195 results match your criteria dictated fate

Modeling reveals no direct role of the extent of HBV DNA integrations on the outcome of infection.

Ashish Goyal

J Theor Biol 2021 Jun 1;526:110793. Epub 2021 Jun 1.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, United States.

Hepatitis B virus (HBV) with its high prevalence and death toll is one of the most important infectious diseases to study. Yet, there is very little progress in the development of within-host models for HBV, which has subsequently hindered our understanding of this virus. The uncertainty around the proliferation of infected hepatocytes has been studied but never in association with other important biological continuous events such as integrations and superinfections. Read More

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Wnt/ß-catenin-mediated p53 suppression is indispensable for osteogenesis of mesenchymal progenitor cells.

Cell Death Dis 2021 May 21;12(6):521. Epub 2021 May 21.

Division of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

The developmental origins of mesenchymal progenitor cells (MPCs) and molecular machineries regulating their fate and differentiation are far from defined owing to their complexity. Osteoblasts and adipocytes are descended from common MPCs. Their fates are collectively determined by an orchestra of pathways in response to physiological and external cues. Read More

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The transcription factor code: a beacon for histone methyltransferase docking.

Trends Cell Biol 2021 May 17. Epub 2021 May 17.

Center for Genomic Regulation, Barcelona Institute for Science and Technology and Universitat Pompeu Fabra, Barcelona, Spain. Electronic address:

Histone methylation is required for the establishment and maintenance of gene expression patterns that determine cellular identity, and its perturbation often leads to aberrant development and disease. Recruitment of histone methyltransferases (HMTs) to gene regulatory elements (GREs) of developmental genes is important for the correct activation and silencing of these genes, but the drivers of this recruitment are largely unknown. Here we propose that lineage-instructive transcription factors (Lin-TFs) act as general recruiters of HMT complexes to cell type-specific GREs through protein-protein interactions. Read More

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Genetic diversity of the Sudanese: insights on origin and implications for health.

Hum Mol Genet 2021 Apr;30(R1):R37-R41

Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan.

By virtue of their cultural, linguistic and genetic legacies, many populations from Sudan have deep histories in the region and retain high genetic diversities. Sudan's location in north east Africa, a unique spot believed to act as a climatic refuge during periods of climate extremes, might have dictated that fate. Among the marked consequences of this diversity is the potential to provide information on the origin and structure of human populations within and outside the continent, as well as migration patterns towards various parts of the African continent, and out of Africa. Read More

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Inter- and Intra-Annual Bacterioplankton Community Patterns in a Deepwater Sub-Arctic Region: Persistent High Background Abundance of Putative Oil Degraders.

mBio 2021 03 16;12(2). Epub 2021 Mar 16.

School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, United Kingdom

Hydrocarbon-degrading bacteria naturally degrade and remove petroleum pollutants, yet baselines do not currently exist for these critical microorganisms in many regions where the oil and gas industry is active. Furthermore, understanding how a baseline community changes across the seasons and its potential to respond to an oil spill event are prerequisites for predicting their response to elevated hydrocarbon exposures. In this study, 16S rRNA gene-based profiling was used to assess the spatiotemporal variability of baseline bacterioplankton community composition in the Faroe-Shetland Channel (FSC), a deepwater sub-Arctic region where the oil and gas industry has been active for the last 40 years. Read More

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The Failed Clinical Story of Myostatin Inhibitors against Duchenne Muscular Dystrophy: Exploring the Biology behind the Battle.

Cells 2020 12 10;9(12). Epub 2020 Dec 10.

Institute for Health and Sport (IHeS), Victoria University, Melbourne, Victoria 8001, Australia.

Myostatin inhibition therapy has held much promise for the treatment of muscle wasting disorders. This is particularly true for the fatal myopathy, Duchenne Muscular Dystrophy (DMD). Following on from promising pre-clinical data in dystrophin-deficient mice and dogs, several clinical trials were initiated in DMD patients using different modality myostatin inhibition therapies. Read More

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December 2020

Commentary: The fate of patients with left main coronary artery disease may be dictated by distorted science.

Walter J Gomes

J Thorac Cardiovasc Surg 2020 Sep 28. Epub 2020 Sep 28.

Cardiovascular Surgery Discipline, Escola Paulista de Medicina and São Paulo Hospital, Federal University of São Paulo, São Paulo, Brazil. Electronic address:

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September 2020

Rethinking peripheral T cell tolerance: checkpoints across a T cell's journey.

Nat Rev Immunol 2021 04 19;21(4):257-267. Epub 2020 Oct 19.

Department of Microbiology and Immunology, Geisel School of Medicine, Norris Cotton Cancer Center, Dartmouth College, Hanover, NH, USA.

Following their exit from the thymus, T cells are endowed with potent effector functions but must spare host tissue from harm. The fate of these cells is dictated by a series of checkpoints that regulate the quality and magnitude of T cell-mediated immunity, known as tolerance checkpoints. In this Perspective, we discuss the mediators and networks that control the six main peripheral tolerance checkpoints throughout the life of a T cell: quiescence, ignorance, anergy, exhaustion, senescence and death. Read More

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Cell fate specification and differentiation in the adult mammalian intestine.

Nat Rev Mol Cell Biol 2021 01 21;22(1):39-53. Epub 2020 Sep 21.

Oncode Institute, Utrecht, Netherlands.

Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of nutrients while acting as a barrier for hostile luminal contents. Recent discoveries have revealed that the lineage plasticity of committed cells - combined with redundant sources of niche signals - enables the epithelium to efficiently repair tissue damage. Read More

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January 2021

Regulation of Germ Cell mRNPs by eIF4E:4EIP Complexes: Multiple Mechanisms, One Goal.

Front Cell Dev Biol 2020 7;8:562. Epub 2020 Jul 7.

Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.

Translational regulation of mRNAs is critically important for proper gene expression in germ cells, gametes, and embryos. The ability of the nucleus to control gene expression in these systems may be limited due to spatial or temporal constraints, as well as the breadth of gene products they express to prepare for the rapid animal development that follows. During development germ granules are hubs of post-transcriptional regulation of mRNAs. Read More

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The conserved AAA-ATPase PCH-2 regulates spindle checkpoint strength.

Mol Biol Cell 2020 09 22;31(20):2219-2233. Epub 2020 Jul 22.

Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064.

Spindle checkpoint strength is dictated by the number of unattached kinetochores, cell volume, and cell fate. We show that the conserved AAA-ATPase PCH-2/TRIP13, which remodels the checkpoint effector Mad2 from an active conformation to an inactive one, controls checkpoint strength in . Having previously established that this function is required for spindle checkpoint activation, we demonstrate that in cells genetically manipulated to decrease in cell volume, PCH-2 is no longer required for the spindle checkpoint or recruitment of Mad2 at unattached kinetochores. Read More

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September 2020

DNA Damage- But Not Enzalutamide-Induced Senescence in Prostate Cancer Promotes Senolytic Bcl-xL Inhibitor Sensitivity.

Cells 2020 07 1;9(7). Epub 2020 Jul 1.

Francis Rodier Lab, Institut du Cancer de Montréal, Centre de Recherche du Centre Hospitalier de L'université de Montréal (CRCHUM), Montreal, QC H2X 0A9, Canada.

Cellular senescence is a natural tumor suppression mechanism defined by a stable proliferation arrest. In the context of cancer treatment, cancer cell therapy-induced senescence (TIS) is emerging as an omnipresent cell fate decision that can be pharmacologically targeted at the molecular level to enhance the beneficial aspects of senescence. In prostate cancer (PCa), TIS has been reported using multiple different model systems, and a more systematic analysis would be useful to identify relevant senescence manipulation molecular targets. Read More

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Extracellular Vesicles in the Tumor Microenvironment: Various Implications in Tumor Progression.

Adv Exp Med Biol 2020 ;1259:155-170

Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.

Extracellular vesicle (EV) shedding is a biologically conserved cellular process across virtually every cell type. In cancer, EVs shed from tumor and stromal cells to the tumor microenvironment play a major role in determining tumor fate, which to a large extent is dictated by the biologically active cargo contained in EVs. Current understanding of various cancer-associated EVs has enabled the outlining of mechanistic connections between cargo and tumor-promoting functions. Read More

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Fueling influenza and the immune response: Implications for metabolic reprogramming during influenza infection and immunometabolism.

Immunol Rev 2020 05;295(1):140-166

Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA.

Recent studies support the notion that glycolysis and oxidative phosphorylation are rheostats in immune cells whose bioenergetics have functional outputs in terms of their biology. Specific intrinsic and extrinsic molecular factors function as molecular potentiometers to adjust and control glycolytic to respiratory power output. In many cases, these potentiometers are used by influenza viruses and immune cells to support pathogenesis and the host immune response, respectively. Read More

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Defining the Design Principles of Skin Epidermis Postnatal Growth.

Cell 2020 04 6;181(3):604-620.e22. Epub 2020 Apr 6.

Université Libre de Bruxelles, Laboratory of Stem Cells and Cancer, Brussels 1070, Belgium; WELBIO, Université Libre de Bruxelles, Brussels 1070, Belgium. Electronic address:

During embryonic and postnatal development, organs and tissues grow steadily to achieve their final size at the end of puberty. However, little is known about the cellular dynamics that mediate postnatal growth. By combining in vivo clonal lineage tracing, proliferation kinetics, single-cell transcriptomics, and in vitro micro-pattern experiments, we resolved the cellular dynamics taking place during postnatal skin epidermis expansion. Read More

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Nanotechnology in agriculture: Current status, challenges and future opportunities.

Sci Total Environ 2020 Jun 6;721:137778. Epub 2020 Mar 6.

Institute of Soil and Environmental Sciences, University of Agriculture, Faisalabad 38040, Pakistan.

Nanotechnology has shown promising potential to promote sustainable agriculture. This article reviews the recent developments on applications of nanotechnology in agriculture including crop production and protection with emphasis on nanofertilizers, nanopesticides, nanobiosensors and nano-enabled remediation strategies for contaminated soils. Nanomaterials play an important role regarding the fate, mobility and toxicity of soil pollutants and are essential part of different biotic and abiotic remediation strategies. Read More

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Zipcode Binding Protein 1 (ZBP1; IGF2BP1): A Model for Sequence-Specific RNA Regulation.

Cold Spring Harb Symp Quant Biol 2019 21;84:1-10. Epub 2020 Feb 21.

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

The fate of an RNA, from its localization, translation, and ultimate decay, is dictated by interactions with RNA binding proteins (RBPs). β-actin mRNA has functioned as the classic example of RNA localization in eukaryotic cells. Studies of β-actin mRNA over the past three decades have allowed understanding of how RBPs, such as ZBP1 (IGF2BP1), can control both RNA localization and translational status. Read More

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February 2020

Occurrence and fate of antimony in plastics.

J Hazard Mater 2020 05 29;390:121764. Epub 2019 Nov 29.

School of Geography, Earth and Environmental Sciences, Plymouth University, Drake Circus, Plymouth, PL4 8AA, UK.

Antimony (Sb) is a technology critical element whose presence is ubiquitous in manufactured products, and in particular in plastics where it is used extensively as a flame retardant synergist for brominated compounds, as a catalyst for polyethylene terephthalate production, and as a pigment for colour. This study reviews the usage, regulations and fate of Sb in plastics by examining primary data on its production, applications, contents in and migration from manufactured objects, and presence in and release from waste, including the disposal and recycling routes for this material (i.e. Read More

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Metabolites Interrogation in Cell Fate Decision of Cultured Human Corneal Endothelial Cells.

Invest Ophthalmol Vis Sci 2020 02;61(2):10


Purpose: Aiming to clarify the metabolic interrogation in cell fate decision of cultured human corneal endothelial cells (cHCECs).

Methods: To analyze the metabolites in the culture supernatants (CS), 34 metabolome measurements were carried out for mature differentiated and a variety of cHCECs with cell state transition through a facility service. Integrated proteomics research for cell lysates by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was performed for 3 aliquots of each high-quality or low-quality cHCEC subpopulations (SP). Read More

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February 2020

The Target of Exuberant Projections in Development.

Cereb Cortex 2020 05;30(6):3820-3826

Department of Neuroscience Karolinska Institutet, Stockholm, Sweden and Signal Processing Laboratory (LT55) Ecole Polytechnique Féderale de Lausanne (EPFL), Lausanne, Switzerland.

In addition to neuronal death and elimination of synapses, the production of transient, exuberant axons, and axonal branches is a general phenomenon in development across species and systems. To understand what drives the decision of which axons are maintained and which are eliminated, it is important to monitor the interaction of juvenile axons at their target. As old and more recent work show, unlike what is claimed by Ribeiro Gomez et al. Read More

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Deciphering Role of Wnt Signalling in Cardiac Mesoderm and Cardiomyocyte Differentiation from Human iPSCs: Four-dimensional control of Wnt pathway for hiPSC-CMs differentiation.

Sci Rep 2019 12 18;9(1):19389. Epub 2019 Dec 18.

Department of Biomedical Engineering, School of Medicine, School of Engineering, University of Alabama at Birmingham, Birmingham, AL35233, USA.

Differentiation of cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) is critically dependent upon the regulation of the Wnt signaling pathway. The mechanisms remain unclear with regard to the dose and timing of each differentiation inducer, and the interaction of the inducers that regulate the Wnt in mesendoderm specification to cardiac mesoderm. Consequently, it remains far from optimal in differentiation efficiency and consistency from hiPSC lines to CMs. Read More

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December 2019

Cellular responses to beating hydrogels to investigate mechanotransduction.

Nat Commun 2019 09 6;10(1):4027. Epub 2019 Sep 6.

DWI - Leibniz-Institut für Interaktive Materialien e.V, Forckenbeckstr. 50, Aachen, 52074, Germany.

Cells feel the forces exerted on them by the surrounding extracellular matrix (ECM) environment and respond to them. While many cell fate processes are dictated by these forces, which are highly synchronized in space and time, abnormal force transduction is implicated in the progression of many diseases (muscular dystrophy, cancer). However, material platforms that enable transient, cyclic forces in vitro to recreate an in vivo-like scenario remain a challenge. Read More

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September 2019

Expression of GnRH receptor and 3βHSD during meiosis and foliculogénesis in Columba livia (Aves: Columbiformes): Histological and immunohistochemical analysis.

Gen Comp Endocrinol 2020 01 23;285:113230. Epub 2019 Jul 23.

Universidad de Buenos Aires, Facultad de Cs Veterinarias, Instituto de Investigación y Tecnología en Reproducción Animal (INITRA), Argentina. Electronic address:

During the ovarian ontogeny in birds, five fundamental events can be recognized: migration and colonization of the primordial germ cells, differentiation and proliferation of oogonies, an organization of germinal nests, beginning of the meiotic process and folliculogenesis. The knowledge of these events is fundamental for the interpretation of the processes involved in the differentiation of female gametes. However, there are only references for some model species such as Gallus gallus domesticus and Coturnix coturnix. Read More

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January 2020

Enzymatic Logic of Ubiquitin Chain Assembly.

Front Physiol 2019 5;10:835. Epub 2019 Jul 5.

Department of Chemistry, University of Massachusetts, Amherst, MA, United States.

Protein ubiquitination impacts virtually every biochemical pathway in eukaryotic cells. The fate of a ubiquitinated protein is largely dictated by the type of ubiquitin modification with which it is decorated, including a large variety of polymeric chains. As a result, there have been intense efforts over the last two decades to dissect the molecular details underlying the synthesis of ubiquitin chains by ubiquitin-conjugating (E2) enzymes and ubiquitin ligases (E3s). Read More

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Compartmentalization of dendritic cell and T-cell interactions in the lymph node: Anatomy of T-cell fate decisions.

Immunol Rev 2019 05;289(1):84-100

Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama.

Upon receiving cognate and co-stimulatory priming signals from antigen (Ag)-presenting dendritic cells (DCs) in secondary lymphoid tissues, naïve CD4 T cells differentiate into distinct effector and memory populations. These alternate cell fate decisions, which ultimately control the T-cell functional attributes, are dictated by programming signals provided by Ag-bearing DCs and by other cells that are present in the microenvironment in which T-cell priming occurs. We know that DCs can be subdivided into multiple populations and that the various DC subsets exhibit differential capacities to initiate development of the different CD4 T-helper populations. Read More

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Chance and pleiotropy dominate genetic diversity in complex bacterial environments.

Nat Microbiol 2019 07 1;4(7):1221-1230. Epub 2019 Apr 1.

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.

How does environmental complexity affect the evolution of single genes? Here, we measured the effects of a set of Bacillus subtilis glutamate dehydrogenase mutants across 19 different environments-from phenotypically homogeneous single-cell populations in liquid media to heterogeneous biofilms, plant roots and soil populations. The effects of individual gene mutations on organismal fitness were highly reproducible in liquid cultures. However, 84% of the tested alleles showed opposing fitness effects under different growth conditions (sign environmental pleiotropy). Read More

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Function without Structures: The Need for In-Depth Analysis of Dietary Carbohydrates.

J Agric Food Chem 2019 Apr 10;67(16):4418-4424. Epub 2019 Apr 10.

Carbohydrates make up the largest component of plant-based foods and have long been known to provide fuel. However, many carbohydrates possess intrinsic biological activities that are dictated by their structures. Carbohydrates are the most abundant biopolymers in nature and are also the most structurally complicated and diverse. Read More

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Substrate mechanics controls adipogenesis through YAP phosphorylation by dictating cell spreading.

Biomaterials 2019 06 16;205:64-80. Epub 2019 Mar 16.

International Clinical Research Center (FNUSA-ICRC), St. Anne's University Hospital, Brno, Czech Republic; Competence Center for Mechanobiology in Regenerative Medicine, INTERREG ATCZ133, Brno, Czech Republic; Department of Biomaterials Science, Institute of Dentistry, University of Turku, Turku, Finland. Electronic address:

The mechanoregulated proteins YAP/TAZ are involved in the adipogenic/osteogenic switch of mesenchymal stem cells (MSCs). MSC fate decision can be unbalanced by controlling substrate mechanics, in turn altering the transmission of tension through cell cytoskeleton. MSCs have been proposed for orthopedic and reconstructive surgery applications. Read More

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Complete photodissociation dynamics of CFI in solution.

Phys Chem Chem Phys 2019 Mar;21(13):6859-6867

Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241, Korea.

Photodissociation dynamics of CF2I2 in cyclohexane were evaluated by probing the C-F stretching mode over a wide time range after ultraviolet excitation using femtosecond infrared spectroscopy. After the ultrafast (<0.2 ps) state-selective photodissociation of CF2I2 as in the gas phase (267 nm excitation led to exclusive three-body dissociation (CF2 + I + I), 350 nm to exclusive two-body dissociation (CF2I + I), and 310 nm to a mixture of three- and two-body dissociations), various secondary reactions were observed. Read More

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Germinal center B cell initiation, GC maturation, and the coevolution of its stromal cell niches.

Immunol Rev 2019 03;288(1):10-27

Department of Microbiology and Immunology, Western University, London, ON, Canada.

Throughout the developing GC response, B cell survival and fate choices made at the single cell level are dependent on signals received largely through interactions with other cells, often with cognate T cells. The type of signals that a given B cell can encounter is dictated by its location within tissue microarchitecture. The focus of this review is on the initiation and evolution of the GC response at the earliest time points. Read More

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