Arterioscler Thromb Vasc Biol 2021 Apr 1:ATVBAHA121315933. Epub 2021 Apr 1.
Department of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary Cumming School of Medicine, Alberta, Canada (Y.-X.C., C.S., J.D., C.D., N.M., M.R., V.S., A.A.H., S.B., A.A., A.U.-L., B.G., Z.B., E.R.O.).
Objective: Elevated HSP27 (heat shock protein 27) levels predict relative freedom from cardiovascular events. Over-expression or twice daily subcutaneous injections of human HSP27 in mice reduces blood and plaque cholesterol levels, as well as inflammation and atherosclerotic plaque burden. Antibodies to HSP27 are present in human blood, and the purpose of the current studies is to explore their role. Read More