66,944 results match your criteria difference functional

Insight into the role of extracellular polymeric substances in denitrifying biofilms under nitrobenzene exposure.

Ecotoxicol Environ Saf 2021 Jul 23;222:112539. Epub 2021 Jul 23.

Department of Environmental Engineering, Peking University, Beijing 100871, China. Electronic address:

Denitrifying biofilm promises to be very useful for remediation of nitro-aromatic compounds (NACs) and nitrates in wastewater. Little is known about the role of extracellular polymeric substances (EPS) in nitrobenzene (NB, a typical NAC) remediation, despite the indispensability of EPS for biofilm formation. Herein, the significance of the mechanistic role of EPS in the response of denitrifying biofilms to various levels of NB was investigated. Read More

View Article and Full-Text PDF

Dysconnectivity of the amygdala and dorsal anterior cingulate cortex in drug-naive post-traumatic stress disorder.

Eur Neuropsychopharmacol 2021 Jul 23;52:84-93. Epub 2021 Jul 23.

Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China; Psychoradiology Research Unit of Chinese Academy of Medical Sciences, Chengdu, China; Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China. Electronic address:

Convergent studies have highlighted the amygdala-based and dorsal anterior cingulate cortex (dACC)-based circuit or network dysfunction in post-traumatic stress disorder (PTSD). However, previous studies are often complicated by various traumatic types, psychiatric comorbidities, chronic illness duration, and medication effect on brain function. Besides, little is known whether the functional integration with amygdala-dACC interaction disrupted or not in PTSD. Read More

View Article and Full-Text PDF

Structure and functional differences of cysteine and 3-mercaptopropionate dioxygenases. A computational study.

Chemistry 2021 Jul 26. Epub 2021 Jul 26.

University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, M1 7DN, Manchester, UNITED KINGDOM.

Thiol dioxygenases are important enzymes for human health involved in the detoxification and catabolism of toxic thiol-containing natural products such as cysteine, which has relevance to the development of Alzheimer's and Parkinson's diseases in the brain. Recent crystal structure coordinates of cysteine and 3-mercaptopropionate dioxygenase (CDO and MDO) showed major differences in the second-coordination spheres of the two enzymes. To understand the difference in activity between these two analogous enzymes, we created large active site cluster models. Read More

View Article and Full-Text PDF

Exploring the ensiling characteristics and bacterial community of red clover inoculated with the epiphytic bacteria from temperate gramineous grasses.

J Appl Microbiol 2021 Jul 26. Epub 2021 Jul 26.

Institute of Ensiling and Processing of Grass, College of Agro-Grassland Science, Nanjing Agricultural University, Nanjing, 210095, China.

Aims: To explore the microbiological factors that cause the difference in silage fermentation characteristics between temperate gramineous (Italian ryegrass and oat) grass and legume forage.

Methods And Results: Through γ-ray irradiation sterilization and bacterial transplantation technology, the sterilized red clover was inoculated as follows: (i) aseptic water (STRC); (ii) epiphytic bacteria on red clover (RCRC); (iii) epiphytic bacteria on oat (RCOT); (iv) epiphytic bacteria on Italian ryegrass (RCIR). Red clover was ensiled in laboratory-scale silos made of vacuum-packed plastic bags for 1, 3, 7, 14, 30 and 60 days. Read More

View Article and Full-Text PDF

Conditioned pain modulation and pain sensitivity in functional somatic disorders: The DanFunD study.

Eur J Pain 2021 Jul 26. Epub 2021 Jul 26.

Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Aarhus, Denmark.

Disrupted pain regulation has been proposed as a component in functional somatic disorders (FSD). The objective of this study was to examine a general population sample, encompassing three delimitations of FSD while assessing pain sensitivity and conditioning pain modulation (CPM). Pressure pain thresholds (PPTs) at the tibialis and trapezius muscles were recorded at baseline. Read More

View Article and Full-Text PDF

Assessment of MUSASHI 1 and MUSASHI 2 expression in spermatozoa and testicular tissue.

Andrologia 2021 Jul 26:e14187. Epub 2021 Jul 26.

Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

MUSASHI (MSI) family plays the main role in the spermatogenesis process. The purpose of this study was the assessment of sperm MSI1 and MSI2, and sperm functional tests in infertile men (n = 30) with varicocele and fertile men (n = 30). Furthermore, MSI1 and MSI2 proteins were assessed in testicular tissue of azoospermic men (n = 9) as well as epididymal spermatozoa and testis of mice. Read More

View Article and Full-Text PDF

Tailored or adapted interventions for adults with chronic obstructive pulmonary disease and at least one other long-term condition: a mixed methods review.

Cochrane Database Syst Rev 2021 Jul 26;7:CD013384. Epub 2021 Jul 26.

Physiotherapy, Alfred Health, Melbourne, Australia.

Background: Chronic obstructive pulmonary disease (COPD) is a chronic respiratory condition characterised by shortness of breath, cough and recurrent exacerbations. People with COPD often live with one or more co-existing long-term health conditions (comorbidities). People with more severe COPD often have a higher number of comorbidities, putting them at greater risk of morbidity and mortality. Read More

View Article and Full-Text PDF

Evaluation of the effect of unilateral late blindness on the retina, optic nerve and choroid parameters in the sighted eye.

Int Ophthalmol 2021 Jul 26. Epub 2021 Jul 26.

Department of Neurology, Alaaddin Keykubat University Alanya Education and Research Hospital, Antalya, Turkey.

Background: To investigate whether unilateral late blindness alters the peripapillary retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), central macular thickness (CMT) and choroidal thickness (CT).

Methods: The 17 healthy eyes of 17 monocular patients with late blindness due to isolated eye trauma in one eye and the 19 eyes of 19 healthy individuals were evaluated in this retrospective study. Patients with at least 10 years of monocular blindness, a refractive error between + 1. Read More

View Article and Full-Text PDF

Tympanoplasty with an Intact Stapes Superstructure in Chronic Otitis Media.

J Int Adv Otol 2021 Jul;17(4):282-287

Department of Otorhinolaryngology, Head and Neck Surgery, Spitalstrasse, Luzern, Switzerland.

Background: The objective of our study was to ascertain the functional results in terms of air bone gap (ABG) closure over 4 frequencies (0.5, 1, 2, 3 kHz) in patients with chronic otitis media (COM) that underwent tympanoplasty in the presence of a mobile stapes superstructure, and in particular excluding those cases in which the malleus was used in the reconstruction.

Methods: A retrospective review of our database between January 1, 2006 and June 1, 2018 identified all cases that underwent one of 3 reconstructive options: the classic Type III tympanoplasty in an open-cavity setting; the "stapes augmentation" (SA) type reconstruction where the stapes superstructure is augmented to the drum by an interposing partial ossiculoplasty of either autologous bone, cartilage, or prosthetic material; and the use of a total articular replacement prosthesis (TORP) from the stapes footplate to the drum in the presence of an intact superstructure. Read More

View Article and Full-Text PDF

A matched comparison of the patient-reported outcome measures of 38,716 total and unicompartmental knee replacements: an analysis of linked data from the National Joint Registry of England, Northern Ireland and Isle of Man and England's National PROM collection programme.

Acta Orthop 2021 Jul 26:1-8. Epub 2021 Jul 26.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Background and purpose - The surgical treatment options for severe knee osteoarthritis are unicompartmental (UKR) and total knee replacement (TKR). For patients, functional outcomes are more important than revision rate. We compared the patient-reported outcome measures (PROMs) of both implant types using a large PROMs dataset. Read More

View Article and Full-Text PDF

Dynamic functional network connectivity associated with musical emotions evoked by different tempi.

Brain Connect 2021 Jul 26. Epub 2021 Jul 26.

Southwest University, 26463, School of Electronic and Information Engineering, Chongqing, Chongqing, China;

Background:Music tempo has strong clinical maneuverability and positive emotional effect in music therapy, which can directly evoke multiple emotions and dynamic neural changes in the whole-brain. However, the precise relationship between music tempo and its emotional effects remains unclear. The present study aimed to investigate the dynamic functional network connectivity (dFNC) associated with emotions elicited by music at different tempi. Read More

View Article and Full-Text PDF

Implantation of one, two or multiple MitraClips for transcatheter mitral valve repair: insights from a 1824-patient multicenter study.

Panminerva Med 2021 Jul 26. Epub 2021 Jul 26.

Division of Cardiology, Centro Alte Specialità e Trapianti (CAST), Azienda Ospedaliero-Universitaria Policlinico-Vittorio Emanuele, University of Catania, Catania, Italy.

Background: Transcatheter mitral valve repair (TMVR) with the MitraClip device is an established treatment for mitral regurgitation (MR). More than one MitraClip may be implanted if a single one does not reduce MR adequately. We aimed at appraising the outlook of patients undergoing implantation of one, two or multiple MitraClips for TMVR. Read More

View Article and Full-Text PDF

Asymmetric left-right hippocampal glutamatergic modulation of cognitive control in ApoE-isoform subjects is unrelated to neuroinflammation.

Eur J Neurosci 2021 Jul 26. Epub 2021 Jul 26.

Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong.

The glutamatergic cycle is essential in modulating memory processing by the hippocampal circuitry. Our combined H-MRS and task-based fMRI study (using face-name paired-associates encoding and retrieval task) of a cognitively-normal cohort of 67 healthy adults (18 ApoE4 carriers and 49 non-ApoE4 carriers) found altered patterns of relationships between glutamatergic-modulated synaptic signaling and neuronal activity or functional hyperaemia in the ApoE4 isoforms. Our study highlighted the asymmetric left-right hippocampal glutamatergic system in modulating neuronal activities in ApoE4 carriers versus non-carriers. Read More

View Article and Full-Text PDF

Sagittal wedging of intervertebral discs and vertebral bodies in the cervical spine and their associations with age, sex and cervical lordosis: a large-scale morphological study.

Clin Anat 2021 Jul 26. Epub 2021 Jul 26.

Institute of Orthopaedic Research and Biomechanics, Trauma Research Center Ulm, Ulm University, Ulm, Germany.

Many recent studies have focused on the functional and clinical importance of cervical lordosis. However, there is little accurate knowledge of the anatomical parameters that constitute cervical lordosis (i.e. Read More

View Article and Full-Text PDF

Role of fish collagen hydrolysate in attenuating inflammation-An in vitro study.

J Food Biochem 2021 Jul 26:e13876. Epub 2021 Jul 26.

Department of Biotechnology, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, Tamilnadu, India.

Collagen hydrolysate, an extensively used protein obtained from different sources, has various beneficial effects on human health and diseases. The benefits of collagen hydrolysate are well known and presently varied sources for the preparation of hydrolysate are being investigated. Food as a therapy to combat inflammation is presently a much-focused field of research. Read More

View Article and Full-Text PDF

Atrial Fibrillation Impact Questionnaire (AFImpact): Validity and reliability of the Turkish version.

Turk Kardiyol Dern Ars 2021 Jul;49(5):395-403

Division of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Bezmialem Vakif University, Istanbul, Turkey.

Objective: Guidelines recommend measuring and addressing health-related quality of life in the management of atrial fibrillation (AF); however, a disease-specific questionnaire is lacking for the Turkish language. Our aim was to translate and adapt the Atrial Fibrillation Impact Questionnaire (AFImpact) into Turkish and to explore its psychometric properties.

Methods: This cross-sectional study was conducted in two phases, including the translation and cultural adaptation of AFImpact into Turkish language and the analysis of psychometric properties of the translated questionnaire. Read More

View Article and Full-Text PDF

Fifth Metatarsal Fracture-A Systematic Review of the Treatment of Fractures of the Base of the Fifth Metatarsal Bone.

Dtsch Arztebl Int 2021 Sep 6(Forthcoming). Epub 2021 Sep 6.

Background: Metatarsal fractures are among the most common foot and ankle injuries, with an annual incidence of 6.7 per 100 000 persons. Approximately 30% of metatarsal fractures affect the base of the fifth metatarsal bone. Read More

View Article and Full-Text PDF
September 2021

Emerging minimally invasive transurethral treatments for benign prostatic hyperplasia: a systematic review with meta-analysis of functional outcomes and description of complications.

Minerva Urol Nephrol 2021 Jul 26. Epub 2021 Jul 26.

Department of Urology, Hospital Universitario 12 Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.

Introduction: Several minimally invasive surgical procedures have been proposed as alternative therapies for benign prostatic hyperplasia (BPH). The present systematic review aimed to describe the functional outcomes and complications of emerging minimally invasive transurethral treatments for BPH.

Evidence Acquisition: A comprehensive bibliographic search on the MEDLINE and Cochrane Library databases was conducted. Read More

View Article and Full-Text PDF

[Comparative study on effectiveness of posterior-posterior triangulation technique and anteroposterior approach for arthroscopic posterior cruciate ligament reconstruction].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jul;35(7):823-828

Department of Sports Medicine, the First Affiliated Hospital of Kunming Medical University, Kunming Yunnan, 650032, P.R.China.

Objective: To investigate the effectiveness of the posterior-posterior triangulation technique for arthroscopic posterior cruciate ligament (PCL) reconstruction by comparing with the anteroposterior approach.

Methods: Retrospective analysis was performed on 40 patients who underwent arthroscopic PCL reconstruction between February 2016 and February 2020. The PCLs were reconstructed via anteroposterior approach in 20 patients (anteroposterior approach group) and posterior-posterior triangulation technique in 20 patients (posterior-posterior triangulation technique group). Read More

View Article and Full-Text PDF

Theoretical Insights into Potential-Dependent C-C Bond Formation Mechanisms during CO Electroreduction into C Products on Cu(100) at Simulated Electrochemical Interfaces.

ACS Omega 2021 Jul 6;6(28):17839-17847. Epub 2021 Jul 6.

Hunan Province Cooperative Innovation Center for the Construction & Development of Dongting Lake Ecologic Economic Zone, Hunan Provincial Key Laboratory of Water Treatment Functional Materials, Hunan Province Engineering Research Center of Electroplating Wastewater Reuse Technology, College of Chemistry and Materials Engineering, Hunan University of Arts and Science, Changde 415000, China.

An improved CO coverage-dependent electrochemical interface model with an explicit solvent effect on Cu(100) is presented in this paper, by which theoretical insights into the potential-dependent C-C bond formation pathways occurring in CO electrochemical reduction to C products can be obtained. Our present studies indicate that CHO is a crucial intermediate toward C products on Cu(111), and dimer OCCO is found to not be a viable species for the production of C products on Cu(100). The reaction pathway of CHO with CO and CHO dimerization into dimers COCHO and CHOCHO may be C-C bond formation mechanisms at low overpotential. Read More

View Article and Full-Text PDF

Coherent Excitation and Control of Plasmons on Gold Using Two-Dimensional Transition Metal Dichalcogenides.

ACS Photonics 2021 Jun 26;8(6):1607-1615. Epub 2021 May 26.

Department of Physics, Lund University, Box 118, 22100 Lund, Sweden.

The hybrid combination of two-dimensional (2D) transition metal dichalcogenides (TMDs) and plasmonic materials open up novel means of (ultrafast) optoelectronic applications and manipulation of nanoscale light-matter interaction. However, control of the plasmonic excitations by TMDs themselves has not been investigated. Here, we show that the ultrathin 2D WSe crystallites permit nanoscale spatially controlled coherent excitation of surface plasmon polaritons (SPPs) on smooth Au films. Read More

View Article and Full-Text PDF

Medium-term efficacy of arthroscopic debridement conservative treatment for knee osteoarthritis of Kellgren-Lawrence grades I-III.

World J Clin Cases 2021 Jul;9(19):5102-5111

Department of Orthopaedics, Shanghai Jing'an District Zhabei Central Hospital, Shanghai 200070, China.

Background: Arthroscopic debridement is a mature treatment for knee osteoarthritis (KOA). Due to the differences in the research subjects, methods, and efficacy evaluation indexes, there are great differences in the surgical efficacy reported in the literature.

Aim: To compare the medium-term efficacy of arthroscopic debridement and conservative treatment for KOA of Kellgren-Lawrence grades I-III. Read More

View Article and Full-Text PDF

Functional Polymorphisms in the p53 Pathway Genes on the Genetic Susceptibility to Zika Virus Teratogenesis.

Front Cell Infect Microbiol 2021 7;11:641413. Epub 2021 Jul 7.

Programa de Pós-Graduação em Genética e Biologia Molecular (PPGBM), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Congenital Zika Syndrome (CZS) occurs in up to 42% of individuals exposed to ZIKV prenatally. Deregulation in gene expression and protein levels of components of the p53 signaling pathway, such as p53 and MDM2, due to ZIKV infection has been reported. Here, we evaluate functional polymorphisms in genes of the p53 signaling pathway as risk factors to CZS. Read More

View Article and Full-Text PDF

Pulmonary Functional Imaging for Lung Adenocarcinoma: Combined MRI Assessment Based on IVIM-DWI and OE-UTE-MRI.

Front Oncol 2021 6;11:677942. Epub 2021 Jul 6.

MR Collaboration, Central Research Institute, United Imaging Healthcare, Shanghai, China.

Purpose: The goal of current study was to introduce noninvasive and reproducible MRI methods for functional assessment of lung adenocarcinoma (LUAD).

Methods: Forty-four patients with pathologically confirmed LUAD were included in this study. All the lesions were classified as adenocarcinoma (AIS), minimally invasive adenocarcinoma (MIA), or invasive adenocarcinoma (IA). Read More

View Article and Full-Text PDF

Effect of oral and transdermal oestrogen therapy on bone mineral density in functional hypothalamic amenorrhoea: a systematic review and meta-analysis.

BMJ Open Sport Exerc Med 2021 7;7(3):e001112. Epub 2021 Jul 7.

Head and Neck Research Group, Division for Research and Innovation, Akershus University Hospital, Lorenskog, Norway.

Background: Female athletes might develop reduced bone mineral density (BMD) and amenorrhoea due to low energy intake.

Objective: To systematically review the literature of randomised controlled trials (RCTs) assessing the effect of oestrogen oral contraceptives (OCP), conjugated oestrogens (CE) and transdermal estradiol (TE) on BMD in premenopausal women with functional hypothalamic amenorrhoea (FHA) due to weight loss, vigorous exercise and/or stress.

Methods: A comprehensive literature search in PubMed, MEDLINE, Cochrane Library, Ovid and CINAHL from inception to 1 October 2020. Read More

View Article and Full-Text PDF

Assessment of ecological impairment of Arctic streams: Challenges and future directions.

Ecol Evol 2021 Jul 26;11(14):9715-9727. Epub 2021 Jun 26.

School for Resource and Environmental Studies Faculty of Management Dalhousie University Halifax Canada.

As increased growth and development put pressure on freshwater systems in Arctic environments, there is a need to maintain a meaningful and feasible framework for monitoring water quality. A useful tool for monitoring the ecological health of aquatic systems is by means of the analysis and inferences made from benthic invertebrates in a biomonitoring approach. Biomonitoring of rivers and streams within the Arctic has been under-represented in research efforts. Read More

View Article and Full-Text PDF

Is Minimally Invasive Plating Osteosynthesis Better Than Conventional Open Plating for Humeral Shaft Fractures? A Systematic Review and Meta-Analysis of Comparative Studies.

Indian J Orthop 2021 Jul 9;55(Suppl 2):283-303. Epub 2021 May 9.

Department of Biostatistics and Health Informatics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh 226029 India.

Introduction: The aim of systematic review and meta-analysis was to find out whether minimally invasive plate osteosynthesis (MIPO) is better than open reduction and internal plate fixation (ORIF) in terms of functional outcome, achieving union (union time and incidence of non-union), intraoperative parameters (surgical duration, blood loss, and radiation exposure), and complications (iatrogenic radial nerve palsy and infection) for humeral shaft fractures.

Materials And Methods: We searched online databases (Pubmed, Embase, Scopus, and The Cochrane Library) from inception till 3rd September 2020 for articles comparing MIPO with ORIF for humeral shaft fractures. The methodological quality of randomized controlled trials (RCTs) was done by Cochrane Risk of Bias assessment tool 2 (RoB2) and of non-randomized studies (case-control and cohort studies) by Methodological Index for non-randomized studies (MINORS). Read More

View Article and Full-Text PDF

The CT morphological characteristics and the clinical management strategy of posterior malleolar fractures with talar subluxation.

Am J Transl Res 2021 15;13(6):6478-6487. Epub 2021 Jun 15.

Department of Orthopaedics, The Second Affiliated Hospital of Soochow University Suzhou 215004, Jiangsu Province, China.

Background: The optimal clinical treatment and the computed tomography (CT) morphological characteristics of posterior malleolar fractures (PMF) with talar subluxation remain inconclusive. Clinically, both plate screws and lag screws are widely used to fix posterior malleolar fragments using a direct or indirect approach. We sought to summarize the morphological characteristics and modified classification on the basis of CT and the intraoperative strategy for posterior talar subluxation in PMF. Read More

View Article and Full-Text PDF

Texture Image Classification Method of Porcelain Fragments Based on Convolutional Neural Network.

Hongchang Wu

Comput Intell Neurosci 2021 30;2021:1823930. Epub 2021 Jun 30.

School of Ceramics, Pingdingshan University, Pingdingshan, Henan 467000, China.

The texture image decomposition of porcelain fragments based on convolutional neural network is a functional algorithm based on energy minimization. It maps the image to a suitable space and can effectively decompose the image structure, texture, and noise. This paper conducts a systematic research on image decomposition based on variational method and compressed sensing reconstruction of convolutional neural network. Read More

View Article and Full-Text PDF

Childhood Maltreatment Was Correlated With the Decreased Cortical Function in Depressed Patients Under Social Stress in a Working Memory Task: A Pilot Study.

Front Psychiatry 2021 8;12:671574. Epub 2021 Jul 8.

Institute of Mental Health, The Sixth Hospital, Peking University, Beijing, China.

Major depressive disorder (MDD) is a common psychiatric disorder associated with working memory (WM) impairment. Neuroimaging studies showed divergent results of the WM process in MDD patients. Stress could affect the occurrence and development of depression, in which childhood maltreatment played an important role. Read More

View Article and Full-Text PDF