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Metabolic Response to Submaximal and Maximal Exercise in People with Severe Obesity, Prediabetes, and Diabetes.

Obes Facts 2021 30;14(4):415-424. Epub 2021 Jul 30.

Sports and Exercise Medicine Division, Department of Medicine, University of Padova, Padova, Italy.

Introduction: Metabolic adaptations to maximal physical exercise in people with obesity (PwO) are scarcely described. This cross-sectional study evaluates the metabolic response to exercise via the respiratory exchange ratio (RER) in PwO and different degrees of glycemic control.

Methods: Eighty-five PwO (body mass index 46. Read More

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Performance of Knee Image Digital Analysis of radiographs of patients with end-stage knee osteoarthritis.

Osteoarthritis Cartilage 2021 Jul 31. Epub 2021 Jul 31.

Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address:

Objective: Knee Image Digital Analysis (KIDA) is standardized radiographic analysis software for measuring osteoarthritis (OA) characteristics. It was validated in mild OA, but used for severe OA as well. The current goal was to evaluate the performance of KIDA in severe OA. Read More

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Impact of including the cause of missing records on genetic evaluations for growth in commercial pigs.

J Anim Sci 2021 Aug 3. Epub 2021 Aug 3.

Department of Animal and Dairy Science, University of Georgia, Athens, GA, USA.

It is of interest to evaluate crossbred pigs for hot carcass weight (HCW) and birth weight (BW); however, obtaining a HCW record is dependent on livability (LIV) and retained tag (RT). The purpose of this study is to analyze how HCW evaluations are affected when herd removal and missing identification are included in the model and examine if accounting for the reasons for missing traits improves the accuracy of predicting breeding values. Pedigree information was available for 1,965,077 purebred and crossbred animals. Read More

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Effect of a Sedation and Ventilator Liberation Protocol vs Usual Care on Duration of Invasive Mechanical Ventilation in Pediatric Intensive Care Units: A Randomized Clinical Trial.

JAMA 2021 Aug;326(5):401-410

Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, Ireland.

Importance: There is limited evidence on the optimal strategy for liberating infants and children from invasive mechanical ventilation in the pediatric intensive care unit.

Objective: To determine if a sedation and ventilator liberation protocol intervention reduces the duration of invasive mechanical ventilation in infants and children anticipated to require prolonged mechanical ventilation.

Design, Setting, And Participants: A pragmatic multicenter, stepped-wedge, cluster randomized clinical trial was conducted that included 17 hospital sites (18 pediatric intensive care units) in the UK sequentially randomized from usual care to the protocol intervention. Read More

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Effect of an Active vs Expectant Management Strategy on Successful Resolution of Pregnancy Among Patients With a Persisting Pregnancy of Unknown Location: The ACT or NOT Randomized Clinical Trial.

JAMA 2021 Aug;326(5):390-400

Department of Biostatistics, Yale University, New Haven, Connecticut.

Importance: Women with an early nonviable pregnancy of unknown location are at high risk of ectopic pregnancy and its inherent morbidity and mortality. Successful and timely resolution of the gestation, while minimizing unscheduled interventions, are important priorities.

Objective: To determine if active management is more effective in achieving pregnancy resolution than expectant management and whether the use of empirical methotrexate is noninferior to uterine evacuation followed by methotrexate if needed. Read More

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Nomograms for Converting Perimetric Sensitivity From Full Threshold and SITA Fast to SITA Standard in Patients With Glaucoma and Healthy Subjects.

Transl Vis Sci Technol 2021 Aug;10(9)

Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada.

Purpose: The purpose of this study was to develop nomograms for converting Full Threshold (FT) and Swedish Interactive Threshold Algorithm (SITA) Fast (SF) tests to SITA Standard (SS) tests with the Humphrey Field Analyzer in patients with glaucoma and healthy subjects.

Methods: One eye each of 49 patients with glaucoma and 50 healthy subjects was tested in 4 and 2 sessions (each containing the 3 strategies), respectively, over 4 weeks. The difference between pointwise Best Available Estimate (BAE; mean of all FT tests) and SS sensitivity at each session was used to derive four nomograms. Read More

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Does COVID-19 vaccination improve mental health? A difference-in-difference analysis of the Understanding Coronavirus in America study.

medRxiv 2021 Jul 28. Epub 2021 Jul 28.

Background: Mental health problems increased during the COVID-19 pandemic. Knowledge that one is less at risk after being vaccinated may alleviate distress, but this hypothesis remains unexplored. Here we test whether psychological distress declined in those vaccinated against COVID-19 in the US and whether changes in perceived risk mediated any association. Read More

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Discrepancy between NTG and POAG with corneal nerves in CCM.

Eye (Lond) 2021 Aug 2. Epub 2021 Aug 2.

Department of Ophthalmology, Peking University Third Hospital, Beijing key laboratory of restoration of damaged ocular nerve, Beijing, China.

Background: To investigate the morphological features of corneal subbasal nerve plexus (CSNP) in normal-tension glaucoma (NTG) and primary open-angle glaucoma (POAG).

Methods: Thirty-four eyes with NTG (16 untreated), 23 eyes with POAG (11 untreated) and 31 eyes of healthy subjects were recruited. CSNP were assessed by corneal confocal microscopy (CCM) and peripapillary retinal nerve fibre layer (RNFL) was measured with optical coherence tomography (OCT). Read More

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Impact of estrogen receptor levels on outcome in non-metastatic triple negative breast cancer patients treated with neoadjuvant/adjuvant chemotherapy.

NPJ Breast Cancer 2021 Aug 2;7(1):101. Epub 2021 Aug 2.

Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.

Although 1% is the recommended cut-off to define estrogen receptor (ER) positivity, a 10% cut-off is often used in clinical practice for therapeutic purposes. We here evaluate clinical outcomes according to ER levels in a monoinstitutional cohort of non-metastatic triple-negative breast cancer (BC) patients undergoing (neo)adjuvant chemotherapy. Clinicopathological data of 406 patients with ER < 10% HER2-negative BC treated with (neo)adjuvant chemotherapy between 01/2000 and 04/2019 were collected. Read More

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Association of Gaming Practices with Scholastic Performance among medical students in India: A Case-Control Study.

JMIR Med Educ 2021 Aug 1. Epub 2021 Aug 1.

Department of Community medicine,Trichy SRM Medical college hospital and Research center, Trichy, IN.

Background: Gaming is a billion-dollar industry growing at a Compound annual growth rate (CAGR) of 9 %- 14.3% with the biggest market in South East Asian countries. The availability of low-cost smartphones, ease of internet access has made gaming popular among youth who enjoy it as a leisure activity. Read More

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Interactive video games to reduce paediatric procedural pain and anxiety: a systematic review and meta-analysis.

Br J Anaesth 2021 Jul 30. Epub 2021 Jul 30.

School of Women's and Children's Health, UNSW Sydney, Kensington, Australia; Kids Cancer Centre, Sydney Children's Hospital, Randwick, Australia. Electronic address:

Background: Procedural pain and anxiety in children can be poorly controlled, leading to significant short- and long-term sequelae, such as longer procedure times or future healthcare avoidance. Caregiver anxiety can exacerbate these effects. We aimed to evaluate the effect of interactive video game interventions on children's procedural pain and anxiety, including the effect of different types of video games on those outcomes. Read More

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Emergency surgery without stabilization prior to surgical repair for total anomalous pulmonary venous connection reduces duration of mechanical ventilation without reducing survival.

J Cardiothorac Surg 2021 Aug 2;16(1):213. Epub 2021 Aug 2.

Department of Cardiothoracic Surgery, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, No.136, Zhongshan 2nd Road, Yuzhong Dis, Chongqing, 400014, China.

Background: To examine two different operation timing for treating patients with a total anomalous pulmonary venous connection (TAPVC) who need emergency surgery and to summarize the effects of the two operation strategies.

Methods: A retrospective review of 54 patients with TAPVC who underwent operations within 72 h of presentation between December 2010 and July 2019 at a single institution was conducted. All patients exhibited respiratory or hemodynamic instability that required mechanical ventilation and inotropic support. Read More

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Frequency specific co-activation pattern analysis via sparse nonnegative tensor decomposition.

J Neurosci Methods 2021 Jul 30:109299. Epub 2021 Jul 30.

School of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian, China; School of Artificial Intelligence, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian, China; Key Laboratory of Integrated Circuit and Biomedical Electronic System, Liaoning Province. Dalian University of Technology, Dalian, China; Faculty of Information Technology, University of Jyvaskyla, Jyvaskyla, Finland.

Background: Traditionally, the diagnosis of Parkinson's disease (PD) has been made based on symptoms. Extensive studies have demonstrated that PD may lead to variation of brain activity in different frequency bands. However, frequency specific dynamic alterations of PD have not yet been explored. Read More

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MRI Assessment of Pulmonary Vascularity in Infants With Congenital Diaphragmatic Hernia: A Novel Tool for Direct Assessment of Severity of Pulmonary Hypertension and Hypoplasia.

J Pediatr 2021 Jul 30. Epub 2021 Jul 30.

The Perinatal Institute, Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center; Department of Pediatrics, University of Cincinnati College of Medicine; Center for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology, Cincinnati Children's Hospital Medical Center; Fetal Care Center, Cincinnati Children's Hospital Medical Center. Electronic address:

Objectives: To assess the feasibility of magnetic resonance imaging (MRI) for postnatal assessment of pulmonary vascularity in infants with congenital diaphragmatic hernia (CDH).

Study Design: Infants with prenatally diagnosed CDH (n=24) received postnatal pulmonary MRI. Infants with non-pulmonary birth defects served as controls (n=5). Read More

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Macronutrient composition of olive baboon (Papio anubis) milk: A comparison to rhesus macaque (Macaca mulatta) milk.

Am J Primatol 2021 Aug 2:e23315. Epub 2021 Aug 2.

Center for Species Survival, Smithsonian National Zoological Park & Conservation Biology Institute, Washington, District of Columbia, USA.

This study was designed to (1) characterize the macronutrient composition of olive baboon (Papio anubis) milk, (2) compare baboon milk composition to that of rhesus macaques (Macaca mulatta), and (3) evaluate the association between the proportion of milk energy derived from protein and relative growth rate within anthropoid primates. A single milk sample was collected from each of eight lactating olive baboons ranging between 47- and 129-days postparturition and six rhesus macaques from 15- to 92-days living at the same institution under identical management conditions. Macronutrient composition (water, fat, protein sugar, and ash) was determined using standard techniques developed at the Nutrition Laboratory at the Smithsonian National Zoological Park. Read More

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Treatment of closed femoral shaft fractures in children aged 2-10 years: a systematic review and meta-analysis.

Eur J Trauma Emerg Surg 2021 Aug 2. Epub 2021 Aug 2.

UMC Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

Objective: To review current literature on treatment of closed femoral shaft fractures in children of 2-10 years old, with subgroup analysis of children aged 2-6 years, comparing intramedullary nailing (IMN) to conservative treatment modalities.

Methods: We included clinical trials and observational studies that compared traction and subsequent casting (TSC), spica casting and IMN for treatment of femur shaft fractures in children of 2-10 years of age. Subgroup analysis of children aged 2-6 years was performed. Read More

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Sex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data.

Eur Heart J 2021 Aug 2. Epub 2021 Aug 2.

Bristol Heart Institute, University of Bristol, Terrell St, Bristol BS2 8ED, UK.

Aims: Data suggest that women have worse outcomes than men after coronary artery bypass grafting (CABG), but results have been inconsistent across studies. Due to the large differences in baseline characteristics between sexes, suboptimal risk adjustment due to low-quality data may be the reason for the observed differences. To overcome this limitation, we undertook a systematic review and pooled analysis of high-quality individual patient data from large CABG trials to compare the adjusted outcomes of women and men. Read More

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Phase II trial of proton therapy versus photon IMRT for GBM: secondary analysis comparison of progression-free survival between RANO versus clinical assessment.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab073. Epub 2021 Jun 1.

Department of Radiation Oncology, MD Anderson Cancer Center, Houston, Texas, USA.

Background: This secondary image analysis of a randomized trial of proton radiotherapy (PT) versus photon intensity-modulated radiotherapy (IMRT) compares tumor progression based on clinical radiological assessment versus Response Assessment in Neuro-Oncology (RANO).

Methods: Eligible patients were enrolled in the randomized trial and had MR imaging at baseline and follow-up beyond 12 weeks from completion of radiotherapy. "Clinical progression" was based on a clinical radiology report of progression and/or change in treatment for progression. Read More

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Evaluation of circulating levels of Interleukin-10 and Interleukin-16 and dietary inflammatory index in Lebanese knee osteoarthritis patients.

Heliyon 2021 Jul 12;7(7):e07551. Epub 2021 Jul 12.

Faculty of Health Sciences, Beirut Arab University, Lebanon.

Objectives: To investigate plasma concentrations of Interleukin-16 (IL-16) and Interleukin-10 (IL-10) in Lebanese knee osteoarthritis (KOA) patients and to examine the association between the diet-associated inflammation and increased risk for KOA.

Methods: A total of 208 study participants were assigned to one of the 3 groups: Diagnosed Knee Osteoarthritis group (DKOA) (N = 78); Undiagnosed Knee Osteoarthritis group (UKOA) (N = 60) and controls matched on age, sex and sociodemographic characteristics (N = 70). UKOA represents KOA features before they are altered by therapeutic intervention and lifestyle modifications that follow the diagnosis. Read More

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Risk Factors for Acute Kidney Injury in Critically Ill Neonates: A Systematic Review and Meta-Analysis.

Front Pediatr 2021 14;9:666507. Epub 2021 Jul 14.

Department of Nephrology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.

Acute kidney injury (AKI) is recognized as an independent risk factor for mortality and long-term poor prognosis in neonates. The objective of the study was to identify the risk factors for AKI in critically ill neonates to provide an important basis for follow-up research studies and early prevention. The PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, WanFang Med, SinoMed, and VIP Data were searched for studies of risk factors in critically ill neonates. Read More

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Radical Non-Radical Resection for Early-Stage Retroperitoneal Sarcoma: A Propensity Score-Matched Analysis.

Front Oncol 2021 14;11:706543. Epub 2021 Jul 14.

Department of Vascular Surgery, West China Hospital, Sichuan University, Chengdu, China.

Background: The appropriate surgical procedure for early-stage retroperitoneal sarcoma (RPS) is unclear. Thus, we used a national database to compare the outcomes of radical and non-radical resection in patients with early stage RPS.

Methods: This retrospective study included 886 stage I RPS patients from 2004 to 2015 in the SEER database. Read More

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Efficacy and Safety of Different Intravenous Glucocorticoid Regimens in the Treatment of Graves' Ophthalmopathy: A Meta-Analysis.

J Ophthalmol 2021 12;2021:9799274. Epub 2021 Jul 12.

The Shengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, China.

Purpose: The intravenous glucocorticoid (iv GC) represents the mainstay of therapy for Graves' ophthalmopathy (GO), but uncertainty remains concerning the optimal regimen. Although the European Group on Graves' Orbitopathy (EUGOGO) regimen has been commonly employed, evidence for its superiority to other regimens is still lacking. The aim of this meta-analysis was to compare the efficacy and safety of the EUGOGO regimen with higher-dose regimens in the management of GO. Read More

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Electroacupuncture in the Contralesional Hemisphere Improves Neurological Function Involving GABA in Ischemia-Reperfusion Injury Rats.

Evid Based Complement Alternat Med 2021 9;2021:5564494. Epub 2021 Jul 9.

Department of Chinese Medicine, China Medical University Hospital, Taichung 40447, Taiwan.

This study investigated the effect and mechanism of electroacupuncture (EA) on the contralesional hemisphere in rats with ischemic stroke. EA of 2 Hz was applied on the contralesionally Luoque (BL8) and Tongtian (BL7) acupoints of the scalp to investigate the neurological status and mechanism in ischemia-reperfusion injury rats. The differences in the neurological deficit score and Rotarod test time between days 3 and 15 after reperfusion were significantly lower in the sham group (0. Read More

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Quantification of Viable in Cold-Smoked Salmon Using PMA/PMAxx-qPCR.

Front Microbiol 2021 14;12:654178. Epub 2021 Jul 14.

UMR 1014, Secalim, INRAE, Oniris, Nantes, France.

The aim of this study was to develop a rapid and accurate PMA-qPCR method to quantify viable in cold-smoked salmon. is one of the main food spoilage bacteria. Among seafood products, cold-smoked salmon is particularly impacted by spoilage. Read More

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Management Based on Multimodal Brain Monitoring May Improve Functional Connectivity and Post-operative Neurocognition in Elderly Patients Undergoing Spinal Surgery.

Front Aging Neurosci 2021 15;13:705287. Epub 2021 Jul 15.

Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disease, Beijing, China.

Perioperative neurocognitive disorder (PND) is a common condition in elderly patients undergoing surgery. Sedation, analgesia, regional cerebral oxygen saturation (rSO), and body temperature are known to be associated with PND, but few studies have examined the contribution of these factors combined in detail. This prospective, randomized, controlled, double-blinded study investigated whether anesthesia management based on multimodal brain monitoring-an anesthesia management algorithm designed by our group-could improve the post-operative cognitive function and brain functional connectivity (FC) in elderly patients undergoing elective spinal surgery with general anesthesia. Read More

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Sensitivity of normalized difference vegetation index (NDVI) to land surface temperature, soil moisture and precipitation over district Gautam Buddh Nagar, UP, India.

Stoch Environ Res Risk Assess 2021 Jul 25:1-11. Epub 2021 Jul 25.

Karunya Institute of Technology and Sciences, Tamil Nadu, Coimbatore, India.

This study examines the trends in MODIS/TERRA derived Normalized Difference Vegetation Index (NDVI) and its correlation with Land Surface Temperature (LST), Soil Moisture (SM), and precipitation over Gautam Buddh Nagar (India), during the period 2005-2018. The region have a sub-humid and quite moderate climate, scattered into cultivable land, forest and fast growing urbanization zone, making it suitable for monitoring vegetation trends and its accompanying factors. The NDVI-derived vegetation growth patterns over the study region of District Gautam Buddh Nagar, illustrate vigorous seasonal cycles, and interannual variations. Read More

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Association of prenatal stress due to maternal bereavement with intellectual disability in the offspring.

Psychosom Med 2021 Jul 23. Epub 2021 Jul 23.

Clincial Research Centre, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China Department of Clinical Medicine-Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark Department of Biostatistics, School of Public Health, and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China Department of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden Centre for Public Health Sciences, University of Iceland, Iceland Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA. Department of Women & Children's Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China Ministry of Education - Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: To examine the association of mother's loss of a close relative before or during pregnancy with intellectual disability (ID) in the offspring.

Methods: We performed a nationwide population-based cohort study based on Danish national registries. All live-born singletons born in Denmark during 1978-2016 (n = 2,) were followed started from birth until up to 38 years of age. Read More

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Evolution of renal function in patients with CT1 renal tumors after laparoscopic partial and radical nephrectomy. Predictive factors for renal function impairment.

Actas Urol Esp 2021 Jul 29. Epub 2021 Jul 29.

Servicio de Urología, Hospital General Universitario Gregorio Marañón, Madrid, España.

Introduction And Objectives: To analyze the evolution of kidney function after laparoscopic partial nephrectomy (PN) and radical nephrectomy (RN) and to identify predictive factors for deterioration in kidney function.

Materials And Method: Retrospective study of patients with two kidneys, glomerular filtration rate (GFR) > 60 mL/min/1.73 m, and single renal tumor cT1, treated in our center between 2005 and 2018. Read More

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Effects of a pharmaceutical care intervention on clinical outcomes and patient adherence in coronary heart disease: the MIMeRiC randomized controlled trial.

BMC Cardiovasc Disord 2021 Aug 1;21(1):367. Epub 2021 Aug 1.

eHealth Institute, Department of Medicine and Optometry, Linnaeus University, Kalmar, Sweden.

Background: In the treatment of coronary heart disease, secondary prevention goals are still often unmet and poor adherence to prescribed drugs has been suggested as one of the reasons. We aimed to investigate whether pharmaceutical care by a pharmacist at the cardiology clinic trained in motivational interviewing improves clinical outcomes and patient adherence.

Methods: This was a prospective, randomized, controlled, outcomes-blinded trial designed to compare pharmaceutical care follow-up with standard care. Read More

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[Real world research on the growth pattern of preterm children with different birth weight].

Zhonghua Er Ke Za Zhi 2021 Aug;59(8):665-671

Department of Child Health Care, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.

To investigate the physical indices and growth status of preterm children aged 0 to 4 years with different birth weight. Following the real world research approach, the current study retrospectively collected e-chart information of 8 496 preterm children from the child health care system of the Children's Hospital of Chongqing Medical University from December 2010 to December 2017, with 203 123 full-term children followed up during the same period as controls. Premature children were divided into normal birth weight (NBW) group, low birth weight (LBW) group, and very low birth weight (VLBW) group based on their birth weights. Read More

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