Mater Sci Eng C Mater Biol Appl 2020 Apr 7;109:110643. Epub 2020 Jan 7.
Programa de pós-graduação em Ciências Veterinárias, Departamento de Ciências Veterinárias, Centro de Ciências Agrárias e Engenharias, Universidade Federal do Espírito Santo - UFES, 29.500-000, Alegre, ES, Brazil; Laboratório de Produção Farmacêutica, Departamento de Farmácia e Nutrição, Centro de Ciências Exatas, Naturais e da Saúde, Universidade Federal do Espírito Santo - UFES, 29.500-000 Alegre, ES, Brazil. Electronic address:
Chronic wounds constitute a serious public health problem, and developing pharmaceutical dosage forms to ensure patient comfort and safety, as well as optimizing treatment effectiveness, are of great interest in the pharmaceutical, medical and biomaterial fields. In this work, the preparation of films based on blends of poly(vinyl alcohol), starch and poly(acrylic acid), polymers widely used as pharmaceutical excipients, and pomegranate peel extract (PPE), a bioactive compound with antimicrobial and healing activities relevant to the use as a bioactive wound dressing, was proposed. Initially, the minimum inhibitory concentration (MIC) of the PPE was investigated by an in vitro method. Read More