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The effects of pre-emptive intravenous ibuprofen on the thiol/disulfide homeostasis and C-reactive protein level as the markers of oxidative stress and inflammation during gynecologic laparoscopy: A randomized clinical trial.

Int J Clin Pract 2021 Sep 15:e14872. Epub 2021 Sep 15.

University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital, The Department of Anesthesiology and Reanimation, Istanbul, Turkey.

Aims: In this study, we aimed to investigate the anti-inflammatory and antioxidant effects of intravenous ibuprofen by using the C-reactive protein level and thiol/disulfide homeostasis as the oxidative stress marker.

Materials And Methods: This study was conducted on 70 patients aged between 30 and 65 who were scheduled for elective laparoscopic hysterectomy. The patients were divided into two groups to receive either preemptive 800mg of intravenous ibuprofen plus 1000 mg of intravenous paracetamol (Group IP) or only 1000 mg of intravenous paracetamol as a control group (Group P). Read More

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September 2021

Biomonitoring of metallic air pollutants in unique habitations of the Brahmaputra Valley using moss species-Atrichum angustatum: spatiotemporal deposition patterns and sources.

Environ Sci Pollut Res Int 2021 Sep 15. Epub 2021 Sep 15.

Department of Environmental Science, Tezpur University, Tezpur, 784028, India.

In this paper, we have evaluated the bioaccumulation of metals by Atrichum angustatum, which is a readily available moss species in the Brahmaputra valley, India. A systematic investigation of metallic pollutants in the atmosphere was carried out using A. angustatum as a biomonitor collected from representative locations during three seasons viz. Read More

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September 2021

Factors Associated With Changes in Pregnancy Intention Among Women Who Were Mothers of Young Children in New York City Following the COVID-19 Outbreak.

JAMA Netw Open 2021 Sep 1;4(9):e2124273. Epub 2021 Sep 1.

Division of Environmental Pediatrics, Department of Pediatrics, NYU Langone Medical Center, New York, New York.

Importance: Early evidence shows a decrease in the number of US births during the COVID-19 pandemic, yet few studies have examined individual-level factors associated with pregnancy intention changes, especially among diverse study populations or in areas highly affected by COVID-19 in the US.

Objective: To study changes in pregnancy intention following the outbreak of the COVID-19 pandemic and identify factors possibly associated with these changes.

Design, Setting, And Participants: A cross-sectional, population-based study was conducted among women who were currently pregnant or had delivered a live infant and responded to a survey emailed to 2603 women (n = 1560). Read More

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September 2021

Cephalometric evaluation of changes in vertical dimension and molar position in adult non-extraction treatment with clear aligners and traditional fixed appliances.

Dental Press J Orthod 2021 10;26(4):e2119360. Epub 2021 Sep 10.

The University of Texas Health Science Center at Houston School of Dentistry, Department of Orthodontics (Houston/TX, USA).

Introduction: Orthodontists have been using clear aligners to treat malocclusions, and one potential effect of treatment with orthodontic aligners is the intrusion and/or resists extrusion of the posterior teeth. This "bite-block effect" is primarily anecdotal due to the frequent occurrence of posterior open bites in patients after clear aligner therapy.

Objective: The purpose of this study was to compare changes promoted by clear aligners and traditional fixed appliances in cephalometric measurements of the vertical dimension and molar position in adult patients with Class I malocclusion treated with non-extraction. Read More

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September 2021

Risk Factors Associated with Aggravation of Cervical Spine Lesions in Patients with Rheumatoid Arthritis.

Spine (Phila Pa 1976) 2021 Sep 14. Epub 2021 Sep 14.

Department of Orthopaedic Surgery, Yokohama City University Medical Center, 4-57 Urafune-cho, Minamai, Yokohama, Kanagawa, 232-0024, Japan.

Study Design: A retrospective cohort study.

Objective: To examine factors related to severe aggravation of pre-existing cervical lesions in patients with rheumatoid arthritis (RA) under current pharmacologic treatments with biologics.

Summary Of Background Data: Advanced RA cervical lesions carry a risk of irreversible damage to the spinal cord; however, risk factors for aggravation are unclear after the use of biologics became more popular. Read More

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September 2021

Impact of COVID-19 on Timing of Hip-Fracture Surgeries: An Interrupted Time-Series Analysis of the Pre/Post-Quarantine Period in Northern Italy.

Int J Health Policy Manag 2021 Sep 1. Epub 2021 Sep 1.

Department of Public Health Sciences and Paediatrics, Università di Torino, Torino, Italy.

Background: To assess whether the imposition of the coronavirus disease 2019 (COVID-19) national quarantine (March 10, 2020) resulted in a shift in the proportion of patients operated for hip fracture on the day of admission, the following day and two days after admission in the region of Piedmont, northern Italy.

Methods: Interrupted time-series analysis (ITSA) comparing hospitalization rate and timing of hip-fracture surgeries between pre- and post-quarantine period. The same data observed in Piedmont the year before were included as a control time series with no "intervention" (quarantine) in the middle of the observation period. Read More

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September 2021

Randomized study of rivaroxaban vs. placebo on disease progression and symptoms resolution in high-risk adults with mild COVID-19.

Clin Infect Dis 2021 Sep 15. Epub 2021 Sep 15.

Bill & Melinda Gates Medical Research Institute, Cambridge, MA, USA.

Background: SARS-CoV-2 infection may be associated with a prothrombotic state, predisposing patients for a progressive disease course. We investigated whether rivaroxaban, a direct oral anticoagulant factor Xa inhibitor would reduce COVID-19 progression.

Methods: Adults (N=497) symptomatic with mild COVID-19 and at high-risk for COVID-19 progression based on age, body mass index, or comorbidity were randomized 1:1 to either daily oral rivaroxaban 10 mg (N=246) or placebo-equivalent (N=251) for 21 days and followed to Day 35. Read More

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September 2021

[Comparison of unicompartmental knee arthroplasty and total knee arthroplasty in the treatment of severe medial compartment osteoarthritis].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Sep;35(9):1125-1132

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.

Objective: To compare the effectiveness of unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) in the treatment of severe medial compartment osteoarthritis (OA).

Methods: A clinical data of 69 patients (69 knees), who underwent joint replacement due to severe medial compartment OA between February 2015 and September 2018 and met the selection criteria, was retrospectively analyzed. Among them, 38 cases were treated with UKA (UKA group) and 31 cases with TKA (TKA group). Read More

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September 2021

AcademyHealth Annual Research Meeting (ARM): A Selection of Abstracts Accepted for Oral Presentation, 2021.

Health Serv Res 2021 09;56 Suppl 2:5-91

University of Wisconsin-Madison, Madison, Wisconsin, USA.

Research Objective: To investigate the extent to which telehealth visits mitigated COVID-19 pandemic-related impacts on in-person outpatient visits among Medicare beneficiaries, including those who are high-cost high-need. High-cost high-need patients were defined as those 65 years or older and with 2 or higher Hierarchical Condition Categories (HCC) scores.

Study Design: A difference-in-difference design was used to estimate the change in outpatient in-person and telehealth utilization for the COVID-19 pandemic cohort compared to the control cohort in the prior year. Read More

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September 2021

Continuing education meetings and workshops: effects on professional practice and healthcare outcomes.

Cochrane Database Syst Rev 2021 Sep 15;9:CD003030. Epub 2021 Sep 15.

Norwegian Institute of Public Health, Oslo, Norway.

Background: Educational meetings are used widely by health personnel to provide continuing medical education and to promote implementation of innovations or translate new knowledge to change practice within healthcare systems. Previous reviews have concluded that educational meetings can result in small changes in behaviour, but that effects vary considerably. Investigations into which characteristics of educational meetings might lead to greater impact have yielded varying results, and factors that might explain heterogeneity in effects remain unclear. Read More

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September 2021

Ethnicity, pre-existing comorbidities, and outcomes of hospitalised patients with COVID-19.

Wellcome Open Res 2021 30;6:32. Epub 2021 Jun 30.

Bradford Institute for Health Research, Bradford, West Yorkshire, BD9 6RJ, UK.

: The coronavirus disease 2019 (COVID-19) pandemic has resulted in thousands of deaths in the UK. Those with existing comorbidities and minority ethnic groups have been found to be at increased risk of mortality. We wished to determine if there were any differences in intensive care unit (ICU) admission and 30-day hospital mortality in a city with high levels of deprivation and a large community of people of South Asian heritage. Read More

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Gummy Smile Management Using Diode Laser Gingivectomy Versus Botulinum Toxin Injection - A Prospective Study.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):70-74. Epub 2021 Jul 24.

Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine for Girls, Al-Azhar University, and Taibah University, Cairo, Egypt.

Introduction: Gummy smile (GS) is a nonesthetic condition that affects the confidence of many young people. The present study aimed to compare the results of two approaches used in the management of GS in a group of Egyptian females.

Materials And Methods: This comparative cohort study included 24 female patients aged 25-35 years, divided into two groups. Read More

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A randomized controlled non-inferiority trial of primary care-based facilitated access to an alcohol reduction website (EFAR Spain).

Internet Interv 2021 Dec 20;26:100446. Epub 2021 Aug 20.

GRAC, Addictions Unit, Department of Psychiatry, Clinical Institute of Neuroscience, Hospital Clínic, RETICS, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Background: Brief interventions (BI) for risky drinkers in primary healthcare have been demonstrated to be cost-effective but they are still poorly implemented. Digital BI seems to be a complementary strategy to overcome some barriers to implementation but there is a scarcity of studies in clinical environments. We present the results of a randomized controlled non-inferiority trial which tests the non-inferiority of facilitated access to a digital intervention (experimental condition) for risky drinkers against a face-to-face BI (control condition) provided by primary healthcare professionals. Read More

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December 2021

Comparison of Colorectal Cancer Surgery Services During COVID-19 First Wave With Pre-COVID Time.

Cureus 2021 Aug 30;13(8):e17585. Epub 2021 Aug 30.

General and Colorectal Surgery, University Hospitals of Derby and Burton NHS Trust, Staffordshire, GBR.

Introduction The first confirmed case of COVID-19 in the United Kingdom (UK) was reported on 29 January 2020. The country saw the peak of infection between March and May of 2020. The result was a change in the practice of how we treat most surgical conditions including cancer. Read More

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Medium- to long-term clinical and functional outcomes of isolated and combined subscapularis tears repaired arthroscopically.

Arch Med Sci 2021 28;17(5):1351-1364. Epub 2020 Jul 28.

Orthopaedic and Traumatology Clinic, Department of Surgery, Oncology and Gastroenterology DiSCOG, University of Padua, Padova, Italy.

Introduction: The purpose of this study was twofold. First, the efficacy of arthroscopic repair in patients with full thickness, isolated subscapularis tendon tears (I-STTs) or combined subscapularis tendon tears (C-STTs) involving the rotator cuff tendons was evaluated. Second, the outcomes between these two groups were compared. Read More

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Elevated Neutrophil-to-Lymphocyte Ratio in Perioperative Periods is Suggestive of Poor Prognosis in Patients with Colorectal Cancer.

J Inflamm Res 2021 7;14:4457-4466. Epub 2021 Sep 7.

Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Recent data suggest that alterations in the neutrophil-to-lymphocyte ratio (NLR) in the perioperative periods can serve as prognostic factors. However, research on the clinical impact has been limited and even discordant in patients with colorectal cancer (CRC).

Patients And Methods: The optimal cut-off value of preoperative NLR (NLR-pre), postoperative NLR (NLR-post), and its change (NLR-delta) were determined to maximize differences in overall survival (OS) between groups. Read More

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September 2021

Evaluating Serum Thymidine Kinase 1 in Hormone Receptor Positive Metastatic Breast Cancer Patients Receiving First Line Endocrine Therapy in the SWOG S0226 Trial.

Clin Cancer Res 2021 Sep 14. Epub 2021 Sep 14.

Internal Medicine, Division of Hematology/Oncology, Department of Pharmacology, University of Michigan Medical School

Purpose: Serum Thymidine Kinase 1 (sTK1) activity is associated with poor prognosis in metastatic breast cancer (MBC). We assessed the prognostic effect of sTK1 in patients with hormone receptor-positive MBC treated on a prospective randomized trial of anastrozole (A) vs. A plus fulvestrant (A+F). Read More

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September 2021

[The development of auditory speech perception and spatial hearing abilities within one year after cochlear implantation in preschool prelingual deaf children].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Aug;56(8):812-818

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.

To investigate the development of auditory speech perception and spatial hearing abilities within one year after cochlear implantation in preschool prelingual deaf children and the relationship between the two abilities. This retrospective study analyzed 31 preschool children with an average age of (2.3±1. Read More

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Sexual selection and sexual size dimorphism in animals.

Biol Lett 2021 09 15;17(9):20210251. Epub 2021 Sep 15.

Centre d'Écologie Fonctionnelle et Évolutive, UMR 5175 CNRS, Université de Montpellier, École Pratique des Hautes Études, Montpellier, France.

Sexual selection is often considered as a critical evolutionary force promoting sexual size dimorphism (SSD) in animals. However, empirical evidence for a positive relationship between sexual selection on males and male-biased SSD received mixed support depending on the studied taxonomic group and on the method used to quantify sexual selection. Here, we present a meta-analytic approach accounting for phylogenetic non-independence to test how standardized metrics of the opportunity and strength of pre-copulatory sexual selection relate to SSD across a broad range of animal taxa comprising up to 95 effect sizes from 59 species. Read More

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September 2021

Development of in-house, indirect ELISAs for the detection of SARS-CoV-2 spike protein-associated serology in COVID-19 patients in Panama.

PLoS One 2021 14;16(9):e0257351. Epub 2021 Sep 14.

Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad de Panama, Panama.

COVID-19 is the name of the acute respiratory disease caused by the new coronavirus SARS-CoV-2, a close relative of those that caused the severe outbreaks of SARS and MERS several years ago. Since first appearance on December of 2019, the COVID-19 pandemic has cause extremely high levels of mortality, morbidity, global economic breakdown, and the consequent human suffering. The main diagnostic test for the confirmation of symptomatic individuals is the detection of viral RNA by reverse transcriptase-quantitative real time PCR (RT-PCR). Read More

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September 2021

The effect of music on fetal well-being and anxiety levels and vital signs of pregnant women during non-stress test: Turkey sample.

Health Care Women Int 2021 Sep 14:1-19. Epub 2021 Sep 14.

Faculty of Medicine, Department of Obstetrics and Gynecology, Erciyes University, Kayseri, Turkey.

To assess the effect of music on fetal well-being and anxiety levels and vital signs of pregnant women during the non-stress test. The study was a randomized controlled clinical trial. The sample comprised of 74 (37 music and 37 control group) pregnant women. Read More

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September 2021

Endograft apposition and infrarenal neck enlargement after endovascular aortic aneurysm repair.

J Cardiovasc Surg (Torino) 2021 Sep 14. Epub 2021 Sep 14.

Department of Surgery, Division of Vascular Surgery, University Medical Center Groningen, Groningen, The Netherlands.

Background: Sufficient apposition and oversizing of the endograft in the aortic neck are both essential for durable endovascular aneurysm repair (EVAR). These measures are however not regularly stated on post-EVAR computed tomography angiography (CTA) scan reports. In this study endograft apposition and neck enlargement (NE) after EVAR with an Endurant II(s) endograft were analyzed and associated with supra- and infrarenal aortic neck morphology. Read More

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September 2021

All cause hepatocellular carcinoma survival in the era of direct-acting antiviral therapy.

J Gastroenterol Hepatol 2021 Sep 14. Epub 2021 Sep 14.

St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, New South Wales, Australia.

Background And Aims: Hepatitis C virus (HCV) cure with direct-acting antiviral (DAA) therapy improves survival in patients with HCV-related hepatocellular carcinoma (HCC). We hypothesised that HCV-HCC survival has increased in the DAA-era, more than other aetiologies of HCC. We aimed to evaluate survival following HCC diagnosis in the pre-DAA and DAA eras, across each aetiology of HCC. Read More

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September 2021

Muscle Flap Reconstruction Based on Muscle Tension Line Groups to Repair the Philtrum of Patients With Microform Cleft Lip or Secondary Cleft Lip.

J Craniofac Surg 2021 Sep 14. Epub 2021 Sep 14.

Department of Cleft Lip and Palate, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, China.

Abstract: The muscle flap reconstruction technique was developed based on the concept of muscle tension line groups, which elucidates how nasolabial muscle tension helps maintain the shape of the philtrum. To investigate the operative effect, we reviewed 43 patients with microform cleft lip and 102 patients with secondary cleft lip treated with muscle flap reconstruction between January 2018 and June 2020. The patients were scanned using the digital three-dimensional stereophotogrammetry face system pre- and post-operatively, and comparative analysis of three-dimensional (3D) images was used to highlight variations of the philtrum. Read More

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September 2021

Effectiveness of ADC Difference Value on Pre-neoadjuvant Chemotherapy MRI for Response Evaluation of Breast Cancer.

Authors:
Bo Bae Choi

Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211039129

26715Chungnam National University Hospital, Daejeon, Republic of Korea.

Neoadjuvant chemotherapy (NAC) is known to be a suitable treatment and first-line defense for locally advanced breast cancer. However, the NAC response may include unexpected outcomes, and it is not easy to predict the NAC response precisely. Especially, early detection of those patients who do not benefit from NAC is needed to reduce unnecessary therapy and side effects. Read More

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September 2021

Non-pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy.

Cochrane Database Syst Rev 2021 Sep 14;9:CD013330. Epub 2021 Sep 14.

Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine / School of Public Health, Kyoto, Japan.

Background: Acute kidney injury (AKI) is a common complication amongst people who are critically ill, and it is associated with an increased risk of death. For people with severe AKI, continuous kidney replacement therapy (CKRT), which is delivered over 24 hours, is needed when they become haemodynamically unstable. When CKRT is interrupted due to clotting of the extracorporeal circuit, the delivered dose is decreased and thus leading to undertreatment. Read More

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September 2021

The impacts of including information about the number of carcinogens in smoke on standardized cigarette packs in the UK.

Eur J Public Health 2021 Sep 14. Epub 2021 Sep 14.

National Addiction Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.

Background: Since May 2017, standardized packaging has been mandatory in the UK, with packs required to display an 'information message' explaining that there are more than 70 carcinogens in tobacco smoke.

Methods: Three waves of a longitudinal online survey in the UK with smokers pre-standardized packaging (Wave 1: April-May 2016) and followed up post-standardized packaging (Wave 2: September-November 2017, Wave 3: May-July 2019). Of the 6233 smokers at Wave 1, 4293 responded at Wave 2 and 3175 at Wave 3. Read More

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September 2021

Precise evaluation of the postoperative cochlear duct length by flat-panel volume computed tomography - Application of secondary reconstructions.

Cochlear Implants Int 2021 Sep 14:1-11. Epub 2021 Sep 14.

Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery and the Comprehensive Hearing Center, University of Würzburg, Würzburg, Germany.

Objective: There is still a lack in precise postoperative evaluation of the cochlea because of strong artifacts. This study aimed to improve accuracy of postoperative two-turn (2TL) and cochlear duct length (CDL) measurements by applying flat-panel volume computed tomography (fpVCT), secondary reconstruction (fpVCT) and three-dimensional curved multiplanar reconstruction.

Methods: First, 10 temporal bone specimens with or without electrode were measured in multi-slice computed tomography (MSCT), fpVCT and fpVCT and compared to high-resolution micro-CT scans. Read More

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September 2021

Comparison of Expanded New Ballard, Eregie and Parkin Scores in Predicting Gestational Age in Newborns.

J Trop Pediatr 2021 08;67(4)

Department of Pediatrics, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry 607402, India.

Background: Postnatal gestational age (GA) estimation is crucial in neonates with absent early trimester ultrasonography (USG) reports to evaluate the risk of morbidity and mortality. Widely used Expanded New Ballard (ENBS) is complex and needs an expert medical professional to assess. Eregie (ES) and Parkin (PS) scores are easy to perform with good inter-observer reliability. Read More

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