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Remote transmission monitoring for postoperative perineural analgesia after major orthopedic surgery: A multicenter, randomized, parallel-group, controlled trial.

J Clin Anesth 2021 Dec 1;77:110618. Epub 2021 Dec 1.

Department of Anesthesiology and Critical Care Medicine, Lapeyronie University Hospital, 34295 Montpellier Cedex 5, France; Department of Medical Statistics, and Epidemiology, Montpellier University Hospital, 34295 Montpellier Cedex 5, France.

Study Objective: After surgery, patients reported the delay in receiving help as the primary factor for poorly controlled pain. This study aimed to compare the effectiveness of patient management through two communication modalities: remote transmission (RT) versus bedside control (BC). We hypothesized that using remote technology for pump programming may provide the best postoperative infusion regimen for the patient's self-assessment of pain and adverse events. Read More

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December 2021

A 3D Mirroring and Colormap Asymmetry Study of Class II Subdivision Patients.

Orthod Craniofac Res 2021 Dec 4. Epub 2021 Dec 4.

Clinical Assistant Professor, Department of Orthodontics, Case Western Reserve University, School of Dental Medicine, Cleveland, Ohio, USA.

Introduction: Patients with Class II subdivision malocclusion present skeletal and dental asymmetries. The purpose of this study is to assess those asymmetries by 3D mirroring and colormap quantification.

Methods: This study analyzed 50 initial CBCTs divided in two groups: Class I (control group) and Class II subdivision (study group) malocclusion patients. Read More

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December 2021

Psychomotor development in infants and young children with Down syndrome-A prospective, repeated measure, post-hoc analysis.

Am J Med Genet A 2021 Dec 4. Epub 2021 Dec 4.

Institut Jérôme Lejeune, Paris, France.

Children with Down syndrome (DS) show delayed acquisition of cognitive and functional skills compared to typically developing children. The objective of this study was to accurately describe early development of infants and young children (children hereafter) with DS based on a large recent sample. We carried out repeated measure analysis of the global development quotient (GDQ) and developmental age using data from the Assessment of Systematic Treatment with Folinic Acid and Thyroid Hormone on Psychomotor Development of Down Syndrome Young Children (ACTHYF) study (NCT01576705). Read More

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December 2021

Comparison of Long-Term Effects After Modified CO Laser-Assisted Deep Sclerectomy and Conventional Trabeculectomy in Chinese Primary Open-Angle Glaucoma.

Ophthalmol Ther 2021 Dec 4. Epub 2021 Dec 4.

Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Dongdan Shuaifuyuan 1#, Beijing, 100730, China.

Introduction: To compare the long-term effect after modified CO laser-assisted sclerectomy surgery (MCLASS) and conventional trabeculectomy (TRAB) in medically uncontrolled Chinese primary open-angle glaucoma (POAG) patients. This was a retrospective comparative study.

Methods: A total of 87 patients were reviewed, including 45 in the MCLASS group and 42 in the TRAB group. Read More

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December 2021

Therapeutic effect of Danhong injection on diabetic patients with cerebral infarction and its influence on vascular endothelial function and hemodynamics.

Pak J Pharm Sci 2021 Sep;34(5(Special)):2065-2069

Neurology Department, Qingdao Chengyang District People's Hospital, Qingdao, China.

To investigate the therapeutic effect of Danhong injection on diabetic patients with cerebral infarction and its influence on vascular endothelial function and hemodynamic level. A total of 100 diabetic patients with cerebral infarction admitted to our hospital from November 2019 to November 2020 were identified as the research subjects and randomly divided into a control group given routine treatment and a study group treated with Danhong injection, with 50 cases in each group. The efficiency of the two groups on vascular endothelial function, blood glucose level, National Institute of Health Stroke Scale (NIHSS) score, the incidence of adverse reactions, and hemodynamic indicators were compared. Read More

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September 2021

A comparative study of olanzapine, aripiprazole and risperidone in the treatment of psychiatric and behavioral symptoms of Alzheimer's disease.

Pak J Pharm Sci 2021 Sep;34(5(Special)):2053-2057

The Yancheng Clinical College of Xuzhou Medical University, The First people's Hospital of Yancheng, Yancheng, China.

To investigate the efficacy and safety of olanzapine, aripiprazole, and risperidone in the treatment of mental and behavioral symptoms of Alzheimer's Disease. A retrospective analysis was performed on the clinical data of 126 patients with Alzheimer's Disease from February 2018 to February 2020. The patients were divided into group A (aripiprazole, n=44), group B (olanzapine, n=42) and group C (risperidone, n=40) based on the treatment method. Read More

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September 2021

Combined anti-cancer effects of curcumin and oxaliplatin on colon carcinoma colo205 cells using transplanted nude mice.

Pak J Pharm Sci 2021 Sep;34(5(Special)):2021-2025

Department of General Surgery, Taian City Central Hospital, Shandong, PR China.

The objective of this study was to investigate the effects of curcumin combined with oxaliplatin on human colon carcinoma Colo205 cells and to analyze the anti-cancer mechanism. Sixty nude mice were inoculated with Colo205 cells as tumor transplanted models which were randomly divided into control group, curcumin group, oxaliplatin group and curcumin plus oxaliplatin group (n=15 in each group). The volume of tumor and the tumor suppressor rate was calculated after continuous administration of the curcumin or oxaliplatin for 10 times. Read More

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September 2021

Analysis of Biofilm Adhesion on CAD/CAM Lithium Disilicates Under Different Types of Intraoral Polishing.

Eur J Prosthodont Restor Dent 2021 Nov 16. Epub 2021 Nov 16.

São Paulo State University (UNESP), School of Dentistry, Araçatuba.

Purpose: To evaluate the adhesion of Streptococcus mutans (S. mutans) on lithium disilicate ceramics, submitted to different intraoral polishing protocols, and the degree of surface smoothness obtained.

Materials And Methods: Fifty lithium disilicate specimens were divided into 5 groups (n=10): G1-Glaze Group (positive control); G2-Glaze Group + Wear + Glaze; G3-Wear Group (negative control); G4-Ceramisté Wear Group; G5-Optrafine Wear Group. Read More

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November 2021

Relaxation time of brain tissue in the elderly assessed by synthetic MRI.

Brain Behav 2021 Dec 4:e2449. Epub 2021 Dec 4.

Division of Neuroradiology, Department of Diagnostics, Geneva University Hospitals, Geneva, Switzerland.

Background: Synthetic MRI (SyMRI) is a quantitative technique that allows measurements of T1 and T2 relaxation times (RTs). Brain RT evolution across lifespan is well described for the younger population. The aim was to study RTs of brain parenchyma in a healthy geriatric population in order to define the normal value of structures in this group population. Read More

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December 2021

Effects of AST-120 on muscle health and quality of life in chronic kidney disease patients: results of RECOVERY study.

J Cachexia Sarcopenia Muscle 2021 Dec 3. Epub 2021 Dec 3.

Department of Internal Medicine, CHA Gumi Medical Center, CHA University, Gumi, Republic of Korea.

Background: The prevalence of sarcopenia is increased with declining renal function. Elevated serum indoxyl sulfate levels are associated with poor skeletal muscle conditions. We aimed to determine the effects of AST-120, the oral adsorbent of indoxyl sulfate, on sarcopenia and sarcopenia-associated factors in chronic kidney disease patients. Read More

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December 2021

Proprioceptive and Clinical Outcomes after Remnant Preserved Anterior Cruciate Ligament Reconstruction: Assessment with Minimal Confounding Factors.

Orthop Surg 2021 Dec 4. Epub 2021 Dec 4.

Department of Sports Medicine, Chinese PLA General Hospital, Beijing, China.

Objective: To evaluate the proprioceptive and clinical function of the knee joint after anterior cruciate ligament reconstruction (ACLR) with various amounts of remnant preserved with as few confounding factors as possible.

Methods: This retrospective study included 46 patients who underwent ACLR with remnant preservation between March 2013 and February 2019. These patients had less than 6 months injury-to-surgery interval and no concomitant injuries. Read More

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December 2021

Use of intermittently scanned continuous glucose monitoring in young people with high-risk type 1 diabetes - extension phase outcomes following a 6-month randomised control trial.

Diabet Med 2021 Dec 4:e14756. Epub 2021 Dec 4.

University of Otago, New Zealand, Department of Women's and Children's Health, Dunedin School of Medicine, Dunedin, 9054, New Zealand.

Aims: To describe the impact of a 12-month intervention using intermittently scanned continuous glucose monitoring (isCGM) on glycaemic control and glucose test frequency in adolescents and young adults with type 1 diabetes (T1D) and high-risk glycaemic control (HbA1c ≥75 mmol/mol [≥9.0 %]).

Methods: In total, 64 young people (aged 13-20 years, 16. Read More

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December 2021

The Role of Superb Microvascular Imaging and Shearwave Elastography in the Evaluation of Intraductal Papilloma-Like Lesions.

J Ultrasound Med 2021 Dec 3. Epub 2021 Dec 3.

Senology Research Institute, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.

Objectives: The aim of this study was to investigate the role of quantitative values obtained by superb microvascular imaging (SMI) and shearwave elastography (SWE) in the prediction of malignancy in intraductal papilloma-like lesions (IDPL).

Methods: In the study, 61 patients between the ages of 14 to 73 years (mean age 44) diagnosed with IDPL on ultrasound (US) examination between the years 2020 and 2021 were included. The B-Mode US findings (shape, margins, size, echo pattern, and accompanying ductal dilatation), SMI vascular index (SMIvi), E-mean, and SWE-ratio values were recorded. Read More

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December 2021

Medicaid Prevalence and Opioid Use Disorder Treatment Access Disparities.

Health Serv Res 2021 Dec 3. Epub 2021 Dec 3.

Vanderbilt Center for Child Health Policy, Department of Pediatrics, Department of Health Policy, Vanderbilt University Medical Center, 2525 West End Ave, Nashville, Tennessee, United States.

Objective: To examine how variation in the size of the local Medicaid population moderates Medicaid-to-private treatment access differentials for women with opioid use disorder (OUD).

Data Sources: County-level information on total Medicaid enrollment combined with randomized field experiment data from ten diverse states that used a simulated patient (audit) methodology to examine buprenorphine providers' appointment granting behavior.

Study Design: We used multiple regression modeling approaches to capture the moderating influence of Medicaid prevalence on differences in the likelihood of receiving an insurance-covered appointment between Medicaid and privately insured female patients. Read More

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December 2021

Mediating role of multimorbidity in inequality in mortality: a register study on the Danish population.

J Epidemiol Community Health 2021 Dec 3. Epub 2021 Dec 3.

Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Background: The social inequality in mortality is due to differential incidence of several disorders and injury types, as well as differential survival. The resulting clustering and possible interaction in disadvantaged groups of several disorders make multimorbidity a potentially important component in the health divide. This study decomposes the effect of education on mortality into a direct effect, a pure indirect effect mediated by multimorbidity and a mediated interaction between education and multimorbidity. Read More

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December 2021

Acute Treatment Effects on GFR in Randomized Clinical Trials of Kidney Disease Progression.

J Am Soc Nephrol 2021 Dec 3. Epub 2021 Dec 3.

L Inker, Division of Nephrology, Tufts Medical Center, Boston, United States

Acute changes in glomerular filtration rate (GFR) can occur following initiation of interventions targeting progression of chronic kidney disease (CKD). These acute changes complicate the interpretation of long-term treatment effects. To assess the magnitude and consistency of acute effects in randomized clinical trials and explore factors that might affect them, we performed a meta-analysis of 53 randomized clinical trials for CKD progression enrolling 56,413 participants with at least one estimated GFR measurement by 6 months following randomization. Read More

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December 2021

Clinical, obstetric and perinatal outcomes after vitrified-warmed euploid blastocyst transfer are independent of cryo-storage duration.

Reprod Biomed Online 2021 Oct 8. Epub 2021 Oct 8.

GeneraLife IVF, Clinica Valle Giulia, Rome, Italy.

Research Question: The study aimed to retrospectively evaluate the impact of cryo-storage duration on clinical, obstetric and perinatal outcomes after vitrified-warmed euploid blastocyst transfer.

Design: This was an observational study including 2688 vitrified-warmed euploid single blastocyst transfers that was conducted at a private IVF centre between May 2013 and March 2020. It included a total of 1884 women (age 38 ± 3 years) undergoing at least one transfer after preimplantation genetic testing for aneuploidies. Read More

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October 2021

Breast cancer surveillance following ovarian cancer in BRCA mutation carriers.

Gynecol Oncol 2021 Nov 30. Epub 2021 Nov 30.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.

Objectives: BRCA 1 or 2 mutation carriers have increased risk of developing breast cancer (BC) and serous epithelial ovarian cancer (EOC). The incidence of BC over time after EOC is unknown. Optimal BC surveillance for BRCA mutation carriers following EOC has not been defined. Read More

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November 2021

Characteristics and outcomes of octogenarians with revascularized critical limb ischemia: Impact of altered cardiac function for early mortality.

J Med Vasc 2021 Oct-Dec;46(5-6):224-231. Epub 2021 Nov 5.

Vascular medicine department, groupe hospitalier Paris Saint-Joseph, Paris, France.

Objective: Patients with critical limb ischemia (CLI) present with advanced age and end-stage organ damage, in particular heart failure. The aim of the present study is to describe clinical and biological characteristics in octogenarian patients with CLI compared to their younger counterparts and to determine the peri-procedural risk and early mortality after endovascular procedure.

Methods: From November 2013 to May 2019, 315 consecutive patients were retrospectively included. Read More

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November 2021

Individualised or liberal red blood cell transfusion after cardiac surgery: a randomised controlled trial.

Br J Anaesth 2021 Nov 30. Epub 2021 Nov 30.

Department of Anesthesiology and Critical Care Medicine, Amiens Picardy University Hospital, Amiens, France.

Background: Current practice guidelines for red blood cell (RBC) transfusion in ICUs are based on haemoglobin threshold, without consideration of oxygen delivery or consumption. We aimed to evaluate an individual physiological threshold-guided by central venous oxygen saturation ScvO.

Methods: In a randomised study in two French academic hospitals, 164 patients who were admitted to ICU after cardiac surgery with postoperative haemoglobin <9 g dl were randomised to receive a transfusion with one unit of RBCs (haemoglobin group) or transfusion only if the ScvO was <70% (individualised group). Read More

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November 2021

Early Recognition Method - Amplifying relapse management in community mental health care; a comprehensive study of the effects on relapse and readmission.

Arch Psychiatr Nurs 2021 Dec 10;35(6):587-594. Epub 2021 Aug 10.

Center for Psychiatric Nursing and Health Research, Department of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Denmark; FPC Dr. S. van Mesdag, Netherlands; Centre for Research and Education in Forensic Psychiatry, Oslo University Hospital-HF, Norway; Faculty of Health and Social Sciences Molde University College, Norway.

This naturalistic multicenter study explored the relationship between participating in the Early Recognition Method (ERM) intervention and relapse, defined as spending at least one night at a psychiatric ward. The intervention was tailored to adult patients with schizophrenia or bipolar disorder in an outpatient mental health care setting. Before the intervention, the staff received training in application of the strategy. Read More

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December 2021

Fluid handling and blood flow patterns in neonatal respiratory distress syndrome versus transient tachypnea: a pilot study.

BMC Pediatr 2021 Dec 3;21(1):541. Epub 2021 Dec 3.

University of Calgary, Cumming School of Medicine, Libin Cardiovascular Institute of Alberta, Calgary, Canada.

Background: Cardiovascular and renal adaptation in neonates with Respiratory Distress Syndrome (RDS) and Transient Tachypnea of the Newborn (TTN) may be different.

Methods: Neonates ≥32 weeks were diagnosed with RDS or TTN based on clinical, radiologic and lung sonographic criteria. Weight loss, feeding, urine output, and sodium levels were recorded for the first 3 days, and serial ultrasounds assessed central and organ Doppler blood flow. Read More

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December 2021

Ultra-mini-percutaneous nephrolithotomy in flank-free modified supine position versus prone position in treatment of pediatric renal pelvic and lower calyceal stones.

J Endourol 2021 Dec 3. Epub 2021 Dec 3.

Zagazig University Faculty of Human Medicine, 68865, urology, Al-Sharqia, Zagazig, Bahr street, Zagazig, Egypt, Zagazig, Egypt, 44519, EGYPT;

Objectives: To report the safety and efficacy of ultra-mini-percutaneous nephrolithotomy (UMPCNL) in flank free modified supine (FFMS) and prone positions in management of pediatric renal calculi.

Patients & Methods: This prospective randomized study included 55 pediatric patients with symptomatic renal stones and suitable for ultra-mini-percutaneous nephrolithotomy. They were randomized into two groups. Read More

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December 2021

Effect of tranexamic acid on bleeding outcomes after percutaneous nephrolithotomy: A systematic review and meta-analysis of randomized controlled trials.

J Endourol 2021 Dec 3. Epub 2021 Dec 3.

Dalhousie University Faculty of Medicine, 12361, Urology, Halifax, Nova Scotia, Canada;

Purpose: We performed a systematic review and meta-analysis of the literature to evaluate the efficacy of the routine use of tranexamic acid during percutaneous nephrolithotomy.

Methods: This systematic review was conducted following best practices from Cochrane and the Institute of Medicine [Cochrane Handbook and IOM citations]. We followed the updated reporting guidelines from PRISMA 2020. Read More

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December 2021

Oxidative damage of canine erythrocytes after treatment with non-steroidal anti-inflammatory drugs.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2021 Nov 3;49(6):407-413. Epub 2021 Dec 3.

Department of Veterinary Clinical Sciences, Clinical Pathophysiology and Clinical Pathology, Justus Liebig University.

Objective: To investigate oxidative erythrocyte damage in dogs treated with different non-steroidal anti-inflammatory drugs.

Material And Methods: Case-controlled prospective observational study using blood obtained from dogs presenting for lameness examinations or standard surgical procedures to a private referral clinic. Sampling was performed from April 2018 to July 2019. Read More

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November 2021

Long-term Follow-Up Results of Dynamic Cervical Implant in Patients with Cervical Disc Diseases: Compared with Prestige LP.

J Neurol Surg A Cent Eur Neurosurg 2021 Dec 3. Epub 2021 Dec 3.

Department of Orthopedics, Sichuan University West China Hospital, Chengdu, China.

Background And Study Aims: Prestige LP arthroplasty has been proven to be a safe and effective treatment for patients with cervical disc degenerative disease (DDD). Dynamic Cervical Implant (DCI) has emerged as a novel implantation device for cervical DDD. This study aimed to compare the outcomes of these procedures after 5 years of follow-up in the DCI and Prestige LP groups. Read More

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December 2021

Endoscopic fenestration for treating Galassi type III middle cranial fossa arachnoid cysts: single- and multiple-stoma have the same curative effect.

J Neurol Surg A Cent Eur Neurosurg 2021 Dec 3. Epub 2021 Dec 3.

Department of Neurosurgery, Beijing Neurosurgical Institute, Beijing, China.

Background and Study Aims For endoscopic fenestration of middle cranial fossa arachnoid cysts (MCFACs), the decisions on the location and number of stomas are key issues in the operation. However, research on this particular topic has been limited. Thus, this study aimed to compare single-stoma versus multiple-stoma endoscopic fenestration for treating Galassi type III MCFACs. Read More

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December 2021

Renin-angiotensin System Blocker in COVID-19. A Single Center Study.

J Cardiovasc Pharmacol 2021 Dec 1. Epub 2021 Dec 1.

Department of Medicine, University of Miami/JFK Medical Center Palm Beach Regional GME Consortium, Atlantis, Florida. Department of Cardiology, University of Miami/JFK Medical Center Palm Beach Regional GME Consortium, Atlantis, Florida.

Early during the Covid-19 pandemic, concerns were raised regarding potential adverse outcomes in patients taking ACEIs/ARBs. These concerns were based on animal studies showing increased ACE-2 expression in mice treated with ACEI/ARB. This is a single-center retrospective cohort study of 289 patients diagnosed with 2019 Novel Coronavirus (SARS-CoV-2) hospitalized between March of 2020 and June of 2020. Read More

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December 2021

Can intraoperative electrocorticography be used to minimize the extent of resection in patients with temporal lobe epilepsy associated with hippocampal sclerosis?

J Neurosurg 2021 Dec 3:1-8. Epub 2021 Dec 3.

Objective: Tailored surgery to extensively resect epileptogenic lesions using intraoperative electrocorticography (ioECoG) may improve seizure outcomes. However, resection of large areas is associated with decreased memory function postoperatively. The authors assessed whether ioECoG could provide useful information on how to minimize the focus resection and obtain better seizure outcomes without memory deterioration. Read More

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December 2021

Concurrent decompression and resection versus decompression with delayed resection of acutely ruptured brain arteriovenous malformations.

J Neurosurg 2021 Dec 3:1-8. Epub 2021 Dec 3.

1Department of Neurological Surgery, University of Washington, Seattle, Washington.

Objective: Brain arteriovenous malformations (bAVMs) most commonly present with rupture and intraparenchymal hemorrhage. In rare cases, the hemorrhage is large enough to cause clinical herniation or intractable intracranial hypertension. Patients in these cases require emergent surgical decompression as a life-saving measure. Read More

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December 2021