115,894 results match your criteria dietary induced


Persistent mTORC1 activation via Depdc5 deletion results in spontaneous hepatocellular carcinoma but does not exacerbate carcinogen- and high-fat diet-induced hepatic carcinogenesis in mice.

Biochem Biophys Res Commun 2021 Sep 20;578:142-149. Epub 2021 Sep 20.

School of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China; Xinxiang Key Laboratory of Metabolism and Integrative Physiology, Xinxiang Medical University, Xinxiang, Henan, China. Electronic address:

The mechanistic target of rapamycin complex 1 (mTORC1) acts as a central regulator of metabolic pathways that drive cellular growth. Abnormal activation of mTORC1 occurs at high frequency in human and mouse hepatocellular carcinoma (HCC). DEP domain-containing protein 5 (DEPDC5), a component of GATOR1 complex, is a repressor of amino acid-sensing branch of the mTORC1 pathway. Read More

View Article and Full-Text PDF
September 2021

Trypsin-mediated sensitization to ferroptosis increases the severity of pancreatitis in mice.

Cell Mol Gastroenterol Hepatol 2021 Sep 22. Epub 2021 Sep 22.

Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. Electronic address:

Background & Aims: Pancreatitis is characterized by acinar cell death and persistent inflammation. Ferroptosis is a type of lipid peroxidation-dependent necrosis, which is negatively regulated by GPX4. We studied how trypsin, a serine protease secreted by pancreatic acinar cells, affects the contribution of ferroptosis to triggering pancreatitis. Read More

View Article and Full-Text PDF
September 2021

Aging, obesity, sarcopenia and the effect of diet and exercise intervention.

Exp Gerontol 2021 Sep 22:111561. Epub 2021 Sep 22.

Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX, USA; Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey VA Medical Center, Houston, TX, USA. Electronic address:

The number of adults 65 years and older is increasing worldwide and will represent the 20% of the population by 2030. Half of them will suffer from obesity. The decline in muscle mass and strength, known as sarcopenia, is very common among older adults with obesity (sarcopenic obesity). Read More

View Article and Full-Text PDF
September 2021

Dietary Euterpe oleracea Mart. attenuates seizures and damage to lipids in the brain of Colossoma macropomum.

Fish Physiol Biochem 2021 Sep 25. Epub 2021 Sep 25.

Tropical Species Aquaculture Laboratory (LAET), Federal Institute of Pará (IFPA), Castanhal Campus, Castanhal, PA, Brazil.

The Amazonian açai fruit (Euterpe oleracea) has shown promising anticonvulsant properties, comparable to those of diazepam (BDZ) in in vivo models submitted to pentylenetetrazole (PTZ). PTZ is a classic convulsant agent used in studies for the purpose of screening anticonvulsants and investigating the mechanisms of epilepsy. Herein, we aimed to determine, for the first time, the effect of dietary administration of lyophilized E. Read More

View Article and Full-Text PDF
September 2021

Effects of β-glucan, probiotics, and synbiotics on obesity-associated colitis and hepatic manifestations in C57BL/6J mice.

Eur J Nutr 2021 Sep 24. Epub 2021 Sep 24.

Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju, 63241, Republic of Korea.

Purpose: Probiotics and prebiotics are commonly used to improve the gut microbiota. Since prebiotics can support the growth of probiotics, co-administration of these is called synbiotics. It has been demonstrated that obesity-induced gut dysbiosis can worsen inflammatory bowel disease symptoms. Read More

View Article and Full-Text PDF
September 2021

Glucose inhibits haemostasis and accelerates diet-induced hyperlipidaemia in zebrafish larvae.

Sci Rep 2021 Sep 24;11(1):19049. Epub 2021 Sep 24.

Tuberculosis Research Program at the Centenary Institute, The University of Sydney, Camperdown, NSW, 2050, Australia.

Hyperglycaemia damages the microvasculature in part through the reduced recruitment of immune cells and interference with platelet signalling, leading to poor wound healing and accelerated lipid deposition in mammals. We investigated the utility of zebrafish larvae to model the effect of exogenous glucose on neutrophil and macrophage recruitment to a tail wound, wound-induced haemostasis, and chicken egg yolk feed challenge-induced hyperlipidaemia by supplementing larvae with exogenous glucose by immersion or injection. Neither method of glucose supplementation affected the recruitment of neutrophils and macrophages following tail transection. Read More

View Article and Full-Text PDF
September 2021

Smilax china L. flavonoid alleviates HFHS-induced inflammation by regulating the gut-liver axis in mice.

Phytomedicine 2021 Sep 5:153728. Epub 2021 Sep 5.

Jiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, China. Electronic address:

Background: Smilax china L., a traditional Chinese herb, has been used to treat various inflammatory disorders, particularly pelvic inflammation. The anti-inflammatory activity of the plant extract has been reported in several in vivo experimental models. Read More

View Article and Full-Text PDF
September 2021

Dietary starch is weight reducing when distally digested in the small intestine.

Carbohydr Polym 2021 Dec 24;273:118599. Epub 2021 Aug 24.

Whistler Center for Carbohydrate Research and Department of Food Science, Purdue University, West Lafayette, IN 47907, USA. Electronic address:

Nowadays, carbohydrate-based foods have a negative consumer connotation and low carb diets have become a popular way to lose weight. Here, we show how digestible starch and flavonoids can be used as a dietary approach to manage food intake and weight gain through elevation of glucagon-like peptide-1 (GLP-1) secretion for gut-brain axis communication. This was achieved by extending the digestion of cooked starch to the distal small intestine using luteolin or quercetin as α-amylase-specific inhibitors with competitive inhibition mechanism. Read More

View Article and Full-Text PDF
December 2021

Obesity induces morphological and functional changes in female reproductive system through increases in NF-κB and MAPK signaling in mice.

Reprod Biol Endocrinol 2021 Sep 24;19(1):148. Epub 2021 Sep 24.

Department of Histology, Embryology, Genetics and Developmental Biology, Shanghai Key Laboratory for Reproductive Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Background: Recently, human infertility incidence is increasing in obese women causing it to become an emerging global health challenge requiring improved treatment. There is extensive evidence that obesity caused female reproductive dysfunction is accompanied by an endocrinological influence. Besides, systemic and tissue-specific chronic inflammatory status are common characteristics of obesity. Read More

View Article and Full-Text PDF
September 2021

Dose-dependent toxicological effects in rats following a 90-day dietary exposure to PCB-156 include retinoid disruption.

Reprod Toxicol 2021 Sep 21. Epub 2021 Sep 21.

Unit of Integrative Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

The toxicity of PCB-156 (2,3,3',4,4',5-hexachlorobiphenyl) was investigated in rats following subchronic dietary exposure. Groups of 10 male and female Sprague-Dawley rats were administered PCB-156 in the diet at 0, 0.01, 0. Read More

View Article and Full-Text PDF
September 2021

Promoting a pro-oxidant state in skeletal muscle: Potential dietary, environmental, and exercise interventions for enhancing endurance-training adaptations.

Free Radic Biol Med 2021 Sep 21. Epub 2021 Sep 21.

Muscle Health Research Centre, School of Kinesiology and Health Sciences, Faculty of Health, York University, M3J 1P3, Toronto, Canada. Electronic address:

Accumulating evidence now shows that supplemental antioxidants including vitamin C, vitamin E and N-Acetylcysteine consumption can suppress adaptations to endurance-type exercise by attenuating reactive oxygen and nitrogen species (RONS) formation within skeletal muscle. This emerging evidence points to the importance of pro-oxidation as an important stimulus for endurance-training adaptations, including mitochondrial biogenesis, endogenous antioxidant production, insulin signalling, angiogenesis and growth factor signaling. Although sustained oxidative distress is associated with many chronic diseases, athletes have, on average, elevated levels of certain endogenous antioxidants to maintain redox homeostasis. Read More

View Article and Full-Text PDF
September 2021

Insight into Shenqi Jiangtang Granule on the improved insulin sensitivity by integrating in silico and in vivo approaches.

J Ethnopharmacol 2021 Sep 21:114672. Epub 2021 Sep 21.

Department of Endocrinology, Jining No. 1 People's Hospital, Jining, Shandong, 272000, China; Institute for Chronic Disease Management, Jining No. 1 People's Hospital, Jining, Shandong, 272000, China. Electronic address:

Ethnopharmacological Relevance: Presently, insulin resistance has been a growing concern that urgently needs to be addressed, because it not only places patients at risk of developing type 2 diabetes mellitus but also results in metabolic syndrome and different aspects of cardiovascular diseases. Shenqi Jiangtang Granule (SJG) is a classic traditional Chinese medicine (TCM) prescription that is widely used to treat diabetes mellitus and its complications in clinical practice. While studies have revealed that SJG with multi-ingredients and multi-targets characteristics possesses potential anti-insulin resistance pharmacological properties, its mechanisms of action and molecular targets for the treatment of insulin resistance are still obscure, which prompt us to conduct an in-depth research. Read More

View Article and Full-Text PDF
September 2021

Safety and efficacy of using heat-killed L-137: High-dose and long-term use effects on immune-related safety and intestinal bacterial flora.

J Immunotoxicol 2021 Dec;18(1):127-135

Ingredient Research Division, Research and Development Institute, House Wellness Foods Corp, Itami, Japan.

Heat-killed L-137 (HK L-137) promotes immune function in animals. In healthy people, T-cell proliferation was shown to be enhanced by taking 10 mg HK L-137 daily for 12 weeks. However, the safety and efficacy of higher doses or longer treatments have not yet been investigated in humans. Read More

View Article and Full-Text PDF
December 2021

Western Diet Changes Gut Microbiota and Ameliorates Liver Injury in a Mouse Model with Human-Like Bile Acid Composition.

Hepatol Commun 2021 Aug 24. Epub 2021 Aug 24.

Division of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.

Western-style high-fat/high-sucrose diet (HFHSD) changes gut microbiota and bile acid (BA) profiles. Because gut microbiota and BAs could influence each other, the mechanism of changes in both by HFHSD is complicated and remains unclear. We first aimed to clarify the roles of BAs in the HFHSD-induced change of gut microbiota. Read More

View Article and Full-Text PDF

Tissue-Specific Regulation of Ferroportin in Wild-Type and Hjv-/- Mice Following Dietary Iron Manipulations.

Hepatol Commun 2021 Jul 16. Epub 2021 Jul 16.

Department of Medicine, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.

Hepcidin is a liver-derived peptide hormone that limits iron egress from tissues to the bloodstream. It operates by binding to the iron exporter ferroportin, which blocks iron transport and tags ferroportin for degradation. Genetic hepcidin inactivation leads to hereditary hemochromatosis, a disease of iron overload. Read More

View Article and Full-Text PDF

The Integrated "Multiomics" Landscape at Peak Injury and Resolution From Alcohol-Associated Liver Disease.

Hepatol Commun 2021 Aug 28. Epub 2021 Aug 28.

Department of Pathology, University of Illinois at Chicago, Chicago, IL, USA.

Alcohol-associated liver disease (ALD) is a significant clinical problem for which the most effective therapy is alcohol abstinence. The two aims of this study were, first, to identify the liver transcriptome, fecal microbiome, and portal serum metabolome at peak injury and during early and late resolution from ALD; and second, to integrate their interactions and understand better the pathogenesis of ALD. To provoke alcohol-induced liver injury, female and male wild-type mice were fed the control or ethanol Lieber-DeCarli diets for 6 weeks. Read More

View Article and Full-Text PDF

RORα Enhances Lysosomal Acidification and Autophagic Flux in the Hepatocytes.

Hepatol Commun 2021 Aug 24. Epub 2021 Aug 24.

College of Pharmacy, Seoul National University, Seoul, Korea.

Lysosomes are intracellular acidic organelles with catabolic functions that contribute to the activation of autophagy. Although autophagy abnormality is associated with defects in lysosomal acidification during the progression of nonalcoholic fatty liver disease (NAFLD), the mechanisms of control of lysosomal acidification are not well understood at the molecular level. Thus, we aimed to elucidate the role of the orphan nuclear receptor retinoic acid-related orphan receptor α (RORα) in lysosomal acidification and autophagic flux, particularly in nutrition-enriched hepatocytes. Read More

View Article and Full-Text PDF

Insulin receptors in the CA1 field of hippocampus and selected blood parameters in diabetic rats fed with bilberry fruit.

Ann Agric Environ Med 2021 Sep 20;28(3):430-436. Epub 2020 Nov 20.

Faculty of Veterinary Medicine, Department of Animal Anatomy and Histology, University of Life Sciences, Lublin, Poland.

Introduction: Bilberry fruit is believed to be a promising factor in the treatment of diabetes mellitus. Chronic hyperglycaemia affects the function of the central nervous system, which may be manifested as changes in hypothalamic insulin signalling.

Material And Methods: Using DPPH and ABTS assays, total phenolic content in bilberry fruit and its antioxidant activities were examined. Read More

View Article and Full-Text PDF
September 2021

A Static Magnetic Field Improves Iron Metabolism and Prevents High-Fat-Diet/Streptozocin-Induced Diabetes.

Innovation (N Y) 2021 Feb 7;2(1):100077. Epub 2021 Jan 7.

High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, P.R. China.

Type 2 diabetes (T2D) is a metabolic disorder with high prevalence and severe complications that has recently been indicated to be treatable by a combined static magnetic field (SMF) and electric field. We systematically compared four types of SMFs and found that a downward SMF of ∼100 mT could effectively reduce the development of hyperglycemia, fatty liver, weight gain, and tissue injury in high-fat-diet (HFD)/streptozocin-induced T2D mice, but not the upward SMF. The downward SMF markedly restored the Bacteroidetes population and reversed the iron complex outer membrane receptor gene reduction in the mice gut microbiota, and reduced iron deposition in the pancreas. Read More

View Article and Full-Text PDF
February 2021

Investigation of Thiol/Disulfide Balance in Obese Rats with Non-Alcoholic Fatty Liver Disease.

Pediatr Gastroenterol Hepatol Nutr 2021 Sep 8;24(5):443-454. Epub 2021 Sep 8.

Department of Biochemistry, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.

Purpose: Due to the increasing prevalence of obesity worldwide, non-alcoholic fatty liver disease (NAFLD) has reached epidemic dimensions over time. NAFLD is the most common cause of childhood chronic liver disease. There is a relationship between NAFLD and oxidative stress. Read More

View Article and Full-Text PDF
September 2021

Short-Chain Inulin Modulates the Cecal Microbiota Structure of Knockout Mice in High-Fat Diet.

Front Microbiol 2021 7;12:703929. Epub 2021 Sep 7.

College of Life Sciences, Shanxi Agricultural University, Jinzhong, China.

The aim of this study was to explore the effect of short-chain inulin on cecal microbiota of high-fat diet-fed knockout mice and the different influences of cecal microbiota on wild-type and knockout mice. A total of 18 specific pathogen-free male C57BL/6J wild-type mice and 18 C57BL/6J knockout mice (OB/OB mice) were selected. Mice were divided into six groups according to their genotype: wild-type mice have three groups, including the normal diet group (CT), 60% high-fat diet group (CH), and 60% high fat with 10% short-chain inulin group (CHI); OB/OB mice were also divided into three groups, including the normal diet group (OT), 60% high-fat diet group (OH), and 60% high fat with 10% short-inulin group (OHI). Read More

View Article and Full-Text PDF
September 2021

Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation.

Nat Immunol 2021 Sep 23. Epub 2021 Sep 23.

Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, College of Future Technology, Peking University, Beijing, China.

Metabolic inflammation is closely linked to obesity, and is implicated in the pathogenesis of metabolic diseases. FTO harbors the strongest genetic association with polygenic obesity, and IRX3 mediates the effects of FTO on body weight. However, in what cells and how IRX3 carries out this control are poorly understood. Read More

View Article and Full-Text PDF
September 2021

MRI-based in vivo detection of coronary microvascular dysfunction before alterations in cardiac function induced by short-term high-fat diet in mice.

Sci Rep 2021 Sep 23;11(1):18915. Epub 2021 Sep 23.

Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, ul. Bobrzynskiego 14, 30-348, Kraków, Poland.

Endothelial dysfunction is one of the hallmarks of vascular abnormalities in metabolic diseases and has been repeatedly demonstrated in coronary and peripheral circulation in mice fed high-fat diet (HFD), particularly after long-term HFD. However, the temporal relationship between development of coronary microvascular endothelial dysfunction and deterioration in diastolic and systolic cardiac function after short-term feeding with HFD has not yet been studied. This study aimed to correlate the changes in coronary microvascular endothelial function and global cardiac performance indices in vivo after short-term feeding with HFD in mice. Read More

View Article and Full-Text PDF
September 2021

Acetate rescues defective brain-adipose metabolic network in obese Wistar rats by modulation of peroxisome proliferator-activated receptor-γ.

Sci Rep 2021 Sep 23;11(1):18967. Epub 2021 Sep 23.

Department of Hematology and Virology, University of Medical Science Teaching Hospital Complex, Akure, Nigeria.

We investigated the hypothesis that acetate ameliorates brain-adipose metabolic dysfunction (BAMED) in high fat diet (HFD)-induced obesity, possibly by modulation of peroxisome proliferator-activated receptor-γ (PPAR-γ). Ten-week-old male Wistar rats were randomly assigned into four groups (n = 6/group): Control, acetate and obese with or without acetate groups received vehicle (distilled water; po), acetate (200 mg/kg, po) and 40% HFD with or without acetate respectively. The treatments lasted for 12 weeks. Read More

View Article and Full-Text PDF
September 2021

Berberine is an insulin secretagogue targeting the KCNH6 potassium channel.

Nat Commun 2021 Sep 23;12(1):5616. Epub 2021 Sep 23.

Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, 100730, Beijing, China.

Coptis chinensis is an ancient Chinese herb treating diabetes in China for thousands of years. However, its underlying mechanism remains poorly understood. Here, we report the effects of its main active component, berberine (BBR), on stimulating insulin secretion. Read More

View Article and Full-Text PDF
September 2021

Green light exposure aggravates high-fat diet feeding-induced hepatic steatosis and pancreatic dysfunction in male mice.

Ecotoxicol Environ Saf 2021 Sep 20;225:112802. Epub 2021 Sep 20.

State Key Laboratory of Natural Medicines, School of Life Science and Technology and Experimental Platform for Drug Chronological Intervention and Therapy, China Pharmaceutical University, Nanjing, Jiangsu, China; Key Laboratory of Active Components of Natural Medicine and Drug Release Technology, School of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang, China. Electronic address:

The increased incidence of metabolic syndrome (MetS) has been demonstrated to be closely associated with external environments, such as unhealthy ambient light exposure. Of note, spectral distribution of the light functions as a critical determinant of light's pathophysiological effects. However, the effects of the lighting spectrum on metabolic homeostasis and the specific target organs remain elusive. Read More

View Article and Full-Text PDF
September 2021

Integration of transcriptomics and metabolomics confirmed hepatoprotective effects of steamed shoot extracts of ginseng (Panax ginseng C.A. Meyer) on toxicity caused by overdosed acetaminophen.

Biomed Pharmacother 2021 Sep 20;143:112177. Epub 2021 Sep 20.

National Engineering Laboratory for Tree Breeding, College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, China. Electronic address:

The study aimed, by integrating transcriptomics and metabolomics, to reveal novel biomarkers caused by overdosed acetaminophen (APAP) and liver protection substances procured by pre-administration of ginseng shoots extract (GSE). Totally 4918 genes and 127 metabolites were identified as differentially expressed genes and differential metabolites, respectively. According to KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment, such pathways as primary bile acid biosynthesis, bile secretion, retinol metabolism, histidine and several other amino-related metabolism were significantly altered by GSE and disturbed by subsequent overdosed APAP at the transcriptomic as well as metabolomic levels. Read More

View Article and Full-Text PDF
September 2021

Lipid metabolism dysfunction and toxicity of BDE-47 exposure in white adipose tissue revealed by the integration of lipidomics and metabolomics.

Sci Total Environ 2021 Sep 16;806(Pt 1):150350. Epub 2021 Sep 16.

State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China. Electronic address:

2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) is one of the main and toxic congeners of polybrominated diphenyl ether (PBDE) family and considered to be associated with the development of obesity. However, little is known about its direct metabolic alterations on white adipose tissue (WAT). In this study, we evaluated the impacts of BDE-47 exposure on WAT dysfunctions in mice fed with low-fat diet (LFD) or high-fat diet (HFD) by the integration analysis of mass spectrometry-based metabolomics and lipidomics. Read More

View Article and Full-Text PDF
September 2021

Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function.

J Hepatol 2021 Sep 20. Epub 2021 Sep 20.

University of Lübeck, Institute for Experimental and Clinical Pharmacology and Toxicology, Lübeck, Germany.

Background & Aims: Autophagy-related gene 3 (ATG3) is an enzyme mainly known for its actions in the LC3 lipidation process, which is essential for autophagy. Whether ATG3 plays a role in lipid metabolism or contributes to nonalcoholic fatty liver disease (NAFLD) remains unknown.

Methods: By performing a liver proteomic analysis from mice with genetic manipulation of hepatic p63, a regulator of fatty acid metabolism, we identified ATG3 as a new target downstream of p63. Read More

View Article and Full-Text PDF
September 2021

Skeletal muscle type-specific mitochondrial adaptation to high-fat diet relies on differential autophagy modulation.

FASEB J 2021 Oct;35(10):e21933

Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas y Facultad de Medicina, Universidad de Chile, Santiago, Chile.

In obesity, skeletal muscle mitochondrial activity changes to cope with increased nutrient availability. Autophagy has been proposed as an essential mechanism involved in the regulation of mitochondrial metabolism. Still, the contribution of autophagy to mitochondrial adaptations in skeletal muscle during obesity is unknown. Read More

View Article and Full-Text PDF
October 2021