methods: Prospective observational study. Read More

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Association of Neighborhood Socioeconomic Status With Outcomes in Patients Surviving Stroke.

Neurology 2021 Apr 28. Epub 2021 Apr 28.

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA

Objective: To examine associations between neighborhood socioeconomic status (nSES) and 90-day post-stroke outcomes.

Methods: The Brain Attack Surveillance in Corpus Christi Project is a population-based surveillance study in Nueces County, Texas. Stroke patients were identified between 2010 and 2016 via active and passive surveillance and enrolled in the study. Read More

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Effectiveness of a primary care-based integrated mobile health intervention for stroke management in rural China (SINEMA): A cluster-randomized controlled trial.

PLoS Med 2021 Apr 28;18(4):e1003582. Epub 2021 Apr 28.

Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia.

Background: Managing noncommunicable diseases through primary healthcare has been identified as the key strategy to achieve universal health coverage but is challenging in most low- and middle-income countries. Stroke is the leading cause of death and disability in rural China. This study aims to determine whether a primary care-based integrated mobile health intervention (SINEMA intervention) could improve stroke management in rural China. Read More

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Does extracorporeal shock wave therapy decrease spasticity of ankle plantar flexor muscles in patients with stroke: A randomized controlled trial.

Clin Rehabil 2021 Apr 28:2692155211011320. Epub 2021 Apr 28.

Department of Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey.

Objective: To evaluate the effectiveness of radial extracorporeal shock wave therapy on ankle flexor spasticity in stroke survivors and to reveal changes in the fibroelastic components of muscle.

Design: Randomized controlled trial.

Setting: Inpatient neuro-rehabilitation clinic of a university hospital. Read More

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Recall of clinical trial participation and attrition rates in survivors of acute respiratory distress syndrome.

J Crit Care 2021 Apr 17;64:160-164. Epub 2021 Apr 17.

VA Center for Clinical Management Research, Health Services Research and Development Center of Innovation, Ann Arbor, MI, United States; Division of Pulmonary and Critical Care, Department of Internal Medicine, University of Michigan, Ann Arbor, United States.

Purpose: To measure the rate of recall of study participation and study attrition in survivors of acute respiratory distress syndrome(ARDS).

Materials/methods: In this ancillary study of the Re-evaluation of Systemic Early neuromuscular blockade(ROSE) trial, we measured the rate of study participation recall 3 months following discharge and subsequent study attrition at 6 months. We compared patient and hospital characteristics, and long-term outcomes by recall. Read More

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Survival outcomes of in-hospital cardiac arrest in pediatric patients in the USA.

Eur J Pediatr 2021 Apr 26. Epub 2021 Apr 26.

Department of Pediatrics Critical Care, Indiana University/Riley Hospital for Children, Indiana University Health Physicians, Indianapolis, IN, USA.

We report on in-hospital cardiac arrest outcomes in the USA. The data were obtained from the National (Nationwide) Inpatient Sample datasets for the years 2000-2017, which includes data from participating hospitals in 47 US states and the District of Columbia. We included pediatric patients (< 18 years of age) with cardiac arrest, and we excluded patients with no cardiopulmonary resuscitation during the hospitalization. Read More

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Medium-term outcome of severe to critically ill patients with SARS-CoV-2 infection.

Clin Infect Dis 2021 Apr 24. Epub 2021 Apr 24.

Department of Diabetes, Endocrinology and Metabolism, Queen Elizabeth Hospital, University Hospitals Birmingham, UK.

Background: The medium and long-term effects of severe SARS-CoV-2 infection on survivors are unknown. Here we studied the medium term effects of COVID-19 on survivors of severe disease.

Methods: This is a retrospective, case series of 200 patients hospitalised across three large Birmingham hospitals with severe-to-critical COVID-19 infection 4-7 months from disease-onset. Read More

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Task-specific training for improving propulsion symmetry and gait speed in people in the chronic phase after stroke: a proof-of-concept study.

J Neuroeng Rehabil 2021 Apr 23;18(1):69. Epub 2021 Apr 23.

Sint Maartenskliniek Research, PO Box 9011, 6500 GM, Nijmegen, The Netherlands.

Background: After stroke, some individuals have latent, propulsive capacity of the paretic leg, that can be elicited during task-specific gait training. The aim of this proof-of-concept study was to investigate the effect of five-week robotic gait training for improving propulsion symmetry by increasing paretic propulsion in chronic stroke survivors.

Methods: Twenty-nine individuals with chronic stroke and impaired paretic propulsion (≥ 8% difference in paretic vs. Read More

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Disparities in Cardiovascular Disease Risk Among Hispanic Breast Cancer Survivors in a Population-Based Cohort.

JNCI Cancer Spectr 2021 Apr 15;5(2):pkab016. Epub 2021 Feb 15.

Division of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.

Background: Breast cancer is the leading cause of cancer death among Hispanic women. The aim of our study was to estimate cardiovascular disease (CVD) risk among Hispanic and non-Hispanic White (NHW) breast cancer survivors compared with their respective general population cohorts.

Methods: Cohorts of 17 469 breast cancer survivors (1774 Hispanic and 15 695 NHW) in the Utah Cancer Registry diagnosed between 1997 and 2016, and 65 866 women (6209 Hispanic and 59 657 NHW) from the general population in the Utah Population Database were identified. Read More

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Transepithelial nasal potential difference in patients with, and at risk of acute respiratory distress syndrome.

Thorax 2021 Apr 22. Epub 2021 Apr 22.

Intensive Care Unit, Royal Victoria Hospital, Belfast, UK

Background: Impaired alveolar fluid clearance, determined in part by alveolar sodium transport, is associated with acute respiratory distress syndrome (ARDS). Nasal sodium transport may reflect alveolar transport. The primary objective of this prospective, observational study was to determine if reduced nasal sodium transport, as measured by nasal potential difference (NPD), was predictive of the development of and outcome from ARDS. Read More

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The association of breast cancer-related lymphedema after unilateral mastectomy with shoulder girdle kinematics and upper extremity function.

J Biomech 2021 Apr 11;121:110432. Epub 2021 Apr 11.

Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey. Electronic address:

The purpose of this study was to examine the association of breast cancer-related lymphedema on shoulder girdle kinematics and upper extremity function. The study included 67 breast cancer survivors with and without unilateral lymphedema. Individuals were divided into non-lymphedema, moderate and severe lymphedema groups according to the volumetric measurement difference between the affected and unaffected upper extremities. Read More

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Effects of Behavioral Weight Loss and Metformin on Insulin-like Growth Factors in Cancer Survivors: A Randomized Trial.

J Clin Endocrinol Metab 2021 Apr 22. Epub 2021 Apr 22.

Department of Medicine, Johns Hopkins University.

Context: Higher levels of insulin-like growth factor-1 (IGF-1) are associated with increased risk of cancers and higher mortality. Therapies that reduce IGF-1 have considerable appeal as means to prevent recurrence.

Design: Randomized, 3-parallel-arm controlled clinical trial. Read More

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Effect of Two Interventions on Sleep Quality for Adolescent and Young Adult Cancer Survivors: A Pilot Randomized Controlled Trial.

Cancer Nurs 2021 Apr 21. Epub 2021 Apr 21.

Author Affiliations: The Third Xiangya Hospital (Ms Li and Drs Duan, Zhou, and Xie), Xiangya Nursing School (Mss Li, Wang, Sun, and Xiao), and Clinical Nursing Safety Management Research Center, Central South University (Drs Duan and Xie); and Hunan Cancer Hospital, Changsha (Dr Liu); and Department of Rehabilitation Sciences, The Hong Kong Polytechnic University (Dr Cheng), China.

Background: Sleep disturbance is common among adolescent and young adult (AYA) cancer survivors. Physical activity (PA) and behavioral activation (BA) therapy have been reported as enhancing sleep quality, but few studies exist on the effects of such interventions combined with technology to promote sleep quality in AYA cancer patients.

Objective: The aim of this study was to investigate the feasibility and effects of intelligent wearable device-based PA therapy and internet-based modified BA therapy to improve sleep quality among AYA cancer patients. Read More

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Symptom Treatment Preferences of Cancer Survivors: Does Fatigue Level Make a Difference?

Cancer Nurs 2021 Apr 21. Epub 2021 Apr 21.

Author Affiliations: Department of Psychology, Indiana University-Purdue University Indianapolis (Mss Krueger and Secinti, and Drs Mosher and Johns); Department of Medicine, Indiana University School of Medicine (Mr Stutz and Dr Johns); Indiana University School of Nursing (Dr Cohee); Center for Health Services Research, Regenstrief Institute (Dr Johns); and Research in Palliative and End-of-Life Communication and Training Center, Indiana University-Purdue University Indianapolis (Dr Johns), Indianapolis, Indiana.

Background: Cancer-related fatigue (CRF) is among the most prevalent symptoms in cancer survivors and often co-occurs with other symptoms. However, little is known about survivors' preferences for treating CRF and associated symptoms.

Objective: The aim of this study was to examine cancer survivors' interest in learning skills to manage CRF and associated symptoms and their interest in various nonpharmacologic interventions and modalities. Read More

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