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Measurement of multiple spleen lengths is not necessary for non-invasive prediction of high-risk esophagogastric varices.

Hepatol Res 2021 Sep 27. Epub 2021 Sep 27.

Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Touon, Ehime, Japan.

Aim: To validate an appropriate spleen size measurement technique for the prediction of high-risk esophagogastric varices.

Methods: This retrospective cross-sectional study included 369 patients who underwent ultrasonography and computed tomography (CT) of the spleen and esophagogastroduodenoscopy between January 2018 and December 2020. Maximum spleen length, width, and craniocaudal length were measured in a longitudinal view. Read More

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September 2021

Developing a Predictive Model for -Susceptible Areas in Malaysia Using Geospatial Data and Artificial Neural Networks.

Asia Pac J Public Health 2021 Sep 27:10105395211048620. Epub 2021 Sep 27.

University of Selangor (UNISEL), Malaysia.

is an emerging species for malaria in Malaysia, particularly in East Malaysia. This infection contributes to almost half of all malaria cases and deaths in Malaysia and poses a challenge in eradicating malaria. The aim of this study was to develop a predictive model for susceptibility areas in Sabah, Malaysia, using geospatial data and artificial neural networks (ANNs). Read More

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September 2021

The Effect of Adiposity on Cardiovascular Function and Myocardial Fibrosis in Patients With Duchenne Muscular Dystrophy.

J Am Heart Assoc 2021 Sep 25:e021037. Epub 2021 Sep 25.

Pediatric Cardiology and Heart Institute, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh Pittsburgh PA.

Background Patients with Duchenne muscular dystrophy (DMD) develop cardiomyopathy because of a dystrophin deficiency causing fibrofatty replacement of the myocardium. Corticosteroid use and mobility limitations place these patients at risk for increased adiposity. We sought to determine the association of adiposity with cardiovascular dysfunction in patients with DMD. Read More

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September 2021

Untargeted LC-MS-based metabonomic analysis of the effect of photoperiod on the testes of broiler roosters.

J Anim Physiol Anim Nutr (Berl) 2021 Sep 26. Epub 2021 Sep 26.

Joint Laboratory of Modern Agricultural Technology International Cooperation, Ministry of Education, Jilin Agricultural University, Changchun, China.

Photoperiod is an important factor that stimulates the reproductive performance of broiler breeder roosters. However, the mechanism by which photoperiod affects the reproductive performance of broiler breeder roosters has not been fully studied. To study the effects of different photoperiods on the reproductive performance of broiler breeder roosters, 120 Arbor Acres broiler breeder roosters aged 20 weeks were randomly assigned to three groups (n = 40), and the three groups were treated with different photoperiod regimes: control (CTR; 12. Read More

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September 2021

Evaluation of the Stress Tolerance of with Different Antibiotic Resistance Profiles.

Biomed Res Int 2021 14;2021:5604458. Epub 2021 Sep 14.

State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, MOA Laboratory of Quality & Safety Risk Assessment for Agro-Products (Hangzhou), Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.

Disease caused by antibiotic-resistant is a serious clinical problem that poses a great threat to public health. The present study is aimed at assessing differences in bacterial kinetics with different antibiotic resistance profiles under environmental stress and at developing microbial tolerance models in lettuce during storage from 4 to 36°C. The drug-resistance phenotypes of 10 Typhimurium (. Read More

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September 2021

MRI-Only Radiotherapy Planning for Nasopharyngeal Carcinoma Using Deep Learning.

Front Oncol 2021 8;11:713617. Epub 2021 Sep 8.

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Radical radiotherapy is the main treatment modality for early and locally advanced nasopharyngeal carcinoma (NPC). Magnetic resonance imaging (MRI) has the advantages of no ionizing radiation and high soft-tissue resolution compared to computed tomography (CT), but it does not provide electron density (ED) information for radiotherapy planning. Therefore, in this study, we developed a pseudo-CT (pCT) generation method to provide necessary ED information for MRI-only planning in NPC radiotherapy. Read More

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September 2021

Olfactory dysfunction is a risk factor for the comorbidity of mild cognitive impairment and Type 2 diabetes mellitus.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Aug;46(8):831-837

Intensive Care Unit, Department of Neurology, Third Xiangya Hospital, Central South University, Changsha 410013.

Objectives: Diabetes can accelerate cognitive decline and hence affect the prognosis of patients with Type 2 diabetes mellitus (T2DM). Olfactory assessment can facilitate the early identification of cognitive impairment among T2DM patients. This study aims to evaluate the effects of olfactory function on mild cognitive impairment (MCI) in patients with T2DM. Read More

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Effects of varying statistical uncertainty using a Monte Carlo based treatment planning system for VMAT.

J BUON 2021 Jul-Aug;26(4):1683

Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.

Purpose: To determine the severity of the effects on VMAT dose calculations caused by varying statistical uncertainties (SU) per control point in a Monte Carlo based treatment planning system (TPS) and to assess the impact of the uncertainty during dose volume histogram (DVH) evaluation.

Methods: For this study, 13 archived patient plans were selected for recalculation. Treatment sites included prostate, lung, and head and neck. Read More

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September 2021

Neuromuscular Adjustments Following Sprint Training with Ischemic Preconditioning in Endurance Athletes: Preliminary Data.

Sports (Basel) 2021 Sep 2;9(9). Epub 2021 Sep 2.

Department of Kinesiology, Laval University, Quebec, QC G1V 0A6, Canada.

This preliminary study examined the effect of chronic ischemic preconditioning (IPC) on neuromuscular responses to high-intensity exercise. In a parallel-group design, twelve endurance-trained males (VOmax 60.0 ± 9. Read More

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September 2021

Estimation of (Acari: Ixodidae) Populations of Kaylaka Park in the Town of Pleven, Bulgaria.

Insects 2021 Sep 9;12(9). Epub 2021 Sep 9.

Department of Infectious Diseases and Epidemiology, Medical University-Pleven, 1 Kliment Ohridski Str., 5800 Pleven, Bulgaria.

(1) Background: Ticks are vectors of a large number of pathogenic microorganisms, which cause serious diseases in both humans and animals. Kaylaka Park is located in northern Bulgaria close to the city of Pleven. Part of the park is urbanized and visited daily by many citizens. Read More

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September 2021

Strides to Achieve a Stable Symmetry Index During Running.

J Sport Rehabil 2021 Sep 25:1-6. Epub 2021 Sep 25.

Context: The quality of running mechanics is often characterized by limb pattern symmetry and used to support clinical decisions throughout the rehabilitation of lower-extremity injuries. It is valuable to ensure that gait analyses provide stable measures while not asking an individual to complete an excessive number of running strides. The present study aimed to determine the minimum number of strides required to establish a stable mean symmetry index (SMSI) of discrete-level measures of spatiotemporal parameters, joint kinematics, and joint kinetics. Read More

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September 2021

Effects of hypertonic saline on intracranial pressure and cerebral autoregulation in pediatric traumatic brain injury.

J Neurosurg Pediatr 2021 Sep 24:1-7. Epub 2021 Sep 24.

2Pediatric Intensive Care Unit, University Children's Hospital of Tuebingen, Tuebingen; and.

Objective: Hypertonic saline (HTS) is commonly used in children to lower intracranial pressure (ICP) after severe traumatic brain injury (sTBI). While ICP and cerebral perfusion pressure (CPP) correlate moderately to TBI outcome, indices of cerebrovascular autoregulation enhance the correlation of neuromonitoring data to neurological outcome. In this study, the authors sought to investigate the effect of HTS administration on ICP, CPP, and autoregulation in pediatric patients with sTBI. Read More

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September 2021

Exercise training and probiotic supplementation effects on skeletal muscle apoptosis prevention in type-Ι diabetic rats.

Life Sci 2021 Sep 21:119973. Epub 2021 Sep 21.

Department of Exercise Physiology, Faculty of Sport Sciences, University of Birjand, Birjand, Iran.

Aims: Hyperglycemia occurring in the diabetic condition can cause apoptosis via the mitochondrial pathway with higher pro-apoptotic protein expression. Probiotics are viable microorganisms that have anti-diabetic and antioxidant effects. Also, exercise may affect the signaling pathways of skeletal muscle apoptosis. Read More

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September 2021

High varus stem alignment in short-stem total hip arthroplasty: a risk for reconstruction of femoro-acetabular offset, leg length discrepancy and stem undersizing?

Arch Orthop Trauma Surg 2021 Sep 23. Epub 2021 Sep 23.

Department for Orthopedics and Traumatology, Kepler University Hospital GmbH, Krankenhausstrasse 9, 4020, Linz, Austria.

Purpose: Short stems are increasingly used in in total hip arthroplasty (THA) because of advantages in bone and soft tissue preservation and reconstruction of hip geometry. Short stems can be inserted in a more varus position compared to conventional straight stems. This poses the risk of final varus misplacement of the femoral component, which is not intended in all femoral short stems. Read More

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September 2021

Quantification of pulmonary perfusion abnormalities using DCE-MRI in COPD: comparison with quantitative CT and pulmonary function.

Eur Radiol 2021 Sep 22. Epub 2021 Sep 22.

Department of Diagnostic and Interventional Radiology, Subdivision of Pulmonary Imaging, University Hospital of Heidelberg, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.

Objectives: Pulmonary perfusion abnormalities are prevalent in patients with chronic obstructive pulmonary disease (COPD), are potentially reversible, and may be associated with emphysema development. Therefore, we aimed to evaluate the clinical meaningfulness of perfusion defects in percent (QDP) using DCE-MRI.

Methods: We investigated a subset of baseline DCE-MRIs, paired inspiratory/expiratory CTs, and pulmonary function testing (PFT) of 83 subjects (age = 65. Read More

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September 2021

Clarifying the Implicit Assumptions of Two-Wave Mediation Models the Latent Change Score Specification: An Evaluation of Model Fit Indices.

Front Psychol 2021 6;12:709198. Epub 2021 Sep 6.

Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Statistical mediation analysis is used to investigate mechanisms through which a randomized intervention causally affects an outcome variable. Mediation analysis is often carried out in a pretest-posttest control group design because it is a common choice for evaluating experimental manipulations in the behavioral and social sciences. There are four different two-wave (i. Read More

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September 2021

Digital Shared Decision-Making Interventions in Mental Healthcare: A Systematic Review and Meta-Analysis.

Front Psychiatry 2021 6;12:691251. Epub 2021 Sep 6.

Copenhagen Research Center for Mental Health - CORE, Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.

Shared decision-making (SDM) in mental healthcare has received increased attention as a process to reinforce person-centered care. With the rapid development of digital health technology, researchers investigate how digital interventions may be utilized to support SDM. Despite the promise of digital interventions to support SDM, the effect of these in mental healthcare has not been evaluated before. Read More

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September 2021

Comparison of individual and combination treatments with naproxen, prednisolone and hydroxychloroquine to treat Complete Freund's Adjuvant induced arthritis.

Inflammopharmacology 2021 Sep 22. Epub 2021 Sep 22.

Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah, 21442, Saudi Arabia.

Aim of this study was to evaluate and compare the efficacy of anti-arthritic drugs (naproxen, prednisolone, and hydroxychloroquine) alone and in combination. The in vitro anti-arthritic activity was evaluated by stabilization of human erythrocytes (HRBCs) membrane assays. In vivo activity was carried out using Complete Freund's Adjuvant (CFA) induced arthritic model in Wistar rat. Read More

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September 2021

Gut Microbiota Dysbiosis Associated with Plasma Levels of Interferon-γ and Viral Load in Patients with Acute Hepatitis E Infection.

J Med Virol 2021 Sep 22. Epub 2021 Sep 22.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Rd, Hangzhou, 310003, China.

Few studies have focused on the effect of hepatitis E virus (HEV) infection on gut microbiota. In order to explore the relationship between changes in gut microbiota and inflammatory factors and viral load, we conducted a comparative study of 33 patients with acute hepatitis E (AHE) patients and 25 healthy controls (HCs) using high-throughput 16S rRNA gene sequencing. Shannon and Simpson indices showed no significant differences in bacterial diversity between the AHE and HCs groups. Read More

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September 2021

Impact of Preoperative Nutritional Indicator on Poor Postoperative Outcomes in Geriatric Patients with Colorectal Cancer.

Nutr Cancer 2021 Sep 21:1-9. Epub 2021 Sep 21.

Department of Surgery, Kyoto Chubu Medical Center, Nantan, Japan.

The present study aimed to analyze the association between preoperative nutritional assessment and poor postoperative outcomes in geriatric patients with colorectal cancer. This retrospective study included 138 patients aged ≥80 years with colorectal cancer who underwent surgery from January 2013 to December 2018. Patients were classified into two groups according to outcomes, poor group and normal group. Read More

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September 2021

Evaluation of the effect of gestational diabetes mellitus on fetal cardiac functions with myocardial performance index.

Minerva Obstet Gynecol 2021 Sep 21. Epub 2021 Sep 21.

Department of Pediatric Cardiology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.

Objective: We aimed to evaluate the fetal cardiac functions with myocardial performance index( MPI) in gestational diabetes mellitus (GDM).

Materials And Methods: In this study, 35 patients who were diagnosed with GDM and 35 pregnant without glucose intolerance and their babies were evaluated. Fetal echocardiographic, biometric measurements, umbilical artery pulsatility indices (UAPI) and ductus venosus pulsatility indices (DVPI) measurements were performed to evaluate fetal well-being between the groups. Read More

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September 2021

Spatial Associations of Key Lepidopteran Pests With Defoliation, NDVI, and Plant Height in Soybean.

Environ Entomol 2021 Sep 21. Epub 2021 Sep 21.

Department of Plant and Environmental Sciences, Edisto Research and Education Center, Clemson University, 64 Research Road, Blackville, SC 29817, USA.

In soybean, Glycine max (L.) Merrill, production, losses to, and control costs for insect pests can be significant limiting factors. Although the heterogeneity of pests has typically been ignored in traditional field management practices, technological advancements have allowed for site-specific pest management systems to be developed for the precise control of pests within a field. Read More

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September 2021

Comparison of angiographic and intravascular ultrasound vessel measurements in infra-popliteal endovascular interventions: The below-the-knee calibration study.

Cardiovasc Revasc Med 2021 Sep 16. Epub 2021 Sep 16.

Cardiology, NC Heart and Vascular Research, LLC, UNC School of Medicine, Raleigh, NC, USA. Electronic address:

Background: Endovascular revascularization (ER) via percutaneous transluminal angioplasty (PTA) and stenting are viable options for revascularization in below-the-knee (BTK) peripheral arterial disease. Two-dimensional angiography has been the standard of practice for estimating vessel size and selecting treatment devices during ER. However, in other vascular territories, intravascular ultrasound (IVUS) offers better visualization of the lumen dimensions. Read More

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September 2021

Analogs of microgravity: the function of Schlemm's canal, intraocular pressure and autonomic nervous during the head-down tilt test in healthy subjects.

Int J Ophthalmol 2021 18;14(9):1419-1423. Epub 2021 Sep 18.

Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China.

Aim: To evaluate the ocular outcomes and to elucidate possible mechanisms underlying intraocular pressure (IOP) change following the head-down tilt (HDT) test.

Methods: The study included 21 participants at the Department of Ophthalmology of Tongji Hospital. Subjects received the test of I-care tonometry, enhanced depth imaging optical coherence tomography and heart rate variability (HRV) analysis before and after 15min HDT test. Read More

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September 2021

Photogrammetric Analysis of Nasal Dimensions in Indian Malaysian Adults.

J Craniofac Surg 2021 Sep 17. Epub 2021 Sep 17.

College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health sciencesKing Abdullah International Medical Research Centre, Al Ahsa, Saudi Arabia.

Abstract: In cosmetic rhinoplasty, knowledge of average nasal dimensions is important to create an aesthetic nose compatible with gender, ethnicity, and other facial feature. This study aimed to establish gender-specific nasal anthropometric data for Indian Malaysians (IMs) and to determine the interracial difference by comparing it with published data of three studies. Evaluation of nasal morphology was done on the standardized frontal, lateral, and basal photographs of 200 male and 200 female IM noses, aged 18-27 years. Read More

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September 2021

[Pre-clinical studies of cold exposure to evaluate the efficiency and functionality of a specialized product].

Vopr Pitan 2021 22;90(4):138-143. Epub 2021 Jul 22.

Military Unit No. 51956, 675000, Blagoveshchensk, Russian Federation.

Strengthening the adaptive capabilities of the human body during cold exposure is one of the conceptual elements of solving the problem of the well-being of the population of the northern regions of Russia. of the work was to determine the dynamic performance, endurance and to study the morphological parameters of the rat tracheal mucosa against the background of the consumption of functional confectionery products containing the juice of Chinese lemongrass berries (Schisandra chinensis) and dry extract of eleutherococcus (Eleutherococcus) in regular exposure to cold. . Read More

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Foliar optical traits capture physiological and phenological leaf plasticity in Tilia×euchlora in the urban environment.

Sci Total Environ 2021 Sep 11;805:150219. Epub 2021 Sep 11.

Department of Earth and Environmental Sciences, KU Leuven, 3001 Heverlee, Belgium. Electronic address:

Knowledge on the response of trees to the urban heat island (UHI) effect and soil sealing is currently limited, yet of vital importance in an era characterized by both climate change and urbanization. We investigated the physiological and phenological leaf plasticity of Tilia×euchlora trees to the UHI effect and soil sealing and explored the potential of leaf optical traits to quantify the magnitude of leaf plasticity. Temporal changes of leaf water content (LWC), specific leaf area (SLA), total chlorophyll (Chl) and carotenoids (Car) content, Car:Chl ratio and leaf reflectance for 46 Tilia×euchlora trees were measured along a soil sealing and urbanization gradient. Read More

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September 2021

Exercise heart rate reserve and recovery as risk factors for sudden cardiac death.

Prog Cardiovasc Dis 2021 Sep 15. Epub 2021 Sep 15.

Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; Graduate School of Urban Public Health, University of Seoul, Seoul, Republic of Korea.

Background: Little is known if heart rate responses during and after exercise test may be associated with the risk of sudden cardiac death (SCD). Our aim was to determine if exercise heart rate reserve and recovery, providing non-invasive indices, may predict SCD risk in general male population.

Methods: We evaluated the impact of delayed heart rate reserve and slow heart rate recovery and the risk of SCD in the Kuopio Ischemic Heart Disease prospective cohort study of randomly selected 1967 men aged 42-61 years at recruitment. Read More

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September 2021

Clinical features of obstructive sleep apnea in children with obesity.

Zhongguo Dang Dai Er Ke Za Zhi 2021 Sept 15;23(9):933-937

Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong 518026, China (Yang Q, Email: com).

Objectives: To study the clinical features of obstructive sleep apnea (OSA) in children with obesity.

Methods: A retrospective analysis was performed on the medical data of 33 obese children aged 7-15 years, who were diagnosed with OSA and received polysomnography (PSG) in the Department of Respiratory Medicine in Shenzhen Children's Hospital. Fifty OSA children with normal body weight, matched for sex and age, were enrolled as the control group. Read More

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September 2021

Efficacy of Huaiqihuang granules as adjuvant therapy for bronchial asthma in children: a real-world study.

Zhongguo Dang Dai Er Ke Za Zhi 2021 Sept 15;23(9):877-881

Children's Hospital of Capital Institute of Pediatrics, Beijing 100020, China(LiuC-H, Email:

Objectives: To study the efficacy of Huaiqihuang granules as adjuvant therapy for bronchial asthma in children.

Methods: A multicenter, prospective, and registered real-world study was performed for the children, aged 2-5 years, who had a confirmed diagnosis of bronchial asthma in the outpatient service of 21 hospitals in China. Among these children, the children treated with medications for long-term asthma control (inhaled corticosteroid and/or leukotriene receptor antagonist) without Huaiqihuang granules were enrolled as the control treatment group, and those treated with medications for long-term asthma control combined with Huaiqihuang granules were enrolled as the combined treatment group. Read More

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September 2021